The influences of leukotriene C4 on the metabolism of labelled glucose in uteri isolated from ovariectomized and from ovariectomized-estrogenized rats. Effects of indomethacin
The effects of leukotriene C4 (LTC4), nordihydroguaiaretic acid (NDGA) and FPL-55712, on the metabolism of labelled glucose (U14C-glucose) in uteri isolated from spayed rats and from spayed-estrogenized rats, incubated in the presence and in the absence of indomethacin, were explored. Indomethacin (...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
1989
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 09994caa a22011177a 4500 | ||
|---|---|---|---|
| 001 | PAPER-17985 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204921.0 | ||
| 008 | 190411s1989 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0024473292 | |
| 024 | 7 | |2 cas |a 7 [3 (4 acetyl 3 hydroxy 2 propylphenoxy) 2 hydroxypropoxy] 4 oxo 8 propyl 4h 1 benzopyran 2 carboxylic acid, 40786-08-1; carbon dioxide, 124-38-9, 58561-67-4; estradiol, 50-28-2; glucose, 50-99-7, 84778-64-3; indometacin, 53-86-1, 74252-25-8, 7681-54-1; nordihydroguaiaretic acid, 500-38-9; leukotriene C4, 72025-60-6; Carbon Dioxide, 124-38-9; Chromones; Estradiol, 50-28-2; FPL 55712, 40786-08-1; Glucose, 50-99-7; Indomethacin, 53-86-1; Nordihydroguaiaretic Acid, 500-38-9; SRS-A | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a PLEAE | ||
| 100 | 1 | |a Gonzalez, E.T. | |
| 245 | 1 | 4 | |a The influences of leukotriene C4 on the metabolism of labelled glucose in uteri isolated from ovariectomized and from ovariectomized-estrogenized rats. Effects of indomethacin |
| 260 | |c 1989 | ||
| 270 | 1 | 0 | |m Gimeno, A.L.; Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Consejo Nacional de Investigaciones Cientificas y Técnicas (CONICET), Universidad Nacional de Buenos AiresArgentina |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Gonzalez, Torres, Gimeno, Gimeno, Substrate Requirements in vitro for the Spontaneous Motility of Uterine Strips from Ovariectomized or Natural Estrus Rats: Relationships with tissue levels of glycogen and triglycerides (1976) Archives Of Physiology And Biochemistry, 84, pp. 213-227 | ||
| 504 | |a Gonzalez, E. T., Gimeno, M. A. F. and Gimeno, A. L. Prostaglandin E2 alters the metabolism of labelled glucose in uteri isolated from ovariectomized rats. Effects of 17-Beta-estradiol and indomethacin. Prost. Leuk. Ess. Fatty Acids (accepted for publication); Mitchell, Grzyboski, Dehar, Hunter, Arachidonic acid metabolism by lipoxygenase pathways in uterine and intrauterine tissues of pregnant sheep (1987) Prost. Leuk. and Med., 27, pp. 197-207 | ||
| 504 | |a Saeed, Mitchell, Lipoxygenase activity in human uterine and intrauterine tissues: new prospects for control of prostacyclin production in preeclampsia. Cli. and Exper (1983) Hyper-Hyper in pregnancy B2, pp. 103-111 | ||
| 504 | |a Thaler-Dao, Jouanen, Benmehdi, Crastes de Paulet, Regulation by estradiol of the lipoxygenase pathway in the rat uterus (1985) Prost. Leuk. and Med., 18, pp. 59-64 | ||
| 504 | |a Borgeat, Samuelsson, Transformation of arachidonic acid by rabbit polymorphonuclear leukocytes (1979) J. Biol. Chem., 254, pp. 2643-2646 | ||
| 504 | |a Malathy, Cheng, Dey, Production of leukotrienes and prostaglandins in the rat uterus during periimplantation period (1986) Prostaglandins, 32, pp. 605-614 | ||
| 504 | |a Neil, Sexual differences in the hypothalamic regulation of prolactin secretion (1972) Endocrinology, 90, pp. 1154-1160 | ||
| 504 | |a Sterin-Speziale, Gimeno, Bonacossa, Gimeno, The effect of estradiol on isolated rat uterine motility and on prostaglandin generation (1980) Prostaglandins, 20, pp. 233-240 | ||
| 504 | |a Chang, Roth, Changes in prostaglandin E1 stimulation of glucose oxidation in rat adipocytes during maturation and aging (1981) Life Sci., 28, pp. 623-627 | ||
| 504 | |a Beatty, Bocek, Prostaglandins: Their effects on carbohydrate metabolism of myometrium from Rhesus Monkeys (1972) Endocrinology, 90, pp. 1295-1300 | ||
| 504 | |a Brass, Garrity, Effects of E-series prostaglandins on cyclic AMP-dependent and independent hormone-stimulated glycogenolysis in hepatocytes (1985) Diabetes, 34, pp. 291-296 | ||
| 504 | |a Morris, Piper, Taylor, Tippins, The role of arachidonate lipoxygenase in the release of SRS-A from guinea pig chopped lung (1980) Prostaglandins, 19, pp. 371-383 | ||
| 504 | |a Augstein, Farmer, Lee, Sheard, Tattersall, Selective inhibition of slow reacting substance of anaphylaxis (1973) Nature (New Biol.), 245, pp. 215-217 | ||
| 504 | |a Chegini, Rao, The presence of leukotriene C4 and prostacyclin binding sites in nonpregnant human uterine tissue (1988) J. Clin. Endocrinol. and Metab., 66, pp. 76-86 | ||
| 504 | |a Cheng, Lang, Againdra, Townley, Tissue distribution and functional correlation of 3H-leukotriene C4 and 3H-leukotriene D4 binding sites in guinea pig uterus and lung preparations (1985) J. Pharmacol. Exp. Ther., 232, pp. 80-85 | ||
| 504 | |a Pakrasi, Becka, Dey, Cyclooxygenase and lipoxygenase pathways in the preimplantation rabbit uterus and blastocyst (1985) Prostaglandins, 29, pp. 481-495 | ||
| 504 | |a Wynn, Histology and ultrastructure of the human endometrium (1977) Biology of the Uterus, p. 341. , R.M. Wynn, Plenum Press, New York | ||
| 520 | 3 | |a The effects of leukotriene C4 (LTC4), nordihydroguaiaretic acid (NDGA) and FPL-55712, on the metabolism of labelled glucose (U14C-glucose) in uteri isolated from spayed rats and from spayed-estrogenized rats, incubated in the presence and in the absence of indomethacin, were explored. Indomethacin (10-6M), enhanced significantly 14CO2 formation from labelled glucose, both in uteri from ovariectomized rats and in uteri from ovariectomized-estrogenized animals. In uteri from spayed not-estrogenized rats, exposed 'in vitro' to indomethacin, NDGA (10-5M), an inhibitor of the 5-lipoxygenase, as well as FPL-55712 (10-5M), a LT antagonist, reduced significantly the enhanced metabolism of glucose evoked by indomethacin, an inhibitor of the cyclo- oxygenase. On the other hand, LTC4 (10-7M) augmented the metabolism of labelled glucose, reaching values even greater than those induced by indomethacin. In the spayed-estrogenized group LTC4 (10-10 - 10-7M) enhanced the formation of labelled CO2 from labelled glucose as much as indomethacin (10-6M) did, whereas neither NDGA nor FPL-55712 were effective. In addition, in uteri from ovariectomized-estrogenized rats, incubated with indomethacin, NDGA and FPL-55712, decreased the augmenting action of indomethacin on glucose metabolism, whereas LTC4 (10-10 - 10-7M) evoked a complete reversal of the inhibitory influence of NDGA on the formation of 14CO2. The force-going results suggest that tissue 5-lipoxygenase products, particularly LTC4, are involved in the metabolism of labelled glucose by rat uteri, mainly when the cyclo-oxygenase pathway is inhibited by indomethacin and the tissue is deprived of estradiol. Moreover, under estrogenic dominance, exogenous LTC4 exhibits a peculiar influence manifested by an enhancement of the uterine metabolism of U14C-glucose. © 1989. |l eng | |
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas, P/D-3068000/85 | ||
| 536 | |a Detalles de la financiación: Centro de Estudios Farmacolhgicos y de Principios Naturales (CEFAPRIN), Consejo National de lnvestigaciones Cientificas y Tknicas KONICET); tDepartamento de Farmacologia y Toxicologia, Facultad de Medicina, Universidad National de Buenos Aires. Supported by Grant from CONICET (P/D-3068000/85) and by a Grant from Fundation Albert0 J. Roemmers. Correspondence and reprints requests to ALG, CEFAPRIN, Serrano 665 (1474), Buenos Aires, Argentina. | ||
| 593 | |a Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Consejo Nacional de Investigaciones Cientificas y Técnicas (CONICET), Universidad Nacional de Buenos Aires, Argentina | ||
| 593 | |a Departamento de Farmacologia y Toxicologia, Facultad de Medicine, Universidad Nacional de Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a 7 [3 (4 ACETYL 3 HYDROXY 2 PROPYLPHENOXY) 2 HYDROXYPROPOXY] 4 OXO 8 PROPYL 4H 1 BENZOPYRAN 2 CARBOXYLIC ACID |
| 690 | 1 | 0 | |a CARBON DIOXIDE |
| 690 | 1 | 0 | |a CHROMONE DERIVATIVE |
| 690 | 1 | 0 | |a ESTRADIOL |
| 690 | 1 | 0 | |a GLUCOSE |
| 690 | 1 | 0 | |a INDOMETACIN |
| 690 | 1 | 0 | |a NORDIHYDROGUAIARETIC ACID |
| 690 | 1 | 0 | |a SLOW REACTING SUBSTANCE |
| 690 | 1 | 0 | |a 7 [3 (4 ACETYL 3 HYDROXY 2 PROPYLPHENOXY) 2 HYDROXYPROPOXY] 4 OXO 8 PROPYL 4H 1 BENZOPYRAN 2 CARBOXYLIC ACID |
| 690 | 1 | 0 | |a ESTRADIOL |
| 690 | 1 | 0 | |a GLUCOSE |
| 690 | 1 | 0 | |a INDOMETACIN |
| 690 | 1 | 0 | |a LEUKOTRIENE C4 |
| 690 | 1 | 0 | |a NORDIHYDROGUAIARETIC ACID |
| 690 | 1 | 0 | |a RADIOISOTOPE |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a ENZYMOLOGY |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a IN VITRO STUDY |
| 690 | 1 | 0 | |a METABOLISM |
| 690 | 1 | 0 | |a OVARIECTOMY |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a RAT STRAIN |
| 690 | 1 | 0 | |a UTERUS |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a METABOLISM |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a SUBCUTANEOUS DRUG ADMINISTRATION |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a CARBON DIOXIDE |
| 690 | 1 | 0 | |a CHROMONES |
| 690 | 1 | 0 | |a ESTRADIOL |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a GLUCOSE |
| 690 | 1 | 0 | |a IN VITRO |
| 690 | 1 | 0 | |a INDOMETHACIN |
| 690 | 1 | 0 | |a NORDIHYDROGUAIARETIC ACID |
| 690 | 1 | 0 | |a OVARIECTOMY |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a RATS, INBRED STRAINS |
| 690 | 1 | 0 | |a SRS-A |
| 690 | 1 | 0 | |a SUPPORT, NON-U.S. GOV'T |
| 690 | 1 | 0 | |a UTERUS |
| 653 | 0 | 0 | |a fpl 55712, fisons, United Kingdom |
| 700 | 1 | |a Gimeno, A.L. | |
| 700 | 1 | |a Gimeno, M.A.F. | |
| 773 | 0 | |d 1989 |g v. 36 |h pp. 113-117 |k n. 2 |p Prostaglandins Leukotrienes Essent. Fatty Acids |x 09523278 |t Prostaglandins, Leukotrienes and Essential Fatty Acids | |
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