Methods for quantitative analysis of axonal cargo transport
Neurons rely on complex axonal transport mechanisms that mediate the intracellular dynamics of proteins, vesicles, and mitochondria along their high polarized structure. The fast improvement of live imaging techniques of fluorescent cargos allowed the identification of the diverse motion properties...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
Humana Press Inc.
2018
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 09127caa a22011057a 4500 | ||
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| 001 | PAPER-17273 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204827.0 | ||
| 008 | 190410s2018 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-85037678656 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 100 | 1 | |a Alloatti, M. | |
| 245 | 1 | 0 | |a Methods for quantitative analysis of axonal cargo transport |
| 260 | |b Humana Press Inc. |c 2018 | ||
| 270 | 1 | 0 | |m Falzone, T.L.; Instituto de Biología Celular y Neurociencias (IBCN) CONICET-UBA, Facultad de Medicina, Universidad de Buenos AiresArgentina; email: tfalzone@fmed.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 504 | |a Lacovich, V., Espindola, S.L., Alloatti, M., Pozo Devoto, V., Cromberg, L.E., Čarná, M.E., Forte, G., Falzone, T.L., Tau isoforms imbalance impairs the axonal transport of the amyloid precursor protein in human neurons (2017) J Neurosci, 37, pp. 58-69 | ||
| 504 | |a Pozo Devoto, V., Dimopoulous, N., Alloatti, M., Cromberg, L., Otero, M., Saez, T., Pardi, B., Falzone, T., α-Synuclein control of mitochondrial homeostasis in human-derived neurons is disrupted by mutations associated with Parkinson’s disease (2017) Sci Rep, 7 (1), 5042p | ||
| 504 | |a Xu, C.-C., Denton, K.R., Wang, Z.-B., Zhang, X., Li, X.-J., Abnormal mitochondrial transport and morphology as early pathological changes in human models of spinal muscular atrophy (2016) Dis Model Mech, 9, pp. 39-49 | ||
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| 504 | |a Perrot, R., Julien, J.-P., Real-time imaging reveals defects of fast axonal transport induced by disorganization of intermediate filaments (2009) FASEB J, 23, pp. 3213-3225 | ||
| 504 | |a Otero, M.G., Alloatti, M., Cromberg, L.E., Almenar-Queralt, A., Encalada, S.E., Pozo Devoto, V.M., Bruno, L., Falzone, T.L., Fast axonal transport of the proteasome complex depends on membrane interaction and molecular motor function (2014) J Cell Sci, 127, pp. 1537-1549 | ||
| 504 | |a Reis, G.F., Yang, G., Szpankowski, L., Weaver, C., Shah, S.B., Robinson, J.T., Hays, T.S., Goldstein, L.S., Molecular motor function in axonal transport in vivo probed by genetic and computational analysis in Drosophila (2012) Mol Biol Cell, 23, pp. 1700-1714 | ||
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| 520 | 3 | |a Neurons rely on complex axonal transport mechanisms that mediate the intracellular dynamics of proteins, vesicles, and mitochondria along their high polarized structure. The fast improvement of live imaging techniques of fluorescent cargos allowed the identification of the diverse motion properties of different transported molecules. These properties arise as the result of molecular interactions between many players involved in axonal transport. Motor proteins, microtubule tracks, cargo association, and even axonal viscosity contribute to the proper axonal dynamics of different cargos. The unique properties in each cargo determine their distribution and location that is relevant to ensure neuronal cell activity and survival. This chapter provides a computational-based method for the generation of cargo trajectories and the identification of different motion regimes while cargo moves along axons. Then, the procedure to extract relevant parameters from active, diffusive, and confined motion is provided. These properties will allow a better comprehension of the nature and characteristics of cargo motion in living cells, therefore contributing to understanding the consequences of transport defects that arise during diseases of the nervous system. © Springer Science+Business Media, LLC 2018. |l eng | |
| 593 | |a Instituto de Biología Celular y Neurociencias (IBCN) CONICET-UBA, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a Facultad de Ciencias Exactas y Naturales, Departamento de Física (IFIBA) CONICET, Universidad de Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a Instituto de Biología y Medicina Experimental (IBYME) CONICET, Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a ANTEROGRADE |
| 690 | 1 | 0 | |a AXONAL TRANSPORT |
| 690 | 1 | 0 | |a DIFFUSIVE |
| 690 | 1 | 0 | |a PAUSES |
| 690 | 1 | 0 | |a RETROGRADE |
| 690 | 1 | 0 | |a REVERSIONS |
| 690 | 1 | 0 | |a RUN LENGTHS |
| 690 | 1 | 0 | |a SEGMENTAL VELOCITIES |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a ANIMAL CELL CULTURE |
| 690 | 1 | 0 | |a DNA VECTOR |
| 690 | 1 | 0 | |a GENETIC TRANSFECTION |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a HUMAN CELL |
| 690 | 1 | 0 | |a HUMAN CELL CULTURE |
| 690 | 1 | 0 | |a IMAGING |
| 690 | 1 | 0 | |a MOUSE |
| 690 | 1 | 0 | |a NERVE CELL CULTURE |
| 690 | 1 | 0 | |a NERVE FIBER TRANSPORT |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PLURIPOTENT STEM CELL |
| 690 | 1 | 0 | |a QUANTITATIVE ANALYSIS |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a AXON |
| 690 | 1 | 0 | |a BIOLOGY |
| 690 | 1 | 0 | |a CYTOLOGY |
| 690 | 1 | 0 | |a METABOLISM |
| 690 | 1 | 0 | |a MOLECULAR IMAGING |
| 690 | 1 | 0 | |a NERVE CELL |
| 690 | 1 | 0 | |a NERVE FIBER TRANSPORT |
| 690 | 1 | 0 | |a PROCEDURES |
| 690 | 1 | 0 | |a SOFTWARE |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a AXONAL TRANSPORT |
| 690 | 1 | 0 | |a AXONS |
| 690 | 1 | 0 | |a COMPUTATIONAL BIOLOGY |
| 690 | 1 | 0 | |a HUMANS |
| 690 | 1 | 0 | |a MICE |
| 690 | 1 | 0 | |a MOLECULAR IMAGING |
| 690 | 1 | 0 | |a NEURONS |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a SOFTWARE |
| 700 | 1 | |a Bruno, L. | |
| 700 | 1 | |a Falzone, T.L. | |
| 773 | 0 | |d Humana Press Inc., 2018 |g v. 1727 |h pp. 217-226 |p Methods Mol. Biol. |x 10643745 |t Methods in Molecular Biology | |
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