A developmental study of adenohypophyseal dopaminergic receptors and of haloperidol-induced prolactin release in rats
The ontogenesis of adenohypophyseal dopamine receptors, assessed by haloperidol-displaceable [3H]didydroergocryptine (DHE) binding of 1-, 12-, 20-, 28-day-old female rats was studied in correlation with the prolactin releasing effect of haloperidol (1 mg/kg), a dopaminergic antagonist. A specific do...
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| Otros Autores: | , , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
1984
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 08213caa a22008297a 4500 | ||
|---|---|---|---|
| 001 | PAPER-18307 | ||
| 003 | AR-BaUEN | ||
| 005 | 20240822123336.0 | ||
| 008 | 190411s1984 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0021339128 | |
| 024 | 7 | |2 cas |a haloperidol, 52-86-8; prolactin, 12585-34-1, 50647-00-2, 9002-62-4 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a DBRRD | ||
| 100 | 1 | |a Becú de Villalobos, D. | |
| 245 | 1 | 2 | |a A developmental study of adenohypophyseal dopaminergic receptors and of haloperidol-induced prolactin release in rats |
| 260 | |c 1984 | ||
| 270 | 1 | 0 | |m Libertun, C.; Instituto de Biología y Medicina Experimental, Obligado 2490, 1428 Buenos Aires, Argentina |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Becú, Libertun, Comparative maturation of the regulation of prolactin and thyrotropin by serotonin and thyrotropin-releasing hormone in male and female rats (1982) Endocrinology, 110, pp. 1879-1883 | ||
| 504 | |a Brown, Seeman, Lee, Dopamine/neuroleptic receptors in basal hypothalamus and pituitary (1976) Endocrinology, 99, pp. 1407-1410 | ||
| 504 | |a Calabró, MacLeod, Binding of dopamine to bovine anterior pituitary gland membranes (1978) Neuroendocrinology, 25, p. 32 | ||
| 504 | |a Caron, Beautie, Raymond, Gagne, Drouin, Lefkowits, Labric, Dopaminergic receptors in the anterior pituitary gland (1978) Correlation of [3H]dihydroergocryptine binding with the dopaminergic control of prolactin release, 253, pp. 2244-2253. , 2nd edn., J. biol. Chem | ||
| 504 | |a Clemens, Shaar, Smalstig, Bach, Korenfeld, Inhibition of prolactin secretion by ergolines (1974) Endocrinology, 94, pp. 1171-1176 | ||
| 504 | |a Cronin, Roberts, Weiner, Dopamine and dihydroergocryptine binding to the anterior pituitary and other brain areas of the rat and sheep (1978) Endocrinology, 103, pp. 302-309 | ||
| 504 | |a Crowley, O'Donohue, Jacobowits, Sex differences in catecholamine content in discrete brain nuclei of the rat: effects of neonatal castration or testosterone treatment (1978) Acta Endocr., 89, pp. 20-28 | ||
| 504 | |a Demarest, McKay, Riegle, Moore, Sexual differences in tuberoinfundibular dopamine nerve activity induced by neonatal androgen exposure (1981) Neuroendocrinology, 32, pp. 108-113 | ||
| 504 | |a Demarest, Moore, Sexual differences in the sensitivity of tuberoinfundibular dopamine neurons to the actions of prolactin (1981) Neuroendocrinology, 33, pp. 230-234 | ||
| 504 | |a Grandison, Meites, Evidence for adrenergic mediation of cholinergic inhibition of prolactin release (1976) Endocrinology, 99, pp. 775-779 | ||
| 504 | |a Hedner, Lundborg, Neurochemical characteristics of cerebral catecholamine neurons during the postnatal development in the rat (1981) Med. Biol., 59, pp. 212-223 | ||
| 504 | |a Heiman, Ben-Jonathan, Dopaminergic receptors in the rat anterior pituitary change during the estrous cycle (1981) Endocrinology, 111, pp. 37-41 | ||
| 504 | |a Lamprecht, Coyle, Dopa decarboxylase in the developing rat brain (1972) Brain Res., 41, pp. 503-506 | ||
| 504 | |a Libertun, Larrea, Vacas, Cardinali, [3H]dihydroergocryptine binding in anterior pituitary and prolactin secretion: further evidence of brain regulation of adenohypophyseal receptors (1980) Endocrinology, 107, pp. 1905-1909 | ||
| 504 | |a MacLeod, Regulation of prolactin secretion (1976) Frontiers in Neuroendocrinology, 4, pp. 169-194. , 2nd edn., L. Martini, W.F. Ganong, Raven Press, New York | ||
| 504 | |a Ojeda, Castro Vásquez, Jameson, Prolactin release in response to blockade of dopaminergic receptors and to TRH injection in developing and adult rats: role of estrogen in determining sex differences (1977) Endocrinology, 100, pp. 427-439 | ||
| 504 | |a Scatchard, The attraction of protein for small molecules and ions (1949) Annals of the New York Academy of Sciences, 51, pp. 660-672 | ||
| 504 | |a Slotkin, Barnes, Lau, Seidler, Trepanier, Weigel, Whitmore, Development of polyamine and biogenic amine systems in brains and hearts of neonatal rats given dexamethasone: role of biochemical alterations in cellular maturation for producing deficits in ontogeny of neurotransmitter levels, uptake, storage and turnover (1982) J. Pharmacol. exp. Ther., 221, pp. 686-693 | ||
| 504 | |a Weiner, Ganong, Role of brain monoamines and histamine in regulation of anterior pituitary secretion (1978) Physiol. Rev., 58, pp. 905-976 | ||
| 520 | 3 | |a The ontogenesis of adenohypophyseal dopamine receptors, assessed by haloperidol-displaceable [3H]didydroergocryptine (DHE) binding of 1-, 12-, 20-, 28-day-old female rats was studied in correlation with the prolactin releasing effect of haloperidol (1 mg/kg), a dopaminergic antagonist. A specific dopaminergic receptor could be quantified at the time of birth (Bmax = 2.5 ± 0.5 fmol/mg; Kd = 1.5 ± 0.2 μM), anterior pituitary receptor density (fmol bound/mg) increased non-significantly henceforth and a slight ontogenic increase of Kd values was also observed. Haloperidol failed to increase prolactin in newborn female rats; at 4 days, a significant increase was evidenced, and from then onwards the response rose markedly with age. As sex differences in the dopaminergic modulation of prolactin release have been documented, the hyperprolactinemic effect of haloperidol in correlation with [3H]DHE binding in anterior pituitary of 28-day-old female and male rats was studied. Though the prolactinemic increment achieved by haloperidol was significantly higher in female than in male rats, [3H]DHE binding was not statistically different between sexes. These data indicate: (a) a specific binding site for [3H]DHE in anterior pituitary of female rats is present from the first postnatal days. From then onwards, a gradual but slight increment in both, Bmax and Kd for the dopaminergic agonist is observed until puberty; (b) at 28 days, no clear difference in Bmax and Kd is present in [3H]DHE binding between male and female rats; (c) by contrast, haloperidol shows a prolactin releasing effect that increases markedly with age in the female. At 28 postnatal days, serum prolactin levels attained after haloperidol in the female were significantly higher than those achieved in the male. Thus, differences of magnitude in the coupled response may sometimes not be accounted for by differences in number, or affinity, of receptor sites. © 1984. |l eng | |
| 593 | |a Instituto de Biología y Medicina Experimental, Obligado 2490, 1428 Buenos Aires, Argentina | ||
| 593 | |a Centro de Estudios Farmacológicos y de Principios Naturales, Serrano 665, 1414 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a ADENOHYPOPHYSIS |
| 690 | 1 | 0 | |a DIHYDROERGOCRYPTINE BINDING |
| 690 | 1 | 0 | |a DOPAMINE RECEPTORS |
| 690 | 1 | 0 | |a HALOPERIDOL |
| 690 | 1 | 0 | |a ONTOGENESIS |
| 690 | 1 | 0 | |a PROLACTIN |
| 690 | 1 | 0 | |a SEX DIFFERENCES |
| 690 | 1 | 0 | |a DOPAMINE RECEPTOR |
| 690 | 1 | 0 | |a HALOPERIDOL |
| 690 | 1 | 0 | |a PROLACTIN |
| 690 | 1 | 0 | |a RADIOISOTOPE |
| 690 | 1 | 0 | |a ADENOHYPOPHYSIS |
| 690 | 1 | 0 | |a AGE |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a DIHYDROERGOCRYPTINE H 3 |
| 690 | 1 | 0 | |a DRUG RECEPTOR BINDING |
| 690 | 1 | 0 | |a ENDOCRINE SYSTEM |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a ONTOGENY |
| 690 | 1 | 0 | |a PHARMACOKINETICS |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a SEX DIFFERENCE |
| 700 | 1 | |a Vacas, M.I. | |
| 700 | 1 | |a Cardinali, D.P. | |
| 700 | 1 | |a Libertun, C. | |
| 773 | 0 | |d 1984 |g v. 12 |h pp. 167-171 |k n. 2 |p Dev. Brain Res. |x 01653806 |w (AR-BaUEN)CENRE-4396 |t Developmental Brain Research | |
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