Effect of a gonadotropin releasing hormone analog on an experimental ovarian tumor: Direct and indirect actions
An ovary autotransplanted into the spleen of a bilaterally ovariectomized rat develops into a luteoma, which grows under constant gonadotropin hyperstimulation. The effect of a long-acting GnRH agonist (GnRH-a), on tumor growth and hormone secretion was investigated. Two experimental models were use...
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1995
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| LEADER | 08965caa a22013097a 4500 | ||
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| 001 | PAPER-18982 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205020.0 | ||
| 008 | 190411s1995 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0029071792 | |
| 024 | 7 | |2 cas |a Estradiol, 50-28-2; Follicle Stimulating Hormone, 9002-68-0; Gonadorelin, 33515-09-2; Luteinizing Hormone, 9002-67-9; Progesterone, 57-83-0 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a LIFSA | ||
| 100 | 1 | |a Lux-Lantos, V.A.R. | |
| 245 | 1 | 0 | |a Effect of a gonadotropin releasing hormone analog on an experimental ovarian tumor: Direct and indirect actions |
| 260 | |c 1995 | ||
| 270 | 1 | 0 | |m Lux-Lantos, V.A.R.; Laboratorio de Neuroendocrinología, Instituto de Biología y Medicina Experimental (CONICET), V. de Obligado 2490, 1428 Buenos Aires, Argentina |
| 506 | |2 openaire |e Política editorial | ||
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| 504 | |a Mortel, Satyaswaroop, Schally, Hamilton, Ozols, Inhibitory effect of GnRH superagonist on the growth of human ovarian carcinoma NIH: OVCAR 3 in the nude mouse (1986) Gynecologic Oncology, 23, pp. 254-255 | ||
| 504 | |a Yano, Pinsky, Halmos, Szepeshazi, Groot, Schally, (1994) Proc. Natl. Acad. Sci. USA, 91, pp. 7090-7094. , 11th ed | ||
| 504 | |a Kullander, Rausing, Schally, (1987) Hormonal manipulation of cancer:peptides, growth factors and new (anti) steroidal agents, pp. 353-356. , J.G.M Klijn, Raven Press, New York | ||
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| 504 | |a Bruckner, Motwani, Treatment of advanced refractory ovarian carcinoma with a gonadotropin-releasing hormone analogue (1989) American Journal of Obstetrics and Gynecology, 161, p. 1219 | ||
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| 520 | 3 | |a An ovary autotransplanted into the spleen of a bilaterally ovariectomized rat develops into a luteoma, which grows under constant gonadotropin hyperstimulation. The effect of a long-acting GnRH agonist (GnRH-a), on tumor growth and hormone secretion was investigated. Two experimental models were used: Model 1: GnRH-a (0.33 mg/rat sc) or estradiol valenanate (50 μg/rat sc injected once a week for four weeks) was administered simultaneously with ovary implantation; Model 2: the drugs were administered after 1 month of tumor development. The treatment with estradiol was used as a control of tumor regression. Saline injected ovarian grafted rats and Sham operated animals were used as controls. In Model 1: The GnRH-a significantly inhibited tumor development (Positive tumors: Saline: 100% vs GnRH-a: 43%, p < 0.01). In Model 2: the GnRH-a and estradiol significantly reduced the volume of one month old tumors (52% and 39% of initial volumes respectively, p < 0.01). Gonadotropin secretion was significantly inhibited or its increase blunted by the GnRH-a and by estradiol treatments in both models. Estradiol and progesterone in portal blood, which collects the steroids secreted by the luteoma, were significantly reduced by GnRH-a treatment in both models. On the other hand, in tumor cells cultured "in vitro", the GnRH-a was able to inhibit the LH induced progesterone secretion in a concentration dependent way. These results clearly show that the GnRH-a is effective in inhibiting tumor growth or reducing its volume, when already developed; furthermore, it suppresses tumor steroid hormone production. These actions were exerted at both the hypophyseal and tumor levels. © 1995. |l eng | |
| 593 | |a Laboratorio de Neuroendocrinología, Instituto de Biología y Medicina Experimental (CONICET), V. de Obligado 2490, 1428 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a GONADOTROPIN RELEASING HORMONE ANALOG |
| 690 | 1 | 0 | |a LUTEOMA |
| 690 | 1 | 0 | |a TUMOR GROWTH |
| 690 | 1 | 0 | |a BUSERELIN |
| 690 | 1 | 0 | |a ESTRADIOL |
| 690 | 1 | 0 | |a ESTRADIOL VALERATE |
| 690 | 1 | 0 | |a FOLLITROPIN |
| 690 | 1 | 0 | |a GONADORELIN AGONIST |
| 690 | 1 | 0 | |a GONADOTROPIN |
| 690 | 1 | 0 | |a LUTEINIZING HORMONE |
| 690 | 1 | 0 | |a PROGESTERONE |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ANIMAL MODEL |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a AUTOTRANSPLANTATION |
| 690 | 1 | 0 | |a CANCER CELL CULTURE |
| 690 | 1 | 0 | |a CANCER GRAFT |
| 690 | 1 | 0 | |a CANCER INHIBITION |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a HORMONE BLOOD LEVEL |
| 690 | 1 | 0 | |a HORMONE RELEASE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a OVARIECTOMY |
| 690 | 1 | 0 | |a OVARY TUMOR |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a SPLEEN |
| 690 | 1 | 0 | |a SUBCUTANEOUS DRUG ADMINISTRATION |
| 690 | 1 | 0 | |a TUMOR GROWTH |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a ESTRADIOL |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a FOLLICLE STIMULATING HORMONE |
| 690 | 1 | 0 | |a GONADORELIN |
| 690 | 1 | 0 | |a LUTEINIZING HORMONE |
| 690 | 1 | 0 | |a LUTEOMA |
| 690 | 1 | 0 | |a OVARIAN NEOPLASMS |
| 690 | 1 | 0 | |a PROGESTERONE |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a RATS, SPRAGUE-DAWLEY |
| 690 | 1 | 0 | |a SUPPORT, NON-U.S. GOV'T |
| 690 | 1 | 0 | |a TUMOR CELLS, CULTURED |
| 690 | 1 | 0 | |a ANIMALIA |
| 653 | 0 | 0 | |a buserelin, hoechst, Argentina |
| 700 | 1 | |a Thyssen, S.M. | |
| 700 | 1 | |a Chamson, A. | |
| 700 | 1 | |a Libertun, C. | |
| 773 | 0 | |d 1995 |g v. 57 |h pp. 291-300 |k n. 3 |p Life Sci. |x 00243205 |w (AR-BaUEN)CENRE-749 |t Life Sciences | |
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| 856 | 4 | 0 | |u https://doi.org/10.1016/0024-3205(95)00272-8 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_00243205_v57_n3_p291_LuxLantos |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00243205_v57_n3_p291_LuxLantos |y Registro en la Biblioteca Digital |
| 961 | |a paper_00243205_v57_n3_p291_LuxLantos |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||