Neuroendocrine integrative mechanisms in mammalian pineal gland: Effects of steroid and adenohypophysial hormones on melatonin synthesis in vitro
The time course for the decrease in norepinephrine concentration of rat pineal explants in culture indicated a significant fall starting at the 4th hour and completed after 16-24 h of incubation. Significant decreases of serotonin and 5-hydroxyindoleacetic acid (HIAA) levels in tissue, an increase o...
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1987
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 14769caa a22014177a 4500 | ||
|---|---|---|---|
| 001 | PAPER-18130 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204930.0 | ||
| 008 | 190411s1987 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0023554228 | |
| 024 | 7 | |2 cas |a 5 hydroxyindoleacetic acid, 1321-73-9, 54-16-0; estradiol, 50-28-2; follitropin, 9002-68-0; growth hormone, 36992-73-1, 37267-05-3, 66419-50-9, 9002-72-6; luteinizing hormone, 39341-83-8, 9002-67-9; melatonin, 73-31-4; noradrenalin, 1407-84-7, 51-41-2; phentolamine, 50-60-2, 73-05-2; prolactin, 12585-34-1, 50647-00-2, 9002-62-4; propranolol, 13013-17-7, 318-98-9, 3506-09-0, 4199-09-1, 525-66-6; serotonin, 50-67-9; Hydroxyindoleacetic Acid, 54-16-0; Melatonin, 73-31-4; Norepinephrine, 51-41-2; Phentolamine, 50-60-2; Pituitary Hormones, Anterior; Propranolol, 525-66-6; Receptors, Estradiol; Serotonin, 50-67-9; Sex Hormones | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a JSTBB | ||
| 100 | 1 | |a Cardinali, D.P. | |
| 245 | 1 | 0 | |a Neuroendocrine integrative mechanisms in mammalian pineal gland: Effects of steroid and adenohypophysial hormones on melatonin synthesis in vitro |
| 260 | |c 1987 | ||
| 270 | 1 | 0 | |m Cardinali, D.P.; Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Serrano 665, 1414 Buenos Aires, Argentina |
| 506 | |2 openaire |e Política editorial | ||
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| 504 | |a Ebadi, Regulation of the synthesis of melatonin and its significance to neuroendocrinology (1984) The Pineal Gland, pp. 1-37. , R.J. Reiter, Raven Press, New York | ||
| 504 | |a Cardinali, Vacas, Rosenstein, Lowenstein, Gonzalez Solveyra, Romeo, Keller Sarmiento, The pineal gland as a multieffector organ (1986) The Pineal Gland, pp. 127-138. , R.J. Reiter, M. Karasek, John Libbey, London | ||
| 504 | |a Reiter, Trakulrungsi, Trakulrungsi, Vriend, Morgan, Vaughan, Johnson, Richardson, Pineal malatonin production: endocrine and age effects (1982) Melatonin Rhythm Generating System, pp. 143-154. , D.C. Klein, Karger, Basel | ||
| 504 | |a Arendt, Laud, Symons, Plasma melatonin increases in ewes following ovariectomy (1983) J. Reprod. Fert., 68, pp. 213-218 | ||
| 504 | |a Werner, Brismar, Wetterberg, Eneroth, Circadian rhythms of melatonin, prolactin, growth hormone and cortisol in patients with pituitary adenomas, empty sella syndrome and Cushing's syndrome due to adrenal tumours (1981) Adv. Biosci., 29, pp. 357-363 | ||
| 504 | |a Birau, Melatonin in human serum: progress in screening investigation and clinic (1981) Adv. Biosci., 29, pp. 297-326 | ||
| 504 | |a Cardinali, Nagle, Rosner, Control of estrogen and androgen receptors in the rat pineal gland by catecholamine transmitter (1975) Life Sci., 16, pp. 93-106 | ||
| 504 | |a Cardinali, Nuclear receptor-estrogen complex in the pineal gland. Modulation by sympathetic nerves (1977) Neuroendocrinology, 24, pp. 333-346 | ||
| 504 | |a Cardinali, Nagle, Rosner, Metabolic fate of androgens in the pineal organ: uptake, binding to cytoplasmic proteins and conversion of testosterone into 5α-reduced metabolites (1974) Endocrinology, 95, pp. 179-187 | ||
| 504 | |a Moeller, Goecke, Gupta, Evidence for the presence androgen receptors in the bovine pineal gland (1984) Neuroendocr. Lett., 6, pp. 311-318 | ||
| 504 | |a Gray, Luttge, A putative glucocorticoid receptor in the rat pineal organ (1983) IRCS med. Sci., 11, pp. 437-439 | ||
| 504 | |a Vacas, Lowenstein, Cardinali, Characterization of a cytosol progesterone receptor in bovine pineal gland (1979) Neuroendocrinology, 24, pp. 84-89 | ||
| 504 | |a Cardinali, Molecular mechanisms of neuroendocrine integration in the central nervous system. An approach through the study of the pineal gland and its innervating sympathetic pathway (1983) Psychoneuroendocrinology, 8, pp. 3-30 | ||
| 504 | |a Vacas, Cardinali, Binding sites for melatonin in bovine pineal gland (1980) Horm. Res., 13, pp. 121-131 | ||
| 504 | |a Jung, Vollrath, Structural dissimilarities in different regions of the pineal gland of Pirbright White guinea-pigs (1982) J. neur. Transm., 54, pp. 117-128 | ||
| 504 | |a Cardinali, Ritta, Pereyra, Gonzalez Solveyra, Role of prostaglandins in rat pineal neuroeffector junction. Changes in melatonin and norepinephrine release in vitro (1982) Endocrinology, 111, pp. 530-534 | ||
| 504 | |a Mefford, HPLC with electrochemical detection neurochemical analysis: assays for catecholamines, serotonin and their metabolites in rat brain (1981) J. Neurosci. Meth., 3, pp. 207-224 | ||
| 504 | |a Cardinali, Vacas, Gonzalez Solveyra, Keller Sarminento, Vollrath, In vitro effects of estradiol, testosterone and progesterone on 5-methoxyindole content, cyclic adenosine 3',5'-monophosphate synthesis and norepinephrine release in different parts of the female guinea-pig pineal complex (1986) J. pineal Res., 3, pp. 351-363 | ||
| 504 | |a Mefford, Chang, Klein, Namboodiri, Sugden, Barchas, Reciprocal day/night relationship between serotonin oxidation and N-acetylation products in the rat pineal gland (1983) Endocrinology, 113, pp. 1582-1586 | ||
| 504 | |a Klein, Notides, Thin-layer Chromatographie separation of pineal gland derivatives of serotonin 14C (1969) Analyt. Biochem., 31, pp. 480-482 | ||
| 504 | |a Emmelin, Trendelenburg, Degeneration activity after parasympathetic or sympathetic denervation (1972) Rev. Physiol. Biochem. exp. Pharmac., 66, pp. 148-204 | ||
| 504 | |a Vacas, Keller Sarmiento, Pereyra, Cardinali, Early changes in cAMP and melatonin levels of rat pineal gland after superior cervical ganglionectomy (1982) Neuroendocr. Lett., 4, pp. 267-271 | ||
| 504 | |a Cardinali, Gejman, Ritta, Further evidence of adrenergic control of translocation and intracellular levels of estrogen receptors in rat pineal gland (1983) Endocrinology, 112, pp. 492-498 | ||
| 504 | |a Walker, Sparks, Slevin, Rush, Temporal effects of norepinephrine on pineal serotonin in vitro (1986) J. pineal Res., 3, pp. 33-40 | ||
| 504 | |a Clementi, Fraschini, Müller, Zanoboni, The pineal gland and the control of electrolyte balance and gonadotropic secretion: functional and morphological observation (1965) Prog. Brain Res., 10, pp. 583-603 | ||
| 504 | |a Ruiz-Navarro, Blanco-Rodriguez, Garquez-Ortiz, Jover-Moyano, Synaptic ribbons in pinealocytes of castrated rats and rats treated with estradiol (1982) Cell Biol. Int. Rev., 6, pp. 629-633 | ||
| 504 | |a Zweens, Alterations of the pineal lipid content in the rat under hormonal influences (1965) Prog. Brain Res., 10, pp. 540-551 | ||
| 504 | |a Nir, Hirschmann, Sulman, The effect of 17β-estradiol on pineal metabolism (1970) Life Sci., 9, pp. 851-858 | ||
| 504 | |a Cardinali, Nagle, Rosner, Effects of estradiol on melatonin and protein synthesis in the rat pineal organ (1974) Horm. Res., 5, pp. 304-310 | ||
| 504 | |a Mizobe, Kurokawa, Enhancement of hydroxyindole-O-methyltransferase and DNA-dependent RNA polymerase activities induced by oestradiol in rat pineals in culture (1976) Eur. J. Biochem., 66, pp. 193-199 | ||
| 504 | |a Mizobe, Kurokawa, Induction of a specific protein by oestradiol in rat pineals in culture (1978) FEBS Lett., 87, pp. 45-48 | ||
| 504 | |a Karavolas, Hodges, O'Brien, Hanukoglu, Progesterone and 5α-dihydrotestosterone uptake and metabolism in the pineal gland of female rats (1978) J. neur. Transm., 13, pp. 370-371. , Suppl | ||
| 504 | |a Cardinali, Nagle, Gomez, Rosner, Norepinephrine turnover in the rat pineal gland. Acceleration by estradiol and testosterone (1975) Life Sci., 16, pp. 1717-1724 | ||
| 504 | |a Vacas, Cardinali, Effects of castration and reproductive hormones on pineal serotonin metabolism in rats (1979) Neuroendocrinology, 28, pp. 187-195 | ||
| 504 | |a Foldes, Hoskinson, Scaramuzzi, Hinks, Maxwell, Modification of sheep pineal β-adrenoceptors by some gonadal steroids but not by melatonin (1983) Neuroendocrinology, 37, pp. 378-382 | ||
| 504 | |a Weiss, Crayton, Gonadal hormones as regulators of pineal adenyl cyclase activity (1970) Endocrinology, 87, pp. 527-533 | ||
| 504 | |a Davis, The response of adenosine 3',5'-monophosphate to norepinephrine in the hypothalamus and pineal organ of female rats in proestrus or diestrus (1978) Endocrinology, 103, pp. 1048-1053 | ||
| 504 | |a Semm, Demaine, Vollrath, The effect of sex hormones, prolactin and chorionic gonadotrophin on pineal electrical activity in guinea pigs (1981) Cell. molec. Neurobiol., 1, pp. 259-269 | ||
| 504 | |a Wurtman, Axelrod, Snyder, Changes in enzymatic synthesis of melatonin in the pineal during the estrous cycle (1965) Endocrinology, 76, pp. 798-800 | ||
| 504 | |a Ozaki, Wurtman, Alonso, Lynch, Melatonin secretion during the proestrous stage of the rat estrous cycle (1978) Proc. natn. Acad. Sci. U.S.A., 75, pp. 531-534 | ||
| 504 | |a Wilkinson, Arendt, Effect of oestrogen and progesterone on rat pineal N-acetyltransferase activity and melatonin production (1978) Experientia, 34, pp. 667-669 | ||
| 504 | |a Daya, Potgieter, Effects of sex steroids on pineal enzymes (1982) S. Afr. J. Sci., 78, p. 174 | ||
| 504 | |a Penny, Goebelsman, Effect of estradiol on plasma melatonin levels (1984) J. endocr. Invest., 7, pp. 55-57 | ||
| 504 | |a Stumpf, Sar, Steroid hormone target cells in the periventricular brain. Relationship to peptide hormone-producing cells (1977) Fedr. Proc. Fedn Am. Socs exp. Biol., 36, pp. 1973-1982 | ||
| 504 | |a Rühle, Autoradiographic demonstration of target cells for synthetic estrogen derivatives in the rat pineal gland (1984) 3rd Colloq. Eur. Pineal Study Group, p. 42. , Pécs, Hungary, (Abstr.) | ||
| 504 | |a Daya, Potgieter, The effect of castration, testosterone and estradiol on [14C]serotonin metabolism by organ cultures of male rat pineal glands (1985) Experientia, 41, pp. 275-276 | ||
| 504 | |a Cardinali, Vacas, Ritta, Gejman, Neurotransmitter-controlled steroid hormone receptors in the central nervous system (1985) Selected Topics from Neurochemistry, pp. 307-316. , N.N. Osborne, Pergamon Press, Oxford | ||
| 520 | 3 | |a The time course for the decrease in norepinephrine concentration of rat pineal explants in culture indicated a significant fall starting at the 4th hour and completed after 16-24 h of incubation. Significant decreases of serotonin and 5-hydroxyindoleacetic acid (HIAA) levels in tissue, an increase of HIAA/serotonin ratio, and an increase of melatonin production rate in vitro were also observed as a function of the incubation time. Estradiol (10-7-10-5 M) increased rat pineal melatonin content, testosterone (10-5 M) decreased it and progesterone was devoid of activity when incubated with explants for up to 6 h. The in vitro stimulatory effect of estradiol on rat pineal methoxyindole synthesis was blocked by propranolol but not by phentolamine; propranolol also blocked the increase of nuclear estradiol-receptor complex produced by estrogen exposure of pineal explants. TSH (1-100 ng/ml), growth hormone (10-100 ng/ml) and LH (10 ng/ml) augmented rat pineal melatonin content while 100 ng/ml of FSH decreased it significantly. Prolactin exerted a biphasic effect on rat pineal explants, the lowest concentration augmenting melatonin content while the high concentration depressed it. Deep, intermediate and superficial segments of guinea-pig pineal glands showed an increase in melatonin concentration after a 6-h incubation in the presence of 10-7-10-5 M estradiol. © 1987. |l eng | |
| 536 | |a Detalles de la financiación: PID-Oh7900/85 | ||
| 536 | |a Detalles de la financiación: Acknowledgements--Thesset udiesw ere supportedin part by grantsf rom the Consejo National de Investigaciones Cientfficas y Tecnicas (CONICET), Argentina (PID-Oh7900/85),t he Stiftung Volskwagenwerk, Hannover, FederalR epublic of Germany,a nd the CIDtech Research Inc., Hamilton, Ontario, Canada.D .P.C. and M.I.V. are establishedI nvestigators,C ONICET; G.S.E. is a Postdoctoral Fellow, Comision National de Investigaciones Cientificasd ela Provinciad e BueonosA ires. The technical assistanceo f Mrs A. T. de1 Castello is gratefully acknowledged. | ||
| 593 | |a Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Serrano 665, 1414 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a 5 HYDROXYINDOLEACETIC ACID |
| 690 | 1 | 0 | |a ESTRADIOL |
| 690 | 1 | 0 | |a FOLLITROPIN |
| 690 | 1 | 0 | |a GROWTH HORMONE |
| 690 | 1 | 0 | |a LUTEINIZING HORMONE |
| 690 | 1 | 0 | |a MELATONIN |
| 690 | 1 | 0 | |a NORADRENALIN |
| 690 | 1 | 0 | |a PHENTOLAMINE |
| 690 | 1 | 0 | |a PROLACTIN |
| 690 | 1 | 0 | |a PROPRANOLOL |
| 690 | 1 | 0 | |a RADIOISOTOPE |
| 690 | 1 | 0 | |a SEROTONIN |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a GUINEA PIG |
| 690 | 1 | 0 | |a METHODOLOGY |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PINEAL BODY |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a COMPARATIVE STUDY |
| 690 | 1 | 0 | |a GUINEA PIGS |
| 690 | 1 | 0 | |a HYDROXYINDOLEACETIC ACID |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MELATONIN |
| 690 | 1 | 0 | |a NOREPINEPHRINE |
| 690 | 1 | 0 | |a ORGAN CULTURE |
| 690 | 1 | 0 | |a PHENTOLAMINE |
| 690 | 1 | 0 | |a PINEAL GLAND |
| 690 | 1 | 0 | |a PITUITARY HORMONES, ANTERIOR |
| 690 | 1 | 0 | |a PROPRANOLOL |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a RECEPTORS, ESTRADIOL |
| 690 | 1 | 0 | |a SEROTONIN |
| 690 | 1 | 0 | |a SEX HORMONES |
| 690 | 1 | 0 | |a SUPPORT, NON-U.S. GOV'T |
| 700 | 1 | |a Vacas, M.I. | |
| 700 | 1 | |a Keller Sarmiento, M.I. | |
| 700 | 1 | |a Etchegoyen, G.S. | |
| 700 | 1 | |a Pereyra, E.N. | |
| 700 | 1 | |a Chuluyan, H.E. | |
| 773 | 0 | |d 1987 |g v. 27 |h pp. 565-571 |k n. 1-3 |p J. Steroid Biochem. |x 00224731 |t Journal of Steroid Biochemistry | |
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| 856 | 4 | 0 | |u https://doi.org/10.1016/0022-4731(87)90355-4 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_00224731_v27_n1-3_p565_Cardinali |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00224731_v27_n1-3_p565_Cardinali |y Registro en la Biblioteca Digital |
| 961 | |a paper_00224731_v27_n1-3_p565_Cardinali |b paper |c PE | ||
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| 999 | |c 79083 | ||