Determining the virus life-cycle stage blocked by an antiviral
Among the members of the Arenaviridae family, Junín virus and Lassa virus represent important human health threats generating annual outbreaks of severe human hemorrhagic fever (HF) in endemic areas of Argentina and Western Africa, respectively. Given the lack of a specific and safe chemotherapy, th...
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| Otros Autores: | , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
Humana Press Inc.
2018
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 14654caa a22014777a 4500 | ||
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| 001 | PAPER-17211 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204822.0 | ||
| 008 | 190410s2018 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-85030763996 | |
| 024 | 7 | |2 cas |a Antiviral Agents | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 100 | 1 | |a Sepúlveda, C.S. | |
| 245 | 1 | 0 | |a Determining the virus life-cycle stage blocked by an antiviral |
| 260 | |b Humana Press Inc. |c 2018 | ||
| 270 | 1 | 0 | |m Damonte, E.B.; Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN), UBA-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)Argentina; email: edamonte@qb.fcen.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 504 | |a García, C.C., Candurra, N.A., Damonte, E.B., Differential inhibitory action of two azoic compounds against arenaviruses (2003) Int J Antimicrob Agents, 21, pp. 319-324 | ||
| 504 | |a García, C.C., Candurra, N.A., Damonte, E.B., Mode of inactivation of arenaviruses by disulfide based compounds (2002) Antivir Res, 55, pp. 437-446 | ||
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| 504 | |a García, C.C., Djavani, M., Topisirovic, I., Borden, K.L., Salvato, M.S., Damonte, E.B., Arenavirus Z protein as an antiviral target: Virus inactivation and protein oligomerization by zinc finger reactive compounds (2006) J Gen Virol, 87, pp. 1217-1228 | ||
| 504 | |a Sepúlveda, C.S., García, C.C., Damonte, E.B., Inhibition of arenavirus infection by thiuram and aromatic disulfides (2010) Antivir Res, 87, pp. 329-337 | ||
| 504 | |a Sepúlveda, C.S., García, C.C., Levingston Macleod, J.M., López, N., Damonte, E.B., Targeting of arenavirus RNA synthesis by a carboxamide-derivatized aromatic disulfide with virucidal activity (2013) Plos One, 8, pp. e81251 | ||
| 504 | |a Ortiz-Riaño, E., Ngo, N., Devito, S., Eggink, D., Munger, J., Inhibition of arenavirus by A3, a pyrimidine biosynthesis inhibitor (2014) J Virol, 88, pp. 878-889 | ||
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| 504 | |a Barradas, J.S., Errea, M.I., D'accorso, N.B., Sepúlveda, C.S., Talarico, L.B., Damonte, E.B., Synthesis and antiviral activity of azoles obtained from carbohydrates (2008) Carbohydr Res, 343, pp. 2468-2474 | ||
| 504 | |a Barradas, J.S., Errea, M.I., D'accorso, N.B., Sepúlveda, C.S., Damonte, E.B., Imidazo[2,1-b]thiazole carbohydrate derivatives: Synthesis and antiviral activity against Junin virus, agent of Argentine hemorrhagic fever (2011) Eur J Med Chem, 46, pp. 259-264 | ||
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| 504 | |a Pasquato, A., Rochat, C., Burri, D.J., Pasqual, G., De La Torre, J.C., Kunz, S., Evaluation of the anti-arenaviral activity of the subtilisin kexin isozyme-1/site-1 protease inhibitor PF-429242 (2012) Virology, 423, pp. 14-22 | ||
| 520 | 3 | |a Among the members of the Arenaviridae family, Junín virus and Lassa virus represent important human health threats generating annual outbreaks of severe human hemorrhagic fever (HF) in endemic areas of Argentina and Western Africa, respectively. Given the lack of a specific and safe chemotherapy, the search for effective antiviral compounds is a continuous demanding effort. During the last two decades, academic research studies originated important results identifying novel molecules to be considered for further in vivo characterization. This chapter summarizes experimental in vitro approaches used to determine the possible mechanism of action of these antiviral agents. © Springer Science+Business Media LLC 2018. |l eng | |
| 593 | |a Laboratorio de Estrategias Antivirales, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales (FCEyN), Universidad de Buenos Aires (UBA), Buenos Aires, Argentina | ||
| 593 | |a Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN), UBA-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a ANTIVIRAL COMPOUND |
| 690 | 1 | 0 | |a ANTIVIRAL MECHANISM |
| 690 | 1 | 0 | |a ARENAVIRUSES |
| 690 | 1 | 0 | |a ANTIVIRUS AGENT |
| 690 | 1 | 0 | |a COMPLEMENTARY DNA |
| 690 | 1 | 0 | |a ANTIVIRUS AGENT |
| 690 | 1 | 0 | |a ARENAVIRIDAE |
| 690 | 1 | 0 | |a CYTOPATHOGENIC EFFECT |
| 690 | 1 | 0 | |a CYTOTOXICITY |
| 690 | 1 | 0 | |a CYTOTOXICITY ASSAY |
| 690 | 1 | 0 | |a DISEASE SEVERITY |
| 690 | 1 | 0 | |a DNA SYNTHESIS |
| 690 | 1 | 0 | |a DRUG MECHANISM |
| 690 | 1 | 0 | |a EC50 |
| 690 | 1 | 0 | |a ENDEMIC DISEASE |
| 690 | 1 | 0 | |a HEMORRHAGIC FEVER |
| 690 | 1 | 0 | |a HIGH THROUGHPUT SCREENING |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a IN VITRO STUDY |
| 690 | 1 | 0 | |a JUNIN VIRUS |
| 690 | 1 | 0 | |a LASSA VIRUS |
| 690 | 1 | 0 | |a LIFE CYCLE STAGE |
| 690 | 1 | 0 | |a MTS ASSAY |
| 690 | 1 | 0 | |a MTT ASSAY |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a POLYACRYLAMIDE GEL ELECTROPHORESIS |
| 690 | 1 | 0 | |a REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION |
| 690 | 1 | 0 | |a RNA SYNTHESIS |
| 690 | 1 | 0 | |a STRUCTURE ACTIVITY RELATION |
| 690 | 1 | 0 | |a VIROGENESIS |
| 690 | 1 | 0 | |a VIRUS ASSEMBLY |
| 690 | 1 | 0 | |a VIRUS ATTACHMENT |
| 690 | 1 | 0 | |a VIRUS CULTURE |
| 690 | 1 | 0 | |a VIRUS LIKE AGENT |
| 690 | 1 | 0 | |a VIRUS PARTICLE |
| 690 | 1 | 0 | |a VIRUS RELEASE |
| 690 | 1 | 0 | |a VIRUS REPLICATION |
| 690 | 1 | 0 | |a VIRUS TRANSCRIPTION |
| 690 | 1 | 0 | |a VIRUS UNCOATING |
| 690 | 1 | 0 | |a WESTERN BLOTTING |
| 690 | 1 | 0 | |a ARENAVIRIDAE |
| 690 | 1 | 0 | |a DRUG EFFECT |
| 690 | 1 | 0 | |a HANTAAN VIRUS |
| 690 | 1 | 0 | |a PHYSIOLOGY |
| 690 | 1 | 0 | |a ANTIVIRAL AGENTS |
| 690 | 1 | 0 | |a ARENAVIRUS |
| 690 | 1 | 0 | |a HANTAAN VIRUS |
| 700 | 1 | |a García, C.C. | |
| 700 | 1 | |a Damonte, E.B. | |
| 773 | 0 | |d Humana Press Inc., 2018 |g v. 1604 |h pp. 371-392 |p Methods Mol. Biol. |x 10643745 |t Methods in Molecular Biology | |
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