Extracellular calcium concentration and calcium blocking agents on the action of ouabain on isolated rat atrium
The influences of calcium blocking agents and different[Ca2+]o on the non toxic (positive inotropism without changes in frequency or resting tension) and toxic (positive chronotropism, negative inotropism, contracture, arrhythmia) effects of ousbain upon isolated rat stris were explored. Decreasing...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
1982
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 07165caa a22010697a 4500 | ||
|---|---|---|---|
| 001 | PAPER-18416 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204947.0 | ||
| 008 | 190411s1982 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0020035229 | |
| 024 | 7 | |2 cas |a calcium, 7440-70-2; diltiazem, 33286-22-5, 42399-41-7; gallopamil, 16662-47-8; ouabain, 11018-89-6, 630-60-4; verapamil, 152-11-4, 52-53-9; Calcium Channel Blockers; Calcium, 7440-70-2; Diltiazem, 42399-41-7; Gallopamil, 16662-47-8; Ouabain, 630-60-4; Verapamil, 52-53-9 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a PLRCA | ||
| 100 | 1 | |a Canga, L. | |
| 245 | 1 | 0 | |a Extracellular calcium concentration and calcium blocking agents on the action of ouabain on isolated rat atrium |
| 260 | |c 1982 | ||
| 270 | 1 | 0 | |m Canga, L.; Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Consejo Nacional de Investigaciones Cientificas y Tecnicas de la Republica Argentina (CONICET). V. d, 1428 Buenos Aires, Argentina |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Akera, Hook, Tobin, Brody, (1972) Res.Comm.Chem.Pathol.Pharmacol., 4, pp. 699-706 | ||
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| 504 | |a Godfraind, Ghysel-Burton, (1980) Proc.Natl.Acad.Sci. U.S.A., 77, pp. 3067-3069 | ||
| 504 | |a Klaus, Kuschinsky, Lüllmann, (1963) Proc.First Intern.Pharmacol.Meeting, 3, pp. 211-218. , W. Wilbrandt, P. Lindgnen, The Mcmillan Co., N.Y | ||
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| 504 | |a Lüllmann, Holland, J.Pharmac.Exp.Ther. (1962) J.Pharmac.Exp.Ther., 137, pp. 186-192 | ||
| 504 | |a Lüllmann, Peter, (1976) Recent Adv.Studies on Cardisc Structure and Metabolism, 9, pp. 311-328. , P.E. Roy, M.S. Dhalls, University Park Press, N.Y | ||
| 504 | |a Masuoka, Saunders, (1950) Proc.Soc.Exp.Biol.Med., 74, pp. 879-882 | ||
| 504 | |a Nayler, (1973) J.Molec.Cell.Cardiol., 5, pp. 101-110 | ||
| 504 | |a Refsum, Landmark, The Effect of a Calcium-antagonistic Drug, Nifedipine, on the Mechanical and Electrical Activity of the Isolated Rat Atrium (1976) Acta Pharmacologica et Toxicologica, 37, pp. 369-376 | ||
| 504 | |a Scott, Beliles, Silverman, (1971) Toxicol.Appl.Pharmacol., 20, pp. 599-601 | ||
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| 504 | |a Sterin-Borda, Gimeno, Gimeno, Frequency-Force Relationship on Isolated Rat and Guinea Pig Atria. Effects of Cholinergic and Adrenergic Receptor Antagonists (1974) Experimental Biology and Medicine, 145, pp. 1151-1157 | ||
| 504 | |a Sterin-Borda, Gimeno, Borda, Gimeno, (1977) Proc.Soc.Exp.Biol.Med., 156, pp. 315-320 | ||
| 504 | |a Sterin-Borda, Canga, Borda, Gimeno, Gimeno, (1980) Naunyn-Schmiedeberg's Arch.Pharmacol., 313, pp. 95-100 | ||
| 504 | |a Sterin-Borda, Canga, Borda, Cossio, Diez, Arans, Gimeno, (1981) Europ.J.Pharmacol., 69, pp. 1-10 | ||
| 504 | |a Tobin, Brody, (1972) Biochem.Pharmacol., 21, pp. 1553-1560 | ||
| 504 | |a Van Rossum, (1963) Arch.Int.Pharmacodyn.Ther., 143, pp. 299-330 | ||
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| 520 | 3 | |a The influences of calcium blocking agents and different[Ca2+]o on the non toxic (positive inotropism without changes in frequency or resting tension) and toxic (positive chronotropism, negative inotropism, contracture, arrhythmia) effects of ousbain upon isolated rat stris were explored. Decreasing the [Ca2]o from 1.2 to 0.3 mM or tresting the auricles with verapamil, D-600 or diltiazem potentisted the positive inotropic influences of ouabain and attenuated and delayed the onset of toxic actions. On the contrary increasing [Ca2+]o from 1.2 to 2.7 mM, reduced the non toxic effect of ouabain and facilitated the toxic action of the drug. These findings suggest that factors known to induce changes in the intracellular calcium concentration (i.e. calcium blocking agents, and variable extracellular calcium concentrations) produce a remarkable modification of the influence of ouabain on rat myocardium. © 1982 The Italian Pharmacological Society. |l eng | |
| 593 | |a Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Consejo Nacional de Investigaciones Cientificas y Tecnicas de la Republica Argentina (CONICET). V. d, 1428 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a BLOCKING AGENT |
| 690 | 1 | 0 | |a CALCIUM |
| 690 | 1 | 0 | |a DILTIAZEM |
| 690 | 1 | 0 | |a GALLOPAMIL |
| 690 | 1 | 0 | |a OUABAIN |
| 690 | 1 | 0 | |a VERAPAMIL |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a CHRONOTROPISM |
| 690 | 1 | 0 | |a HEART |
| 690 | 1 | 0 | |a HEART ATRIUM |
| 690 | 1 | 0 | |a HEART MUSCLE CONTRACTILITY |
| 690 | 1 | 0 | |a IN VITRO STUDY |
| 690 | 1 | 0 | |a INOTROPISM |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a CALCIUM |
| 690 | 1 | 0 | |a CALCIUM CHANNEL BLOCKERS |
| 690 | 1 | 0 | |a DILTIAZEM |
| 690 | 1 | 0 | |a ELECTRIC STIMULATION |
| 690 | 1 | 0 | |a GALLOPAMIL |
| 690 | 1 | 0 | |a HEART |
| 690 | 1 | 0 | |a IN VITRO |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MYOCARDIAL CONTRACTION |
| 690 | 1 | 0 | |a MYOCARDIUM |
| 690 | 1 | 0 | |a OUABAIN |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a RATS, INBRED STRAINS |
| 690 | 1 | 0 | |a VERAPAMIL |
| 653 | 0 | 0 | |a d 600 |
| 700 | 1 | |a Sterin-Borda, L. | |
| 700 | 1 | |a Gimeno, A.L. | |
| 773 | 0 | |d 1982 |g v. 14 |h pp. 15-30 |k n. 1 |p Pharmacol. Res. Commun. |x 00316989 |t Pharmacological Research Communications | |
| 856 | 4 | 1 | |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-0020035229&doi=10.1016%2fS0031-6989%2882%2980048-9&partnerID=40&md5=f6303804e4a12c6741106b6fefc6a466 |y Registro en Scopus |
| 856 | 4 | 0 | |u https://doi.org/10.1016/S0031-6989(82)80048-9 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_00316989_v14_n1_p15_Canga |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00316989_v14_n1_p15_Canga |y Registro en la Biblioteca Digital |
| 961 | |a paper_00316989_v14_n1_p15_Canga |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 999 | |c 79369 | ||