Variable inotropic effect of immune cells on mice atria - Participation of metabolic products of arachidonic acid
The effect of BALB/c anti CF1 lymph node cells and thymocytes on the spontaneous activity of isolated CF1 mouse atria was studied. Immune lymph node cells induced opposite effects depending on the number of immunizations. Immune lymph node cells from mice which received two immunizations decreased t...
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| Formato: | Capítulo de libro |
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1984
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 09266caa a22010217a 4500 | ||
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| 001 | PAPER-18322 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204941.0 | ||
| 008 | 190411s1984 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0021723851 | |
| 024 | 7 | |2 cas |a 7 [3 (4 acetyl 3 hydroxy 2 propylphenoxy) 2 hydroxypropoxy] 4 oxo 8 propyl 4h 1 benzopyran 2 carboxylic acid, 40786-08-1; acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; dithizone, 60-10-6; indometacin, 53-86-1, 74252-25-8, 7681-54-1; nordihydroguaiaretic acid, 500-38-9; Arachidonic Acid, 506-32-1; Arachidonic Acids; Aspirin, 50-78-2; Catechols; Dithizone, 60-10-6; Indomethacin, 53-86-1; Nordihydroguaiaretic Acid, 500-38-9 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a IJIMD | ||
| 100 | 1 | |a Borda, E. | |
| 245 | 1 | 0 | |a Variable inotropic effect of immune cells on mice atria - Participation of metabolic products of arachidonic acid |
| 260 | |c 1984 | ||
| 270 | 1 | 0 | |m Borda, E.; Centro de Estudios Farmacológicos, Principios Naturales (CEFAPRIN). Consejo Nacional de Investigaciones Cientificas y Tecnicas de la Re, Serrano 665/69, 1414 Buenos Aires, Argentina |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Bauminger, Differences in prostaglandin formation between thymocyte subpopulations (1978) Prostaglandins, 16, pp. 351-355 | ||
| 504 | |a Belo, Talesnik, Coronary vasoconstrictor and vasodilator actions of arachidonic acid in the isolated perfused heart of the rat (1982) Br. J. Pharmac., 75, pp. 269-286 | ||
| 504 | |a Borbola, Susskind, Siess, Szekeres, The effects of arachidonic acid in isolated atria of guinea pig (1977) Eur. J. Pharmac., 41, pp. 27-36 | ||
| 504 | |a Borgeat, Samuelsson, Arachidonic acid metabolism in polymorphonuclear leukocytes: unstable intermediate in formation of dihydroxyacids (1979) Proc. natn. Acad. Sci., U.S.A., 76, pp. 3213-3217 | ||
| 504 | |a Burka, Paterson, The effect of SRS-A and histamine antagonists on antigen-induced contraction of guinea pig trachea (1981) Eur. J. Pharmac., 70, pp. 489-499 | ||
| 504 | |a Bracco, Sterin-Borda, Fink, Finiasz, Borda, Stimulatory effect of lymphocytes from Chagas' patients on spontaneously beating rat atria (1983) Clin. exp. Immun., , (in press) | ||
| 504 | |a Braun, Seal, Pasqualini, Aspectos immunológicos del crecimiento tumoral murino alogeneico (1974) Sangre, Barcelona, 19, pp. 153-156 | ||
| 504 | |a Goldyne, Stobo, Immunoregulatory role of prostaglandins and related lipids (1981) Crit. Rev. Immun., 2, pp. 189-223 | ||
| 504 | |a Hamberg, Samuelsson, Prostaglandin endoperoxides. Novel transformations of arachidonic acid in human platelets (1974) Proc. natn. Acad. Sci. U.S.A., 71, pp. 3400-3404 | ||
| 504 | |a Kennedy, Stobo, Goldyne, In vitro synthesis of prostaglandin and related lipids by populations of human peripheral blood mononuclear cells (1980) Prostaglandins, 20, pp. 135-145 | ||
| 504 | |a Melmon, Bourne, Weinstein, Shearer, Kram, Bauminger, Hemolytic plaque formation by leukocytes in vitro (1974) J. clin. Invest., 53, pp. 13-18 | ||
| 504 | |a Murphy, Hammarstrom, Samuelsson, Leukotriene C: A Slow Reacting Substance from murine mastocytoma cells (1979) Proc. natn. Acad. Sci. U.S.A., 76, pp. 4275-4279 | ||
| 504 | |a Parker, Kelly, Falkemhein, Huber, Release of arachidonic acid from human lymphocytes in response to mitogenic lectins (1979) J. exp. Med., 149, pp. 1487-1503 | ||
| 504 | |a Parker, Stenson, Huber, Kelly, Formation of TXB2 and hydroxyarachidonic acids in purified human lymphocytes in the presence and absence of PHA (1979) J. Immun., 122, pp. 1572-1578 | ||
| 504 | |a Pistorius, Axelrod, Iron, an essential component of lipoxygenase (1974) J. biol. Chem., 249, pp. 3183-3186 | ||
| 504 | |a Sirois, Roy, Borgeat, The lung parenchymal strip as a sensitive assay for leukotriene B4 (1981) Prostaglandins Med., 6, pp. 153-159 | ||
| 504 | |a Sterin-Borda, Borda, Fink, Bracco, Effect of phytohemagglutinin-stimulated human lymphocytes on isolated rat atria Participation of lipoxygenase products of arachidonic acid metabolism (1983) Naunyn-Schmiedeberg's Archives of Pharmacology, 324, pp. 58-63 | ||
| 504 | |a Sterin-Borda, Canga, Pissani, Gimeno, Inotropic effect of PGE1 and PGE2 on isolated rat atria. Influence of adrenergic mechanisms (1980) Prostaglandins, 20, pp. 825-836 | ||
| 504 | |a Terashita, Fukui, Hirata, Terac, Ohkawa, Nishitawa, Kikudi, Coronary vasoconstriction and PGI2 release by leukotrienes in isolated guinea pig hearts (1981) Eur. J. Pharmac., 73, pp. 357-361 | ||
| 504 | |a Vane, Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs (1971) Nature New Biol., 231, pp. 232-233 | ||
| 504 | |a Vane, Mode of action of aspirin and similar compounds (1974) Prostaglandin Synthetase Inhibitors, pp. 155-165. , H.J. Robinson, J.R. Vane, Raven Press, New York | ||
| 504 | |a Van Rossum, Cumulative dose - response curve. II Technique for the making of dose - response curves in isolated organs and the evaluation of drug parameters (1963) Archs. int. Pharmacodyn. Thér., 143, pp. 239-319 | ||
| 504 | |a Webb, Nowowiojaki, Mitogen-induced changes in lymphocyte prostaglandin levels: a signal for the induction of suppressor cell activity (1978) Cell. Immunol., 41, pp. 72-79 | ||
| 520 | 3 | |a The effect of BALB/c anti CF1 lymph node cells and thymocytes on the spontaneous activity of isolated CF1 mouse atria was studied. Immune lymph node cells induced opposite effects depending on the number of immunizations. Immune lymph node cells from mice which received two immunizations decreased the contractile tension of the atrium, whereas, cells from mice exposed to three and five immunizations strongly increased the tension. Immune thymocytes induced only negative inotropic action and this effect did not depend on the number of immunizations. Indeed, it was similar after two, three or five immunizations. Control normal lymph node cells or thymocytes from BALB/c or CF1 mice had no effect on CF1 atria. Furthermore, BALB/c anti CF1 cells had no effect on BALB/c atria. Inhibitors of cyclooxygenase activity prevented the negative inotropic influence of immune thymocytes and lymph node cells seen after two immunizations. In contrast, inhibitors of the lipoxygenase pathway abolished the positive inotropic action induced by lymph node cells obtained after three and five immunizations. Cell-free supernatants of lymph node cells from animals receiving five immunizations, stimulated the contractile activity of atrium, while those from thymocytes inhibited it, indicating that soluble factors are generated by contact of immune cells with the myocardium. It is proposed that upon recognition of alloantigens expressed by atrial cells, lymph node cells and thymocytes are activated and release either arachidonic acid metabolites or some factor(s) that induces this release by other cells, which in turn triggers different effects in myocardial tissue depending on the set of cells involved in the primary immune response. © 1984. |l eng | |
| 593 | |a Centro de Estudios Farmacológicos, Principios Naturales (CEFAPRIN). Consejo Nacional de Investigaciones Cientificas y Tecnicas de la Re, Serrano 665/69, 1414 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a 7 [3 (4 ACETYL 3 HYDROXY 2 PROPYLPHENOXY) 2 HYDROXYPROPOXY] 4 OXO 8 PROPYL 4H 1 BENZOPYRAN 2 CARBOXYLIC ACID |
| 690 | 1 | 0 | |a ACETYLSALICYLIC ACID |
| 690 | 1 | 0 | |a DITHIZONE |
| 690 | 1 | 0 | |a INDOMETACIN |
| 690 | 1 | 0 | |a NORDIHYDROGUAIARETIC ACID |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a HEART |
| 690 | 1 | 0 | |a HEART ATRIUM |
| 690 | 1 | 0 | |a HEART MUSCLE CONTRACTILITY |
| 690 | 1 | 0 | |a IMMUNE RESPONSE |
| 690 | 1 | 0 | |a LYMPH NODE CELL |
| 690 | 1 | 0 | |a LYMPHATIC SYSTEM |
| 690 | 1 | 0 | |a MOUSE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a THYMOCYTE |
| 690 | 1 | 0 | |a THYMUS |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a ARACHIDONIC ACID |
| 690 | 1 | 0 | |a ARACHIDONIC ACIDS |
| 690 | 1 | 0 | |a ASPIRIN |
| 690 | 1 | 0 | |a CATECHOLS |
| 690 | 1 | 0 | |a DITHIZONE |
| 690 | 1 | 0 | |a INDOMETHACIN |
| 690 | 1 | 0 | |a LYMPH NODES |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MICE |
| 690 | 1 | 0 | |a MICE, INBRED BALB C |
| 690 | 1 | 0 | |a MYOCARDIAL CONTRACTION |
| 690 | 1 | 0 | |a MYOCARDIUM |
| 690 | 1 | 0 | |a NORDIHYDROGUAIARETIC ACID |
| 690 | 1 | 0 | |a T-LYMPHOCYTES |
| 653 | 0 | 0 | |a fpl 55712 |
| 700 | 1 | |a Genaro, A.M. | |
| 700 | 1 | |a Cremaschi, G. | |
| 700 | 1 | |a Sales, M.E. | |
| 700 | 1 | |a Sterin-Borda, L. | |
| 773 | 0 | |d 1984 |g v. 6 |h pp. 629-636 |k n. 6 |p Int. J. Immunopharmacol. |x 01920561 |w (AR-BaUEN)CENRE-5267 |t International Journal of Immunopharmacology | |
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| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_01920561_v6_n6_p629_Borda |y Handle |
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