Mitoxantrone affects topoisomerase activities in human breast cancer cells
The effects of mitoxantrone, an antineoplastic DNA intercalator, on topoisomerase I and II were studied in two human breast cancer cell lines. A large increase of topoisomerase I activity was found when cells were exposed to various doses of mitoxantrone. Maximal effect was achieved with 20 and 40 n...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
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1986
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 06536caa a22010457a 4500 | ||
|---|---|---|---|
| 001 | PAPER-18152 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204931.0 | ||
| 008 | 190411s1986 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0022481289 | |
| 024 | 7 | |2 cas |a dactinomycin, 1402-38-6, 1402-58-0, 50-76-0; DNA topoisomerase, 80449-01-0; DNA, 9007-49-2; mitoxantrone, 65271-80-9, 70476-82-3; puromycin, 53-79-2, 58-58-2; Anthraquinones; Dactinomycin, 50-76-0; DNA Topoisomerases, Type I, EC 5.99.1.2; DNA Topoisomerases, Type II, EC 5.99.1.3; Doxorubicin, 23214-92-8; Mitoxantrone, 65271-80-9; Puromycin, 53-79-2 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a BBRCA | ||
| 100 | 1 | |a Crespi, M.D. | |
| 245 | 1 | 0 | |a Mitoxantrone affects topoisomerase activities in human breast cancer cells |
| 260 | |c 1986 | ||
| 270 | 1 | 0 | |m Crespi, M.D.; Instituto de Biologia y Medicina Experimental Obligado 2490, 1428 Buenos Aires, Argentina |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Ross, Glaubiger, Kohn, (1979) Biochim. Biophys. Acta, 562, pp. 41-50 | ||
| 504 | |a Zwelling, Michaels, Erickson, Ungerleider, Nichols, Kohn, (1981) Biochemistry, 20, pp. 6553-6563 | ||
| 504 | |a Kohn, (1979) Methods Cancer Res, 16, pp. 291-345 | ||
| 504 | |a Walsh, Suicide Substrates, Mechanism-Based Enzyme Inactivators: Recent Developments (1984) Annual Review of Biochemistry, 53, pp. 524-535 | ||
| 504 | |a Zwelling, Michaels, Kerrigan, Pommier, Kohn, (1982) Biochem. Pharmacol, 31, pp. 3261-3267 | ||
| 504 | |a Wosniak, Ross, (1983) Cancer Res, 43, pp. 120-124 | ||
| 504 | |a Liu, Rowe, Yang, Tewey, Chen, (1983) J. Biol. Chem, 258, pp. 15365-15370 | ||
| 504 | |a Rowe, Tewey, Liu, (1984) J. Biol. Chem, 259, pp. 9177-9181 | ||
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| 504 | |a Nelson, Tewey, Liu, (1984) Proc. Natl. Acad. Sci. USA, 81, pp. 1361-1365. , 2nd ed | ||
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| 504 | |a Martin, McCowbrey, Jr., McConaughy, Young, Been, Brewer, Champoux, (1983) Meth. in Enzymol, 100, pp. 137-144 | ||
| 504 | |a Schlomai, Zadok, Reversible decatenation of kinetoplast DNA by a DNA topoisomerase from trypanosomatids (1983) Nucleic Acids Research, 11, pp. 4019-4034 | ||
| 504 | |a Bradford, (1976) Anal. Biochem, 72, pp. 248-254 | ||
| 504 | |a McMaster, Samulski, Stein, Stein, (1980) Anal. Biochem, 109, pp. 47-54 | ||
| 504 | |a Frasch, Goijman, Cazzulo, Stoppani, (1981) Mol. Biochem. Parasitol, 4, pp. 163-170 | ||
| 504 | |a Tewey, Chen, Nelson, Liu, (1984) J. Biol. Chem, 259, pp. 9182-9187 | ||
| 504 | |a Ralph, Marshall, Darkin, (1983) TIBS, 8, pp. 212-214 | ||
| 504 | |a Marshall, Darkin, Ralph, (1983) FEBS Lett, 161, pp. 75-78 | ||
| 504 | |a Marshall, Ralph, Hancock, (1983) Nuc. Acids Res, 11, pp. 4251-4256 | ||
| 504 | |a Tewey, Rowe, Yang, Halligan, Liu, (1984) Science (Wash. DC), 226, pp. 466-468 | ||
| 504 | |a Pommier, Zwelling, Kao Shan, Whan Peng, Bradley, (1985) Cancer Res, 45, pp. 3143-3149 | ||
| 504 | |a Chen, Yang, Rowe, Halligan, Tewey, Liu, (1984) J. Biol. Chem, 259, pp. 13560-13566 | ||
| 504 | |a Durban, Mills, Roll, Busch, (1983) Biochem. Biophys. Res. Commun, 111, pp. 897-905 | ||
| 504 | |a Crespi, M.D. and Baldi, A. (1985) Submitted; Goldberg, Wong, Tse-Dinh, (1985) Cancer Cells 3/Cold Spring Harbor Laboratory — Growth Factors and transformation, pp. 369-379. , J. Feramisco, B. Ozanne, C. Stiles | ||
| 504 | |a Ferro, McElwain, Olivera, (1984) Cold Spring Harbor Symposia Quant. Biol, 49, pp. 683-690. , 2nd ed | ||
| 504 | |a Krasnow, Cozzarelli, (1983) Cell, 32, pp. 1313-1324 | ||
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| 520 | 3 | |a The effects of mitoxantrone, an antineoplastic DNA intercalator, on topoisomerase I and II were studied in two human breast cancer cell lines. A large increase of topoisomerase I activity was found when cells were exposed to various doses of mitoxantrone. Maximal effect was achieved with 20 and 40 ng/mL in T47D and MCF-7 cells respectively. The enhancement on topoisomerase I activity seemed to be reversible, to be dependent on time of exposure to the drug and to require cellular integrity. Type II topoisomerase was inhibited in T47D cells after treatment for one hour with 10ng/mL of mitoxantrone and enzyme activity was undetectable at higher doses (40 ng/mL). This inhibitory effect did not take place in vitro unless the concentration of the intercalator was increased to 400-500 ng/mL. © 1986. |l eng | |
| 593 | |a Instituto de Biologia y Medicina Experimental Obligado 2490, 1428 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a DACTINOMYCIN |
| 690 | 1 | 0 | |a DNA |
| 690 | 1 | 0 | |a DNA TOPOISOMERASE |
| 690 | 1 | 0 | |a MITOXANTRONE |
| 690 | 1 | 0 | |a PUROMYCIN |
| 690 | 1 | 0 | |a BREAST |
| 690 | 1 | 0 | |a BREAST CANCER |
| 690 | 1 | 0 | |a CANCER CHEMOTHERAPY |
| 690 | 1 | 0 | |a DRUG CYTOTOXICITY |
| 690 | 1 | 0 | |a ENZYME INHIBITION |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a HUMAN CELL |
| 690 | 1 | 0 | |a INTOXICATION |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a THERAPY |
| 690 | 1 | 0 | |a ANTHRAQUINONES |
| 690 | 1 | 0 | |a BREAST NEOPLASMS |
| 690 | 1 | 0 | |a CELL LINE |
| 690 | 1 | 0 | |a COMPARATIVE STUDY |
| 690 | 1 | 0 | |a DACTINOMYCIN |
| 690 | 1 | 0 | |a DNA TOPOISOMERASES, TYPE I |
| 690 | 1 | 0 | |a DNA TOPOISOMERASES, TYPE II |
| 690 | 1 | 0 | |a DOXORUBICIN |
| 690 | 1 | 0 | |a ENZYME INDUCTION |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a KINETICS |
| 690 | 1 | 0 | |a MITOXANTRONE |
| 690 | 1 | 0 | |a PUROMYCIN |
| 690 | 1 | 0 | |a SUPPORT, NON-U.S. GOV'T |
| 700 | 1 | |a Ivanier, S.E. | |
| 700 | 1 | |a Genovese, J. | |
| 700 | 1 | |a Baldi, A. | |
| 773 | 0 | |d 1986 |g v. 136 |h pp. 521-528 |k n. 2 |p Biochem. Biophys. Res. Commun. |x 0006291X |w (AR-BaUEN)CENRE-905 |t Biochemical and Biophysical Research Communications | |
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| 856 | 4 | 0 | |u https://doi.org/10.1016/0006-291X(86)90471-7 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_0006291X_v136_n2_p521_Crespi |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0006291X_v136_n2_p521_Crespi |y Registro en la Biblioteca Digital |
| 961 | |a paper_0006291X_v136_n2_p521_Crespi |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 963 | |a VARI | ||
| 999 | |c 79105 | ||