Oxidative stress and cellular and tissue damage in organogenic outbred mouse embryos after moderate perigestational alcohol intake
Perigestational alcohol consumption by CF-1 mouse, from before mating up to the period of embryo organogenesis, leads to retarded early embryo development and neural tube defects. Here, we addressed if perigestational alcohol ingestion up to Day 10 of pregnancy induces oxidative stress and changes i...
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John Wiley and Sons Inc.
2017
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| LEADER | 25687caa a22024137a 4500 | ||
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| 001 | PAPER-17537 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204849.0 | ||
| 008 | 190410s2017 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-85031726618 | |
| 024 | 7 | |2 cas |a 3 nitrotyrosine, 3604-79-3; alcohol, 64-17-5; caspase 3, 169592-56-7; catalase, 9001-05-2; glutathione, 70-18-8; nitrite, 14797-65-0; superoxide dismutase, 37294-21-6, 9016-01-7, 9054-89-1; Antioxidants; Ethanol | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a MREDE | ||
| 100 | 1 | |a Coll, T.A. | |
| 245 | 1 | 0 | |a Oxidative stress and cellular and tissue damage in organogenic outbred mouse embryos after moderate perigestational alcohol intake |
| 260 | |b John Wiley and Sons Inc. |c 2017 | ||
| 270 | 1 | 0 | |m Cebral, E.; Universidad de Buenos Aires, Facultad de Ciencias Exactas y NaturalesArgentina; email: ecebral@hotmail.com |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a Perigestational alcohol consumption by CF-1 mouse, from before mating up to the period of embryo organogenesis, leads to retarded early embryo development and neural tube defects. Here, we addressed if perigestational alcohol ingestion up to Day 10 of pregnancy induces oxidative stress and changes in macromolecules and organ tissues of early organogenic embryos. Adult CF-1 female mice were administered 10% ethanol in their drinking water for 17 days prior to mating and until Day 10 of gestation, whereas control females were administered ethanol-free water. Our results demonstrated significantly reduced Catalase abundance and activity and increased glutathione content in the embryos of ethanol-treated females. The nitrite level was significantly reduced, but TBARS (thiobarbituric acid reactive substances) content, an index of lipid peroxidation, did not change. Embryos derived from ethanol-treated females also showed higher abundance of 3-nitrotyrosine (3-NT)-containing proteins in all tissues, compared to the control group. Apoptosis was significantly increased in the ectoderm and mesoderm, but not in the heart—although this organ did contain more cleaved Caspase-3-positive cardiomyocytes per area of ventricular myocardium than controls. In sum, moderate perigestational alcohol ingestion up to Day 10 of gestation in mice induces oxidative stress by altering radical nitrogen species and antioxidant enzymatic and non-enzymatic mechanisms in embryos. Further, generalized protein nitration, due to unbalanced nitric oxide levels associated with tissue-specific apoptosis, was detected in embryos, suggesting that oxidative mechanisms may play an important role in the perigestational alcohol-induced malformation of organogenic embryos exposed to ethanol. © 2017 Wiley Periodicals, Inc. |l eng | |
| 536 | |a Detalles de la financiación: Agencia Nacional de Promoción Científica y Tecnológica, BID-PICT-2008-2210 | ||
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas, PIP-11220090100492, PIP-114-200801-00014 | ||
| 536 | |a Detalles de la financiación: Fondo para la Investigación Científica y Tecnológica | ||
| 536 | |a Detalles de la financiación: Agencia Nacional de Promoción Científica y Tecnológica | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: Agencia Nacional de Promoción Científica y Tecnológica, BID-PICT-2008-2210 | ||
| 536 | |a Detalles de la financiación: European Commission, 11220090100492 | ||
| 536 | |a Detalles de la financiación: Fondo para la Investigación Científica y Tecnológica | ||
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires, UBACyT X187 | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas, Grant numbers: PIP-11220090100492, PIP-114-200801-00014; FONCYT from the Agencia Nacional de Promoción Científica y Tecnológica, Grant number: BID-PICT-2008-2210; Universidad de Buenos Aires, Grant number: UBACyT X187 | ||
| 536 | |a Detalles de la financiación: The authors acknowledge the CONICET, the Agencia Nacional de Promoción Científica y Tecnológica and Universidad de Buenos Aires, Argentina, for their financial support. The R. de M., MC and C., E thank financial support from CONICET, the FONCYT from the Agencia Nacional de Promoción Científica y Tecnológica and Universidad de Buenos Aires, Argentina. This work was supported by the Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) (PIP-CONICET, grant numbers: 114-200801-00014, EC; and 11220090100492, R.de M.); Agencia Nacional de Promoción Científ-ica y Tecnológica (grant number BID-PICT-2008-2210); the Universi-dad de Buenos Aires, Argentina (grant number UBACyT X187). | ||
| 593 | |a Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a CONICET-Universidad de Buenos Aires, Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE), Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a CONICET-Universidad de Buenos Aires, Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN), Departamento de Química Biológica, Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a CONICET-Universidad de Buenos Aires, Instituto de Biodiversidad y Biología Experimental y Aplicada (IBBEA-CONICET), Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a Universidad de Buenos Aires, Facultad de Medicina, CONICET- Universidad de Buenos Aires, Instituto de Investigaciones Biomédicas (INBIOMED), Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a APOPTOSIS |
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| 690 | 1 | 0 | |a GENETICS |
| 690 | 1 | 0 | |a MAMMALIAN EMBRYO |
| 690 | 1 | 0 | |a METABOLISM |
| 690 | 1 | 0 | |a OUTBRED STRAIN |
| 690 | 1 | 0 | |a OXIDATIVE STRESS |
| 690 | 1 | 0 | |a PATHOLOGY |
| 690 | 1 | 0 | |a PREGNANCY |
| 690 | 1 | 0 | |a PRENATAL EXPOSURE |
| 690 | 1 | 0 | |a ALCOHOL DRINKING |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a ANIMALS, OUTBRED STRAINS |
| 690 | 1 | 0 | |a ANTIOXIDANTS |
| 690 | 1 | 0 | |a APOPTOSIS |
| 690 | 1 | 0 | |a DNA DAMAGE |
| 690 | 1 | 0 | |a EMBRYO, MAMMALIAN |
| 690 | 1 | 0 | |a EMBRYONIC DEVELOPMENT |
| 690 | 1 | 0 | |a ETHANOL |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a MICE |
| 690 | 1 | 0 | |a ORGANOGENESIS |
| 690 | 1 | 0 | |a OXIDATIVE STRESS |
| 690 | 1 | 0 | |a PREGNANCY |
| 690 | 1 | 0 | |a PRENATAL EXPOSURE DELAYED EFFECTS |
| 700 | 1 | |a Chaufan, G. | |
| 700 | 1 | |a Pérez-Tito, L. | |
| 700 | 1 | |a Ventureira, M.R. | |
| 700 | 1 | |a Sobarzo, C.M.A. | |
| 700 | 1 | |a Ríos de Molina, M.D.C. | |
| 700 | 1 | |a Cebral, E. | |
| 773 | 0 | |d John Wiley and Sons Inc., 2017 |g v. 84 |h pp. 1086-1099 |k n. 10 |p Mol. Reprod. Dev. |x 1040452X |t Molecular Reproduction and Development | |
| 856 | 4 | 1 | |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-85031726618&doi=10.1002%2fmrd.22865&partnerID=40&md5=e174aa526c6991ffb992f3b77b149ef1 |y Registro en Scopus |
| 856 | 4 | 0 | |u https://doi.org/10.1002/mrd.22865 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_1040452X_v84_n10_p1086_Coll |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_1040452X_v84_n10_p1086_Coll |y Registro en la Biblioteca Digital |
| 961 | |a paper_1040452X_v84_n10_p1086_Coll |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 999 | |c 78490 | ||