Sexual differences in the serotonergic control of prolactin and luteinizing hormone secretion in the rat
The effects of serotonin on PRL and LH release were investigated in female and male rats under different experimental conditions. At a dose of 5 mg/kg ip, serotonin increased serum PRL titers in intact males and in females during diestrus and estrus; the levels attained in the male rats were much hi...
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| Otros Autores: | , , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
1984
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 13072caa a22012257a 4500 | ||
|---|---|---|---|
| 001 | PAPER-18314 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204941.0 | ||
| 008 | 190411s1984 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0021278362 | |
| 024 | 7 | |2 cas |a estradiol benzoate, 50-50-0; estradiol, 50-28-2; luteinizing hormone, 39341-83-8, 9002-67-9; prolactin, 12585-34-1, 50647-00-2, 9002-62-4; serotonin, 50-67-9; testosterone propionate, 57-85-2; testosterone, 58-22-0; Estradiol, 50-28-2; Luteinizing Hormone, 9002-67-9; Prolactin, 9002-62-4; Serotonin, 50-67-9; Testosterone, 57-85-2 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 100 | 1 | |a De Villalobos, D.B. | |
| 245 | 1 | 0 | |a Sexual differences in the serotonergic control of prolactin and luteinizing hormone secretion in the rat |
| 260 | |c 1984 | ||
| 270 | 1 | 0 | |m Libertun, C.; Laboratorio de Neuroendocrinologia, Institute de Biologia y Medicina Exerimental, Obligado, Buenos Aires, 2490 (1428), Argentina |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Becu, D., Libertun, C., Comparative maturation of the regulation of prolactin and thyrotropin by serotonin and thyrotropin releasing hormone in male and female rats (1982) Endocrinology, 110, p. 1879 | ||
| 504 | |a Hery, M., Laplante, E., Pattou, E., Kordon, C., Interaction de la serotonine cerebrale avec la liberation cyclique de LH chez la ratte (1975) Ann Endocrinol (Paris), 36, p. 123 | ||
| 504 | |a Hery, M., Laplante, E., Kordon, C., Participation of serotonin in the phasic release of LH I. Evidence from pharmacological experiment (1976) Endocrinology, 99, p. 496 | ||
| 504 | |a Hery, M., Laplante, E., Kordon, C., Participation of serotonin in the phasic release of luteinizing hormone II. Effects of lesions of serotonin-containing pathways in the central nervous system (1978) Endocrinology, 102, p. 1019 | ||
| 504 | |a Coen, C.W., MacKinnon, P.C.B., Serotonin involvement in the control of phasic luteinizing hormone release in the rat: Evidence for a critical period (1979) J Endocrinol, 82, p. 105 | ||
| 504 | |a Chen, H.T., Sylvester, P.W., Ieri, T., Meites, J., Potentiation of luteinizing hormone release by serotonin agonists in ovariectomized steroid-primed rats (1981) Endocrinology, 108, p. 948 | ||
| 504 | |a Marco, J., Rosero, O., Villa, I., Esquifino, A., Efecto de la pclorofenilalanina sobre la LH, FSH, prolactina y ovulacion en rata (1982) Rev esp Fisiol, 38, p. 285 | ||
| 504 | |a Ruzsas, C., Limonta, P., Marini, L., Role of serotoninergic neu rones in the control of gonadotropin and prolactin secretion in the rat (1982) J Endocrinol, 94, p. 83 | ||
| 504 | |a Kordon, C., Glowinski, J., Role of hypothalamic monoaminergic neurones in the gonadotropin release-regulating mechanisms (1972) Neuropharmacology, 11, p. 153 | ||
| 504 | |a Wuttke, W., Hancke, J.L., Hohn, K.G., Baumgarten, H.G., Effect of intraventricular injection of 5-7 dihydroxytryptamine on serum gonadotropins and prolactin (1978) Ann NY Acad Sci, 305, p. 423 | ||
| 504 | |a Mess, B., Ruzsas, C., Role of the serotoninergic neuron system of the brain stem on the release of thyrotropic and luteinizing hormone (1981) J Physiol (Paris), 77, p. 501 | ||
| 504 | |a Schneider, H.P.G., McCann, S.M., Mono- and indolamines and control of LH secretion (1970) Endocrinology, 86, p. 1127 | ||
| 504 | |a Kamberi, I.A., Mical, R.S., Porter, J.C., Effect of anterior pituitary perfusion and intraventricular injection of cathecolamines and indoleamines on LH release (1970) Endocrinology, 87, p. 1 | ||
| 504 | |a Cramer, O.M., Barraclough, C.A., The actions of serotonin, norepinephrine and epinephrine on hypothalamic processes leading to adenohypophyseal luteinizing hormone release (1978) Endocrinology, 103, p. 694 | ||
| 504 | |a Pilotte, N.S., Porter, J.C., Circulating Luteinizing hormone and prolactin concentrations in intact or castrated male rats treated with 5-hydroxytryptamine (1979) Endocrinology, 105, p. 875 | ||
| 504 | |a Gallo, R.V., Moberg, G.P., Serotonin mediated inhibition of episodic luteinizing hormone release during electrical stimulation of the arcuate nucleus in ovariectomized rats (1977) Endocrinology, 100, p. 945 | ||
| 504 | |a Arendash, G.W., Gallo, R.V., Serotonin involvement in the inhibition of episodic luteinizing hormone release during electrical stimulation of the medbrain dorsal raphe nucleus in ovariectomized rats (1978) Endocrinology, 102, p. 1199 | ||
| 504 | |a Gurzon, G., Green, A.R., Rapid method for the determination of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in small regions of rat brain (1970) Br J Pharmacol, 39, p. 653 | ||
| 504 | |a Larsson, Studies on the extrinsic neural control of serotonin release from the small intestine (1981) Acta Physiol Scand, 113, p. 499 | ||
| 504 | |a Neill, J.D., Sexual differences in the hypothalamic regulation of prolactin secretion (1972) Endocrinology, 90, p. 1154 | ||
| 504 | |a Gunnet, J.W., Freeman, M.E., Sexual differences in regulation of prolactin secretion by two hypothalamic areas (1982) Endocrinology, 110, p. 697 | ||
| 504 | |a Ojeda, S.R., Castro Vazquez, A., Jameson, H.E., Prolactin release in response to blockade of dopaminergic receptors and to TRH injection in developing and adult rats: Role of estrogen in determining sex differences (1977) Endocrinology, 100, p. 427 | ||
| 504 | |a Demarest, K.T., McKay, D.W., Riegle, G.D., Moore, K.E., Sexual differences in tuberoinfundibular dopamine nerve activity induced by neonatal androgen exposure (1981) Neuroendocrinology, 32, p. 108 | ||
| 504 | |a Demarest, K.T., Moore, K.E., Sexual differences in the sensitivity of tuberoinfundibular dopamine neurons to the actions of prolactin (1981) Neuroendocrinology, 33, p. 230 | ||
| 504 | |a Crowley, W.R., O’Donohue, T.L., Jacobowitz, D.M., Sex differences in the catecholamine content in discrete brain nuclei of the rat: Effects of neonatal castration or testosterone treatment (1978) Acta Endocrinol (Copenh), 89, p. 20 | ||
| 504 | |a Dorner, G., Sexual differentiation of the brain (1980) Vit Horm, 38, p. 325 | ||
| 504 | |a Weisz, J., Ward, I.L., Plasma testosterone and progesterone titers of pregnant rats, their male and female fetuses, and neonatal offsprings (1980) Endocrinology, 106, p. 306 | ||
| 504 | |a Wilson, C.A., McDonald, P.G., Inhibitory effect of serotonin on ovulation in adult rats (1974) J Endocrinol, 60, p. 253 | ||
| 504 | |a Marko, M., Fluckiger, E., Role of serotonin in the regulation of ovulation (1980) Neuroendocrinology, 30, p. 228 | ||
| 504 | |a Meyer, D.C., Hypothalamic and raphe serotoninergic systems in ovulation control (1978) Endocrinology, 103, p. 1067 | ||
| 504 | |a Biegon, A., McEwen, B.S., Modulation by estradiol of serotoninx receptors in brain (1981) J Neurosci, 2, p. 199 | ||
| 504 | |a Biegon, A., Fischette, C.T., Rainbow, T.C., McEwen, B.S., Serotonin receptor modulation by estrogen in discrete brain nuclei (1982) Neuroendocrinology, 35, p. 287 | ||
| 504 | |a Hery, M., Faudon, M., Dusticier, G., Hery, F., Daily variations in serotonin metabolism in the suprachismatic nucleus of the rat: Influence of oestradiol impregnation (1982) J Endocrinol, 94, p. 157 | ||
| 504 | |a Ladosky, W., Gaziri, L.C.J., Brain serotonin and sexual differentiation of the Nervous System (1970) Neuroendocrinology, 6, p. 168 | ||
| 504 | |a Giulian, D., Pohorecky, L.A., McEwen, B.S., Effects of gonadal steroids upon brain 5-hydroxytryptamine levels in the neonatal rat (1973) Endocrinology, 93, p. 1329 | ||
| 504 | |a Hyyppa, M., Rinne, U.K., Hypothalamic monoamines after neonatal androgenization, catration or reserpine treatment of the rat (1971) Acta Endocrinol (Copenh), 66, p. 317 | ||
| 504 | |a Kato, R., Serotonin content of rat brain in relation to sex and age (1960) J Neurochem, 5, p. 202 | ||
| 504 | |a Vaccari, A., Brotman, S., Cimino, J., Timiras, P.S., Sex differentiation of neurotransmitter enzymes in central and peripheral nervous systems (1977) Brain Res, 132, p. 176 | ||
| 504 | |a Oldendorf, W.H., Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection (1971) Am J Physiol, 221, p. 1629 | ||
| 504 | |a Bulat, M., Supek, Z., Passage of 5-hydroxytryptamine through the blood brain barrier, its metabolism in the brain and elimination of 5-hydroxyindolacetic acid from the brain tissue (1968) J Neurochem, 15, p. 383 | ||
| 504 | |a Johns, M.A., Azmitia, E.C., Krieger, D.T., Specific in vitro uptake of serotonin by cells in the anterior pituitary of the rat (1982) Endocrinology, 110, p. 754 | ||
| 520 | 3 | |a The effects of serotonin on PRL and LH release were investigated in female and male rats under different experimental conditions. At a dose of 5 mg/kg ip, serotonin increased serum PRL titers in intact males and in females during diestrus and estrus; the levels attained in the male rats were much higher than in the females. At a lower dose (2.5 mg/kg) the PRLreleasing effect of serotonin was only evident in male rats. Thus, we chose this dose for the following experiments to investigate the apparent sexual difference. To evaluate the importance of the hormonal status characteristic of male and female in conditioning the serotonin effect, an experiment was performed in gonadectomized rats, untreated or treated with estradiol benzoate (EB), or testosterone propionate (TP). In the three hormonal conditions the sexual difference was maintained: serotonin released PRL in males and failed to do so in females. However, if males were castrated within 24 h of birth, and females androgenized by a single perinatal injection of TP, the sexual difference in adulthood were reversed; thus, androgenized females responded to serotonin and males castrated at birth failed to do so. These results suggest that a male differentiated brain is more sensitive to the PRL-releasing effect of serotonin, irrespective of the hormonal environment of the rat. On the other hand, serotonin increased serum LH in female rats in estrus and in adult ovariectomized rats treated with EB; but not in females in diestrus or in ovariectomized rats, treated with TP or untreated. Neither did it modify serum LH titers in male rats whether intact, orchidectomized, or orchidectomized plus steroids. However, if male rats were castrated a few hours after birth and then treated in adulthood with EB, serotonin effectively released LH. Thus, two components, estradiol and a feminine differentiated brain, may be necessary for the facilitatory action of serotonin on LH release. Since no sex differences were observed in the increase of serum serotonin after the injection of 2.5 mg/kg of the drug, it can be discounted that the differences described for the endocrine effect of the drug could be due to different levels of circulating indolamine achieved in male and female rats. Taken together, our results indicate that serotonergic control of anterior pituitary secretion is sexually differentiated and that it presents individual characteristics for PRL and LH release. © 1984 by The Endocrine Society. |l eng | |
| 593 | |a Laboratorio de Neuroendocrinologia, Institute de Biologia y Medicina Exerimental, Obligado, Buenos Aires, 2490 (1428), Argentina | ||
| 690 | 1 | 0 | |a ESTRADIOL |
| 690 | 1 | 0 | |a ESTRADIOL BENZOATE |
| 690 | 1 | 0 | |a LUTEINIZING HORMONE |
| 690 | 1 | 0 | |a PROLACTIN |
| 690 | 1 | 0 | |a SEROTONIN |
| 690 | 1 | 0 | |a TESTOSTERONE |
| 690 | 1 | 0 | |a TESTOSTERONE PROPIONATE |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a DRUG EFFICACY |
| 690 | 1 | 0 | |a ENDOCRINE SYSTEM |
| 690 | 1 | 0 | |a FEMALE GENITAL SYSTEM |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a SEX DIFFERENCE |
| 690 | 1 | 0 | |a SEXUALITY |
| 690 | 1 | 0 | |a AGING |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a CASTRATION |
| 690 | 1 | 0 | |a COMPARATIVE STUDY |
| 690 | 1 | 0 | |a DIESTRUS |
| 690 | 1 | 0 | |a ESTRADIOL |
| 690 | 1 | 0 | |a ESTRUS |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a LUTEINIZING HORMONE |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a PREGNANCY |
| 690 | 1 | 0 | |a PROLACTIN |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a RATS, INBRED STRAINS |
| 690 | 1 | 0 | |a SEROTONIN |
| 690 | 1 | 0 | |a SEX CHARACTERISTICS |
| 690 | 1 | 0 | |a SEX DIFFERENTIATION |
| 690 | 1 | 0 | |a SUPPORT, NON-U.S. GOV'T |
| 690 | 1 | 0 | |a TESTOSTERONE |
| 700 | 1 | |a Lux, V.A.R. | |
| 700 | 1 | |a De Mengido, I.L. | |
| 700 | 1 | |a Libertun, C. | |
| 773 | 0 | |d 1984 |g v. 115 |h pp. 84-89 |k n. 1 |p Endocrinology |x 00137227 |w (AR-BaUEN)CENRE-4573 |t Endocrinology | |
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| 856 | 4 | 0 | |u https://doi.org/10.1210/endo-115-1-84 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_00137227_v115_n1_p84_DeVillalobos |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00137227_v115_n1_p84_DeVillalobos |y Registro en la Biblioteca Digital |
| 961 | |a paper_00137227_v115_n1_p84_DeVillalobos |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 963 | |a VARI | ||