Melatonin reverses pinealectomy-induced decrease of benzodiazepine binding in rat cerebral cortex
Pinealectomy of rats resulted in significant depression of benzodiazepine receptors (assessed by [3H]flunitrazepam binding) in cerebral cortex 3-14 days after surgery without affecting their affinity significantly. A single s.c. injection of melatonin (800 μg/kg body wt) restored the depressed brain...
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1985
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| LEADER | 11512caa a22012017a 4500 | ||
|---|---|---|---|
| 001 | PAPER-18250 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204937.0 | ||
| 008 | 190411s1985 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0021878564 | |
| 024 | 7 | |2 cas |a 4' chlorodiazepam, 14439-61-3; benzodiazepine, 12794-10-4; clonazepam, 1622-61-3; flumazenil, 78755-81-4; flunitrazepam, 1622-62-4; melatonin, 73-31-4 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a NEUID | ||
| 100 | 1 | |a Lowenstein, P.R. | |
| 245 | 1 | 0 | |a Melatonin reverses pinealectomy-induced decrease of benzodiazepine binding in rat cerebral cortex |
| 260 | |c 1985 | ||
| 270 | 1 | 0 | |m Lowenstein, P.R.; Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Serrano 665, 1414 Buenos Aires, Argentina |
| 506 | |2 openaire |e Política editorial | ||
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| 504 | |a Sugden, Psychopharmacological effects of melatonin in mouse and rat (1983) J. Pharmac. exp. Ther., 227, pp. 587-591 | ||
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| 520 | 3 | |a Pinealectomy of rats resulted in significant depression of benzodiazepine receptors (assessed by [3H]flunitrazepam binding) in cerebral cortex 3-14 days after surgery without affecting their affinity significantly. A single s.c. injection of melatonin (800 μg/kg body wt) restored the depressed brain benzodiazepine receptor sites. Single melatonin injections (up to 1600 μg/kg) to intact rats did not affect brain benzodiazepine binding when injected at either morning or evening hours. Daily melatonin treatment to intact rats for 5 days augmented benzodiazepine receptor density in brain (morning injections) or its dissociation constant (evening injections). Melatonin added in vitro to rat cerebral cortex membranes only slightly depressed [3H]flunitrazepam binding at 100 μM concentrations. These results point out a link between pineal activity and benzodiazepine receptor function in rats. They also indicate that pharmacological doses of melatonin affect benzodiazepine binding sites in rat cerebral cortex. © 1985. |l eng | |
| 536 | |a Detalles de la financiación: 5-4864, 15-1788 | ||
| 536 | |a Detalles de la financiación: F. Hoffmann-La Roche | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: Acknowledgements--These studies were supported by grant No 6638 from CONICET, Argentina, and by Hoecbst AG, Werk Albert, Wiesbanden, F.R.G. Clonazepam, Ro 15-1788, Ro 5-4864 and FNZP were a generous gift from Productos Roche, Buenos Aires, and Hoffmann-La Roche, Basel, Switzerland. | ||
| 593 | |a Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Serrano 665, 1414 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a 4' CHLORODIAZEPAM |
| 690 | 1 | 0 | |a BENZODIAZEPINE |
| 690 | 1 | 0 | |a CLONAZEPAM |
| 690 | 1 | 0 | |a FLUMAZENIL |
| 690 | 1 | 0 | |a FLUNITRAZEPAM |
| 690 | 1 | 0 | |a MELATONIN |
| 690 | 1 | 0 | |a RADIOISOTOPE |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a BIOLOGICAL MODEL |
| 690 | 1 | 0 | |a BRAIN CORTEX |
| 690 | 1 | 0 | |a CENTRAL NERVOUS SYSTEM |
| 690 | 1 | 0 | |a DOSE RESPONSE |
| 690 | 1 | 0 | |a DOSE TIME EFFECT RELATION |
| 690 | 1 | 0 | |a DRUG COMPARISON |
| 690 | 1 | 0 | |a DRUG INTERACTION |
| 690 | 1 | 0 | |a DRUG MECHANISM |
| 690 | 1 | 0 | |a DRUG RECEPTOR BINDING |
| 690 | 1 | 0 | |a DRUG RESPONSE |
| 690 | 1 | 0 | |a ENDOCRINE SYSTEM |
| 690 | 1 | 0 | |a FLUNITRAZEPAM H 3 |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PHARMACOKINETICS |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a SUBCUTANEOUS DRUG ADMINISTRATION |
| 653 | 0 | 0 | |a ro 15 1788; ro 5 4864 |
| 700 | 1 | |a Rosenstein, R. | |
| 700 | 1 | |a Cardinali, D.P. | |
| 773 | 0 | |d 1985 |g v. 7 |h pp. 675-681 |k n. 4 |p Neurochem. Int. |x 01970186 |w (AR-BaUEN)CENRE-6251 |t Neurochemistry International | |
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