Cellular and molecular oxidative stress-related effects in uterine myometrial and trophoblast-decidual tissues after perigestational alcohol intake up to early mouse organogenesis
The placenta plays a major role in embryo-fetal defects and intrauterine growth retardation after maternal alcohol consumption. Our aims were to determine the oxidative status and cellular and molecular oxidative stress effects on uterine myometrium and trophoblast-decidual tissue following perigest...
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Springer New York LLC
2018
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| LEADER | 20248caa a22019097a 4500 | ||
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| 001 | PAPER-17082 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204812.0 | ||
| 008 | 190410s2018 xx ||||fo|||| 00| 0 eng|d | ||
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| 024 | 7 | |2 cas |a 3 nitrotyrosine, 3604-79-3; alcohol, 64-17-5; catalase, 9001-05-2; glutathione, 70-18-8; glutathione transferase, 50812-37-8; nitrite, 14797-65-0; superoxide dismutase, 37294-21-6, 9016-01-7, 9054-89-1 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a MCBIB | ||
| 100 | 1 | |a Coll, T.A. | |
| 245 | 1 | 0 | |a Cellular and molecular oxidative stress-related effects in uterine myometrial and trophoblast-decidual tissues after perigestational alcohol intake up to early mouse organogenesis |
| 260 | |b Springer New York LLC |c 2018 | ||
| 270 | 1 | 0 | |m Cebral, E.; IBBEA-UBA/CONICET, Intendente Güiraldes, 2620, Ciudad Universitaria, Pabellón 2, 4to. Piso, Lab 22. (CP: 1428EGA), Ciudad Autónoma de Buenos Aires, Argentina; email: ecebral@hotmail.com |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a The placenta plays a major role in embryo-fetal defects and intrauterine growth retardation after maternal alcohol consumption. Our aims were to determine the oxidative status and cellular and molecular oxidative stress effects on uterine myometrium and trophoblast-decidual tissue following perigestational alcohol intake at early organogenesis. CF-1 female mice were administered with 10% alcohol in drinking water for 17 days prior to and up to day 10 of gestation. Control females received ethanol-free water. Treated mice had smaller implantation sites compared to controls (p < 0.05), diminished maternal vascular lumen, and irregular/discontinuous endothelium of decidual vessels. The trophoblast giant cell layer was disorganized and presented increased abnormal nuclear frequency. The myometrium of treated females had reduced nitrite content, increased superoxide dismutase activity, and reduced glutathione (GSH) content (p < 0.05). However, the trophoblast-decidual tissue of treated females had increased nitrite content (p < 0.05), increased GSH level (p < 0.001), increased thiobarbituric acid-reactive substance concentration (p < 0.001), higher 3-nitrotyrosine immunoreaction, and increased apoptotic index (p < 0.05) compared to controls. In summary, perigestational alcohol ingestion at organogenesis induced oxidative stress in the myometrium and trophoblast-decidual tissue, mainly affecting cells and macromolecules of trophoblast and decidual tissues around early organogenesis, in CF-1 mouse, and suggests that oxidative-induced abnormal early placental formation probably leads to risk of prematurity and fetal growth impairment at term. © 2017, Springer Science+Business Media, LLC. |l eng | |
| 536 | |a Detalles de la financiación: 114-200801-00014 | ||
| 536 | |a Detalles de la financiación: 11220090100 492 | ||
| 536 | |a Detalles de la financiación: Agencia Nacional de Promoción Científica y Tecnológica, ANPCyT, BID-PICT-2008-2210 | ||
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires, UBA, UBACyT X187 | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas, CONICET | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas, CONICET | ||
| 536 | |a Detalles de la financiación: Acknowledgements This work was supported by the Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) (PIP-CONICET, Grant Numbers: 114-200801-00014 and 11220090100 492); the Agencia Nacional de Promoción Científica y Tecnológica (Grant Number BID-PICT-2008-2210); and the Universidad de Buenos Aires, Argentina (Grant Number UBACyT X187). The authors are very grateful to Dr. Cristian Sobarzo for his technical assistance in confecting the figures. | ||
| 593 | |a Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a CONICET-Universidad de Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a Departamento de Química Biológica, Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN), CONICET-Universidad de Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a Instituto de Biodiversidad y Biología Experimental y Aplicada (IBBEA), CONICET-Universidad de Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a IBBEA-UBA/CONICET, Intendente Güiraldes, 2620, Ciudad Universitaria, Pabellón 2, 4to. Piso, Lab 22. (CP: 1428EGA), Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a CELLULAR AND TISSUE DAMAGE |
| 690 | 1 | 0 | |a DECIDUA |
| 690 | 1 | 0 | |a MOUSE ORGANOGENESIS |
| 690 | 1 | 0 | |a OXIDATIVE STRESS |
| 690 | 1 | 0 | |a PERIGESTATIONAL ALCOHOL |
| 690 | 1 | 0 | |a 3 NITROTYROSINE |
| 690 | 1 | 0 | |a ALCOHOL |
| 690 | 1 | 0 | |a CATALASE |
| 690 | 1 | 0 | |a DRINKING WATER |
| 690 | 1 | 0 | |a GLUTATHIONE |
| 690 | 1 | 0 | |a GLUTATHIONE TRANSFERASE |
| 690 | 1 | 0 | |a NITRITE |
| 690 | 1 | 0 | |a SUPEROXIDE DISMUTASE |
| 690 | 1 | 0 | |a THIOBARBITURIC ACID REACTIVE SUBSTANCE |
| 690 | 1 | 0 | |a ADULT |
| 690 | 1 | 0 | |a ALCOHOL CONSUMPTION |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ANIMAL MODEL |
| 690 | 1 | 0 | |a ANIMAL TISSUE |
| 690 | 1 | 0 | |a APOPTOSIS |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CELL NUCLEUS |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a DECIDUA |
| 690 | 1 | 0 | |a ENDOTHELIUM |
| 690 | 1 | 0 | |a ENZYME ACTIVITY |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a GIANT CELL |
| 690 | 1 | 0 | |a HISTOPATHOLOGY |
| 690 | 1 | 0 | |a IMMUNOHISTOCHEMISTRY |
| 690 | 1 | 0 | |a IMMUNOREACTIVITY |
| 690 | 1 | 0 | |a MACROMOLECULE |
| 690 | 1 | 0 | |a MORPHOMETRY |
| 690 | 1 | 0 | |a MOUSE |
| 690 | 1 | 0 | |a MYOMETRIUM |
| 690 | 1 | 0 | |a NIDATION |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a ORGANOGENESIS |
| 690 | 1 | 0 | |a OXIDATIVE STRESS |
| 690 | 1 | 0 | |a PREGNANCY |
| 690 | 1 | 0 | |a TROPHOBLAST |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a DECIDUA |
| 690 | 1 | 0 | |a FETAL ALCOHOL SYNDROME |
| 690 | 1 | 0 | |a MATERNAL EXPOSURE |
| 690 | 1 | 0 | |a METABOLISM |
| 690 | 1 | 0 | |a MYOMETRIUM |
| 690 | 1 | 0 | |a PATHOLOGY |
| 690 | 1 | 0 | |a PREGNANCY |
| 690 | 1 | 0 | |a TROPHOBLAST |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a DECIDUA |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a FETAL ALCOHOL SPECTRUM DISORDERS |
| 690 | 1 | 0 | |a MATERNAL EXPOSURE |
| 690 | 1 | 0 | |a MICE |
| 690 | 1 | 0 | |a MYOMETRIUM |
| 690 | 1 | 0 | |a ORGANOGENESIS |
| 690 | 1 | 0 | |a OXIDATIVE STRESS |
| 690 | 1 | 0 | |a PREGNANCY |
| 690 | 1 | 0 | |a TROPHOBLASTS |
| 650 | 1 | 7 | |2 spines |a PLACENTA |
| 700 | 1 | |a Chaufan, G. | |
| 700 | 1 | |a Pérez-Tito, L.G. | |
| 700 | 1 | |a Ventureira, M.R. | |
| 700 | 1 | |a Ríos de Molina, M.C. | |
| 700 | 1 | |a Cebral, E. | |
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