Inotropic effect of prostacyclin (PGI2) on isolated rat atria at different contraction frequencies

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The effects of a wide range of Prostacyclin (PGI2) concentrations on the Isometric Developed Tension (IDT) of isolated left auricles driven at different frequencies (0.8, 1.6 or 3.3 Hz) were explored. A comparison of the positive inotropism of PGI2, norepinephrine (NE), tyramine and phenylephrine (P...

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Detalles Bibliográficos
Autor principal: Sterin-Borda, L.
Otros Autores: Canga, L., Borda, E.S, Gimeno, M.F, Gimeno, A.L
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: Springer-Verlag 1980
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u 0521
Acceso en línea:Registro en Scopus
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Biblioteca Central Dr. Luis F. Leloir (FCEN) de Universidad de Buenos Aires
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024 7 |2 scopus  |a 2-s2.0-0018853136 
024 7 |2 cas  |a 3',4' dihydroxy 2 methylpropiophenone, 5466-89-7; cocaine, 50-36-2, 53-21-4, 5937-29-1; noradrenalin, 1407-84-7, 51-41-2; normetadrenalin, 97-31-4; oxidopamine, 1199-18-4, 28094-15-7, 636-00-0; phenylephrine, 532-38-7, 59-42-7, 61-76-7; propranolol, 13013-17-7, 318-98-9, 3506-09-0, 4199-09-1, 525-66-6; prostacyclin, 35121-78-9, 61849-14-7; tyramine, 51-67-2, 60-19-5; Cocaine, 50-36-2; Epoprostenol, 35121-78-9; Norepinephrine, 51-41-2; Phenylephrine, 59-42-7; Propranolol, 525-66-6; Prostaglandins; Tyramine, 51-67-2 
040 |a Scopus  |b spa  |c AR-BaUEN  |d AR-BaUEN 
030 |a NSAPC 
100 1 |a Sterin-Borda, L. 
245 1 0 |a Inotropic effect of prostacyclin (PGI2) on isolated rat atria at different contraction frequencies 
260 |b Springer-Verlag  |c 1980 
270 1 0 |m Gimeno, A.L.; Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), V. de Obligado 2490, Buenos Aires, 1428, Argentina 
506 |2 openaire  |e Política editorial 
504 |a Borda, L.S., Canga, L., Gimeno, M.F., Gimeno, A.L., An adrenergic participation subserving a positive inotropism and chronotropism of prostacyclin on isolated rat atria (1979) Experientia, 135, pp. 529-530 
504 |a Burgen, A.S.V., Iversen, L.L., Inhibition of noradrenaline uptake by sympathomimetic amines in the rat isolated heart (1965) Br. J. Pharm, 25, pp. 34-42 
504 |a Deckeve, E.A.M., Nugteven, D.H., Hoor, F.T., Prostacyclin is the major prostaglandin released from the isolated perfused rabbit and rat heart (1977) Nature, 268, pp. 160-163 
504 |a Dusting, G.J., Moncada, S., Vane, J.R., Prostacyclin (PGX) is the endogenous metabolite responsible for relaxation of coronary arteries induced by arachidonic acid (1977) Prostaglandins, 13, pp. 3-16 
504 |a Fisher, R.A., Yates, F., (1957) Statistical tables for biological agricultural and medical research, , 5th Ed., Hafner Publishing Co., New York 
504 |a Furchgott, R.F., The pharmacology of vascular smooth muscle (1955) Pharmacol. Rev., 7, pp. 183-265 
504 |a Giles, R.E., Miller, J.W., A comparison of certain properties of catechol-O-methyl transferase to those of adrenergic beta receptors (1967) J. Pharmacol. Exp. Ther., 156, pp. 201-206 
504 |a Gimeno, A.L., Sterin-Borda, L., Borda, E., Gimeno, M.F., Factors underlying the variable inotropic effect of ouabain on isolated rat atria. Changes in contractile frequency and adrenergic mechanism (1979) J. Pharm. Pharmacol., 31, pp. 545-550 
504 |a Goldman, H., Jacobowitz, D., Correlation of norepinephrine content with observations of adrenergic nerves after a single dose of 6-hydroxydopamine in the rat (1971) J. Pharmacol. Exp. Ther., 176, pp. 119-133 
504 |a Gryglewski, R.J., Bunting, S., Moncada, S., Flower, R.J., Vane, J.R., Arterial walls are protected against deposition of platelet thrombi by a substance (Prostaglandin X) which they make from prostaglandin endoperoxides (1976) Prostaglandins, 12, pp. 685-713 
504 |a Isakson, P.C., Raz, A., Denny, S.E., Pure, E., Needleman, P.A., A nobel prostaglandin is the major product of arachidonic acid metabolism in rabbit heart (1977) Proc. Natl. Acad. Sci. USA, 74, pp. 101-105 
504 |a Karmazyn, M., Horrobin, D.F., Manku, M.S., Cunnaue, S.C., Karmali, R.A., Ally, A.I., Morgan, R.O., Barnette, W.E., Effects of prostacyclin on perfusion pressure, electrical activity, rate and force of contraction in isolated rat and rabbit hearts (1978) Life Sci., 22, pp. 2079-2086 
504 |a Koch-Weser, J., Blinks, J.R., The influences of intervals between beats on myocardial contractility (1963) Pharmacol. Rev., 15, pp. 601-652 
504 |a Lefer, A.M., Ogletree, M.L., Smith, J.B., Silver, M.J., Nicolaou, K.C., Barnette, W.E., Gasic, G.P., Prostacyclin: A potentially valuable agent for preserving myocardial tissue in acute myocardial ischemia (1978) Science, 200, pp. 52-54 
504 |a Moncada, S., Gryglewski, R.J., Bunting, S., Vane, J.R., An enzyme isolated from arteries transform PG endooperoxide to an unstable substance that inhibits platelet aggregation (1976) Nature, 263, pp. 663-665 
504 |a Schrör, K., Moncada, S., Ubatuba, F.B., Vane, J.R., Transformation of arachidonic acid and PG endoperoxides by the guinea pig heart. Formation of RCS and prostacyclin (1978) Eur. J. Pharmacol., 47, pp. 103-114 
504 |a Sterin-Borda, L., Gimeno, A.L., Gimeno, M.F., Frequency-force relationship on isolated rat and guinea pig atria. Effects of cholinergic and adrenergic receptor antagonists (1974) Proc. Soc. Exp. Biol. Med., 145, pp. 1151-1157 
504 |a Sterin-Borda, L., Gimeno, M.F., Borda, E., Gimeno, A.L., A positive influence of frequency on the inotropic responses of isolated rat atria to certain adrenergic amines. Effects of cocaine and U-0521 (1977) Proc. Soc. Exp. Biol. Med., 156, pp. 315-320 
504 |a Stjärne, G., Wenmalm, A., Quantitative stimulation of secretion an reuptake of adrenergic trasmitter in the rabbit heart (1971) Acta Physiol. Scand., 81, pp. 286-288 
504 |a Sun, F.F., Chapman, J.P., Mcguire, J.C., Metabolism of prostaglandin endoperoxide in animal tissues (1977) Prostaglandins, 14, pp. 1055-1074 
504 |a Trendelenburg, U., Supersensitivity and subsensitivity to sympathomimetic amines (1963) Pharmacol. Rev., 15, pp. 225-276 
504 |a Van Rossum, J.M., Cumulative dose response curves. II. Technique for the making of dose response curves in isolated organs and the evaluation of drug parameters (1963) Arch. Int. Pharmacodyn. Ther., 143, pp. 299-330 
520 3 |a The effects of a wide range of Prostacyclin (PGI2) concentrations on the Isometric Developed Tension (IDT) of isolated left auricles driven at different frequencies (0.8, 1.6 or 3.3 Hz) were explored. A comparison of the positive inotropism of PGI2, norepinephrine (NE), tyramine and phenylephrine (Phenyl) indicated that PGI2, NE and tyramine enhanced peak tension significantly less at slow (0.8 and 1.6 Hz) than at higher rates (3.3 Hz); whereas Phenyl augmented equally the IDT at all of these three driving frequencies. The positive inotropism evoked by PGI2 was inhibited by (-)-propranolol and also by a treatment with 6-OHDA. Cocaine, normetanephrine and U-0521, augmented the positive inotropic influence of PGI2 on atria paced at a slow rate (0.8 Hz) but not at a faster one (3.3 Hz). These results suggest that the action of PGI2 on atrial contractions is apparently indirect and mediated by the release of tissue catecholamines. In addition the effect of PGI2 and NE at slow and fast rates appears associated with a different relative relevance of the processes which terminate the action of added sympathomimetic agonists, namely, neuronal or extraneuronal uptake as well as metabolization via COMT. These mechanisms seen to be more prominent at slower driving frequencies and could explain the diminished effect of PGI2 and NE on slowly paced atria. © 1980 Springer-Verlag.  |l eng 
593 |a Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), V. de Obligado 2490, Buenos Aires, 1428, Argentina 
690 1 0 |a CATECHOLAMINES 
690 1 0 |a INOTROPIC EFFECT 
690 1 0 |a MYOCARIUM 
690 1 0 |a PGI2 
690 1 0 |a RATE OF CONTRACTION 
690 1 0 |a 3',4' DIHYDROXY 2 METHYLPROPIOPHENONE 
690 1 0 |a COCAINE 
690 1 0 |a NORADRENALIN 
690 1 0 |a NORMETADRENALIN 
690 1 0 |a OXIDOPAMINE 
690 1 0 |a PHENYLEPHRINE 
690 1 0 |a PROPRANOLOL 
690 1 0 |a PROSTACYCLIN 
690 1 0 |a TYRAMINE 
690 1 0 |a ANIMAL EXPERIMENT 
690 1 0 |a CONTROLLED STUDY 
690 1 0 |a DRUG COMPARISON 
690 1 0 |a DRUG RESPONSE 
690 1 0 |a HEART 
690 1 0 |a HEART ATRIUM 
690 1 0 |a HEART MUSCLE CONTRACTILITY 
690 1 0 |a HEART RATE 
690 1 0 |a IN VITRO STUDY 
690 1 0 |a INOTROPISM 
690 1 0 |a RAT 
690 1 0 |a ANIMALS 
690 1 0 |a COCAINE 
690 1 0 |a EPOPROSTENOL 
690 1 0 |a HEART RATE 
690 1 0 |a MALE 
690 1 0 |a MYOCARDIAL CONTRACTION 
690 1 0 |a NOREPINEPHRINE 
690 1 0 |a PHENYLEPHRINE 
690 1 0 |a PROPRANOLOL 
690 1 0 |a PROSTAGLANDINS 
690 1 0 |a RATS 
690 1 0 |a STIMULATION, CHEMICAL 
690 1 0 |a SYMPATHETIC NERVOUS SYSTEM 
690 1 0 |a TYRAMINE 
653 0 0 |a u 0521 
700 1 |a Canga, L. 
700 1 |a Borda, E.S. 
700 1 |a Gimeno, M.F. 
700 1 |a Gimeno, A.L. 
773 0 |d Springer-Verlag, 1980  |g v. 313  |h pp. 95-100  |k n. 2  |p Naunyn-Schmiedeberg's Arch. Pharmacol.  |x 00281298  |t Naunyn-Schmiedeberg's Archives of Pharmacology 
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856 4 0 |u https://doi.org/10.1007/BF00498563  |y DOI 
856 4 0 |u https://hdl.handle.net/20.500.12110/paper_00281298_v313_n2_p95_SterinBorda  |y Handle 
856 4 0 |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00281298_v313_n2_p95_SterinBorda  |y Registro en la Biblioteca Digital 
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999 |c 79461 

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