Functions and dysfunctions of receptors for adrenal corticoids in the central nervous system
Glucocorticoids (GC) have several known effects on the function of the nervous system, and GC receptors have been identified in regions responding to hormonal action. In the spinal cord, GC receptors have been characterized in vitro, which share several biochemical properties in common with receptor...
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1987
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| LEADER | 15345caa a22014417a 4500 | ||
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| 001 | PAPER-18108 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204929.0 | ||
| 008 | 190411s1987 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0023575448 | |
| 024 | 7 | |2 cas |a corticosterone, 50-22-6; dexamethasone, 50-02-2; glycerol 3 phosphate dehydrogenase, 9001-49-4; ornithine decarboxylase, 9024-60-6; RNA, 63231-63-0; 11,17-dihydroxy-6-methyl-17-(1-propynyl)androsta-1,4,6-triene-3-one, 74915-64-3; Aldosterone, 52-39-1; Androstanols; Corticosterone, 50-22-6; Dexamethasone, 50-02-2; DNA-Binding Proteins; Receptors, Glucocorticoid | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a JSTBB | ||
| 100 | 1 | |a De Nicola, A.F. | |
| 245 | 1 | 0 | |a Functions and dysfunctions of receptors for adrenal corticoids in the central nervous system |
| 260 | |c 1987 | ||
| 270 | 1 | 0 | |m De Nicola, A.F.; Laboratorio de Esteroides, Instituto de Biologiá y Medicina Experimental, Obligado 2490, 1428 Buenos Aires, Argentina |
| 506 | |2 openaire |e Política editorial | ||
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| 504 | |a Coirini, Marusic, De Nicola, Rainbow, McEwen, Identification of mineralocorticoid binding sites in rat brain by competition studies and density gradient centrifugation (1983) Neuroendocrinology, 37, pp. 354-360 | ||
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| 504 | |a Duncan, Stumpf, Target neurons for [3H]corticosterone in rat spinal cord (1984) Brain Res., 307, pp. 321-326 | ||
| 504 | |a Ortí, Coirini, De Nicola, Properties and distribution of glucocorticoid-binding sites in cytosol of the spinal cord (1985) Neuroendocrinology, 40, pp. 225-231 | ||
| 504 | |a Ortí, Tornello, De Nicola, Dynamic aspects of glucocorticoid receptors in the spinal cord of the rat (1985) J. Neurochem., 45, pp. 1699-1707 | ||
| 504 | |a Ortí, Magarinos, De Nicola, Evidence of high affinity, stereoselective binding sites for [3H]aldosterone in the spinal cord (1986) Neuroendocrinology, 43, pp. 404-409 | ||
| 504 | |a Hall, Glucocorticoid effects on central nervous excitability and synaptic transmission (1982) Int. Rev. Neurobiol., 23, pp. 165-195 | ||
| 504 | |a Hall, Braughler, Acute effects of intravenous glucocorticoid pretreatment on the in vitro peroxidation of cat spinal cord tissue (1981) Exp. Neurol., 73, pp. 321-324 | ||
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| 504 | |a Stastny, Lisy, Sedlacek, Hajkova, The effect of cortisol on gamma-glutamyl transpeptidase activity in the glycogen body and lumbosacral segments of developing chick spinal cord (1985) Int. J. devl. Neurosci., 3, pp. 19-22 | ||
| 504 | |a Beaumont, Fanestil, Characterization of rat brain aldosterone receptors reveals high affinity for corticosterone (1983) Endocrinology, 113, pp. 2043-2051 | ||
| 504 | |a Krozowski, Funder, Mineralocorticoid receptors in rat anterior pituitary: toward a redefinition of “mineralocorticoid hormone” (1981) Endocrinology, 109, pp. 1221-1224 | ||
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| 504 | |a Palkovits, Isolated removal of hypothalamic or other brain nuclei of the rat (1973) Brain Res., 59, pp. 449-450 | ||
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| 504 | |a Schmidt, Litwack, Activation of the glucocorticoid-receptor complex (1982) Physiol. Rev., 62, pp. 1131-1192 | ||
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| 504 | |a Beato, Kalimi, Konstan, Feigelson, Interaction of glucocorticoids with rat liver nuclei. II. Studies on the nature of the cytosol transfer factor and the nuclear acceptor site (1973) Biochemistry, 12, pp. 3372-3379 | ||
| 504 | |a Simons, Martínez, Garcea, Baxter, Tomkins, Interactions of glucocorticoid receptor-steroid complexes with acceptor sites (1976) J. biol. Chem., 251, pp. 334-343 | ||
| 504 | |a Moses D. F., Ortí E., De Nicola A. F.: A comparison of the glucocorticoid receptor system in the spinal cord and hippocampus. Brain Res. (in press); McEwen, Glucocorticoid and hippocampus: receptors in search of a function (1982) Adrenal Action on Brain, pp. 1-22. , D. Gauten, D. Pfaff, Springer-Verlag, Berlin | ||
| 504 | |a Dahmer, Mousley, Pratt, Effects of molybdate and endogenous inhibitors on steroid-receptor inactivation, transformation and translocation (1984) Ann. Rev. Physiol., 46, pp. 67-81 | ||
| 504 | |a Economidis, Rousseau, Association of the glucocorticoid hormone receptor with ribonucleic acid (1985) FEBS, 181, pp. 47-82 | ||
| 504 | |a Feldman, Kallos, Hollander, RNA inhibits estrogen receptor binding to DNA (1981) J. biol. Chem., 256, pp. 1145-1148 | ||
| 504 | |a Hutches, Markland, Hawkins, RNA induced reversal of glucocorticoid receptor activation (1982) Biochem. biophys. Res. Commun., 195, pp. 20-27 | ||
| 504 | |a Chong, Lippman, Effects of RNA and ribonuclease on the binding of estrogen and glucocorticoid receptors from MCF-7 cells to DNA-cellulose (1982) J. biol. Chem., 257, pp. 2996-3002 | ||
| 504 | |a Rossini, RNAse effects on sedimentation and DNA binding properties of dexamethasone-receptor complexes from HeLa-cell cytosol (1985) J. steroid Biochem., 22, pp. 47-56 | ||
| 504 | |a Tymoczko, Phillips, The effects of ribonuclease on rat liver dexamethasone receptor: increased affinity for deoxyribonucleic acid and alternated sedimentation profile (1983) Endocrinology, 112, pp. 142-149 | ||
| 504 | |a Kovacic-Milivojevic, La Pointe, Reker, Vedeckis, Ribonucleic acid is a component of the oligomeric, transformed mouse AtT-20 cell glucocorticoid receptor (1985) Biochemistry, 24, pp. 7357-7366 | ||
| 504 | |a Ortí E., Moses D. F., Grillo C. and De Nicola A. F.: Glucocorticoid regulation of glycerolphosphate dehydrogenase and ornithine decarboxylase activities in the spinal cord of the rat. J. Neurochem. (in press); De Vellis, Inglish, Hormonal control of gylcerolphosphate dehydrogenase in the rat brain (1968) J. Neurochem., 15, pp. 1061-1070 | ||
| 504 | |a Leveille, McGinnis, Maxwell, De, Immunochemical localization of glycerol-3-phosphate dehydrogenase in rat oligodendrocytes (1980) Brain Res., 196, pp. 287-305 | ||
| 504 | |a Cousin, Lando, Moguilewsky, Ornithine decarboxylase induction by glucocorticoids in brain and liver of adrenalectomized rats (1982) J. Neurochem., 38, pp. 1296-1304 | ||
| 504 | |a McGinnis, De Vellis, Glucocorticoid regulation in rat brain cell cultures: hydrocortisone increases the rate of synthesis of glycerol-phosphate dehydrogenase in CG glioma cells (1978) J. biol. Chem., 253, pp. 8483-8492 | ||
| 504 | |a Russell, Snyder, Amine synthesis in rapidly growing tissues: ornithine decarboxylase activity in regenerating rat liver, chick embryo and various tumors (1968) Proc. natn. Acad. Sci. U.S.A., 60, pp. 1420-1427 | ||
| 504 | |a Kumar, Weingarten, Callahan, Sachar, De Vellis, Regulation of m-RNAs for three enzymes in the glial cell model CG cell line (1984) J. Neurochem., 43, pp. 1455-1463 | ||
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| 504 | |a Endo, Induction of ornithine decarboxylase in mouse tissue following the injection of mitogenic substances. Enhancement by actynomycin D (1984) Biochem. Pharmac., 33, pp. 2123-2127 | ||
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| 520 | 3 | |a Glucocorticoids (GC) have several known effects on the function of the nervous system, and GC receptors have been identified in regions responding to hormonal action. In the spinal cord, GC receptors have been characterized in vitro, which share several biochemical properties in common with receptors in better studied areas such as the hippocampus. Moreover, enzymes which are induced by GC in the hippocampus, such as glycerolphosphate dehydrogenase and ornithine decarboxylase, are also under specific GC control in the spinal cord. Yet GC receptors in the latter tissue divert from those in hippocampus during some in vivo as well as in vitro studies. In vivo, uptake of [3H]corticosterone by purified cell nuclei was 5-8-fold higher in the hippocampus as compared to the cord. In vitro, a higher percentage of GC receptors previously transformed by heating, showed affinity towards DNA-cellulose in the spinal cord than in the hippocampus. The enzyme RNAse A effectively increased receptor binding to DNA-cellulose in hippocampus, whereas the cord was insensitive to its action. These results suggest that there is a "receptor dysfunction" in the spinal cord, the significance of which is poorly understood in terms of the accepted model of steroid hormone action. © 1987. |l eng | |
| 536 | |a Detalles de la financiación: National Council for Scientific Research, PID 3089300/85a | ||
| 536 | |a Detalles de la financiación: National Institutes of Health, NS 20866 | ||
| 536 | |a Detalles de la financiación: Acknowledgements-This work was supported by the National Research Council of Argentina (PID 3089300/85a)n d by NIH grant NS 20866.W e thankM rs Elsa di Matte0 for technical assistancea nd Mrs Dora Beatriz Desttfano for editoriala ssistance. | ||
| 593 | |a Laboratorio de Esteroides, Instituto de Biologiá y Medicina Experimental, Obligado 2490, 1428 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a CORTICOSTERONE |
| 690 | 1 | 0 | |a DEXAMETHASONE |
| 690 | 1 | 0 | |a GLUCOCORTICOID RECEPTOR |
| 690 | 1 | 0 | |a GLYCEROL 3 PHOSPHATE DEHYDROGENASE |
| 690 | 1 | 0 | |a ORNITHINE DECARBOXYLASE |
| 690 | 1 | 0 | |a RADIOISOTOPE |
| 690 | 1 | 0 | |a RNA |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a CENTRAL NERVOUS SYSTEM |
| 690 | 1 | 0 | |a HIPPOCAMPUS |
| 690 | 1 | 0 | |a METHODOLOGY |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a SPINAL CORD |
| 690 | 1 | 0 | |a ALDOSTERONE |
| 690 | 1 | 0 | |a ANDROSTANOLS |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a BIOLOGICAL TRANSPORT |
| 690 | 1 | 0 | |a CELL NUCLEUS |
| 690 | 1 | 0 | |a COMPARATIVE STUDY |
| 690 | 1 | 0 | |a CORTICOSTERONE |
| 690 | 1 | 0 | |a CYTOSOL |
| 690 | 1 | 0 | |a DEXAMETHASONE |
| 690 | 1 | 0 | |a DNA-BINDING PROTEINS |
| 690 | 1 | 0 | |a ENZYME INDUCTION |
| 690 | 1 | 0 | |a HIPPOCAMPUS |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a RECEPTORS, GLUCOCORTICOID |
| 690 | 1 | 0 | |a SPINAL CORD |
| 690 | 1 | 0 | |a SUPPORT, NON-U.S. GOV'T |
| 690 | 1 | 0 | |a SUPPORT, U.S. GOV'T, NON-P.H.S. |
| 690 | 1 | 0 | |a SUPPORT, U.S. GOV'T, P.H.S. |
| 700 | 1 | |a Ortí, E. | |
| 700 | 1 | |a Moses, D.F. | |
| 700 | 1 | |a Magariños, A.M. | |
| 700 | 1 | |a Coirini, H. | |
| 773 | 0 | |d 1987 |g v. 27 |h pp. 599-607 |k n. 1-3 |p J. Steroid Biochem. |x 00224731 |t Journal of Steroid Biochemistry | |
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| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_00224731_v27_n1-3_p599_DeNicola |y Handle |
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