H1 and H2 histamine receptor participation in the brain control of prolactin secretion in lactating rats

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The aim of the present research was to evaluate the histaminergic regulation of prolactin secretion in the lactating rat and the possible involvement of HI and H2 histamine receptors in this control. Prolactin was measured by radioimmunoassay in blood samples withdrawnthrough an intrajugular silasti...

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Detalles Bibliográficos
Autor principal: Arakelian, M.C
Otros Autores: Libertun, C.
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: 1977
Acceso en línea:Registro en Scopus
DOI
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Registro en la Biblioteca Digital
Aporte de:Registro referencial: Solicitar el recurso aquí
Biblioteca Central Dr. Luis F. Leloir (FCEN) de Universidad de Buenos Aires
LEADER 07576caa a22009977a 4500
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005 20230518205001.0
008 190411s1977 xx ||||fo|||| 00| 0 eng|d
024 7 |2 scopus  |a 2-s2.0-0017359562 
024 7 |2 cas  |a 4 methylhistamine, 36507-31-0; diphenhydramine, 147-24-0, 58-73-1; histamine, 51-45-6, 56-92-8, 93443-21-1; mepyramine maleate, 59-33-6; metiamide, 34839-70-8; prolactin, 12585-34-1, 50647-00-2, 9002-62-4; 4-methylhistamine, 36507-31-0; Diphenhydramine, 58-73-1; Histamine, 51-45-6; Methylhistamines; Metiamide, 34839-70-8; Prolactin, 9002-62-4; Receptors, Histamine H1; Receptors, Histamine H2 
040 |a Scopus  |b spa  |c AR-BaUEN  |d AR-BaUEN 
100 1 |a Arakelian, M.C. 
245 1 0 |a H1 and H2 histamine receptor participation in the brain control of prolactin secretion in lactating rats 
260 |c 1977 
270 1 0 |m Libertun, C.; Laboratorio de Neuroendocrinologia, Instituto de Biología y Medicina Experimental, V. Obligado 2490, Buenos Aires, 1428, Argentina 
506 |2 openaire  |e Política editorial 
504 |a Snyder, S.H., Glowinsky, J., Axelrod, J., (1966) J Pharmacol Exp Ther, 153, p. 8 
504 |a Brownstein, M.J., Saavedra, J.M., Palkovits, M., Axelrod, J., (1974) Brain Res, 77, p. 151 
504 |a Snyder, S.H., (1972) Perspective in Neuroendocrinology Oxford Univ., p. 43. , Snyder, S. H. (ed.), Press, New York 
504 |a Garbarg, M., Barbin, G., Feger, J., Schwartz, J.C., (1974) Science, 186, p. 833 
504 |a Guillemin, R., Fortier, C., (1953) Trans NY Acad Sci (Series II), 15, p. 138 
504 |a Taylor, K.M., Snyder, S.H., (1971) Science, 172, p. 1037 
504 |a Björklund, A., Häkanson, R., Nobin, A., Sjöberg, N.O., (1972) Experientia, 28, p. 1232 
504 |a Libertun, C., McCann, S.M., (1976) Neuroendocrinology, 20, p. 110 
504 |a Ash, A.S.F., Schild, H.O., (1966) Brj Pharmacol Chemother, 27, p. 427 
504 |a Black, J.W., Duncan, W.A.M., Durant, C.J., Ganellin, C.R., Parsons, E.M., (1972) Nature, 236, p. 385 
504 |a Baudry, M.M., Martres, P., Schwartz, J.C., (1975) Nature, 253, p. 362 
504 |a Brimble, M.J., Wallis, D.I., (1973) Nature, 246, p. 156 
504 |a Harms, P.G., Ojeda, S.R., (1974) J Appl Physiol, 36, p. 391 
504 |a Lawson, D.M., Gala, R.R., (1974) J Endocrinol, 62, p. 75 
504 |a Amenomori, Y., Chen, C.L., Meites, J., (1970) Endocrinology, 86, p. 506 
504 |a Krulich, L., Kuhn, E.K., Illner, P., McCann, S.M., (1970) Fed Proc, 29, p. 579 
504 |a Shiino, M., Williams, G., Rennels, E.G., (1972) Endocrinology, 90, p. 176 
504 |a Terkel, J., Blake, C.A., Sawyer, C.H., (1972) Endocrinology, 91, p. 49 
504 |a Subramanian, M.G., Reece, R.P., (1975) Proc Soc Exp Biol Med, 149, p. 754 
504 |a McCann, S.M., Ojeda, S.R., Fawcett, C.P., Krulich, L., (1974) Advances in Neurology, 5, p. 435. , Me Dowell, F., and A. Barbeau, (eds.), Raven Press, New York 
504 |a Meites, J., Lu, K.H., Wuttke, W., Welsch, C.W., Nagasawa, H., Quadri, S.K., (1972) Recent Prog Horm Res, 28, p. 471 
504 |a Chen, H.G., Meites, J., (1975) Endocrinology, 96, p. 10 
504 |a Lawson, D.M., Gala, R.R., (1976) Endocrinology, 98, p. 42 
504 |a Libertun, C., McCann, S.M., (1973) Endocrinology, 92, p. 1714 
504 |a Libertun, C., McCann, S.M., (1974) Proc Soc Exp Biol Med, 147, p. 498 
520 3 |a The aim of the present research was to evaluate the histaminergic regulation of prolactin secretion in the lactating rat and the possible involvement of HI and H2 histamine receptors in this control. Prolactin was measured by radioimmunoassay in blood samples withdrawnthrough an intrajugular silastic catheter from undisturbed lactating mothers 10 to 15 days after delivery. In some of those rats a stainless steel cannula was placed in the third ventricle. The tested drugs, HI and H2 receptor agonists and antagonists, were injected either by the intrasilastic route or intraventricularly immediately before the onset of suckling and after abasal sample was taken. New samples were withdrawn 10, 20, 30 and 60 min thereafter. Suckling caused a 12-to 18-fold increase in serum prolactin by 10 min in control saline-injected mothers. In non-suckled mothers (NSM) injected with saline, prolactin levels were low at all times. Systemic or intraventricular diphenydramine and mepyramine, HI receptor antagonists, suppressed the increment in prolactin observed in suckledmothers (SM). Intraventricular metiamide, an H2 receptor antagonist, did not modify prolactin secretion in SM but drastically increased serum prolactin in NSM. A small but significant increase in prolactin titers was observed in NSM injected intraventricularly with histamine. 4-Methylhistamine, an H2 agonist, was ineffective when used intraventricularly in NSM, but clearly suppressed prolactin enhancement in SM. It is postulated that in lactating mothers, brain histamine has a dual control on prolactinsecretion. H2 receptors mediate events related to inhibition of prolactin release, since the agonist 4-methylhistamine blocked the prolactin rise in SM, while the antagonist metiamide promoted release of the hormone in NSM. HI receptors seem to be related to a facilitatory mechani m since classical antihistamines suppress the serum prolactin increase that follows the onset of suckling, while histamine itself is able to release prolactin in NSM. © 1977 by The Endocrine Society.  |l eng 
593 |a Laboratorio de Neuroendocrinologia, Instituto de Biología y Medicina Experimental, V. Obligado 2490, Buenos Aires, 1428, Argentina 
593 |a Consejo Nacional de Investigaciones Científicas y Técnicas, Argentina 
690 1 0 |a 4 METHYLHISTAMINE 
690 1 0 |a DIPHENHYDRAMINE 
690 1 0 |a HISTAMINE 
690 1 0 |a HISTAMINE H1 RECEPTOR 
690 1 0 |a HISTAMINE H2 RECEPTOR 
690 1 0 |a HISTAMINE RECEPTOR 
690 1 0 |a MEPYRAMINE MALEATE 
690 1 0 |a METIAMIDE 
690 1 0 |a PROLACTIN 
690 1 0 |a BRAIN 
690 1 0 |a INTRACEREBROVENTRICULAR DRUG ADMINISTRATION 
690 1 0 |a LACTATION 
690 1 0 |a PROLACTIN BLOOD LEVEL 
690 1 0 |a PROLACTIN RELEASE 
690 1 0 |a RAT 
690 1 0 |a THEORETICAL STUDY 
690 1 0 |a ANIMAL 
690 1 0 |a DIPHENHYDRAMINE 
690 1 0 |a FEMALE 
690 1 0 |a HISTAMINE 
690 1 0 |a INJECTIONS, INTRAVENTRICULAR 
690 1 0 |a LACTATION 
690 1 0 |a METHYLHISTAMINES 
690 1 0 |a METIAMIDE 
690 1 0 |a PREGNANCY 
690 1 0 |a PROLACTIN 
690 1 0 |a RATS 
690 1 0 |a RATS, INBRED STRAINS 
690 1 0 |a RECEPTORS, HISTAMINE H1 
690 1 0 |a RECEPTORS, HISTAMINE H2 
690 1 0 |a SECRETORY RATE 
690 1 0 |a SUPPORT, NON-U.S. GOV'T 
700 1 |a Libertun, C. 
773 0 |d 1977  |g v. 100  |h pp. 890-895  |k n. 3  |p Endocrinology  |x 00137227  |w (AR-BaUEN)CENRE-4573  |t Endocrinology 
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856 4 0 |u https://doi.org/10.1210/endo-100-3-890  |y DOI 
856 4 0 |u https://hdl.handle.net/20.500.12110/paper_00137227_v100_n3_p890_Arakelian  |y Handle 
856 4 0 |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00137227_v100_n3_p890_Arakelian  |y Registro en la Biblioteca Digital 
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962 |a info:eu-repo/semantics/article  |a info:ar-repo/semantics/artículo  |b info:eu-repo/semantics/publishedVersion 
963 |a VARI 

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