On the inotropic effects of leukotrienes in the isolated urinary bladder of guinea pigs and rats
Leukotrienes (LTs) B4, C4 and D4 were tested on the motility of rings isolated from the urinary bladder of guinea pigs and rats. LTB4 did not evoke inotropic influences in any of the preparations, whereas LTC4 and LTD4 augmented the magnitudes of tonic and phasic contractions in the guinea pig but n...
Guardado en:
| Autor principal: | |
|---|---|
| Otros Autores: | , , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
1985
|
| Materias: | |
| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 08981caa a22011057a 4500 | ||
|---|---|---|---|
| 001 | PAPER-18263 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204937.0 | ||
| 008 | 190411s1985 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0022367105 | |
| 024 | 7 | |2 cas |a 7 [3 (4 acetyl 3 hydroxy 2 propylphenoxy) 2 hydroxypropoxy] 4 oxo 8 propyl 4h 1 benzopyran 2 carboxylic acid, 40786-08-1; acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; leukotriene B4, 71160-24-2; leukotriene C4, 72025-60-6; leukotriene D4, 73836-78-9; nordihydroguaiaretic acid, 500-38-9; Aspirin, 50-78-2; Catechols; Leukotriene B4, 71160-24-2; Nordihydroguaiaretic Acid, 500-38-9; SRS-A | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a PLMED | ||
| 100 | 1 | |a Viggiano, J.M. | |
| 245 | 1 | 3 | |a On the inotropic effects of leukotrienes in the isolated urinary bladder of guinea pigs and rats |
| 260 | |c 1985 | ||
| 270 | 1 | 0 | |m Gimeno, A.L.; Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Consejo Nacional de Investigaciones Cientificas y Tecnicas de la Republica Argentina (CONICET). Serr, 1414 Buenos Aires, Argentina |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Borgeat, Samuelsson, Arachidonic acid metabolism in polymorphonuclear leukocytes: effect of ionophore A 23187 (1979) Proc. Natl. Acad. Sci. USA, 76, p. 2148 | ||
| 504 | |a Piper, Leukotrienes (1983) Trends Pharmacol. Sci., 4, p. 75 | ||
| 504 | |a Piper, Letts, Samhoum, Tippins, Palmer, Actions of leukotrienes on vascular, airway and gastrointestinal smooth muscle (1982) Advances in Prostaglandin, Thromboxane and Leukatriene Research. Leukotrienes and other hypoxygenase Products, 9, p. 169. , B. Samuelsson, R. Paoletti, Raven Press, New York | ||
| 504 | |a Peck, Piper, Williams, The effects of leukatrienes C4 and D4 on the microvasculature of guinea-pig skin (1981) Prostaglandins, 21, p. 315 | ||
| 504 | |a Ueno, Tanaka, Katori, Hayashi, Arai, Species differences in increased vascular permeability by synthetic leukotrienes C4 and D4 (1981) Prostaglandins, 21, p. 637 | ||
| 504 | |a Letts, Piper, Cardiac actions of leukotrienes B4, C4, D4 and E4 in guinea pig and rat in vitro (1983) Advances in Prostaglandin, Thromboxane and Leukotriene Research. Fifth International Frostsglandin Conference, 11, p. 391. , B. Samuelsson, R. Paoletti, P.W. Ramwell, Raven Press, New York | ||
| 504 | |a Folco, Hansson, Granström, Leukatriene C4 stimulates TXA2 formation in isolated sensitized guinea pig lungs (1981) Biochem. Pharmacol., 30, p. 2491 | ||
| 504 | |a Ezeamuzie, Assem, Effects of leukotrienes C4 and D4 on guinea pig heart and the participation of SRS-A in the manifestation of guinea pig cardiac anaphylaxis (1983) Agents and Actions, 13, p. 182 | ||
| 504 | |a Piper, Seale, Non-immunological release of slow-reacting substance from qguinea pig lung (1979) Br. J. Pharmacol., 67, p. 67 | ||
| 504 | |a Yusko, Hall, Ford-Hutchinson, Contraction of guinea pig gallbladder strips by leukotrienes and other agonists (1983) Prostaglandins, 24, p. 397 | ||
| 504 | |a Gimeno, Borda, Sterin-Borda, Vidal, Gimeno, Pharmacological influences on human ovarian contractions (1976) Obstet.Gynecol., 47, p. 218 | ||
| 504 | |a Van Rossum, Cumulative dose-response curves (1963) Arch. Int. Pharmacodyn. Ther., 143, p. 299 | ||
| 504 | |a Vane, Inhibition of prostaglandin synthesis as a mechanism of action of aspirin-like drugs (1976) Nature New Biology, 231, p. 232 | ||
| 504 | |a Hedqvist, Dahlen, Gustafsson, Hammassström, Samuelsson, Biological profile of leukotrienes C4 and D4 (1980) Acta Physiol. Scand., 110, p. 331 | ||
| 504 | |a Piper, Formation and actions of leukotrienes (1984) Physiol. Rev., 64, p. 744 | ||
| 504 | |a Weichman, Tucker, Contraction of guinea pig uterus by synthetic leukotrienes (1982) Prostaglandins, 24, p. 245 | ||
| 504 | |a Ulmsten, Prostaglandins and the urinary tract (1983) Acta Obstetricia et Gynecologica Scandinavica, 113, p. 55 | ||
| 504 | |a Borda, Chaud, Gutnisky, Contreras-Ortiz, Gimeno, Gimeno, Relationships between prostaglandins and estrogens on the motility of isolated rings from the rat urinary bladder (1983) J. Urol., 129, p. 1250 | ||
| 504 | |a Flower, Drugs which inhibit prostaglandin biosynthesis (1974) Pharmacol. Rev., 26, p. 33 | ||
| 504 | |a Terashita, Fukui, Hirata, Terao, Okawa, Nishikawa, Kikuchi, Coronary vasoconstriction and PGI2 release by leukotrienes in isolated guinea pig hearts (1981) Eurp. J. Pharmacol., 73, p. 357 | ||
| 504 | |a Piper, Tippins, Interactions of leukotrienes with cyclooxygenase products in guinea-pig isolated trachea (1982) Leukotrienes and other lipoxygenase products, 9, p. 183. , B. Samuelsson, R. Paoletti, Raven Press, New York | ||
| 504 | |a Ambache, Zar, Non-cholinergic transmission by port-ganglionic motor neurones in the mammalian bladder (1970) J. Physiol., 210, p. 761 | ||
| 504 | |a Hill, Prostaglandins and tone in isolated strips of mammalian bladder (1976) Br. J. Pharmacol., 57, p. 464. , P | ||
| 520 | 3 | |a Leukotrienes (LTs) B4, C4 and D4 were tested on the motility of rings isolated from the urinary bladder of guinea pigs and rats. LTB4 did not evoke inotropic influences in any of the preparations, whereas LTC4 and LTD4 augmented the magnitudes of tonic and phasic contractions in the guinea pig but not in the rat detrusor muscle, LTC4 evoking a greater enhancement than LTD4. On molar bases, acetylcholine induced smaller positive inotropic effects. In the presence of 10-4 M acetylsalicylic acid (ASA), cumulative dose-response curves of phasic and tonic: contractions for LTC4 were shifted to the right of controls, whereas curves of the phasic motility for LTD4 remained unaltered. However, ASA shifted to the left the dose-response curve of tonic contractions for LTD4 and in addition evoked an augmentation of the absolute developed tension. The initial (postequilibrium) contractile levels of basal phasic contractions did not differ between controls and preparations incubated with ASA (10-4 M), nordihydroguaiaretic acid (10-7 M) or FPL-55712 (3×10-6 M). The findings suggest that some musculo-active prostanoid(s) could be modulating, in opposite directions, the smooth muscle contractile reactivity of the guinea pig urinary bladder when challenged in vitro with LTC4 and LTD4. Our data reported hereing also suggest that the role, if any, of endogenous prostanoids and leukotrienes for the normal basal contractile functioning of the guinea pig urinary bladder, remains obscure. © 1985. |l eng | |
| 593 | |a Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Consejo Nacional de Investigaciones Cientificas y Tecnicas de la Republica Argentina (CONICET). Serr, 1414 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a 7 [3 (4 ACETYL 3 HYDROXY 2 PROPYLPHENOXY) 2 HYDROXYPROPOXY] 4 OXO 8 PROPYL 4H 1 BENZOPYRAN 2 CARBOXYLIC ACID |
| 690 | 1 | 0 | |a ACETYLSALICYLIC ACID |
| 690 | 1 | 0 | |a LEUKOTRIENE |
| 690 | 1 | 0 | |a LEUKOTRIENE B4 |
| 690 | 1 | 0 | |a LEUKOTRIENE C4 |
| 690 | 1 | 0 | |a LEUKOTRIENE D4 |
| 690 | 1 | 0 | |a NORDIHYDROGUAIARETIC ACID |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a BLADDER |
| 690 | 1 | 0 | |a CONTRACTION |
| 690 | 1 | 0 | |a DETRUSOR MUSCLE |
| 690 | 1 | 0 | |a DOSE RESPONSE |
| 690 | 1 | 0 | |a DRUG ADMINISTRATION |
| 690 | 1 | 0 | |a DRUG COMPARISON |
| 690 | 1 | 0 | |a DRUG EFFICACY |
| 690 | 1 | 0 | |a DRUG RESPONSE |
| 690 | 1 | 0 | |a GUINEA PIG |
| 690 | 1 | 0 | |a IN VITRO STUDY |
| 690 | 1 | 0 | |a INOTROPISM |
| 690 | 1 | 0 | |a MUSCLE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PRELIMINARY COMMUNICATION |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a SMOOTH MUSCLE CONTRACTION |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a ASPIRIN |
| 690 | 1 | 0 | |a BLADDER |
| 690 | 1 | 0 | |a CATECHOLS |
| 690 | 1 | 0 | |a COMPARATIVE STUDY |
| 690 | 1 | 0 | |a GUINEA PIGS |
| 690 | 1 | 0 | |a IN VITRO |
| 690 | 1 | 0 | |a LEUKOTRIENE B4 |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MUSCLE CONTRACTION |
| 690 | 1 | 0 | |a NORDIHYDROGUAIARETIC ACID |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a RATS, INBRED STRAINS |
| 690 | 1 | 0 | |a SRS-A |
| 690 | 1 | 0 | |a SUPPORT, NON-U.S. GOV'T |
| 653 | 0 | 0 | |a fpl 55712 |
| 700 | 1 | |a Chaud, M.A. | |
| 700 | 1 | |a Gimeno, M.F. | |
| 700 | 1 | |a Gimeno, A.L. | |
| 773 | 0 | |d 1985 |g v. 20 |h pp. 89-97 |k n. 1 |p Prostaglandins Leukotrienes Med. |x 02621746 |t Prostaglandins, Leukotrienes and Medicine | |
| 856 | 4 | 1 | |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-0022367105&doi=10.1016%2f0262-1746%2885%2990097-6&partnerID=40&md5=f3c82783d2f885eb8428514085b8e2b9 |y Registro en Scopus |
| 856 | 4 | 0 | |u https://doi.org/10.1016/0262-1746(85)90097-6 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_02621746_v20_n1_p89_Viggiano |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02621746_v20_n1_p89_Viggiano |y Registro en la Biblioteca Digital |
| 961 | |a paper_02621746_v20_n1_p89_Viggiano |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 999 | |c 79216 | ||