Glucocorticoid negative feedback and glucocorticoid receptors after hippocampectomy in rats
In rats with dorsal hippocampectomy, glucocorticoid receptors in the hypothalamus and anterior pituitary, as well as the pituitary transcortin-like compound, are preserved, in spite of a 60% depletion of glucocorticoid receptors in the hippocampus. In the hippocampectomized group, basal levels of se...
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| Otros Autores: | , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
1987
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 03017caa a22004697a 4500 | ||
|---|---|---|---|
| 001 | PAPER-18110 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204929.0 | ||
| 008 | 190411s1987 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0023121117 | |
| 024 | 7 | |2 cas |a dexamethasone, 50-02-2 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a HMMRA | ||
| 100 | 1 | |a Magarinos, A.M. | |
| 245 | 1 | 0 | |a Glucocorticoid negative feedback and glucocorticoid receptors after hippocampectomy in rats |
| 260 | |c 1987 | ||
| 506 | |2 openaire |e Política editorial | ||
| 520 | 3 | |a In rats with dorsal hippocampectomy, glucocorticoid receptors in the hypothalamus and anterior pituitary, as well as the pituitary transcortin-like compound, are preserved, in spite of a 60% depletion of glucocorticoid receptors in the hippocampus. In the hippocampectomized group, basal levels of serum corticosterone (CORT) were increased, although there was a normal response to ether stress. Inhibition of the response to ether with dexamethasone (DEX) was dose-dependent: whereas 100 μg/kg completely suppressed serum CORT, 10 μg/kg were ineffective. However, we observed a reduced sensitivity to DEX inhibition with 25 μg/kg in hippocampectomized animals. These results indicate that the hippocampus is involved in negative feedback mechanisms, although different doses of DEX are needed for this demonstration. The inhibition of serum CORT due to 100 μg/kg DEX suggests that negative feedback at sites other than the hippocampus was still operative, in agreement with normal levels of glucocorticoid receptors in the anterior pituitary and hypothalamus of hippocampectomized rats. |l eng | |
| 593 | |a Laboratorios de Esteroides and Neuroendocrinologia, Instituto de Biologia y Medicina Experimental, 1428 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a DEXAMETHASONE |
| 690 | 1 | 0 | |a GLUCOCORTICOID |
| 690 | 1 | 0 | |a ADENOHYPOPHYSIS |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a BIOLOGICAL MODEL |
| 690 | 1 | 0 | |a ENDOCRINE SYSTEM |
| 690 | 1 | 0 | |a FEEDBACK SYSTEM |
| 690 | 1 | 0 | |a HIPPOCAMPUS |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a STRESS |
| 690 | 1 | 0 | |a ANIMALIA |
| 700 | 1 | |a Somoza, G. | |
| 700 | 1 | |a De Nicola, A.F. | |
| 773 | 0 | |d 1987 |g v. 19 |h pp. 105-109 |k n. 3 |p HORM. METAB. RES. |x 00185043 |t Hormone and Metabolic Research | |
| 856 | 4 | 1 | |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-0023121117&doi=10.1055%2fs-2007-1011753&partnerID=40&md5=a489aa060b16de9526dcb5006d84c396 |y Registro en Scopus |
| 856 | 4 | 0 | |u https://doi.org/10.1055/s-2007-1011753 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_00185043_v19_n3_p105_Magarinos |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00185043_v19_n3_p105_Magarinos |y Registro en la Biblioteca Digital |
| 961 | |a paper_00185043_v19_n3_p105_Magarinos |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 999 | |c 79063 | ||