Precancerous pathology evoked by hexachlorobenzene treatment.
The porphyrinogenic and carcinogenic ability of hexachlorobenzene (HCB) was assayed in male and female gold hamsters, and histological examinations of tissue alterations were performed. So it was studied, in liver: a) porphyrin content which was significantly increased at five months of HCB treatmen...
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| Otros Autores: | , , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
1996
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| Acceso en línea: | Registro en Scopus Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 04029caa a22006737a 4500 | ||
|---|---|---|---|
| 001 | PAPER-18853 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518205013.0 | ||
| 008 | 190411s1996 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0030341334 | |
| 024 | 7 | |2 cas |a heme, 14875-96-8; hexachlorobenzene, 118-74-1, 55600-34-5; porphyrin, 24869-67-8; Heme, 14875-96-8; Hexachlorobenzene, 118-74-1; Porphyrins | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 100 | 1 | |a Ríos de Molina, M.C. | |
| 245 | 1 | 0 | |a Precancerous pathology evoked by hexachlorobenzene treatment. |
| 260 | |c 1996 | ||
| 270 | 1 | 0 | |m Ríos de Molina, M.C. |
| 506 | |2 openaire |e Política editorial | ||
| 520 | 3 | |a The porphyrinogenic and carcinogenic ability of hexachlorobenzene (HCB) was assayed in male and female gold hamsters, and histological examinations of tissue alterations were performed. So it was studied, in liver: a) porphyrin content which was significantly increased at five months of HCB treatment, specially in males, and the pattern of accumulated porphyrins which was altered independent of the sex, b) haem pathway enzymes:delta aminolaevulinic acid synthase, ferrochelatase and porphyrinogen carboxylyase (PCL); among which only PCL appeared to be altered just at ten months of HCB feeding. While thyroid gland and kidney remained unaltered along the treatment time, liver and spleen exhibited a noticeable size variation and morphological alterations. In fact the spleen in treated animals was hypotrophic showing a red pulp less developed with respect to the Malpighian corpuscles and many macrophages with iron deposits. Respect to the liver, enlargement in size of hepatocytes, high content of iron deposits, no PAS positive structures in the cytoplasm, several small lipid droplets, microsteatosis although no cytonecrosis, polymorphic nuclei, and proliferations of nucleoli were observed. Therefore HCB is able to cause precancerous pathology and to induce porphyria in hamsters, but not hyperthyroidism, upon this experimental conditions. By the way, males were found to be a good experimental model, better than females, to study the earliest relations between porphyria and cancer. |l eng | |
| 593 | |a Departamento de Química Biológica, Universidad de Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a HEME |
| 690 | 1 | 0 | |a HEXACHLOROBENZENE |
| 690 | 1 | 0 | |a PORPHYRIN |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a DRUG EFFECT |
| 690 | 1 | 0 | |a ENZYMOLOGY |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a HAMSTER |
| 690 | 1 | 0 | |a KIDNEY |
| 690 | 1 | 0 | |a LIVER |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a METABOLISM |
| 690 | 1 | 0 | |a ORGAN SIZE |
| 690 | 1 | 0 | |a PATHOLOGY |
| 690 | 1 | 0 | |a SPLEEN |
| 690 | 1 | 0 | |a SYRIAN HAMSTER |
| 690 | 1 | 0 | |a THYROID GLAND |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a CRICETINAE |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a HEME |
| 690 | 1 | 0 | |a HEXACHLOROBENZENE |
| 690 | 1 | 0 | |a KIDNEY |
| 690 | 1 | 0 | |a LIVER |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MESOCRICETUS |
| 690 | 1 | 0 | |a ORGAN SIZE |
| 690 | 1 | 0 | |a PORPHYRINS |
| 690 | 1 | 0 | |a SPLEEN |
| 690 | 1 | 0 | |a THYROID GLAND |
| 700 | 1 | |a Iglesias, S. | |
| 700 | 1 | |a Lauría, L. | |
| 700 | 1 | |a San Martín de Viale, L.C. | |
| 773 | 0 | |d 1996 |g v. 46 |h pp. 71-81 |k n. 2 |p Acta Physiol Pharmacol Ther Latinoam |x 03276309 |w (AR-BaUEN)CENRE-1948 |t Acta physiologica, pharmacologica et therapeutica latinoamericana : órgano de la Asociación Latinoamericana de Ciencias Fisiológicas y [de] la Asociación Latinoamericana de Farmacología | |
| 856 | 4 | 1 | |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030341334&partnerID=40&md5=f5b435e38a886a8d130e67b07b66c076 |y Registro en Scopus |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_03276309_v46_n2_p71_RiosdeMolina |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03276309_v46_n2_p71_RiosdeMolina |y Registro en la Biblioteca Digital |
| 961 | |a paper_03276309_v46_n2_p71_RiosdeMolina |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||