Fluorination methods in drug discovery

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Fluorination reactions of medicinal and biologically-active compounds will be discussed. Late stage fluorination strategies of medicinal targets have recently attracted considerable attention on account of the influence that a fluorine atom can impart to targets of medicinal importance, such as modu...

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Autor principal: Yerien, D.E
Otros Autores: Bonesi, S., Postigo, A.
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: Royal Society of Chemistry 2016
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Biblioteca Central Dr. Luis F. Leloir (FCEN) de Universidad de Buenos Aires
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024 7 |2 scopus  |a 2-s2.0-84988360266 
024 7 |2 cas  |a fluorine, 7782-41-4; Fluorine; Hydrocarbons, Fluorinated 
040 |a Scopus  |b spa  |c AR-BaUEN  |d AR-BaUEN 
030 |a OBCRA 
100 1 |a Yerien, D.E. 
245 1 0 |a Fluorination methods in drug discovery 
260 |b Royal Society of Chemistry  |c 2016 
270 1 0 |m Postigo, A.; Departamento de Química Orgánica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires-CONICET, Junín 954, Argentina; email: apostigo@ffyb.uba.ar 
506 |2 openaire  |e Política editorial 
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520 3 |a Fluorination reactions of medicinal and biologically-active compounds will be discussed. Late stage fluorination strategies of medicinal targets have recently attracted considerable attention on account of the influence that a fluorine atom can impart to targets of medicinal importance, such as modulation of lipophilicity, electronegativity, basicity and bioavailability, the latter as a consequence of membrane permeability. Therefore, the recourse to late-stage fluorine substitution on compounds with already known and relevant biological activity can provide the pharmaceutical industry with new leads with improved medicinal properties. The fluorination strategies will take into account different fluorinating reagents, either of nucleophilic or electrophilic, and of radical nature. Diverse families of organic compounds such as (hetero)aromatic rings, and aliphatic substrates (sp3, sp2, and sp carbon atoms) will be studied in late-stage fluorination reaction strategies. © 2014 The Royal Society of Chemistry.  |l eng 
593 |a Departamento de Química Orgánica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires-CONICET, Junín 954, Buenos Aires, CP 1113, Argentina 
593 |a Departamento de Química Orgánica, CIHIDECAR-CONICET, Pabellón II, Ciudad Universitaria, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, 1428, Argentina 
690 1 0 |a BIOACTIVITY 
690 1 0 |a BIOCHEMISTRY 
690 1 0 |a CHEMICAL BONDS 
690 1 0 |a ELECTRONEGATIVITY 
690 1 0 |a FLUORINATION 
690 1 0 |a HALOGENATION 
690 1 0 |a AROMATIC RINGS 
690 1 0 |a BIOLOGICALLY ACTIVE COMPOUNDS 
690 1 0 |a DRUG DISCOVERY 
690 1 0 |a FLUORINATION REACTIONS 
690 1 0 |a FLUORINE ATOMS 
690 1 0 |a FLUORINE SUBSTITUTION 
690 1 0 |a MEMBRANE PERMEABILITY 
690 1 0 |a PHARMACEUTICAL INDUSTRY 
690 1 0 |a FLUORINE 
690 1 0 |a FLUORINATED HYDROCARBON 
690 1 0 |a FLUORINE 
690 1 0 |a CHEMICAL STRUCTURE 
690 1 0 |a CHEMISTRY 
690 1 0 |a DRUG DEVELOPMENT 
690 1 0 |a HALOGENATION 
690 1 0 |a SYNTHESIS 
690 1 0 |a DRUG DISCOVERY 
690 1 0 |a FLUORINE 
690 1 0 |a HALOGENATION 
690 1 0 |a HYDROCARBONS, FLUORINATED 
690 1 0 |a MOLECULAR STRUCTURE 
650 1 7 |2 spines  |a CARBON 
700 1 |a Bonesi, S. 
700 1 |a Postigo, A. 
773 0 |d Royal Society of Chemistry, 2016  |g v. 14  |h pp. 8398-8427  |k n. 36  |p Org. Biomol. Chem.  |x 14770520  |w (AR-BaUEN)CENRE-2303  |t Organic and Biomolecular Chemistry 
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856 4 0 |u https://doi.org/10.1039/c6ob00764c  |y DOI 
856 4 0 |u https://hdl.handle.net/20.500.12110/paper_14770520_v14_n36_p8398_Yerien  |y Handle 
856 4 0 |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14770520_v14_n36_p8398_Yerien  |y Registro en la Biblioteca Digital 
961 |a paper_14770520_v14_n36_p8398_Yerien  |b paper  |c PE 
962 |a info:eu-repo/semantics/article  |a info:ar-repo/semantics/artículo  |b info:eu-repo/semantics/publishedVersion 
999 |c 77234 

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