Thyroid autoregulation. Inhibitory effects of iodinated derivatives of arachidonic acid on iodine metabolism
Thyroid autoregulation has been linked to an organified iodocompound. Since several iodolipids are produced by the gland their possible role in thyroid autoregulation was examined. The following pure synthetic compounds were prepared: 1) 14-iodo-15-hydroxy-5,8,11-eicosatrienoic acid (I-OH-A); 2) its...
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1988
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 08728caa a22008897a 4500 | ||
|---|---|---|---|
| 001 | PAPER-18043 | ||
| 003 | AR-BaUEN | ||
| 005 | 20250821084503.0 | ||
| 008 | 190411s1988 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0023762325 | |
| 024 | 7 | |2 cas |a liothyronine, 6138-47-2, 6893-02-3 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 100 | 1 | |a Chazenbalk, G.D. | |
| 245 | 1 | 0 | |a Thyroid autoregulation. Inhibitory effects of iodinated derivatives of arachidonic acid on iodine metabolism |
| 260 | |c 1988 | ||
| 270 | 1 | 0 | |m Chazenbalk, G.D.; Division Bioquimica Nuclear, Gerencia de Radioisótopos, Comisión Nacional de Energía, Atómica; Depto. Química Orgánica, Facultad de Ciencias Exastas y Naturales, Buenos Aires, Argentina |
| 504 | |a Nagataki, S., Effect of excess quantities of iodide (1974) Thyroid, Handbook of Physiology, p. 329. , M.A. Greer, D.H. Solomon, American Physiological Society, Washington, DC, sect. 7 | ||
| 504 | |a Greer, M.A., DeGroot, L.J., The effect of stable iodine on thyroid secretion in man (1956) Metabolism, 5, p. 682 | ||
| 504 | |a Pisarev, M.A., DeGroot, L.J., Hati, R., KI and amidazole inhibition of TSH and cyclic AMP-induced thyroidal iodine secretion (1971) Endocrinology, 88, p. 1217 | ||
| 504 | |a Pisarev, M.A., Aiello, L.O., Studies on the mechanism of action of KI on thyroid protein biosynthesis (1976) Acta Endocrinol. (Kbh), 82, p. 298 | ||
| 504 | |a Pisarev, M.A., Aiello, L.O., Kleiman de Pisarev, D.L., Action of KI, thyroxine and cyclic AMP on 3H-uridine incorporation into thyroid RNA (1976) Acta Endocrinol. (Kbh), 83, p. 313 | ||
| 504 | |a Van Sande, J., Dumont, J.E., Effects of thyrotropin, prostaglandin E1 and iodide on cyclic 3′ 5′ AMP concentration in dog thyroid slices (1973) Biochem. Biophys. Acta, 313, p. 320 | ||
| 504 | |a Rapoport, B., West, M., Ingbar, S.H., On the mechanism of inhibition by iodine on the thyroid adenylate cyclase response to thyrotropic hormone (1976) Endocrinology, 99, p. 11 | ||
| 504 | |a Uchimura, H., Cheng Chiu, S., Kuzaya, N., Ikeda, H., Ito, K., Nagataki, S., Effect of iodine enrichment in vitro on the adenylate cyclase-cyclic 3′5′ adenosine monophosphate system in thyroid glands from normal subjects and patients with Grave's disease (1980) J. clin. Endocrinol. Metab., 50, p. 1066 | ||
| 504 | |a Pisarev, M.A., Itoiz, M.E., Action of KI on stimulated thyroid protein biosynthesis (1972) Endocrinology, 90, p. 1409 | ||
| 504 | |a Pisarev, M.A., Thyroid autoregulation (1985) J. Endocrinol. Invest., 8, p. 475 | ||
| 504 | |a Chazenbalk, G.D., Pisarev, M.A., Juvenal, G.J., Kleiman de Pisarev, D.L., Mercuri, H., DeTomas, M., Biosynthesis and regulation of iodolipids in calf thyroid (1985) Acta Endocrinol. (Kbh), 108, p. 72 | ||
| 504 | |a Boeynaems, J.M., Hubbard, W.C., Transformation of arachidonic acid into idolactone by the rat thyroid (1980) J. biol. Chem., 255, p. 9001 | ||
| 504 | |a Boeynames, J.M., Reagan, D., Hubbard, W.C., Lactoperoxidase-catalyzed iodination of arachidonic acid: formation of macrolides (1981) Lipids, 16, p. 246 | ||
| 504 | |a Turk, J., Henderson, W.R., Klebanoff, S.J., Hubbard, W.C., Iodination of arachidonic acid mediated eosinophil peroxidase, myeloperoxidase and lactoperoxidase: identification and comparison of products (1983) Biochim. Biophys. Acta, 751, p. 189 | ||
| 504 | |a Chazenbalk, G.D., Pisarev, M.A., Krawiec, L., Juvenal, G.J., Burton, G., Valsecchi, R.M., In vitro inhibitory effects of an iodinated derivative of arachidonic acid on calf thyroid (1984) Acta Physiol. Pharmacol. Lat. amer., 34, p. 367 | ||
| 504 | |a Krawiec, L., Chazenbalk, G.D., Puntarulo, S.A., Burton, G., Boveris, A., Valsecchi, R.M., Pisarev, M.A., The inhibition of the PB125I formation in calf thyroid caused by 14-iodo-15-hdyroxy-eicosatrienoic acid is due to decreased H2O2 availability (1988) Horm. Metab. Res., 20, p. 86 | ||
| 504 | |a Corda, D., Kohn, L.D., Phorbol myristate acetate inhibits α-adrenergically but not thyrotropin-regulated functions in FRTL-5 rat thyroid cells (1987) Endocrinology, 120, p. 1152 | ||
| 504 | |a Corey, E.J., Niwa, H., Falk, J.R., Selective epoxydation of eicosacis-5,8,11,14-tetranoic(arachidonic)acid and eicosa-cis-8,11,14-trienoic acid (1979) J. Amer. Che. Soc., 101, p. 586 | ||
| 504 | |a Bartlett, P.A., Myerson, J., Stereoselective epoxydation of acyclic olefinic carboxylic acid via iodolactonization (1978) J. Amer. Chem. Soc., 100, p. 3950 | ||
| 504 | |a Berkowitz, M., Daughttridge, D., Sherwin, J.R., Autoregulation of the thyroid iodide transport: possible mediation by modifying sodium cotransport (1981) Amer. J. Physiol., 240, p. E37 | ||
| 504 | |a Socolow, E., Dunlap, D., Sobel, R., Ingbar, S.H., A correlative study of the effect of iodide administration on thyroidal iodide and organic iodine content (1968) Endocrinology, 83, p. 737 | ||
| 504 | |a Pisarev, M.A., Burton, G., Busse Grawitz, P., Chazenbalk, G.D., Juvenal, G.J., Kleiman de Pisarev, D.L., Krawiec, L., Valsecchi, R.M., Postreceptor events in growth control (1986) Frontiers in Thyroidology, 1, p. 125. , G. Medeiros-Neto, E. Gaitan, Plenum Medical Book Co, New York | ||
| 506 | |2 openaire |e Política editorial | ||
| 520 | 3 | |a Thyroid autoregulation has been linked to an organified iodocompound. Since several iodolipids are produced by the gland their possible role in thyroid autoregulation was examined. The following pure synthetic compounds were prepared: 1) 14-iodo-15-hydroxy-5,8,11-eicosatrienoic acid (I-OH-A); 2) its omega lactone (IL-ω);3)5-hydroxy-6-iodo-8,11,14-eicosatrienoic acid delta lactone (IL-δ). Their action on iodine metabolism was studied. Iodine uptake was measured in calf thyroid slices. At 10-4M I-OH-A caused a 64% decrease in the T/M ratio while IL-ω inhibited it by 36% and IL-δ was without effect. At 10−5M the inhibition was 44% for I-OH-A and 19% for IL-ω, while T3 was without action. A possible isotopic dilution effect was excluded, and no change in iodine efflux was observed. The inhibition by I-OH-A of iodine uptake was observed after only 15 min preincubation. This compound alse decreased 125I accumulation in rats. In calf thyroid slice, I-OH-A at 10−4M, inhibited PB125I formation by 80%, IL-ω 62% and IL-ω by 37% and arachidonic acid were without action. I-OH-A also caused a dose-dependent inhibition of TSH-stimulated iodide organification. The present results demonstrate, for the first time, that iodinated derivatives of arachidonic acid inhibition thyroid function and mimic the effect of iodine on thyroid autoregulation. © 1988, All rights reserved. |l eng | |
| 536 | |a Detalles de la financiación: Acknowledgements : To Miss Mariana B.Alegre technical assistance.This tine National Research and Mrs.Beatriz Alderete de Manto for expert work was supported by grants from the Argerl-Council(CONTCET). | ||
| 593 | |a Division Bioquimica Nuclear, Gerencia de Radioisótopos, Comisión Nacional de Energía, Atómica; Depto. Química Orgánica, Facultad de Ciencias Exastas y Naturales, Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a 15 HYDROXY 14 IODO 5,8,11 ICOSATRIENOIC ACID |
| 690 | 1 | 0 | |a 15 HYDROXY 14 IODO 5,8,11 ICOSATRIENOIC ACID |
| 690 | 1 | 0 | |a ARACHIDONIC ACID DERIVATIVE |
| 690 | 1 | 0 | |a LIOTHYRONINE |
| 690 | 1 | 0 | |a RADIOISOTOPE |
| 690 | 1 | 0 | |a THYROID IODINE |
| 690 | 1 | 0 | |a UNCLASSIFIED DRUG |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a AUTOREGULATION |
| 690 | 1 | 0 | |a CATTLE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a INTRAPERITONEAL DRUG ADMINISTRATION |
| 690 | 1 | 0 | |a NEWBORN |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a THYROID GLAND |
| 690 | 1 | 0 | |a ANIMALIA |
| 690 | 1 | 0 | |a BOS TAURUS |
| 700 | 1 | |a Valsecchi, R.M. | |
| 700 | 1 | |a Krwaiec, L. | |
| 700 | 1 | |a Burton, G. | |
| 700 | 1 | |a Juvenal, G.J. | |
| 700 | 1 | |a Monteagudo, E. | |
| 700 | 1 | |a Chester, H.A. | |
| 700 | 1 | |a Pisarev, Mario Alberto | |
| 773 | 0 | |d 1988 |g v. 36 |h pp. 163-172 |k n. 2 |p Prostaglandins |x 00906980 |t Prostaglandins | |
| 856 | 4 | 1 | |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-0023762325&doi=10.1016%2f0090-6980%2888%2990303-6&partnerID=40&md5=59e5d29aa7727fef7160f909bc9d37ee |y Registro en Scopus |
| 856 | 4 | 0 | |u https://doi.org/10.1016/0090-6980(88)90303-6 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_00906980_v36_n2_p163_Chazenbalk |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00906980_v36_n2_p163_Chazenbalk |y Registro en la Biblioteca Digital |
| 961 | |a paper_00906980_v36_n2_p163_Chazenbalk |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 999 | |c 78996 | ||