Factors underlying the variable inotropic effect of ouabain on isolated rat atria. Changes in contractile frequency and adrenergic mechanisms

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The effects of concentrations of ouabain on the isometric developed tension (IDT) of isolated left auricles driven at 0·4, 0·8 and 3·3 Hz, were explored. With 0·4 or 0·8 Hz, increasing concentrations of ouabain (3·4 or 6·8 times 10−6; 1·0; 3·4 or 6·8 times 10−6M) elicited a decreasing enhancement of...

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Detalles Bibliográficos
Autor principal: GIMENO, A.L
Otros Autores: STERIN‐BORDA, L., BORDA, E.S, GIMENO, M.F
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: 1979
Materias:
mj 1999; u 0521
Acceso en línea:Registro en Scopus
DOI
Handle
Registro en la Biblioteca Digital
Aporte de:Registro referencial: Solicitar el recurso aquí
Biblioteca Central Dr. Luis F. Leloir (FCEN) de Universidad de Buenos Aires
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024 7 |2 scopus  |a 2-s2.0-0018746505 
024 7 |2 cas  |a 3',4' dihydroxy 2 methylpropiophenone, 5466-89-7; cocaine, 50-36-2, 53-21-4, 5937-29-1; ouabain, 11018-89-6, 630-60-4; reserpine, 50-55-5, 8001-95-4; sotalol, 3930-20-9, 80456-07-1, 959-24-0; tyramine, 51-67-2, 60-19-5; Catecholamines; Cocaine, 50-36-2; Ouabain, 630-60-4; Reserpine, 50-55-5; Sotalol, 3930-20-9; Tyramine, 51-67-2 
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100 1 |a GIMENO, A.L. 
245 1 0 |a Factors underlying the variable inotropic effect of ouabain on isolated rat atria. Changes in contractile frequency and adrenergic mechanisms 
260 |c 1979 
270 1 0 |m GIMENO, A.L.; Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Obligado 2490, Buenos Aires, 1428, Argentina 
506 |2 openaire  |e Política editorial 
504 |a Bell, C., Grabsch, B.J., (1976) J. Physiol., 254, pp. 203-212 
504 |a Benforado, J.M., (1958) J. Pharmacol. Exp. Ther., 122, pp. 86-100 
504 |a Bloomquist, E.I., Angelakos, E.T., (1970) Arch. Int. Physiol. Biochem., 78, pp. 43-57 
504 |a Bloomquist, E.T., Angelakos, E.T., (1970) Arch. Int. Physiol. Biochem., 78, pp. 59-68 
504 |a Fujimoto, S., Iwata, H., Yoneda, Y., (1976) Jpn. J. Pharmacol., 26, pp. 105-110 
504 |a Furchgott, R.F., Gubareff, T., (1958) J. Pharmacol. Exp. Ther., 124, pp. 203-218 
504 |a Gersmeyer, E.F., Holland, W.C., (1963) Am. J. Physiol., 205, pp. 795-798 
504 |a Giles, R.E., Miller, J.W., (1967) J. Pharmacol. Exp. Ther., 156, pp. 201-206 
504 |a Govier, W.C., (1965) J. Pharmacol. Exp. Ther., 148, pp. 100-105 
504 |a Koch‐Wesser, J., Blinks, J.R., (1962) J. Pharmacol. Exp. Ther., 136, pp. 305-317 
504 |a Koch‐Wesser, J., Myocardial Contraction Frequency and Onset of Cardiac Glycoside Action (1971) Circulation Research, 28, pp. 34-48 
504 |a Ku, D.D., Akera, T., Brody, T.M., (1976) J. Pharmacol. Exp. Ther., 197, pp. 458-469 
504 |a Lacuara, J.L., Gimeno, A.L., Gimeno, M.F., (1971) Proc. Soc. Exp. Biol. Med., 136, pp. 1369-1373 
504 |a Masuoka, D.T., Saunders, P.R., (1950) Proc. Soc. Exp. Biol. Med., 74, pp. 879-882 
504 |a Morrow, D.H., Gaffney, T.E., Braunwald, E., (1963) J. Pharmacol. Exp. Ther., 140, pp. 236-242 
504 |a Sanyal, P.N., Saunders, P.R., Relationship between cardiac rate and the positive inotropic action of ouabain. (1958) J Pharmacol Exp Ther, 122, pp. 499-503 
504 |a Seifen, E., (1974) Br. J. Pharmacol., 51, pp. 481-490 
504 |a Shudo, I., Saito, H., Tanabe, T., (1975) Jpn. J. Pharmacol., 25, pp. 639-643 
504 |a Spann, J.F., Sonnenblick, E.H., Cooper, T., Chidsey, C.A., Willman, V.L., Braunwald, E., (1966) Circ. Res., 19, pp. 317-325 
504 |a Spann, J.F., Sonnenblinck, E.H., Cooper, T., Chidsey, C.A., Willman, V.L., Braunwald, E., (1966) Circ. Res., 19, pp. 326-331 
504 |a Sterin‐Borda, L., Gimeno, A.L., Gimeno, M.F., (1974) Proc. Soc. Exp. Biol. Med., 145, pp. 1151-1157 
504 |a Sterin‐Borda, L., Gimeno, M.F., Borda, E.S., Gimeno, A.L., (1977) Proc. Soc. Exp. Biol. Med., 156, pp. 315-325 
504 |a Tanz, R.D., (1964) J. Pharmacol. Exp. Ther., 144, pp. 205-213 
504 |a Trendelenburg, V., (1963) Pharmacol. Rev., 15, pp. 225-276 
504 |a Vincenzi, F.F., (1967) J. Pharmacol. Exp. Ther., 155, pp. 279-287 
520 3 |a The effects of concentrations of ouabain on the isometric developed tension (IDT) of isolated left auricles driven at 0·4, 0·8 and 3·3 Hz, were explored. With 0·4 or 0·8 Hz, increasing concentrations of ouabain (3·4 or 6·8 times 10−6; 1·0; 3·4 or 6·8 times 10−6M) elicited a decreasing enhancement of atrial contractile peak tension, whereas with 3·3 Hz the effect was augmented with concentration. Ouabain (3·4 times 10−6 M) enhanced comparably the IDT at all the driving rates, but at higher concentrations the effect varied with the frequency. The positive inotropic action of ouabain at 3·4 times 10−6 M on preparations driven at faster frequencies was antagonized by Sotalol (MJ‐1999) and also after catecholamine depletion by in vivo reserpinization followed by addition of tyramine in vitro. Cocaine or U‐0521 significantly enhanced the positive inotropic effect of ouabain (3·4 times 10−5 M) in atria stimulated at low rates. On the contrary, Sotalol, cocaine, U‐0521 or catecholamine depletion did not alter the positive inotropic influence of ouabain at 3·4 times 10−6 M at any of the frequencies used. It is suggested that ouabain influenced contractile peak tension of rat isolated atria through two mechanisms: one, seen after higher concentrations, which appeared to be associated with adrenergic factors and dependent on the frequency of stimulation; the other, observable with the lower concentrations, which did not appear to have a direct relationship with adrenergic processes and which was independent of the frequency of stimulation. 1979 Royal Pharmaceutical Society of Great Britain  |l eng 
593 |a Centro de Estudios Farmacológicos y de Principios Naturales, Consejo Nacional de Investigaciones Cientificas y Técnicas, Buenos Aires, Argentina 
690 1 0 |a 3',4' DIHYDROXY 2 METHYLPROPIOPHENONE 
690 1 0 |a ADRENERGIC RECEPTOR 
690 1 0 |a COCAINE 
690 1 0 |a OUABAIN 
690 1 0 |a RESERPINE 
690 1 0 |a SOTALOL 
690 1 0 |a TYRAMINE 
690 1 0 |a 3',4' DIHYDROXY O METHYLPROPIOPHENONE 
690 1 0 |a ANIMAL EXPERIMENT 
690 1 0 |a CATECHOLAMINE DEPLETION 
690 1 0 |a DRUG RESPONSE 
690 1 0 |a DRUG SCREENING 
690 1 0 |a DRUG SENSITIVITY 
690 1 0 |a HEART 
690 1 0 |a HEART ATRIUM 
690 1 0 |a HEART ATRIUM CONTRACTION 
690 1 0 |a HEART CONTRACTION 
690 1 0 |a IN VITRO STUDY 
690 1 0 |a ISOMETRIC TENSION 
690 1 0 |a RAT 
690 1 0 |a ANIMAL 
690 1 0 |a CATECHOLAMINES 
690 1 0 |a COCAINE 
690 1 0 |a DRUG INTERACTIONS 
690 1 0 |a HEART RATE 
690 1 0 |a IN VITRO 
690 1 0 |a MALE 
690 1 0 |a MYOCARDIAL CONTRACTION 
690 1 0 |a OUABAIN 
690 1 0 |a RATS 
690 1 0 |a RESERPINE 
690 1 0 |a SOTALOL 
690 1 0 |a SYMPATHETIC NERVOUS SYSTEM 
690 1 0 |a TYRAMINE 
653 0 0 |a mj 1999; u 0521 
700 1 |a STERIN‐BORDA, L. 
700 1 |a BORDA, E.S. 
700 1 |a GIMENO, M.F. 
773 0 |d 1979  |g v. 31  |h pp. 545-550  |k n. 1  |p J. Pharm. Pharmacol.  |x 00223573  |w (AR-BaUEN)CENRE-1020  |t Journal of Pharmacy and Pharmacology 
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856 4 0 |u https://doi.org/10.1111/j.2042-7158.1979.tb13581.x  |y DOI 
856 4 0 |u https://hdl.handle.net/20.500.12110/paper_00223573_v31_n1_p545_GIMENO  |y Handle 
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999 |c 79552 

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