Inhibition of Prolactin Secretion by GABA in Female and Male Rats
The effect of GABA on prolactin secretion from the pituitary under physiological conditions in lactating female rats and in normal male rats was investigated. Prolactin was measured by RIA in blood samples taken from lactating mothers by means of an intrajugular silastic catheter, 10-15 days after d...
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| Otros Autores: | , , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
1979
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 06253caa a22008657a 4500 | ||
|---|---|---|---|
| 001 | PAPER-18591 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204958.0 | ||
| 008 | 190411s1979 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0018777854 | |
| 024 | 7 | |2 cas |a 4 aminobutyric acid, 28805-76-7, 56-12-2; aminooxyacetic acid, 2921-14-4, 645-88-5; ether, 60-29-7; Aminooxyacetic Acid, 645-88-5; gamma-Aminobutyric Acid, 56-12-2; Prolactin, 9002-62-4 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 100 | 1 | |a Libertun, C. | |
| 245 | 1 | 0 | |a Inhibition of Prolactin Secretion by GABA in Female and Male Rats |
| 260 | |c 1979 | ||
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Roberts, E., Chase, T.N., GABA in Nervous System Function (1976), Tower and, D. B. (Eds.) Raven Press, New York; Enna, S.J., Kuhar, J., Snyder, S., (1975) Brain Res, 93, p. 168 | ||
| 504 | |a Libertun, C., McCann, S.M., (1976) Int. Res. Commun. Sys, 4, p. 374 | ||
| 504 | |a Schally, A.V., Redding, T.W., Arimura, A., Dupont, A., Linthicum, G.L., (1977) Endocrinology, 100, p. 681 | ||
| 504 | |a Hall, T.R., Mioduszewski, R., Campbell, G.A., Grandison, L., Meites, J., (1977) Int. Res. Commun. Sys, 5, p. 112 | ||
| 504 | |a Rivier, C., Vale, W., (1977) Endocrinology, 101, p. 506 | ||
| 504 | |a Vijayan, E., McCann, S.M., Brain Res., , in press | ||
| 504 | |a Lamberts, S.W.J., McLead, R.M., (1978) Proc. Soc. Exp. Biol. Med, 158 (10) | ||
| 504 | |a Pass, K.A., Ondo, J.G., (1977) Endocrinology, 100, p. 1437 | ||
| 504 | |a Mioduszewski, R., Grandison, L., Meites, J., (1976) Proc. Soc. Exp. Biol. Med, 151 (44) | ||
| 504 | |a Arakelian, M.C., Libertun, C., (1977) Endocrinology, 100, p. 890 | ||
| 504 | |a Turnbull, M.J., Slater, P., (1970) Life Sci, 9 (83) | ||
| 504 | |a Biswas, B., Carlsson, A., (1977) Arch. Pharmacol, 299 (41) | ||
| 504 | |a Biswas, B., Carlsson, A., (1977) Arch. Pharmacol, 299 (47) | ||
| 504 | |a Libertun, C., Kaplan, S.E., De Nicola, A.F., (1979) Neuroendocrinology, 28 (64) | ||
| 504 | |a Fuxe, M., Perez de la Mora, M., Agneti, L., Eneroth, P., Gustafesen, J.A., Skett, P., Ogren, S.D., (1977) Acta Endocrinol., 85, p. 15. , (Abstract) | ||
| 520 | 3 | |a The effect of GABA on prolactin secretion from the pituitary under physiological conditions in lactating female rats and in normal male rats was investigated. Prolactin was measured by RIA in blood samples taken from lactating mothers by means of an intrajugular silastic catheter, 10-15 days after delivery. GABA in doses of 825 μg, but not 150 μg, microinjected into the third ventricle partially suppressed the serum prolactin rise due to suckling. Aminooxyacetic acid (AOAA), 30 mg/kg ip, which has been reported to produce a sharp increase in GABA content in the CNS, significantly suppressed the prolactin increment during the suckling period. By contrast, in non suckled mothers, GABA or AOAA was ineffective in altering serum prolactin. In normal male rats, GABA and AOAA were able to partially suppress prolactin release due to ether stress. These results clearly show that increments in GABA content in the brain after microinjection of exogenous GABA or following suppression of enzymatic inactivation of the endogenous amino acid were able to inhibit prolactin release under physiological conditions. © 1979, SAGE Publications. All rights reserved. |l eng | |
| 536 | |a Detalles de la financiación: Secretaría de Estado de Ciencia, Tecnología e Innovación | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: 1 Libertun C. 2 Arakelian M. C. 3 Larrea G. A. 4 Foglia V. G. 2 Laboratorio de Neuroendocrinologia. Instituto de Biologia y Medicina Experimental; V. Obligado 2490; 1428 Buenos Aires; Argentina 1 Supported by grants from Consejo Nacional de Investigaciones Cientificas y Técnicas and Secretaría de Estado de Ciencia y Tecnologia, Argentina. 2 Established Investigator. 3 Research Fellow. 4 Assistant Professional, Consejo Nacional de Investigaciones Cientificas y Técnicas, Argentina. Address correspondence to Dr. C. Libertun, Laboratorio de Neuroendocrinología, Instituto de Biología y Medicina Experimental, V. Obligado 2490, 1428 Buenos Aires, Argentina. 5 1979 161 1 28 31 | ||
| 593 | |a Laboratorio de Neuroendocrinologia, Instituto de Biologia y Medicina Experimental, V. Obligado 2490, 1428 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a 4 AMINOBUTYRIC ACID |
| 690 | 1 | 0 | |a AMINOOXYACETIC ACID |
| 690 | 1 | 0 | |a ESTROGEN |
| 690 | 1 | 0 | |a ETHER |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ENDOCRINE SYSTEM |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a INTRACEREBROVENTRICULAR DRUG ADMINISTRATION |
| 690 | 1 | 0 | |a INTRAPERITONEAL DRUG ADMINISTRATION |
| 690 | 1 | 0 | |a LACTATION |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a PROLACTIN BLOOD LEVEL |
| 690 | 1 | 0 | |a PROLACTIN RELEASE |
| 690 | 1 | 0 | |a RADIOIMMUNOASSAY |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a AMINOOXYACETIC ACID |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a COMPARATIVE STUDY |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a GAMMA-AMINOBUTYRIC ACID |
| 690 | 1 | 0 | |a INJECTIONS, INTRAPERITONEAL |
| 690 | 1 | 0 | |a INJECTIONS, INTRAVENTRICULAR |
| 690 | 1 | 0 | |a LACTATION |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a PITUITARY GLAND |
| 690 | 1 | 0 | |a PREGNANCY |
| 690 | 1 | 0 | |a PROLACTIN |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a STRESS |
| 700 | 1 | |a Arakelian, M.C. | |
| 700 | 1 | |a Larrea, G.A. | |
| 700 | 1 | |a Foglia, V.G. | |
| 773 | 0 | |d 1979 |g v. 161 |h pp. 28-31 |k n. 1 |p Proc. Soc. Exp. Biol. Med. |x 00379727 |w (AR-BaUEN)CENRE-2685 |t Proceedings of the Society for Experimental Biology and Medicine | |
| 856 | 4 | 1 | |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-0018777854&doi=10.3181%2f00379727-161-40482&partnerID=40&md5=981d105bd82a4e46bfdf4b9c133043cd |y Registro en Scopus |
| 856 | 4 | 0 | |u https://doi.org/10.3181/00379727-161-40482 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_00379727_v161_n1_p28_Libertun |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00379727_v161_n1_p28_Libertun |y Registro en la Biblioteca Digital |
| 961 | |a paper_00379727_v161_n1_p28_Libertun |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||