Functions and dysfunctions of receptors for adrenal corticoids in the central nervous system
Glucocorticoids (GC) have several known effects on the function of the nervous system, and GC receptors have been identified in regions responding to hormonal action. In the spinal cord, GC receptors have been characterized in vitro, which share several biochemical properties in common with receptor...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
1987
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| Sumario: | Glucocorticoids (GC) have several known effects on the function of the nervous system, and GC receptors have been identified in regions responding to hormonal action. In the spinal cord, GC receptors have been characterized in vitro, which share several biochemical properties in common with receptors in better studied areas such as the hippocampus. Moreover, enzymes which are induced by GC in the hippocampus, such as glycerolphosphate dehydrogenase and ornithine decarboxylase, are also under specific GC control in the spinal cord. Yet GC receptors in the latter tissue divert from those in hippocampus during some in vivo as well as in vitro studies. In vivo, uptake of [3H]corticosterone by purified cell nuclei was 5-8-fold higher in the hippocampus as compared to the cord. In vitro, a higher percentage of GC receptors previously transformed by heating, showed affinity towards DNA-cellulose in the spinal cord than in the hippocampus. The enzyme RNAse A effectively increased receptor binding to DNA-cellulose in hippocampus, whereas the cord was insensitive to its action. These results suggest that there is a "receptor dysfunction" in the spinal cord, the significance of which is poorly understood in terms of the accepted model of steroid hormone action. © 1987. |
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| Bibliografía: | McEwen, Biegon, Davis, Krey, Luine, McGinnis, Paden, Rainbow, Steroid hormones: humoral signals which alter brain cell properties and functions (1982) Rec. Progr. Horm. Res., 38, pp. 41-92 Stumpf, Sar, Glucocorticosteroid and mineralocorticosteroid hormone target sites in the brain: autoradiographic studies with corticosterone, aldosterone and dexamethasone (1979) Interactions within the Brain-Pituitary-Adrenocortical System, pp. 137-147. , M.T. Jones, B. Gillham, M.F. Dallman, S. Chattopahyay, Academic Press, New York Warembourgh, Steroid receptors in the brain: topography and some functional implications (1985) Neurochem. Int., 7, pp. 941-952 Coirini, Magariños, De Nicola, Rainbow, McEwen, Further studies of brain aldosterone binding sites employing new mineralo-corticoid and glucocorticoid receptor markers in vitro (1985) Brain Res., 361, pp. 212-216 Coirini, Marusic, De Nicola, Rainbow, McEwen, Identification of mineralocorticoid binding sites in rat brain by competition studies and density gradient centrifugation (1983) Neuroendocrinology, 37, pp. 354-360 Birmingham, Sar, Stumpf, Localization of aldosterone and corticosterone in the central nervous system, assessed by quantitative autoradiography (1984) Neurochem. Res., 9, pp. 333-350 Wrange, Yu, Mineralocorticoid receptor in rat kidney and hippocampus: characterization and quantitation by isoelectric focusing (1983) Endocrinology, 113, pp. 243-250 Luttge, Emadian, Densmore, Slatick, Efficacy of five methods for the bound-free separation of gluco- and mineralocorticoids form Type I, II and III receptors found in Hepes- and Tris-buffered mouse brain cytosol (1984) Steroids, 43, pp. 429-444 Marver, Aldosterone action in target epithelia (1980) Vitamins Horm., 38, pp. 57-117 Veldhuis, Van Kippen, Van Ittersum, De Kloett, Specificity of the adrenal steroid receptor system in rat hippocampus (1982) Endocrinology, 110, pp. 2044-2051 Fuxe, Wikstrom, Okret, Agnati, Harfstrand, Yu, Granholm, Gustafsson, Mapping of glucocorticoid receptor immunoreactive neurons in the rat tel- and diencephalon using a monoclonal antibody against rat liver glucocorticoid receptor (1985) Endocrinology, 117, pp. 1803-1812 Reul, De Kloet, Two receptor Systems for corticosterone in rat brain: microdistribution and differential occupation (1985) Endocrinology, 117, pp. 2502-2511 De Fiore, Turner, [3H]Corticosterone binding in the caudate-putamen (1983) Brain Res., 278, pp. 93-101 Meaney, Aitken, [3H]Dexamethasone binding in rat frontal cortex (1985) Brain Res., 328, pp. 176-182 McEwen, Lambdin, Rainbow, De Nicola, Aldosterone effects on salt appetite in adrenalectomized rats (1986) Newoendocrinology, 43, pp. 38-43 Meyer, Leveille, de Vellis, Gerlach, McEwen, Evidence for glucocorticoid target cells in the rat optic nerve. Hormone binding and glycerolphosphate dehydrogenase induction (1982) J. Neurochem., 39, pp. 423-434 Towle, Sze, [3H]Corticosterone binding in rat superior cervical ganglion (1982) Brain Res., 253, pp. 221-229 Duncan, Stumpf, A combined autoradiographic and immunocitochemical study of [3H]corticosterone target neurons and catecholamine neurons in rat and mouse lower brain stem (1985) Neuroendocrinology, 40, pp. 262-271 Clark, Maclusky, Naftolin, Glucocorticoid receptors in the spinal cord (1981) Brain Res., 217, pp. 412-415 Duncan, Stumpf, Target neurons for [3H]corticosterone in rat spinal cord (1984) Brain Res., 307, pp. 321-326 Ortí, Coirini, De Nicola, Properties and distribution of glucocorticoid-binding sites in cytosol of the spinal cord (1985) Neuroendocrinology, 40, pp. 225-231 Ortí, Tornello, De Nicola, Dynamic aspects of glucocorticoid receptors in the spinal cord of the rat (1985) J. Neurochem., 45, pp. 1699-1707 Ortí, Magarinos, De Nicola, Evidence of high affinity, stereoselective binding sites for [3H]aldosterone in the spinal cord (1986) Neuroendocrinology, 43, pp. 404-409 Hall, Glucocorticoid effects on central nervous excitability and synaptic transmission (1982) Int. Rev. Neurobiol., 23, pp. 165-195 Hall, Braughler, Acute effects of intravenous glucocorticoid pretreatment on the in vitro peroxidation of cat spinal cord tissue (1981) Exp. Neurol., 73, pp. 321-324 Hall, McGinley, Effects of a single intravenous glucocorticoid dose on biogenic amine levels in cat lumbar spinal cord (1982) J. Neurochem., 39, pp. 1787-1790 Riker, Baker, Sastre, Electrophysiological and clinical aspects of glucocorticoids on certain neural systems (1982) Adrenal Actions on Brain, pp. 69-105. , D. Ganten, D. Pfaff, Springer-Verlag, Berlin Stastny, Lisy, Sedlacek, Hajkova, The effect of cortisol on gamma-glutamyl transpeptidase activity in the glycogen body and lumbosacral segments of developing chick spinal cord (1985) Int. J. devl. Neurosci., 3, pp. 19-22 Beaumont, Fanestil, Characterization of rat brain aldosterone receptors reveals high affinity for corticosterone (1983) Endocrinology, 113, pp. 2043-2051 Krozowski, Funder, Mineralocorticoid receptors in rat anterior pituitary: toward a redefinition of “mineralocorticoid hormone” (1981) Endocrinology, 109, pp. 1221-1224 Kornell, Kanamarlapudi, Travers, Taff, Tael, Chen, Baum, Raynor, Studies on high affinity binding of mineralo- and glucocorticoids in rabbit aorta cytosols (1982) J. steroid Biochem., 16, pp. 245-264 Palkovits, Isolated removal of hypothalamic or other brain nuclei of the rat (1973) Brain Res., 59, pp. 449-450 Munck, Wira, Young, Mosher, Hallahan, Bell, Glucocorticoid-receptor complexes and the earliest steps in the action of glucocorticoids on thymus cells (1972) J. steroid Biochem., 3, pp. 567-578 Schmidt, Litwack, Activation of the glucocorticoid-receptor complex (1982) Physiol. Rev., 62, pp. 1131-1192 Sakahue, Thompson, Characterization of two forms of glucocorticoid hormone-receptor complex separated by DEAE cellulose column chromatography (1977) Biochem. biophys. Res. Commun., 77, pp. 533-541 Beato, Kalimi, Konstan, Feigelson, Interaction of glucocorticoids with rat liver nuclei. II. Studies on the nature of the cytosol transfer factor and the nuclear acceptor site (1973) Biochemistry, 12, pp. 3372-3379 Simons, Martínez, Garcea, Baxter, Tomkins, Interactions of glucocorticoid receptor-steroid complexes with acceptor sites (1976) J. biol. Chem., 251, pp. 334-343 Moses D. F., Ortí E., De Nicola A. F.: A comparison of the glucocorticoid receptor system in the spinal cord and hippocampus. Brain Res. (in press); McEwen, Glucocorticoid and hippocampus: receptors in search of a function (1982) Adrenal Action on Brain, pp. 1-22. , D. Gauten, D. Pfaff, Springer-Verlag, Berlin Dahmer, Mousley, Pratt, Effects of molybdate and endogenous inhibitors on steroid-receptor inactivation, transformation and translocation (1984) Ann. Rev. Physiol., 46, pp. 67-81 Economidis, Rousseau, Association of the glucocorticoid hormone receptor with ribonucleic acid (1985) FEBS, 181, pp. 47-82 Feldman, Kallos, Hollander, RNA inhibits estrogen receptor binding to DNA (1981) J. biol. Chem., 256, pp. 1145-1148 Hutches, Markland, Hawkins, RNA induced reversal of glucocorticoid receptor activation (1982) Biochem. biophys. Res. Commun., 195, pp. 20-27 Chong, Lippman, Effects of RNA and ribonuclease on the binding of estrogen and glucocorticoid receptors from MCF-7 cells to DNA-cellulose (1982) J. biol. Chem., 257, pp. 2996-3002 Rossini, RNAse effects on sedimentation and DNA binding properties of dexamethasone-receptor complexes from HeLa-cell cytosol (1985) J. steroid Biochem., 22, pp. 47-56 Tymoczko, Phillips, The effects of ribonuclease on rat liver dexamethasone receptor: increased affinity for deoxyribonucleic acid and alternated sedimentation profile (1983) Endocrinology, 112, pp. 142-149 Kovacic-Milivojevic, La Pointe, Reker, Vedeckis, Ribonucleic acid is a component of the oligomeric, transformed mouse AtT-20 cell glucocorticoid receptor (1985) Biochemistry, 24, pp. 7357-7366 Ortí E., Moses D. F., Grillo C. and De Nicola A. F.: Glucocorticoid regulation of glycerolphosphate dehydrogenase and ornithine decarboxylase activities in the spinal cord of the rat. J. Neurochem. (in press); De Vellis, Inglish, Hormonal control of gylcerolphosphate dehydrogenase in the rat brain (1968) J. Neurochem., 15, pp. 1061-1070 Leveille, McGinnis, Maxwell, De, Immunochemical localization of glycerol-3-phosphate dehydrogenase in rat oligodendrocytes (1980) Brain Res., 196, pp. 287-305 Cousin, Lando, Moguilewsky, Ornithine decarboxylase induction by glucocorticoids in brain and liver of adrenalectomized rats (1982) J. Neurochem., 38, pp. 1296-1304 McGinnis, De Vellis, Glucocorticoid regulation in rat brain cell cultures: hydrocortisone increases the rate of synthesis of glycerol-phosphate dehydrogenase in CG glioma cells (1978) J. biol. Chem., 253, pp. 8483-8492 Russell, Snyder, Amine synthesis in rapidly growing tissues: ornithine decarboxylase activity in regenerating rat liver, chick embryo and various tumors (1968) Proc. natn. Acad. Sci. U.S.A., 60, pp. 1420-1427 Kumar, Weingarten, Callahan, Sachar, De Vellis, Regulation of m-RNAs for three enzymes in the glial cell model CG cell line (1984) J. Neurochem., 43, pp. 1455-1463 Tomkins, Martin, Hormones and gene expression (1970) Ann. Rev. Genet., 4, pp. 91-106 Endo, Induction of ornithine decarboxylase in mouse tissue following the injection of mitogenic substances. Enhancement by actynomycin D (1984) Biochem. Pharmac., 33, pp. 2123-2127 Sheridan, Androgen receptors in the brain: What are we measuring? (1983) Endocr. Rev., 4, pp. 171-178 |
| ISSN: | 00224731 |
| DOI: | 10.1016/0022-4731(87)90359-1 |