Inotropic effect of PGE1 and PGE2 on isolated rat atria. Influence of adrenergic mechanisms
The effects of a wide range of PGE1 and PGE2 concentrations on the isometric developed tension of isolated rat atria beating spontaneously or paced at a fixed rate, were explored. PGE1 only produced a negative inotropic effect (NIE), whereas PGE2 elicited a biphasic inotropic action; negative at low...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
1980
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 08499caa a22011897a 4500 | ||
|---|---|---|---|
| 001 | PAPER-18528 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204954.0 | ||
| 008 | 190411s1980 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0019225591 | |
| 024 | 7 | |2 cas |a methoxamine, 390-28-3, 61-16-5; noradrenalin, 1407-84-7, 51-41-2; prostaglandin E, 11042-70-9; phenoxybenzamine, 59-96-1, 63-92-3; phentolamine, 50-60-2, 73-05-2; propranolol, 13013-17-7, 318-98-9, 3506-09-0, 4199-09-1, 525-66-6; prostaglandin E1, 745-65-3; prostaglandin E2, 363-24-6; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Methoxamine, 390-28-3; Norepinephrine, 51-41-2; Prostaglandins E | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 100 | 1 | |a Sterin-Borda, L. | |
| 245 | 1 | 0 | |a Inotropic effect of PGE1 and PGE2 on isolated rat atria. Influence of adrenergic mechanisms |
| 260 | |c 1980 | ||
| 270 | 1 | 0 | |m Sterin-Borda, L.; Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), CONICET. V. de Obligado 2490, Buenos Aires, 1428, Argentina |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Nakano, J., McCurdy, J.R., Cardiovascular effects of prostaglandin E1 (1967) J.Pharmacol.Exp.Ther., 156, p. 538 | ||
| 504 | |a Malik, K.U., McGiff, J.C., Cardiovascular actions of prostaglandins (1976) Prostaglandins: Physiological, Pharmacological and Pathological Aspects, p. 103. , SMM Karim, MTP Lancaster, UPP Baltimore | ||
| 504 | |a Nutter, D.O., Crumly, H.R., Canine coronary vascular and cardiac responses to the prostaglandins (1972) Cardiovascular.Res., 6, p. 217 | ||
| 504 | |a Szekeres, L., Borbola, J., Papp, J.G., Cardiac actions of arachidonic acid (1976) Acta Biol.Med.Germ., 35, p. 1119 | ||
| 504 | |a Berti, F., Naimzada, M.K., Lentati, R., Mantegazza, P., Paoletti, R., Relations between some in vitro and in vivo effects of Prostaglandin E1 (1967) Prog.Biochem.Pharmacol., 3, p. 110 | ||
| 504 | |a Levy, J.V., Killebrew, E., Inotropic effects of Prostaglandin E2 on isolated cardiac tissue (1971) Proc.Soc.Exp.Biol.Med., 136, p. 1227 | ||
| 504 | |a Sterin-Borda, L., Gimeno, A.L., Gimeno, M.F., Frequency-force relationship on isolated rat and guinea pig atria. Effects of cholinergic and adrenergic receptor antagonists (1974) Proc.Soc.Exp.Biol.Med., 145, p. 1151 | ||
| 504 | |a Van Rossum, J.M., Cumulative dose-response Curve II:Technique for the making of dose response curves in isolated organs and the evaluation of drug parameter (1963) Arch.Int.Pharmacodyn.Ther., 143, p. 299 | ||
| 504 | |a Langer, S.Z., The metabolism of 3H Noradrenaline by electrical stimulation from the isolated nictitating membrane of the cat and from the vas deferens of the rat (1970) J.Physiol., 208, p. 515 | ||
| 504 | |a Vergroesen, A.J., De Boer, J., Gottenbos, J.S., Effects of Prostaglandins on perfused isolated rat hearts (1969) Acta Physiol.Pharmacol., 15, p. 72 | ||
| 504 | |a Hedqvist, P., Stjärne, L., Wennmalm, A., Inhibition by PGE2 of sympathetic neurotransmission in the rabbit heart (1970) Acta physiol.Scand., 79, p. 139 | ||
| 504 | |a Hedqvist, P., Wennmalm, A., Comparison of the effects of Prostaglandins E1, E2 and F2 on the sympathetically stimulated rabbit heart (1971) Acta physiol.Scand., 83, p. 156 | ||
| 504 | |a Hedqvist, P., Basic mechanisms of prostaglandin action on autonomic neurotransmission (1977) Ann.Rev.Pharmacol.Toxicol., 17, p. 259 | ||
| 504 | |a Westfall, T.C., Local regulation of adrenergic neurotransmition (1977) Physiol.Rev., 57, p. 672 | ||
| 504 | |a Wennmalm, A., Hedqvist, P., Prostaglandin E1 as inhibitor of the sympathetic neuroeffector system in the rabbit heart (1970) Life Sci., 9, p. 931 | ||
| 504 | |a Wennmalm, A., Prostaglandin-mediated inhibition of noradrenaline release: II dual mechanism behind its frequency (1978) Acta physiol.Scand., 102, p. 199 | ||
| 504 | |a Hedqvist, P., Studies on the effect of prostaglandins E1 and E2 on the sympathetic neuromuscular transmission in some animal tissues (1970) Acta physiol.Scand., 79, p. 1 | ||
| 504 | |a Stjärne, L., Alpha-adrenoceptor mediated feed-back control of sympathetic neurotransmitter secretion in guinea pig vas deferens (1973) Nature New Biol., 241, p. 189 | ||
| 504 | |a Stjärne, L., Dual alpha-adrenoceptor mediated of secretion of sympathetic neurotransmitter: one mechanism dependent and one independent of prostaglandin E (1973) Prostaglandins, 3, p. 111 | ||
| 504 | |a Sterin-Borda, L., Canga, L., Gimeno, M.F., Gimeno, A.L., An adrenergic participation subserving a positive inotropism and chronotropism of prostacyclin on isolated rat atria (1979) Experientia, 35, p. 529 | ||
| 504 | |a Malik, K., Prostaglandin-modulation of adrenergic nervous system (1978) Fed.Proc., 37, p. 203 | ||
| 520 | 3 | |a The effects of a wide range of PGE1 and PGE2 concentrations on the isometric developed tension of isolated rat atria beating spontaneously or paced at a fixed rate, were explored. PGE1 only produced a negative inotropic effect (NIE), whereas PGE2 elicited a biphasic inotropic action; negative at low concentrations and positive (PIE) at higher ones. Phenoxybenzamine and phentolamine failed to modify either the NIE or the PIE, but subthreshold exogenous norepinephrine abolished the NIE, suggesting a presynaptic inhibitory effect of PGEs on the adrenergic neurotransmitter release. Auricles pretreated with subthreshold norepinephrine react with a PIE to PGE1, but not to PGE2. On the contrary in the presence of subthreshold methoxamine the PIE of PGE2 was increased whereas the action of PGE1 was not modified. © 1980, All rights reserved. |l eng | |
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: This work waa aupportad by Grant 6638 from the Conaejo National da Invaatlgacionaa Ciantfticaa y TC?cnicaa (CONICET) da la Rephblica Argentina. | ||
| 593 | |a Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), CONICET. V. de Obligado 2490, Buenos Aires, 1428, Argentina | ||
| 690 | 1 | 0 | |a ADRENERGIC ALPHA AGONISTS |
| 690 | 1 | 0 | |a ADRENERGIC BETA AGONISTS |
| 690 | 1 | 0 | |a ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT |
| 690 | 1 | 0 | |a BETA ADRENERGIC RECEPTOR STIMULATING AGENT |
| 690 | 1 | 0 | |a METHOXAMINE |
| 690 | 1 | 0 | |a NORADRENALIN |
| 690 | 1 | 0 | |a PROSTAGLANDIN E |
| 690 | 1 | 0 | |a METHOXAMINE |
| 690 | 1 | 0 | |a NORADRENALIN |
| 690 | 1 | 0 | |a PHENOXYBENZAMINE |
| 690 | 1 | 0 | |a PHENTOLAMINE |
| 690 | 1 | 0 | |a PROPRANOLOL |
| 690 | 1 | 0 | |a PROSTAGLANDIN E1 |
| 690 | 1 | 0 | |a PROSTAGLANDIN E2 |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a DOSE RESPONSE |
| 690 | 1 | 0 | |a DRUG EFFECT |
| 690 | 1 | 0 | |a HEART ATRIUM |
| 690 | 1 | 0 | |a HEART CONTRACTION |
| 690 | 1 | 0 | |a IN VITRO STUDY |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a ADRENERGIC SYSTEM |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a AUTONOMIC NERVOUS SYSTEM |
| 690 | 1 | 0 | |a DRUG COMPARISON |
| 690 | 1 | 0 | |a HEART |
| 690 | 1 | 0 | |a HEART ATRIUM |
| 690 | 1 | 0 | |a HEART ATRIUM CONTRACTION |
| 690 | 1 | 0 | |a HEART CONTRACTION |
| 690 | 1 | 0 | |a HEART INOTROPIC EFFECT |
| 690 | 1 | 0 | |a INOTROPISM |
| 690 | 1 | 0 | |a ISOLATED HEART |
| 690 | 1 | 0 | |a PRELIMINARY COMMUNICATION |
| 690 | 1 | 0 | |a ADRENERGIC ALPHA-AGONISTS |
| 690 | 1 | 0 | |a ADRENERGIC BETA-AGONISTS |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a DOSE-RESPONSE RELATIONSHIP, DRUG |
| 690 | 1 | 0 | |a HEART ATRIUM |
| 690 | 1 | 0 | |a IN VITRO |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a METHOXAMINE |
| 690 | 1 | 0 | |a MYOCARDIAL CONTRACTION |
| 690 | 1 | 0 | |a NOREPINEPHRINE |
| 690 | 1 | 0 | |a PROSTAGLANDINS E |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a SUPPORT, NON-U.S. GOV'T |
| 690 | 1 | 0 | |a ANIMALIA |
| 700 | 1 | |a Canga, L. | |
| 700 | 1 | |a Pissani, A. | |
| 700 | 1 | |a Gimeno, A.L. | |
| 773 | 0 | |d 1980 |g v. 20 |h pp. 825-836 |k n. 5 |p Prostaglandins |x 00906980 |t Prostaglandins | |
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