Testicular interstitial cells as targets for peripheral benzodiazepines
We evaluated the 'in vitro' effect of a selective peripheral benodiazepine (BZD) receptor agonist, Ro 5-4864, on basal and hCG-stimulated androgen production by testicular interstitial cell suspensions. Ro 5-4864 (10-9-10-5 M) induced a significant increment of basal testosterone release i...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
1989
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| Materias: | |
| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 03332caa a22005177a 4500 | ||
|---|---|---|---|
| 001 | PAPER-17967 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204920.0 | ||
| 008 | 190411s1989 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0024503813 | |
| 024 | 7 | |2 cas |a 4' chlorodiazepam, 14439-61-3; benzodiazepine, 12794-10-4; chorionic gonadotropin, 9002-61-3; clonazepam, 1622-61-3; diazepam, 439-14-5; n sec butyl 1 (2 chlorophenyl) n methyl 3 isoquinolinecarboxamide, 85532-75-8; testosterone, 58-22-0 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a NUNDA | ||
| 100 | 1 | |a Ritta, M.N. | |
| 245 | 1 | 0 | |a Testicular interstitial cells as targets for peripheral benzodiazepines |
| 260 | |c 1989 | ||
| 506 | |2 openaire |e Política editorial | ||
| 520 | 3 | |a We evaluated the 'in vitro' effect of a selective peripheral benodiazepine (BZD) receptor agonist, Ro 5-4864, on basal and hCG-stimulated androgen production by testicular interstitial cell suspensions. Ro 5-4864 (10-9-10-5 M) induced a significant increment of basal testosterone release into the medium. In addition, under conditions of hCG stimulation, Ro 5-4864 (10-7 M) induced a potentiated response to the gonadotropin in a dose-dependent manner. The selective peripheral BZD antagonist PK 11195 fully prevented the stimulatory effect of Ro 5-4864. On the other hand, clonazepam, a central BZD agonist, failed to affect androgen production significantly, whereas diazepam (10-5-10-4 M), which binds to both central and peripheral BZD receptors, was able to induce a significant increment of basal and hCG-stimulated testosterone production. These results suggest that under our experimental conditions Ro 5-4864 exerts an effect on testicular steroidogenesis, presumably through binding to the previously described peripheral-type BZD receptor. |l eng | |
| 593 | |a Instituto de Biologia y Medicina Experimental, 1428 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a 4' CHLORODIAZEPAM |
| 690 | 1 | 0 | |a ANDROGEN |
| 690 | 1 | 0 | |a BENZODIAZEPINE |
| 690 | 1 | 0 | |a CHORIONIC GONADOTROPIN |
| 690 | 1 | 0 | |a CLONAZEPAM |
| 690 | 1 | 0 | |a DIAZEPAM |
| 690 | 1 | 0 | |a N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE |
| 690 | 1 | 0 | |a TESTOSTERONE |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a LEYDIG CELL |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a STEROIDOGENESIS |
| 690 | 1 | 0 | |a TESTIS |
| 690 | 1 | 0 | |a TOPICAL DRUG ADMINISTRATION |
| 653 | 0 | 0 | |a pk 11195, Pharmuka, France; ro 5 4864, Hoffmann La Roche, United States |
| 700 | 1 | |a Calandra, R.S. | |
| 773 | 0 | |d 1989 |g v. 49 |h pp. 262-266 |k n. 3 |p NEUROENDOCRINOLOGY |x 00283835 |w (AR-BaUEN)CENRE-6253 |t Neuroendocrinology | |
| 856 | 4 | 1 | |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-0024503813&doi=10.1159%2f000125126&partnerID=40&md5=6f3c406aa2cbe450de8658e1f55f7b9b |y Registro en Scopus |
| 856 | 4 | 0 | |u https://doi.org/10.1159/000125126 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_00283835_v49_n3_p262_Ritta |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00283835_v49_n3_p262_Ritta |y Registro en la Biblioteca Digital |
| 961 | |a paper_00283835_v49_n3_p262_Ritta |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 999 | |c 78920 | ||