Identifying restriction factors for hemorrhagic fever viruses: Dengue and junín

Host restriction factors are cellular components that interfere with viral multiplication. They are up-regulated and expressed upon viral infection and in consequence their activity is specific. So far several important restriction factors have been described against diverse viruses. The cellular an...

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Autor principal: Giovannoni, F.
Otros Autores: Cárcamo, J.R.P, Morell, M.L, Cordo, S.M, García, C.C
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: Humana Press Inc. 2018
Acceso en línea:Registro en Scopus
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100 1 |a Giovannoni, F. 
245 1 0 |a Identifying restriction factors for hemorrhagic fever viruses: Dengue and junín 
260 |b Humana Press Inc.  |c 2018 
270 1 0 |m García, C.C.; Laboratorio de Estrategias Antivirales, Departamento de Química Biológica (QB), Facultad de Ciencias Exactas y Naturales (FCEyN), Universidad de Buenos Aires (UBA), Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Intendente Guiraldes 2160, Argentina; email: cygarcia@qb.fcen.uba.ar 
506 |2 openaire  |e Política editorial 
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520 3 |a Host restriction factors are cellular components that interfere with viral multiplication. They are up-regulated and expressed upon viral infection and in consequence their activity is specific. So far several important restriction factors have been described against diverse viruses. The cellular antiviral mechanisms defined include proteins with the ability to interfere with early steps of viral replication and others that have been shown to block viral morphogenesis. However, other strategies by which the antiviral action is exerted still remain elusive. An additional interesting matter is how viruses also developed ways to by-pass these host-specific obstacles. Thus, unusual cell localization or re-localization represents a frequent virus choice to evade the cellular surveillance. In the present chapter, we summarize methods to identify cell restriction factors, their antiviral activity, and possible subcellular locations where their activity can take place. © Springer Science+Business Media LLC 2018.  |l eng 
593 |a Laboratorio de Estrategias Antivirales, Departamento de Química Biológica (QB), Facultad de Ciencias Exactas y Naturales (FCEyN), Universidad de Buenos Aires (UBA), Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Intendente Guiraldes 2160, Buenos Aires, 1428, Argentina 
593 |a Laboratorio de Bioquímica y Biología del virus Junín, QB, FCEyN, UBA-IQUIBICEN, CONICET, Buenos Aires, Argentina 
690 1 0 |a ANTIVIRAL PROTEINS 
690 1 0 |a DENGUE 
690 1 0 |a JUNIN 
690 1 0 |a LIPID DROPLETS 
690 1 0 |a MICROSCOPY 
690 1 0 |a SIRNA 
690 1 0 |a VIRAL RESTRICTION 
690 1 0 |a ANTIVIRAL ACTIVITY 
690 1 0 |a CELLULAR DISTRIBUTION 
690 1 0 |a DENGUE VIRUS 
690 1 0 |a GENE OVEREXPRESSION 
690 1 0 |a HEMORRHAGIC FEVER 
690 1 0 |a JUNIN VIRUS 
690 1 0 |a NONHUMAN 
690 1 0 |a VIRUS GENE 
690 1 0 |a VIRUS INFECTIVITY 
690 1 0 |a VIRUS MORPHOGENESIS 
690 1 0 |a VIRUS REPLICATION 
690 1 0 |a ANIMAL 
690 1 0 |a DENGUE 
690 1 0 |a DENGUE VIRUS 
690 1 0 |a HEMORRHAGIC FEVER WITH RENAL SYNDROME 
690 1 0 |a HUMAN 
690 1 0 |a JUNIN VIRUS 
690 1 0 |a METABOLISM 
690 1 0 |a VIROLOGY 
690 1 0 |a SMALL INTERFERING RNA 
690 1 0 |a ANIMALS 
690 1 0 |a DENGUE 
690 1 0 |a DENGUE VIRUS 
690 1 0 |a HEMORRHAGIC FEVER WITH RENAL SYNDROME 
690 1 0 |a HUMANS 
690 1 0 |a JUNIN VIRUS 
690 1 0 |a RNA, SMALL INTERFERING 
700 1 |a Cárcamo, J.R.P. 
700 1 |a Morell, M.L. 
700 1 |a Cordo, S.M. 
700 1 |a García, C.C. 
773 0 |d Humana Press Inc., 2018  |g v. 1604  |h pp. 351-370  |p Methods Mol. Biol.  |x 10643745  |t Methods in Molecular Biology 
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