Prostacyclin induces a surprising long-lasting motility in quiescent uterine strips (indomethacin-treated) isolated from ovariectomized rats
Dose-response curves for several prostaglandins (PGI2; PGD2; PGF2 and PGE2); BaCl2 or prostaglandin metabolites (15-keto-PGF2α; 13, 14-diOH-15-keto-PGF2α; 6-keto-PGF1α and 6-keto-PGE1 in quiescent (indomethacin-treated) uterine strips from ovariectomized rats, were constructed. All PGs tested as wel...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
1983
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 09864caa a22011417a 4500 | ||
|---|---|---|---|
| 001 | PAPER-18384 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204945.0 | ||
| 008 | 190411s1983 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0021048161 | |
| 024 | 7 | |2 cas |a barium chloride, 10361-37-2; indometacin, 53-86-1, 74252-25-8, 7681-54-1; prostacyclin, 35121-78-9, 61849-14-7; prostaglandin D2, 41598-07-6; prostaglandin E2, 363-24-6; prostaglandin F2 alpha, 551-11-1; Barium, 7440-39-3; Barium Compounds; Chlorides; Dinoprost, 551-11-1; Dinoprostone, 363-24-6; Epoprostenol, 35121-78-9; Indomethacin, 53-86-1; Prostaglandin D2, 41598-07-6; Prostaglandins D; Prostaglandins E; Prostaglandins F; barium chloride, 10361-37-2 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a PRGLB | ||
| 100 | 1 | |a Gimeno, A.L. | |
| 245 | 1 | 0 | |a Prostacyclin induces a surprising long-lasting motility in quiescent uterine strips (indomethacin-treated) isolated from ovariectomized rats |
| 260 | |c 1983 | ||
| 270 | 1 | 0 | |m Gimeno, A.L.; Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Consejo Nacional de Investigaciones Cientificas y Tecnicas de la Republica Argentina (CONICET). Serr, 1414 Buenos Aires, Argentina |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Moncada, Gryglewski, Bunting, Vane, An enzyme isolated from arteries transform prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation (1976) Nature (Lond.), 263, p. 663 | ||
| 504 | |a Johnson, Norton, Kinner, Gorman, McGuirre, Sun, Whittaker, Vane, The chemical characterization of prostaglandin X (prostacyclin) (1976) Prostaglandins, 12, p. 915 | ||
| 504 | |a Williams, Demnibska-Kiéc, Zmuda, Gryglewski, Prostacyclin formation by myometrial and decidual fractions of the pregnant rat uterus (1978) Prostaglandins, 15, p. 343 | ||
| 504 | |a El-Tahir, Williams, Studies on prostacyclin formation by the rat pregnant myometrium (1980) Br. J. Pharmac., 70, p. 85P | ||
| 504 | |a Gimeno, Borda, Lazzari, Gimeno, Ovarian hormones inhibit the release of prostacyclin like material from isolated rat uterus (1980) Prostaglandins, 20, p. 223 | ||
| 504 | |a Mitchell, Flint, Hicke, Kinston, Thorburn, Robinson, Uterine tissues from pregnant goats produce 6-oxo-prostaglandin F1 in vitro (1978) J. Endocr., 79, p. 401 | ||
| 504 | |a Fenwick, Jones, Naylor, Poyser, Wilson, Production of prostaglandins by the pseudo pregnant rat uterus in vitro and the effect of tamoxifen with the identification of 6-keto-prostaglandin F1 as a major product (1977) Br. J. Pharmacol., 59, p. 191 | ||
| 504 | |a Omini, Moncada, Vane, The effects of prostacyclin (PGI2) on tissues which detect prostaglandins (PG's) (1977) Prostaglandins, 14, p. 625 | ||
| 504 | |a Omini, Pasargiklin, Folco, Fano, Berti, Pharmacological activity of PGI2 and its metabolite 6-oxo-PGF1 on human uterus and fallopian tubes (1978) Prostaglandins, 15, p. 1045 | ||
| 504 | |a Cho, Allen, Chemical stability of prostacyclin (PGI2) in aqueous solution (1978) Prostaglandins, 15, p. 943 | ||
| 504 | |a Dusting, Moncada, Vane, Recirculation of prostacyclin (PGI2) in the dog (1978) Br. J. Pharmacol., 64, p. 315 | ||
| 504 | |a Borda, Lazzari, Gimeno, Gimeno, Human platelet rich plasma and human serum protects from inactivation the antiaggregatory capacity of prostacyclin like material (PGI2) produced by the rat stomach fundus (1980) Prostaglandins, 19, p. 899 | ||
| 504 | |a Pifer, Cagen, Chesney, Stability of prostaglandin I2 in human blood (1981) Prostaglandins, 21, p. 165 | ||
| 504 | |a Sterin-Speziale, Gimeno, Bonacossa, Gimeno, The effect of estradiol on isolated rat uterine motility and on prostaglandin generation (1980) Prostaglandins, 20, p. 233 | ||
| 504 | |a Gimeno, Borda, Sterin-Borda, Vidal, Gimeno, Pharmacologic influences on human ovarian contractions (1976) Obstet. Gynecol., 47, p. 218 | ||
| 504 | |a Van Rossum, Cumulative dose-response curves (1963) Arch. Int. Pharmacodyn. Ther., 143, p. 299 | ||
| 504 | |a Bergström, Carñson, Weeks, The prostaglandins a family of biologically active lipids (1968) Pharmacol Rev, 20, p. 1 | ||
| 504 | |a Bygdeman, Green, Toppozada, Mirvist, Bergström, The influence of prostaglandin metabolites on the uterine response to PGF2. A clinical and pharmacokinetic study (1974) Life Sci., 14, p. 521 | ||
| 504 | |a Wong, Malik, Desiderio, McGiff, Sun, Hepatic metabolism of prostacyclin (PGI2) in the rabbit: formation of a potent novel inhibitor of platelet aggregation (1980) Biochem. Biophys. Res. Commun., 93, p. 486 | ||
| 504 | |a Wong, Lee, Chao, Reiss, McGiff, Metabolism of prostacyclin by 9-hydroxy prostaglandin dehydrogenase in human latelets (1980) J. Biol. Chem., 255, p. 9021 | ||
| 504 | |a Clark, Kennedy, Patrick, Challis, Effect of bisenoic prostaglandins on the uterine vasculature of the non-pregnant sheep (1981) Prostaglandins, 22, p. 333 | ||
| 504 | |a Borda, Agostini, Sterin-Speziale, Gimeno, Gimeno, Spontaneous contractile activity of isolated ovarian human vein. A dual influence of prostacyclin (PGI2) (1979) Prostaglandins, 18, p. 829 | ||
| 504 | |a Lye, Challis, Inhibition by PGI2 of myometrial activity in vivo in non-pregnant ovariectomized sheep (1982) J. Reprod. Fert., 66, p. 311 | ||
| 504 | |a Williams, El-Tahir, Marcinkiewicz, Dual actions of prostacyclin (PGI2) on the rat pregnant uterus (1979) Prostaglandins, 17, p. 667 | ||
| 504 | |a Gimeno, Sterin-Borda, Borda, Lazzari, Gimeno, Human plasma transforms prostacyclin (PGI2) into a platelet antiaggregatory substance with contracts isolated bovine coronary arteries (1980) Prostaglandins, 19, p. 807 | ||
| 520 | 3 | |a Dose-response curves for several prostaglandins (PGI2; PGD2; PGF2 and PGE2); BaCl2 or prostaglandin metabolites (15-keto-PGF2α; 13, 14-diOH-15-keto-PGF2α; 6-keto-PGF1α and 6-keto-PGE1 in quiescent (indomethacin-treated) uterine strips from ovariectomized rats, were constructed. All PGs tested as well as BaCl2, triggered at different concentrations, evident phasic contractions. Within the range of concentrations tested the portion of the curves for the metabolites of PGF2α was shifted to the right of that for PGF2α itself; the curve for 6-keto-PGF1α was displaced to the right of the curve for PGI2 and that for 6-keto-PGE1 to the left. It was also demonstrated that the uterine motility elicited by 10-5 M PGF2α and its metabolites was long lasting (more than 3 hours) and so it was the activity evoked by PGI2; 6-keto-PGF1α and BaCl2, but not the contractions following 6-keto-PGE1, which disappeared much earlier. The contractile tension after PGF2α; 15-keto-PGF2α; 13, 14-diOH-15-keto-PGF2α and PGI2, increased as time progressed whilst that evoked by 6-keto-PGF2α or BaCl2 fluctuated during the same period around more constant levels. The surprising sustained and gradually increasing contractile activity after a single dose of an unstable prostaglandin such as PGI2, on the isolated rat uterus rendered quiescent by indomethacin, is discussed in terms of an effect associated to its transformation into more stable metabolites (6-keto-PGF1α, or another not tested) or as a consequence of a factor which might protects prostacyclin from inactivation. © 1983. |l eng | |
| 536 | |a Detalles de la financiación: Centro de Estudios Farmacologicos y de Principios (CEFAPRIN), Consejo National de Investigaciones Tecnicas de la Repljblica Argentina (CONICET). (1414) Buenos Aires, Argentina. | ||
| 536 | |a Detalles de la financiación: work has been supported by Grant 6638 from CDNICET. | ||
| 593 | |a Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Consejo Nacional de Investigaciones Cientificas y Tecnicas de la Republica Argentina (CONICET). Serr, 1414 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a BARIUM CHLORIDE |
| 690 | 1 | 0 | |a INDOMETACIN |
| 690 | 1 | 0 | |a PROSTACYCLIN |
| 690 | 1 | 0 | |a PROSTAGLANDIN D2 |
| 690 | 1 | 0 | |a PROSTAGLANDIN E2 |
| 690 | 1 | 0 | |a PROSTAGLANDIN F2 ALPHA |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a BIOLOGICAL MODEL |
| 690 | 1 | 0 | |a DOSE RESPONSE |
| 690 | 1 | 0 | |a DOSE TIME EFFECT RELATION |
| 690 | 1 | 0 | |a DRUG ADMINISTRATION |
| 690 | 1 | 0 | |a DRUG COMPARISON |
| 690 | 1 | 0 | |a DRUG EFFICACY |
| 690 | 1 | 0 | |a DRUG RESPONSE |
| 690 | 1 | 0 | |a FEMALE GENITAL SYSTEM |
| 690 | 1 | 0 | |a METHODOLOGY |
| 690 | 1 | 0 | |a MYOMETRIUM |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a UTERUS CONTRACTILITY |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a BARIUM |
| 690 | 1 | 0 | |a BARIUM COMPOUNDS |
| 690 | 1 | 0 | |a CASTRATION |
| 690 | 1 | 0 | |a CHLORIDES |
| 690 | 1 | 0 | |a DINOPROST |
| 690 | 1 | 0 | |a DINOPROSTONE |
| 690 | 1 | 0 | |a DOSE-RESPONSE RELATIONSHIP, DRUG |
| 690 | 1 | 0 | |a EPOPROSTENOL |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a INDOMETHACIN |
| 690 | 1 | 0 | |a PROSTAGLANDIN D2 |
| 690 | 1 | 0 | |a PROSTAGLANDINS D |
| 690 | 1 | 0 | |a PROSTAGLANDINS E |
| 690 | 1 | 0 | |a PROSTAGLANDINS F |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a RATS, INBRED STRAINS |
| 690 | 1 | 0 | |a UTERINE CONTRACTION |
| 690 | 1 | 0 | |a ANIMALIA |
| 700 | 1 | |a Chaud, M. | |
| 700 | 1 | |a Bonacossa, A. | |
| 700 | 1 | |a Franchi, A.M. | |
| 700 | 1 | |a Gimeno, M.F. | |
| 773 | 0 | |d 1983 |g v. 26 |h pp. 663-676 |k n. 4 |p Prostaglandins |x 00906980 |t Prostaglandins | |
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| 856 | 4 | 0 | |u https://doi.org/10.1016/0090-6980(83)90202-2 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_00906980_v26_n4_p663_Gimeno |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00906980_v26_n4_p663_Gimeno |y Registro en la Biblioteca Digital |
| 961 | |a paper_00906980_v26_n4_p663_Gimeno |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 999 | |c 79337 | ||