A double-blind placebo-controlled study of clomipramine in depressed patients with Alzheimer's disease
Twenty-one depressed patients with probable Alzheimer's disease (AD) were randomized to receive a 6-week treatment with clomipramine or placebo in a study with a double-blind crossover design. Main outcome measures were Hamilton Depression, Mini-Mental State (MMSE), and Functional Independence...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
American Psychiatric Association
1996
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 08274caa a22010577a 4500 | ||
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| 001 | PAPER-18935 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205017.0 | ||
| 008 | 190411s1996 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0029833194 | |
| 024 | 7 | |2 cas |a clomipramine, 17321-77-6, 303-49-1 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a JNCNE | ||
| 100 | 1 | |a Petracca, G. | |
| 245 | 1 | 2 | |a A double-blind placebo-controlled study of clomipramine in depressed patients with Alzheimer's disease |
| 260 | |b American Psychiatric Association |c 1996 | ||
| 270 | 1 | 0 | |m Starkstein, S.E.; Inst. Investigaciones Neurologicas, Montaneses 2325, 1428 Buenos Aires, Argentina |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Loreck, D.J., Folstein, M.F., Depression in Alzheimer's disease (1993) Depression in Neurologic Disease, pp. 50-62. , edited by Starkstein SE, Robinson RG. Baltimore, Johns Hopkins University Press | ||
| 504 | |a Migliorelli, R., Teson, A., Sabe, L., Prevalence and correlates of dysthymia and major depression in Alzheimer's disease (1994) Am J Psychiatry, 152, pp. 37-44 | ||
| 504 | |a Reisberg, B., Gordon, B., McCarthy, M., Insight and denial accompanying progressive cognitive decline in normal aging and Alzheimer's disease (1985) Geriatric Psychiatry: Ethical and Legal Issues, pp. 37-79. , edited by Stanley B. Washington, DC, American Psychiatric Press | ||
| 504 | |a Zweig, R.M., Ross, C.A., Hedreen, J.C., The neuropathology of aminergic nuclei in Alzheimer's disease (1988) Ann Neurol, 24, pp. 233-242 | ||
| 504 | |a Zubenko, G.S., Moosy, J., Major depression in primary dementia: Clinical and neuropathologic correlates (1988) Arch Neurol, 45, pp. 1182-1186 | ||
| 504 | |a Förstl, H., Burns, A., Luthert, P., Clinical and neuropathological correlates of depression in Alzheimer's disease (1992) Psychol Med, 22, pp. 877-884 | ||
| 504 | |a Zubenko, G.S., Moosy, J., Kopp, U., Neurochemical correlates of major depression in primary dementia (1990) Arch Neurol, 47, pp. 209-214 | ||
| 504 | |a Ashford, J.W., Ford, C.V., Use of MAO inhibitors in elderly patients (1979) Am J Psychiatry, 136, pp. 1466-1467 | ||
| 504 | |a Jenike, M.A., Monoamine oxidase inhibitors as treatment for depressed patients with primary degenerative dementia (Alzheimer's disease) (1985) Am J Psychiatry, 142, pp. 763-764 | ||
| 504 | |a Reding, M.J., Young, R., DiPonte, P., Amitriptyline in Alzheimer's disease (1983) Neurology, 33, p. 522 | ||
| 504 | |a Reynolds, C.F., Perel, J.M., Kupfer, D.J., Open-trial response to antidepressant treatment in elderly patients with mixed depression and cognitive impairment (1987) Psychiatry Res, 21, pp. 111-122 | ||
| 504 | |a Reifler, B.V., Teri, L., Raskind, M., Double-blind trial of imipramine in Alzheimer's disease in patients with and without depression (1989) Am J Psychiatry, 146, pp. 45-49 | ||
| 504 | |a Meltzer, H.Y., (1987) Psychopharmacology: The Third Generation of Progress, , New York, Raven | ||
| 504 | |a McKhann, G., Drachman, D., Folstein, M.F., Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease (1984) Neurology, 34, pp. 939-944 | ||
| 504 | |a Hachinski, V.C., Iliff, L.D., Zilhka, L., Cerebral blood flow in dementia (1975) Arch Neurol, 40, pp. 97-103 | ||
| 504 | |a (1987) Diagnostic and Statistical Manual of Mental Disorders, 3rd Edition, Revised, , Washington, DC, American Psychiatric Press | ||
| 504 | |a Hamilton, M.A., A rating scale for depression (1960) J Neurol Neurosurg Psychiatry, 23, pp. 56-62 | ||
| 504 | |a Folstein, M.F., Folstein, S.E., McHugh, P.R., "Mini-Mental State": A practical method for grading the cognitive state of patients for the clinician (1975) J Psychiatr Res, 12, pp. 189-198 | ||
| 504 | |a Spitzer, R.L., Williams, J.B.W., Gibbon, M., The structured clinical interview for DSM-III-R (SCID), I: History, rationale, and description (1992) Arch Gen Psychiatry, 49, pp. 624-629 | ||
| 504 | |a Granger, C.V., Hamilton, B.B., Kayton, R., (1986) Guide for Use of the Uniform Data Set for Medical Rehabilitation, , Buffalo, NY, Uniform Data System for Medical Rehabilitation | ||
| 504 | |a Marin, D.B., Kocsis, J.H., Frances, A.J., Desipramine for the treatment of "pure" dysthymia versus "double" depression (1994) Am J Psychiatry, 151, pp. 1079-1080 | ||
| 504 | |a Pollock, B.G., Prel, J.M., Kupfer, D.J., Early response patterns associated with successful clomipramine treatment (1993) J Clin Psychopharmacol, 13, pp. 442-447 | ||
| 504 | |a Gearing, M., Mirra, S.S., Hedreen, J.C., The Consortium to Establish a Registry for Alzheimer's Disease (CERAD), part X: Neuropathology confirmation of the clinical diagnosis of Alzheimer's disease (1995) Neurology, 45, pp. 461-466 | ||
| 504 | |a Gottfries, C.G., Nyth, A.L., Effect of citalopram, a selective 5-HT reuptake blocker, in emotionally disturbed patients with dementia (1991) Ann NY Acad Sci, 640, pp. 276-279 | ||
| 504 | |a Teri, L., Reifler, B.V., Veith, R.C., Imipramine in the treatment of depressed Alzheimer's patients: Impact on cognition (1991) J Gerontol, 46, pp. 372-377 | ||
| 520 | 3 | |a Twenty-one depressed patients with probable Alzheimer's disease (AD) were randomized to receive a 6-week treatment with clomipramine or placebo in a study with a double-blind crossover design. Main outcome measures were Hamilton Depression, Mini-Mental State (MMSE), and Functional Independence Measure (FIM) scores. Mood improved significantly on both clomipramine and placebo, but clomipramine was significantly more effective than placebo during the first 6-week treatment period. Patients started on clomipramine maintained improvement during the washout and placebo periods, whereas patients started on placebo worsened during the washout period. However, patients on clomipramine showed significantly lower MMSE scores overall than patients on placebo. No significant drug effects were found on FIM scores. Clomipramine proved to be a useful treatment of depression in patients with probable AD. |l eng | |
| 593 | |a Department of Neuropsychiatry, Raul Carrea Inst. of Neurol. Res., Buenos Aires, Argentina | ||
| 593 | |a Inst. Invest. Neurologicas Raul C., Montañeses 2325, 1428 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a CLOMIPRAMINE |
| 690 | 1 | 0 | |a TRICYCLIC ANTIDEPRESSANT AGENT |
| 690 | 1 | 0 | |a ADULT |
| 690 | 1 | 0 | |a AGED |
| 690 | 1 | 0 | |a ALZHEIMER DISEASE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CLINICAL ARTICLE |
| 690 | 1 | 0 | |a CLINICAL TRIAL |
| 690 | 1 | 0 | |a CONFUSION |
| 690 | 1 | 0 | |a CONSTIPATION |
| 690 | 1 | 0 | |a CONTROLLED CLINICAL TRIAL |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a CROSSOVER PROCEDURE |
| 690 | 1 | 0 | |a DEPRESSION |
| 690 | 1 | 0 | |a DOUBLE BLIND PROCEDURE |
| 690 | 1 | 0 | |a DRUG EFFICACY |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a FUNCTIONAL ASSESSMENT |
| 690 | 1 | 0 | |a HAMILTON SCALE |
| 690 | 1 | 0 | |a HEADACHE |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MOOD |
| 690 | 1 | 0 | |a NAUSEA |
| 690 | 1 | 0 | |a ORAL DRUG ADMINISTRATION |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a RANDOMIZED CONTROLLED TRIAL |
| 690 | 1 | 0 | |a SLEEP DISORDER |
| 690 | 1 | 0 | |a STOMACH PAIN |
| 690 | 1 | 0 | |a TIME |
| 690 | 1 | 0 | |a TREATMENT OUTCOME |
| 690 | 1 | 0 | |a TREMOR |
| 690 | 1 | 0 | |a VERTIGO |
| 700 | 1 | |a Tesón, A. | |
| 700 | 1 | |a Chemerinski, E. | |
| 700 | 1 | |a Leiguarda, R. | |
| 700 | 1 | |a Starkstein, S.E. | |
| 773 | 0 | |d American Psychiatric Association, 1996 |g v. 8 |h pp. 270-275 |k n. 3 |p J. NEUROPSYCHIATRY CLIN. NEUROSCI. |x 08950172 |t Journal of Neuropsychiatry and Clinical Neurosciences | |
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