Reprogramming human A375 amelanotic melanoma cells by catalase overexpression: Upregulation of antioxidant genes correlates with regression of melanoma malignancy and with malignant progression when downregulated

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Reactive oxygen species (ROS) are implicated in tumor transformation. The antioxidant system (AOS) protects cells from ROS damage. However, it is also hijacked by cancers cells to proliferate within the tumor. Thus, identifying proteins altered by redox imbalance in cancer cells is an attractive pro...

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Autor principal: Bracalente, C.
Otros Autores: Ibañez, I.L, Berenstein, A., Notcovich, C., Cerda, M.B, Klamt, F., Chernomoretz, A., Durán, H.
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: Impact Journals LLC 2016
Acceso en línea:Registro en Scopus
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Biblioteca Central Dr. Luis F. Leloir (FCEN) de Universidad de Buenos Aires
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024 7 |2 scopus  |a 2-s2.0-85010274083 
024 7 |2 cas  |a catalase, 9001-05-2; ubiquitin, 60267-61-0; Antioxidants; Catalase; Reactive Oxygen Species 
040 |a Scopus  |b spa  |c AR-BaUEN  |d AR-BaUEN 
100 1 |a Bracalente, C. 
245 1 0 |a Reprogramming human A375 amelanotic melanoma cells by catalase overexpression: Upregulation of antioxidant genes correlates with regression of melanoma malignancy and with malignant progression when downregulated 
260 |b Impact Journals LLC  |c 2016 
270 1 0 |m Durán, H.; Departamento de Micro y Nanotecnología, Comisión Nacional de Energía AtómicaArgentina; email: hduran@cnea.gov.ar 
506 |2 openaire  |e Política editorial 
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520 3 |a Reactive oxygen species (ROS) are implicated in tumor transformation. The antioxidant system (AOS) protects cells from ROS damage. However, it is also hijacked by cancers cells to proliferate within the tumor. Thus, identifying proteins altered by redox imbalance in cancer cells is an attractive prognostic and therapeutic tool. Gene expression microarrays in A375 melanoma cells with different ROS levels after overexpressing catalase were performed. Dissimilar phenotypes by differential compensation to hydrogen peroxide scavenging were generated. The melanotic A375-A7 (A7) upregulated TYRP1, CNTN1 and UCHL1 promoting melanogenesis. The metastatic A375-G10 (G10) downregulated MTSS1 and TIAM1, proteins absent in metastasis. Moreover, differential coexpression of AOS genes (EPHX2, GSTM3, MGST1, MSRA, TXNRD3, MGST3 and GSR) was found in A7 and G10. Their increase in A7 improved its AOS ability and therefore, oxidative stress response, resembling less aggressive tumor cells. Meanwhile, their decrease in G10 revealed a disruption in the AOS and therefore, enhanced its metastatic capacity. These gene signatures, not only bring new insights into the physiopathology of melanoma, but also could be relevant in clinical prognostic to classify between non aggressive and metastatic melanomas. © 2018 Impact Journals.  |l eng 
593 |a Departamento de Micro y Nanotecnología, Comisión Nacional de Energía Atómica, San Martín, Buenos Aires, Argentina 
593 |a Consejo Nacional de Investigaciones Científicas y Tecnológicas, Buenos Aires, Argentina 
593 |a Fundación Instituto Leloir and Departamento de Física, Facultad Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina 
593 |a Laboratório de Bioquímica Celular, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil 
593 |a Escuela de Ciencia y Tecnología, Universidad Nacional de San Martín, San Martín, Buenos Aires, Argentina 
690 1 0 |a AOS NETWORK 
690 1 0 |a MELANOGENESIS 
690 1 0 |a MELANOMA 
690 1 0 |a METASTASIS 
690 1 0 |a MICROARRAYS 
690 1 0 |a ANTIOXIDANT 
690 1 0 |a CATALASE 
690 1 0 |a CONTACTIN 1 
690 1 0 |a REACTIVE OXYGEN METABOLITE 
690 1 0 |a TYROSINASE RELATED PROTEIN 1 
690 1 0 |a UBIQUITIN 
690 1 0 |a CATALASE 
690 1 0 |a REACTIVE OXYGEN METABOLITE 
690 1 0 |a TRANSCRIPTOME 
690 1 0 |a A-375 CELL LINE 
690 1 0 |a ANIMAL CELL 
690 1 0 |a ANTIPROLIFERATIVE ACTIVITY 
690 1 0 |a ARTICLE 
690 1 0 |a CANCER GROWTH 
690 1 0 |a CANCER PROGNOSIS 
690 1 0 |a CANCER REGRESSION 
690 1 0 |a CNTN1 GENE 
690 1 0 |a CONTROLLED STUDY 
690 1 0 |a DOWN REGULATION 
690 1 0 |a EMBRYO 
690 1 0 |a EPHX2 GENE 
690 1 0 |a GENE 
690 1 0 |a GENE EXPRESSION PROFILING 
690 1 0 |a GENE EXPRESSION REGULATION 
690 1 0 |a GENE OVEREXPRESSION 
690 1 0 |a GSR GENE 
690 1 0 |a GSTM3 GENE 
690 1 0 |a HUMAN 
690 1 0 |a HUMAN CELL 
690 1 0 |a HYDROGEN PEROXIDE SCAVENGING ASSAY 
690 1 0 |a MELANOGENESIS 
690 1 0 |a MELANOMA 
690 1 0 |a METASTATIC MELANOMA 
690 1 0 |a MGST1 GENE 
690 1 0 |a MGST3 GENE 
690 1 0 |a MOUSE 
690 1 0 |a MSRA GENE 
690 1 0 |a NONHUMAN 
690 1 0 |a NUCLEAR REPROGRAMMING 
690 1 0 |a OXIDATIVE STRESS 
690 1 0 |a PATHOPHYSIOLOGY 
690 1 0 |a PHENOTYPE 
690 1 0 |a TUMOR CELL 
690 1 0 |a TXNRD3 GENE 
690 1 0 |a TYRP1 GENE 
690 1 0 |a UCHL1 GENE 
690 1 0 |a UPREGULATION 
690 1 0 |a AMELANOTIC MELANOMA 
690 1 0 |a CELL PROLIFERATION 
690 1 0 |a DISEASE EXACERBATION 
690 1 0 |a GENE EXPRESSION REGULATION 
690 1 0 |a GENETICS 
690 1 0 |a METABOLISM 
690 1 0 |a METASTASIS 
690 1 0 |a MICROARRAY ANALYSIS 
690 1 0 |a PATHOLOGY 
690 1 0 |a SKIN TUMOR 
690 1 0 |a TUMOR CELL LINE 
690 1 0 |a ANTIOXIDANTS 
690 1 0 |a CATALASE 
690 1 0 |a CELL LINE, TUMOR 
690 1 0 |a CELL PROLIFERATION 
690 1 0 |a DISEASE PROGRESSION 
690 1 0 |a DOWN-REGULATION 
690 1 0 |a GENE EXPRESSION PROFILING 
690 1 0 |a GENE EXPRESSION REGULATION, NEOPLASTIC 
690 1 0 |a HUMANS 
690 1 0 |a MELANOMA, AMELANOTIC 
690 1 0 |a MICROARRAY ANALYSIS 
690 1 0 |a NEOPLASM METASTASIS 
690 1 0 |a OXIDATIVE STRESS 
690 1 0 |a REACTIVE OXYGEN SPECIES 
690 1 0 |a SKIN NEOPLASMS 
690 1 0 |a TRANSCRIPTOME 
690 1 0 |a UP-REGULATION 
700 1 |a Ibañez, I.L. 
700 1 |a Berenstein, A. 
700 1 |a Notcovich, C. 
700 1 |a Cerda, M.B. 
700 1 |a Klamt, F. 
700 1 |a Chernomoretz, A. 
700 1 |a Durán, H. 
773 0 |d Impact Journals LLC, 2016  |g v. 7  |h pp. 41154-41171  |k n. 27  |p Oncotarget  |x 19492553  |t Oncotarget 
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856 4 0 |u https://hdl.handle.net/20.500.12110/paper_19492553_v7_n27_p41154_Bracalente  |y Handle 
856 4 0 |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19492553_v7_n27_p41154_Bracalente  |y Registro en la Biblioteca Digital 
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962 |a info:eu-repo/semantics/article  |a info:ar-repo/semantics/artículo  |b info:eu-repo/semantics/publishedVersion 
999 |c 77766 

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