Altered inotropic and chronotropic effects of noradrenaline on isolated rat atria exposed to chagasic sera. Influences of cocaine, normetanephrine and U-0521 (3′-4′-dihydroxy-2-methyl propiophenone
Summary: The effects of chagasic sera containing an antibody (EVI antibody), which reacts with the plasma membrane of striated muscle fibres and endothelial cells, on the inotropic and chronotropic influences of noradrenaline upon isolated rat atria suspended in different media, were explored. Also...
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| Lenguaje: | Inglés |
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Oxford University Press
1979
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 09080caa a22006977a 4500 | ||
|---|---|---|---|
| 001 | PAPER-18601 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230607131910.0 | ||
| 008 | 190411s1979 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-85047680404 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a CVREA | ||
| 100 | 1 | |a Gimeno, A.L. | |
| 245 | 1 | 0 | |a Altered inotropic and chronotropic effects of noradrenaline on isolated rat atria exposed to chagasic sera. Influences of cocaine, normetanephrine and U-0521 (3′-4′-dihydroxy-2-methyl propiophenone |
| 260 | |b Oxford University Press |c 1979 | ||
| 270 | 1 | 0 | |m Arana, R.M.; CEMIC, Sanchez de Bustamante 2560, 1425 Buenos Aires, Argentina |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Laranja, F.S., Diez, E., Nobrega, G., Miranda, A., Chagas' disease A clinical epidemiologic and pathologic study (1956) Circulation, 14, pp. 1035-1060 | ||
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| 504 | |a Cossio, P.M., Diez, C., Szarfman, A., Kreutzer, E., Candiolo, B., Arana, R.M., Chagasic Cardiopathy Demonstration of a serum gamma globulin factor which reacts with endocardium and vascular structures (1974) Circulation, 49, pp. 13-21 | ||
| 504 | |a Cossio, P.M., Laguens, R.P., Diez, C., Szarfman, A., Segal, A., Arana, R.M., Chagasic Cardiopathy Antibodies reacting with plasma membrane of striated muscle and endothelial cells (1974) Circulation, 50, pp. 1252-1259 | ||
| 504 | |a Cossio, P.M., Laguena, R.P., Kreutzer, E., Diez, C., Segal, A., Arana, R.M., Chagasic Cardiopathy Immunopathologic and morphologic studies in myocardial biopsies (1977) Am J Pathol, 86, pp. 533-544 | ||
| 504 | |a Borda, L.S., Cossio, P.M., Gimeno, M.F., Gimeno, A.L., Diez, C., Laguens, R.P., Meckert, P.C., Arana, R.M., Effect of chagasic sera on the rat isolated atrial preparation Immunological morphological and functional aspects (1976) Cardiovasc Res, 10, pp. 613-622 | ||
| 504 | |a Kabat, E.A., Mayer, M.M., (1964) Experimental Immunochemistry, p. 135. , Springfield Illinois Thomas | ||
| 504 | |a Gimeno, A.L., Gimeno, M.F., Webb, J.L., Action of sex steroids on the electrical and mechanical properties of rat atrium (1963) Am J Physiol, 205, pp. 198-199 | ||
| 504 | |a Lacuara, J.L., Gimeno, A.L., Gimeno, M.F., Effects of mono-sacharides pyruvate acetate and butyrate on the developed tension and ATP levels in hypodynamic isolated rat atria (1971) Proc Soc Exp Biol Med, 136, pp. 1369-1373 | ||
| 504 | |a Borda, L.S., Gimeno, A.L., Gimeno, M.F., Frequency force relationship of isolated rat and guinea pig atria. Effects of cholinergic and adrenergic receptor antagonists (1974) Proc Soc Exp Biol Med, 145, pp. 1151-1157 | ||
| 504 | |a Van Rossum, J.M., Cumulative dose-response curves II Technique for the maing of dose-response curves in isolated organs and the evaluation of drugs parameters (1963) Arch Int Pharmacodyn Ther, 143, pp. 299-330 | ||
| 504 | |a Fisher, R.A., Yates, F., (1957) Statistical Tables for Biological Agricultural and Medical Research, , New York | ||
| 504 | |a Koch-Weser, J., Blinko, J.R., The influences of the intervals between beats on myocardial contractility (1963) Pharmacol Rev, 15, pp. 601-652 | ||
| 504 | |a Blinks, J.R., Koch-Weser, J., Physical factors in the analysis of the actions of drugs on myocardial contractility (1963) Pharmacol Rev, 15, pp. 531-599 | ||
| 504 | |a Trendelemburg, V., Supersensitivity and subsensitivity to sympathetic amines (1963) Pharmacol Rev, 15, pp. 225-276 | ||
| 504 | |a Stjärme, L., Wennmals, A., Quantitative stimation of secretion and reuptake of adrenergic transmitter in the rabbit heart (1971) Acta Physiol Scand, 81, pp. 286-288 | ||
| 504 | |a Giles, R.E., Miller, J.W., A comparison of certain properties of catechol-O-methyl transferase to those of adrenergic beta receptor (1967) J Pharmacol Exp Ther, 156, pp. 201-206 | ||
| 504 | |a Burgen, A., Iversen, L.L., The inhibition of noradrenaline uptake by sympathomimetic amines in the rat isolated heart (1965) Br J Pharmacol, 25, pp. 34-42 | ||
| 504 | |a El, B., Angelakos, T., Frequency dependent epinephrine uptake in isolated atria (1970) Arch Int Physiol Biochim, 78, pp. 59-68 | ||
| 504 | |a Bell, C., Gravach, B., Involvement of uptake2 in the termination of activity of neurogenic noradrenaline in the rat isolated atrium (1976) J Physiol, 254, pp. 203-212 | ||
| 504 | |a (1974) Lancet, 2, pp. 443-444. , Lancet | ||
| 504 | |a Smith, B.R., Hall, R., Thyroid-stimulating immunoglobulins in Graves' disease (1974) Lancet, 2, pp. 427-430 | ||
| 520 | 3 | |a Summary: The effects of chagasic sera containing an antibody (EVI antibody), which reacts with the plasma membrane of striated muscle fibres and endothelial cells, on the inotropic and chronotropic influences of noradrenaline upon isolated rat atria suspended in different media, were explored. Also explored were the action of cocaine, normetanephrine and U-0521 (3′-4′-dihydroxy-2- methyl propiophenone) on the atrial effects of the agonist in preparations immersed in Krebs-Ringer bicarbonate, alone and with the addition of normal human sera or EVI positive human chagasic sera (EVI(+)S). The positive inotropic action of a single dose of noradrenaline (3.0 x 10-7 mol·litre-1) was significantly smaller in spontaneously beating auricles exposed to the EVI(+)S. Cumulative dose-response curves for the agonist showed depression and reduced slope suggesting that EVI(+)S may nihilate the effect of the amine by means of a "noncompetitive-like" mechanism.A similar diminished reactivity towards noradrenaline was found regarding atrial contractile rate. Incubation in a solution with U-0521 enhanced the maximal augmentation of atrial isometric tension evoked by the amine in the three media whereas cocaine failed to elicit significant changes. However, normal human sera not only restored but actually potentiated the inotropic influence of noradrenaline although only in auricles bathed with a solution containing EVI(+)S. None of these three agents altered the reduced chronotropic effect of the agonist exposed to the EVI antibody. Contractile influences on atria paced at single fixed rates were similar to those observed in spontaneously beating preparations. The experimental findings suggest that: a) at the contractile frequencies in the present studies neuronal uptake is neither an important mechanism for terminating the contractile effect of exogenously added noradrenaline, nor a factor involved in the altered action of the agonist in the presence of EVI(+)S; and b) the importance of extraneuronal uptake of noradrenaline became clear after the incubation in a media containing EVI(+)S. It is, therefore plausible to suggest that the EVI antibody might influence the contractile effect of the agonist through a reversible enhancement of extraneuronal uptake. This would in turn modify the interaction between the amine and adrenoceptive sites needed for the full positive inotropic effectiveness of noradrenaline. The possible significance of these findings in the alterations observed in chronic Chagas heart disease is discussed. |l eng | |
| 536 | |a Detalles de la financiación: Secretaria de Estado de Ciência e Tecnologia, SECT | ||
| 536 | |a Detalles de la financiación: Universidad Nacional del Centro de la Provincia de Buenos Aires | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas, 6638/C, 5863/8 | ||
| 536 | |a Detalles de la financiación: This work was supported by Grants from CONICET (6638/C and 5863/8), Secretaria de Estado de Ciencia y Tecnologia de la Repiblica Argentina; Fundaci6n Cossio; ADAR and Academia Nacional de Medicina de Buenos Aires. | ||
| 593 | |a Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Consejo Nacional de Investigacions Cientificas, Técnicas de la República Argentina (CONICET), Buenos Aires, Argentina | ||
| 593 | |a The Laboratory of Rheumatology and Immunology, Cardiology Unit, CEMIC, Buenos Airs, Argentina | ||
| 700 | 1 | |a Gimeno, M.F. | |
| 700 | 1 | |a Sterin-Borda, L. | |
| 700 | 1 | |a Cossio, P.M. | |
| 700 | 1 | |a Sterin-Speziale, N. | |
| 700 | 1 | |a Diez, C. | |
| 700 | 1 | |a Seara, S.M. | |
| 700 | 1 | |a Arana, R.M. | |
| 773 | 0 | |d Oxford University Press, 1979 |g v. 13 |h pp. 723-731 |k n. 12 |p Cardiovasc. Res. |x 00086363 |t Cardiovascular Research | |
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| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_00086363_v13_n12_p723_Gimeno |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00086363_v13_n12_p723_Gimeno |y Registro en la Biblioteca Digital |
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