α-Difluoromethylornithine modifies FSH secretion and puberty onset in the female rat (43954)
FSH secretion is high in immature female rats from Postnatal Day 5 to 18 and decreases thereafter. This is a relatively steroid-independent event of cerebral origin and of importance for puberty onset. Polyamines, a group of ubiquitous amines, play an essential role in tissue growth and differentiat...
Guardado en:
| Autor principal: | |
|---|---|
| Otros Autores: | |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
1996
|
| Acceso en línea: | Registro en Scopus Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 10745caa a22009617a 4500 | ||
|---|---|---|---|
| 001 | PAPER-18915 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205016.0 | ||
| 008 | 190411s1996 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0029671347 | |
| 024 | 7 | |2 cas |a Eflornithine, 70052-12-9; Enzyme Inhibitors; Follicle Stimulating Hormone, 9002-68-0; Ornithine Decarboxylase, EC 4.1.1.17; Prolactin, 9002-62-4 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a EBMMB | ||
| 100 | 1 | |a Thyssen, S.M. | |
| 245 | 1 | 0 | |a α-Difluoromethylornithine modifies FSH secretion and puberty onset in the female rat (43954) |
| 260 | |c 1996 | ||
| 270 | 1 | 0 | |m Libertun, C.; Lab. de Neuroendocrinología, Inst. de Biol. y Med. Experimental, V Obligado 2490, 1428 Buenos Aires, Argentina |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Becu-Villalobos, D., Lacau-Mengido, I.M., Libertun, C., Ontogenic studies of the neural control of the adenohypophyseal hormones in the rat: Gonadotropins (1990) Cell Mol Neurobiol, 10, pp. 473-484 | ||
| 504 | |a Becu-Villalobos, D., Lacau-Mengido, I.M., Diaz-Torga, G., Libertun, C., Ontogenic studies of the neural control of adenohypophyseal hormones in the rat: Prolactin (1992) Cell Mol Neurobiol, 12, pp. 1-19 | ||
| 504 | |a Lacau De Mengido, I.M., Becu-Villalobos, D., Diaz, G., Libertun, C., Chronic activation of dopamine receptors in the female infantile rat: Effect on hypophyseal hormones and on the onset of puberty (1989) Endocrinology, 124, pp. 746-753 | ||
| 504 | |a Hage, A.J., Groen-Klevant, A.C., Welschen, R., Follicle growth in the immature rat ovary (1978) Acta Endocrinol, 88, pp. 375-382 | ||
| 504 | |a Schwartz, N.B., The role of FSH and LH and of their antibodies on follicle growth and on ovulation (1974) Biol Reprod, 10, pp. 236-272 | ||
| 504 | |a Ojeda, S.R., Urbanski, H.F., Puberty in the rat (1994) The Physiology of Reproduction, p. 363. , Knobil E, Neill J, Eds. New York: Raven Press | ||
| 504 | |a Becu-Villalobos, D., Lacau De Mengido, I.M., Libertun, C., Developmental changes in FSH secretion induced by 5-hydroxytryptophan, naloxone and haloperidol in male and female rats (1989) Dev Brain Res, 47, pp. 181-186 | ||
| 504 | |a Becu-Villalobos, D., Lacau-Mengido, I.M., Libertun, C., Sexual differentiation of the brain is involved in 5-hydroxytryptophan-and naloxone-induced FSH release in the infantile rat (1990) Neuroendocrinol Lett, 12, pp. 435-442 | ||
| 504 | |a Dohler, K.D., Wuttke, W., Serum LH, FSH, prolactin and progesterone from birth to puberty in female and male rats (1974) Endocrinology, 94, pp. 1003-1008 | ||
| 504 | |a Van Den Dungen, H.M., Van Dieten, J.A.M.J., Tilders, F.J.H., Van Rees, G.P., Schoemaker, J., Administration of a GnRH-antagonist to immature rats affects subsequent female and male pubertal development differently (1989) Acta Endocrinol, 120, pp. 778-784 | ||
| 504 | |a Wray, S., Gainer, H., Effect of neonatal gonadectomy on postnatal development in rat LHRH cell subtypes in male and female rats (1987) Neuroendocrinology, 45, pp. 413-419 | ||
| 504 | |a Lamberts, S.W.J., MacLeod, R.M., Regulation of prolactin secretion at the level of the lactotroph (1990) Physiol Rev, 70, pp. 279-318 | ||
| 504 | |a Slotkin, T.A., Bartolome, J., Role of ornithine decarboxylase and the polyamines in nervous system development: A review (1986) Brain Res Bull, 17, pp. 307-320 | ||
| 504 | |a Gilad, G.M., Dornay, M., Gilad, V.H., Polyamines induce precocious development in rats. Possible interaction with growth factors (1989) Int J Devel Neurosci, 7, pp. 641-653 | ||
| 504 | |a Khan, N.A., Quemener, V., Moulinoux, J.-P.H., Polyamine membrane transport regulation (1991) Cell Biol Int Reports, 15, pp. 9-24 | ||
| 504 | |a Scalabrino, G., Lorenzini, E.C., Ferioli, M.E., Polyamines and mammalian hormones. Part I: Biosynthesis, interconversion and hormone effects (1991) Mol Cell Endocrinol, 77, pp. 1-35 | ||
| 504 | |a Scalabrino, G., Lorenzini, E.C., Polyamines and mammalian hormones. Part II: Paracrine signals and intracellular regulators (1991) Mol Cell Endocrinol, 77, pp. 37-56 | ||
| 504 | |a Slotkin, T.A., Seidler, F.J., Trepanier, P.A., Whitmore, W.L., Lerea, L., Barnes, G.A., Weigel, S.J., Bartolome, J., Ornithine decarboxylase and polyamines in tissues of the neonatal rat: Effects of α-difluoromethylornithine, a specific, irreversible inhibitor of ornithine decarboxylase (1982) J Pharmacol Exp Ther, 222, pp. 741-745 | ||
| 504 | |a Najm, I., Vanderklish, P., Lynch, G., Baudry, M., Effect of treatment with difluoromethylornithine on polyamine and spectrin breakdown levels in neonatal rat brain (1991) Dev Brain Res, 63, pp. 287-289 | ||
| 504 | |a Bartolome, J.V., Schweitzer, L., Slotkin, T.A., Nadler, J.V., Impaired development of cerebellar cortex in rats treated postnatally with α-difluoromethylornithine (1985) Neuroscience, 15, pp. 203-213 | ||
| 504 | |a Slotkin, T.A., Grignolo, A., Whitmore, W.L., Lerea, L., Trepanier, P.A., Barnes, G.A., Weigel, S.J., Bartolome, J., Impaired development of central and peripheral catecholamine neurotransmitter systems in preweanling rats treated with α-difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase (1982) J Pharmacol Exp Ther, 222, pp. 746-751 | ||
| 504 | |a White, W.F., Cohen, A.I., Rippel, R.H., Story, J.C., Schally, A.V., Some hypothalamic polyamines that deplete pituitary follicle stimulating hormone (1968) Endocrinology, 82, pp. 742-752 | ||
| 504 | |a Persson, L., Nilsson, M., Rosengren, E., Ornithine decarboxylase activity and polyamines in the anterior pituitary gland during the rat oestrous cycle (1985) J Endocrinol, 107, pp. 83-87 | ||
| 504 | |a Aslam, M., Nicholson, S., Gillham, B., Jones, M., Permissive role for ornithine decarboxylase and putrescine in the luteinizing hormone surge (1987) Neuroendocrinology, 45, pp. 473-478 | ||
| 504 | |a Nicholson, S.A., Wynne-Jones, G.A., Differential effect of difluoromethylornithine on the increases in plasma concentrations of reproductive hormones on the afternoon of pro-oestrus in the rat (1989) J Endocrinol, 121, pp. 495-499 | ||
| 504 | |a Kamberi, L.A., McCann, S.M., Effect of biogenic amines, FSH-releasing factor (FRF) and other substances on the release of FSH by pituitaries incubated "in vitro" (1969) Endocrinology, 85, pp. 815-824 | ||
| 504 | |a Thyssen, S.M., Becu-Villalobos, D., Lacau-Mengido, I.M., Libertun, C., Participación de las poliaminas en la maduración del control neurológico de la función reproductora de la hipófisis (1994) Acta Phisiol Pharmacol Therap Latinoam, 44, p. 153 | ||
| 504 | |a Ramaley, J.A., Pituitary gonadotropin-releasing hormone responsiveness in the prepubertal period: Effect of delayed puberty onset (1982) Neuroendocrinology, 34, pp. 387-394 | ||
| 504 | |a Becu-Villalobos, D., Libertun, C., Development of GnRH neuron regulation in the female rat (1995) Cell Mol Neurobiol, 15, pp. 165-176 | ||
| 520 | 3 | |a FSH secretion is high in immature female rats from Postnatal Day 5 to 18 and decreases thereafter. This is a relatively steroid-independent event of cerebral origin and of importance for puberty onset. Polyamines, a group of ubiquitous amines, play an essential role in tissue growth and differentiation, body weight increment, brain organization, and molecular mechanisms of hormonal action. Polyamine levels as well as the activity of ornithine decarboxylase, the limiting enzyme in polyamines biosynthesis, are highest during development. Inhibition of their synthesis during this period by α-difluoromethylornithine (DFMO), a specific and irreversible inhibitor of ornithine decarboxylase, impairs normal brain development. The present study tested the hypothesis that polyamines play a role during brain organization of reproduction. DFMO was administered following different schedules in female newborn rats, and the effect on pituitary secretion, puberty onset, and fertility was evaluated. In three groups (daily injections from Day 1 to 9, or from Day 1 to 6, or injections on alternate days from Day 1 to 9), a delay in vaginal opening and first estrous was observed. When vaginal opening was plotted against body weight, it was evident that in groups daily injected with DFMO vaginal opening occurred at a lower body weight. In the group treated on alternate days, a delay occurred but at a higher body weight than in controls. In this group, serum FSH levels on Day 10 and 20, but not on Day 30, were higher in DFMO rats. In the group treated from Day 1 to 6 daily, DFMO Increased serum FSH on Postnatal Day 20. After vaginal opening, estrous cyclicity in control and DFMO injected rats was similar. There was no significant effect of treatment on fertility and litter weight or number of offspring at birth. It is concluded that DFMO, an inhibitor of ornithine decarboxylase, administered during the first week of life in female rats is followed by prolonged high FSH serum levels and delayed puberty, but once puberty occurs, fertility is normal. |l eng | |
| 593 | |a Lab. de Neuroendocrinología, Inst. de Biol. y Med. Experimental, 1428 Buenos Aires, Argentina | ||
| 593 | |a Lab. de Neuroendocrinología, Inst. de Biol. y Med. Experimental, V Obligado 2490, 1428 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a EFLORNITHINE |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a BRAIN DEVELOPMENT |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a ESTRUS CYCLE |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a FERTILITY |
| 690 | 1 | 0 | |a FOLLITROPIN BLOOD LEVEL |
| 690 | 1 | 0 | |a FOLLITROPIN RELEASE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PUBERTY |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a REPRODUCTION |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a BODY WEIGHT |
| 690 | 1 | 0 | |a EFLORNITHINE |
| 690 | 1 | 0 | |a ENZYME INHIBITORS |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a FOLLICLE STIMULATING HORMONE |
| 690 | 1 | 0 | |a ORNITHINE DECARBOXYLASE |
| 690 | 1 | 0 | |a PROLACTIN |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a RATS, SPRAGUE-DAWLEY |
| 690 | 1 | 0 | |a SEXUAL MATURATION |
| 690 | 1 | 0 | |a ANIMALIA |
| 700 | 1 | |a Libertun, C. | |
| 773 | 0 | |d 1996 |g v. 211 |h pp. 76-80 |k n. 1 |p Exp. Biol. Med. |x 00379727 |w (AR-BaUEN)CENRE-2685 |t Experimental Biology and Medicine | |
| 856 | 4 | 1 | |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-0029671347&partnerID=40&md5=3e7651b8b690926260daec9cd457f0c6 |y Registro en Scopus |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_00379727_v211_n1_p76_Thyssen |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00379727_v211_n1_p76_Thyssen |y Registro en la Biblioteca Digital |
| 961 | |a paper_00379727_v211_n1_p76_Thyssen |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||