Melatonin increases cGMP and decreases cAMP levels in rat medial basal hypothalamus in vitro
Measurement of cyclic nucleotide accumulation in rat medial basal hypothalamus (MBH) incubated in vitro with methoxyindoles indicated that melatonin (10-8 M or greater) increased significantly cGMP and depressed cAMP levels. Only the effect on MBH cAMP was shared by 5-methoxytryptophol which exhibit...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
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1981
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 07915caa a22009377a 4500 | ||
|---|---|---|---|
| 001 | PAPER-18446 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204949.0 | ||
| 008 | 190411s1981 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0019521835 | |
| 024 | 7 | |2 cas |a 5 methoxytryptophol, 712-09-4; 6 hydroxymelatonin, 2208-41-5; cyclic AMP, 60-92-4; cyclic GMP, 7665-99-8; melatonin, 73-31-4; Cyclic AMP, 60-92-4; Cyclic GMP, 7665-99-8; Melatonin, 73-31-4 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a BRREA | ||
| 100 | 1 | |a Vacas, M.I. | |
| 245 | 1 | 0 | |a Melatonin increases cGMP and decreases cAMP levels in rat medial basal hypothalamus in vitro |
| 260 | |c 1981 | ||
| 270 | 1 | 0 | |m Vacas, M.I.; Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), V. de Obligado 2490, 1428 Buenos Aires, Argentina |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Anton-Tay, Pineal-brain relationships (1971) The Pineal Gland, pp. 213-227. , G.E.W. Wolstenholme, J. Knight, Churchill Livingstone, London | ||
| 504 | |a Anton-Tay, Chou, Anton, Wurtman, Brain serotonin concentration: elevation following intraperitoneal administration of melatonin (1968) Science, 162, pp. 277-278 | ||
| 504 | |a Brown, Albano, Ekins, Sgherzi, Tampion, A simple and sensitive saturation assay method for the measurement of adenosine-3′,5′-cyclic monophosphate (1971) Biochem. J., 121, pp. 561-562 | ||
| 504 | |a Cardinali, D. P., Melatonin. A mammalian pineal hormone,Endocrine Rev., in press; Cardinali, Freire, Melatonin effects on brain. Interaction with microtubule protein, inhibition of fast axoplasmic flow and induction of crystaloid and tubular formations in the hypothalamus (1975) Molec. Cell. Endocr., 2, pp. 317-330 | ||
| 504 | |a Cardinali, Nagle, Freire, Rosner, Effects of melatonin on neurotransmitter uptake and release by synaptosome-rich homogenates of the rat hypothalamus (1975) Neuroendocrinology, 18, pp. 72-85 | ||
| 504 | |a Cardinali, Nagle, Rosner, Incorporation of3H-leucine into proteins in the hypothalamus and the anterior hypophysis. Effects of pinealectomy, superior cervical sympathectomy and continuous exposure to light or darkness (1974) Neuroendocrinology, 16, pp. 74-83 | ||
| 504 | |a Cardinali, Ritta, Fuentes, Gimeno, Gimeno, Prostaglandin E release by rat medial basal hypothalamus in vitro. Inhibition by melatonin at submicromolar concentrations (1980) Europ. J. Pharmacol., 67, pp. 151-153 | ||
| 504 | |a Cardinali, Vacas, Boyer, Specific binding of melatonin in bovine brain (1979) Endocrinology, 105, pp. 437-441 | ||
| 504 | |a Cohen, Roselle, Chabner, Schmidt, Lippman, Evidence for a cytoplasmic melatonin receptor (1978) Nature (Lond.), 274, pp. 894-895 | ||
| 504 | |a Flaugh, Crowell, Clemens, Sawyer, Synthesis and evaluation of the antiovulatory activity of a variety of melatonin analogues (1979) J. Med. Chem., 22, pp. 63-64 | ||
| 504 | |a Greengard, (1978) Cyclic Nucleotides, Phosphorylated Proteins, and Neuronal Function. Distinguished Lecture Series of the Society of General Physiologists, 1, p. 124. , Raven Press, New York | ||
| 504 | |a Kano, Miyachi, Direct action of melatonin on testosterone and cyclic GMP production using rat testis tissue in vitro (1976) Biochem. Biophys. Res. Commun., 72, pp. 969-975 | ||
| 504 | |a Kao, Weisz, Release of gonadotrophin-releasing hormone (Gn-RH) from isolated, perifused medial basal hypothalamus by melatonin (1977) Endocrinology, 100, pp. 1723-1726 | ||
| 504 | |a Lowry, Rosebrough, Farr, Randall, Protein measurement with the Folin phenol reagent (1951) J. Biol. Chem., 193, pp. 265-275 | ||
| 504 | |a Martin, Kirk, Klein, Effects of 6-hydroxy-, 6-fluoro-, and 4, 6-difluoromelatonin on the in vitro pituitary response to luteinizing hormone-releasing hormone (1980) Endocrinology, 106, pp. 398-401 | ||
| 504 | |a Mullen, Leone, Hooper, Smith, Silman, Finnie, Carter, Linsell, Pineal 5-methoxy tryptophol in man (1979) Psychoneuroendocrinology, 2, pp. 117-126 | ||
| 504 | |a Ojeda, Negro-Vilar, McCann, Release of prostaglandin Es by hypothalamic tissue: evidence for their involvement in catecholamine-induced luteinizing hormone-releasing hormone release (1979) Endocrinology, 104, pp. 617-624 | ||
| 504 | |a Reiter, The pineal and its hormones in the control of reproduction in mammals (1980) Endocrine Rev., 1, pp. 109-131 | ||
| 504 | |a Rudman, Injection of melatonin into cisterna magna increases concentration of 3′,5′-cyclic guanosine monophosphate in cerebrospinal fluid (1976) Neuroendocrinology, 20, pp. 235-242 | ||
| 504 | |a Sandler, Clyman, Manganiello, Vaughan, The effect of serotonin (5-hydroxytryptamine) and derivatives on guanosine 3′,5′-monophosphate in human monocytes (1975) J. clin. Invest., 55, pp. 431-435 | ||
| 504 | |a Vesely, Melatonin enhances guanylate cyclase activity in a variety of tissues (1981) Molecular and Cellular Biochemistry, 35, pp. 55-58 | ||
| 520 | 3 | |a Measurement of cyclic nucleotide accumulation in rat medial basal hypothalamus (MBH) incubated in vitro with methoxyindoles indicated that melatonin (10-8 M or greater) increased significantly cGMP and depressed cAMP levels. Only the effect on MBH cAMP was shared by 5-methoxytryptophol which exhibited a greater activity than melatonin. 6-Fluromelatonin (10-7 M) increased cGMP, whereas the effect of 6-hydroxymelatonin was not significant. Both 6-fluoro- and 6-hydroxymelatonin (10-5 M) depressed MBH cAMP accumulation while only 6-fluoromelatonin affected it at 10-7 M concentrations. These data suggest that melatonin and 5-methoxytryptophol affect differently cyclic nucleotide content of MBH at physiological concentrations. © 1981. |l eng | |
| 536 | |a Detalles de la financiación: The authors wish to thank Dr. Michael E. Flaugh, Lilly Research Laboratories, Indianapolis, IN, for kindly supplying 6-fluoromelatonin. This study was supported by Grant 6638 from the Consejo Nacional de Investi-gaciones Cientificas y T6cnicas (CONICET), Argentina. M.I.V. and D.P.C. are Established Investigators, CONICET. | ||
| 593 | |a Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), V. de Obligado 2490, 1428 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a 5-METHOXYTRYPTOPHOL |
| 690 | 1 | 0 | |a CAMP |
| 690 | 1 | 0 | |a CGMP |
| 690 | 1 | 0 | |a MEDIAL BASAL HYPOTHALAMUS |
| 690 | 1 | 0 | |a MELATONIN |
| 690 | 1 | 0 | |a PINEAL GLAND |
| 690 | 1 | 0 | |a 5 METHOXYTRYPTOPHOL |
| 690 | 1 | 0 | |a 6 HYDROXYMELATONIN |
| 690 | 1 | 0 | |a CYCLIC AMP |
| 690 | 1 | 0 | |a CYCLIC GMP |
| 690 | 1 | 0 | |a MELATONIN |
| 690 | 1 | 0 | |a 6 FLUOROMELATONIN |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a CENTRAL NERVOUS SYSTEM |
| 690 | 1 | 0 | |a HYPOTHALAMUS |
| 690 | 1 | 0 | |a IN VITRO STUDY |
| 690 | 1 | 0 | |a NERVOUS SYSTEM |
| 690 | 1 | 0 | |a PINEAL BODY |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a CYCLIC AMP |
| 690 | 1 | 0 | |a CYCLIC GMP |
| 690 | 1 | 0 | |a DOSE-RESPONSE RELATIONSHIP, DRUG |
| 690 | 1 | 0 | |a HYPOTHALAMUS |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MELATONIN |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a RATS, INBRED STRAINS |
| 690 | 1 | 0 | |a SUPPORT, NON-U.S. GOV'T |
| 700 | 1 | |a Keller Sarmiento, M.I. | |
| 700 | 1 | |a Cardinali, D.P. | |
| 773 | 0 | |d 1981 |g v. 225 |h pp. 207-211 |k n. 1 |p Brain Res. |x 00068993 |w (AR-BaUEN)CENRE-4052 |t Brain Research | |
| 856 | 4 | 1 | |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-0019521835&doi=10.1016%2f0006-8993%2881%2990332-2&partnerID=40&md5=ab8f78e90bc77bb7a4b011bf53de23df |y Registro en Scopus |
| 856 | 4 | 0 | |u https://doi.org/10.1016/0006-8993(81)90332-2 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_00068993_v225_n1_p207_Vacas |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00068993_v225_n1_p207_Vacas |y Registro en la Biblioteca Digital |
| 961 | |a paper_00068993_v225_n1_p207_Vacas |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 999 | |c 79399 | ||