Inotropic effect of PGF2α on isolated rat atria. Influence of adrenergic mechanisms
Dose-response curves of the positive inotropic effect of PGF2α on isolated rat atria, were examined. It was found a distinct efficacy stimulating the contractile tension of isolated rat atria. The compound elicited a positive inotropism which was augmented in the presence of (-)-propranolol, subthre...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
1981
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 06926caa a22012377a 4500 | ||
|---|---|---|---|
| 001 | PAPER-18482 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204951.0 | ||
| 008 | 190411s1981 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0019390817 | |
| 024 | 7 | |2 cas |a methoxamine, 390-28-3, 61-16-5; noradrenalin, 1407-84-7, 51-41-2; phentolamine, 50-60-2, 73-05-2; propranolol, 13013-17-7, 318-98-9, 3506-09-0, 4199-09-1, 525-66-6; prostaglandin F2 alpha, 551-11-1; oxidopamine, 1199-18-4, 28094-15-7, 636-00-0; tyramine, 51-67-2, 60-19-5; Dinoprost, 551-11-1; Methoxamine, 390-28-3; Norepinephrine, 51-41-2; Phentolamine, 50-60-2; Propranolol, 525-66-6; Prostaglandins F | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a PLRCA | ||
| 100 | 1 | |a Canga, L. | |
| 245 | 1 | 0 | |a Inotropic effect of PGF2α on isolated rat atria. Influence of adrenergic mechanisms |
| 260 | |c 1981 | ||
| 270 | 1 | 0 | |m Canga, L.; Centro de Estudios Farmacológicos, Principios Naturales (CEFAPRIN). Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET, 1428 Buenos Aires, Argentina |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Deckere, Vergroesen, Hoor, PGF2α stimulates release of PGE2 and PGI2 in the isolated perfused rat heart (1979) European Journal of Pharmacology, 55, pp. 345-346 | ||
| 504 | |a Gimeno, Gimeno, Webb, (1963) Am.J.Physiol., 205, pp. 198-199 | ||
| 504 | |a Gimeno, Sterin-Borda, Borda, Gimeno, (1979) J.Pharm.Pharmacol., 31, pp. 545-550 | ||
| 504 | |a Goldman, Jacobowitz, (1971) J.Pharmacol.Exp.Ther., 176, pp. 119-133 | ||
| 504 | |a Gutman, Boonyaviroj, (1979) Eur.J.Pharmacol., 55, pp. 129-136 | ||
| 504 | |a Hedqvist, Inhibition by Prostaglandin E2of Sympathetic Neurotransmission in the Rabbit Heart (1970) Acta Physiologica Scandinavica, 79, pp. 1-40 | ||
| 504 | |a Hedqvist, Wennmalm, (1971) Acta Physiol.Scand., 83, pp. 156-162 | ||
| 504 | |a Hedqvist, (1977) Ann.Rev.Pharmacol.Toxicol., 17, pp. 259-279 | ||
| 504 | |a Kaumann, Birnbaumer, (1974) Nature, 251, pp. 515-517 | ||
| 504 | |a Malik, (1978) Fed.Proc., 37, pp. 203-207 | ||
| 504 | |a Sterin-Borda, Gimeno, Gimeno, Frequency-Force Relationship on Isolated Rat and Guinea Pig Atria. Effects of Cholinergic and Adrenergic Receptor Antagonists (1974) Experimental Biology and Medicine, 145, pp. 1151-1157 | ||
| 504 | |a Sterin-Borda, Cossio, Gimeno, Gimeno, Diez, Laguens, Meckert, Arana, (1976) Cardiovascular Res., 10, pp. 613-622 | ||
| 504 | |a Sterin-Borda, Gimeno, Borda, Gimeno, (1977) Proc.Soc.Exp.Biol.Med., 156, pp. 315-320 | ||
| 504 | |a Sterin-Borda, Canga, Gimeno, Gimeno, (1979) Experientia, 35, pp. 529-530 | ||
| 504 | |a Sterin-Borda, Canga, Borda, Gimeno, Gimeno, (1980) Naunyn Schmiedeberg's Arch.Pharmacol., 313, pp. 95-100 | ||
| 504 | |a Sterin-Borda, Canga, Pissani, Gimeno, (1980) Prostaglandins, 20, pp. 825-836 | ||
| 504 | |a Van Rossum, (1963) Arch.Int.Pharmacodyn.Ther., 143, pp. 299-330 | ||
| 504 | |a Vapaatalo, Parantainen, Metsä-Ketela, Kangasano, (1978) Pol.J.Pharmacol.Pharm., 30, pp. 195-198 | ||
| 504 | |a Wennmalm, Hedqvist, (1970) Life Sci., 9, pp. 931-937 | ||
| 504 | |a Westfall, (1977) Physiol.Rev., 57, pp. 659-728 | ||
| 504 | |a Wennmalm, (1978) Acta Physiol.Scand., 102, pp. 199-204 | ||
| 520 | 3 | |a Dose-response curves of the positive inotropic effect of PGF2α on isolated rat atria, were examined. It was found a distinct efficacy stimulating the contractile tension of isolated rat atria. The compound elicited a positive inotropism which was augmented in the presence of (-)-propranolol, subthreshold doses of methoxamine, as well as after a treatment with 6-OHDA. On the contrary subthreshold concentrations of norepinephrine or the presence of phentolamine decreased the augmenting inotropic effect of PGF2α. The results suggest that the action of PGF2α is apparently direct and not mediated by the release of the tissue catecholamines. However, adrenergic mechanism appear to be somehow involved in the inotropic influence of PGF2α on the rat atria. © 1981 The Italian Pharmacological Society. |l eng | |
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: (') This work has been supporteO by Grant 6638 from CONICET. | ||
| 593 | |a Centro de Estudios Farmacológicos, Principios Naturales (CEFAPRIN). Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET, 1428 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a METHOXAMINE |
| 690 | 1 | 0 | |a NORADRENALIN |
| 690 | 1 | 0 | |a PHENTOLAMINE |
| 690 | 1 | 0 | |a PROPRANOLOL |
| 690 | 1 | 0 | |a PROSTAGLANDIN F |
| 690 | 1 | 0 | |a PROSTAGLANDIN F2 ALPHA |
| 690 | 1 | 0 | |a ADRENERGIC RECEPTOR |
| 690 | 1 | 0 | |a METHOXAMINE |
| 690 | 1 | 0 | |a NORADRENALIN |
| 690 | 1 | 0 | |a OXIDOPAMINE |
| 690 | 1 | 0 | |a PHENTOLAMINE |
| 690 | 1 | 0 | |a PROPRANOLOL |
| 690 | 1 | 0 | |a PROSTAGLANDIN F2 ALPHA |
| 690 | 1 | 0 | |a TYRAMINE |
| 690 | 1 | 0 | |a ADRENERGIC SYSTEM |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CHEMICAL SYMPATHECTOMY |
| 690 | 1 | 0 | |a DRUG EFFECT |
| 690 | 1 | 0 | |a HEART ATRIUM |
| 690 | 1 | 0 | |a HEART CONTRACTION |
| 690 | 1 | 0 | |a IN VITRO STUDY |
| 690 | 1 | 0 | |a INNERVATION |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a RAT STRAIN |
| 690 | 1 | 0 | |a STIMULATION |
| 690 | 1 | 0 | |a ADRENERGIC SYSTEM |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a AUTONOMIC NERVOUS SYSTEM |
| 690 | 1 | 0 | |a DRUG RESPONSE |
| 690 | 1 | 0 | |a HEART |
| 690 | 1 | 0 | |a HEART ATRIUM |
| 690 | 1 | 0 | |a HEART MUSCLE CONTRACTILITY |
| 690 | 1 | 0 | |a INOTROPISM |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a DINOPROST |
| 690 | 1 | 0 | |a HEART ATRIUM |
| 690 | 1 | 0 | |a IN VITRO |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a METHOXAMINE |
| 690 | 1 | 0 | |a MYOCARDIAL CONTRACTION |
| 690 | 1 | 0 | |a NOREPINEPHRINE |
| 690 | 1 | 0 | |a PHENTOLAMINE |
| 690 | 1 | 0 | |a PROPRANOLOL |
| 690 | 1 | 0 | |a PROSTAGLANDINS F |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a RATS, INBRED STRAINS |
| 690 | 1 | 0 | |a STIMULATION, CHEMICAL |
| 690 | 1 | 0 | |a SUPPORT, NON-U.S. GOV'T |
| 690 | 1 | 0 | |a SYMPATHECTOMY, CHEMICAL |
| 690 | 1 | 0 | |a SYMPATHETIC NERVOUS SYSTEM |
| 700 | 1 | |a Sterin-Borda, L. | |
| 700 | 1 | |a Pissani, A. | |
| 700 | 1 | |a Gimeno, A.L. | |
| 773 | 0 | |d 1981 |g v. 13 |h pp. 559-570 |k n. 6 |p Pharmacol. Res. Commun. |x 00316989 |t Pharmacological Research Communications | |
| 856 | 4 | 1 | |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-0019390817&doi=10.1016%2fS0031-6989%2881%2980025-2&partnerID=40&md5=fdfb9c7876f048529bc36c6af2d3f7ca |y Registro en Scopus |
| 856 | 4 | 0 | |u https://doi.org/10.1016/S0031-6989(81)80025-2 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_00316989_v13_n6_p559_Canga |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00316989_v13_n6_p559_Canga |y Registro en la Biblioteca Digital |
| 961 | |a paper_00316989_v13_n6_p559_Canga |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 999 | |c 79435 | ||