Immunohistochemical analysis of the hypothalamic-pituitary-adrenal axis in dogs: Sex-linked and seasonal variation
This study evaluated sexual dimorphism and seasonal variations in corticotrophs and adrenal zona fasciculata in dogs, as well as the expression of oestrogen receptor alpha (ERα). An immunohistochemical analysis was conducted in pituitaries for ACTH and in adrenal glands for ERα and for the melanocor...
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| Otros Autores: | , , , , , , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
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Elsevier B.V.
2016
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 13703caa a22014777a 4500 | ||
|---|---|---|---|
| 001 | PAPER-16243 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204713.0 | ||
| 008 | 190411s2016 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-84957665392 | |
| 024 | 7 | |2 cas |a corticotropin, 11136-52-0, 9002-60-2, 9061-27-2; Estrogen Receptor alpha | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a RVTSA | ||
| 100 | 1 | |a Gallelli, M.F. | |
| 245 | 1 | 0 | |a Immunohistochemical analysis of the hypothalamic-pituitary-adrenal axis in dogs: Sex-linked and seasonal variation |
| 260 | |b Elsevier B.V. |c 2016 | ||
| 270 | 1 | 0 | |m Gallelli, M.F.; Facultad de Ciencias Veterinarias, UBA, Av. Chorroarín 280, Argentina; email: mgallelli@fvet.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 504 | |a Rhodes, M.E., Rubin, R.T., Functional sex differences ("sexual diergism") of central nervous system cholinergic systems, vasopressin, and hypothalamic-pituitary-adrenal axis activity in mammals: a selective review (1999) Brain Res. Rev., 30, pp. 135-152 | ||
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| 504 | |a Weiser, M.J., Handa, R.J., Estrogen impairs glucocorticoid dependent negative feedback on the hypothalamic-pituitary-adrenal axis via oestrogen receptor alpha within the hypothalamus (2009) Neuroscience, 159, pp. 883-895 | ||
| 520 | 3 | |a This study evaluated sexual dimorphism and seasonal variations in corticotrophs and adrenal zona fasciculata in dogs, as well as the expression of oestrogen receptor alpha (ERα). An immunohistochemical analysis was conducted in pituitaries for ACTH and in adrenal glands for ERα and for the melanocortin-2-receptor (MC2R) in winter and summer. Double immunofluorescence was performed to identify ERα in corticotrophs. Females had a greater proportion of corticotrophs per field (p < 0.01), with a greater cellular area and optical density (p < 0.001) than males. Optical density of corticotrophs was greater in winter for both sexes (p < 0.001). In zona fasciculata, ERα and MC2R expression was greater in females (p < 0.001) and was greater in winter (p < 0.001). ERα was identified in corticotrophs. This study is the first to demonstrate ERα expression in corticotrophs and the adrenal cortex in dogs, providing evidence for sexual dimorphism and seasonal variations. © 2015 Elsevier Ltd. |l eng | |
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires, 20020100100246, V006 | ||
| 536 | |a Detalles de la financiación: Secretaría de Ciencia y Técnica, Universidad de Buenos Aires | ||
| 536 | |a Detalles de la financiación: We would like to thank Dr. Dante Paz, Dr. Paula Di Yorio and Lic. Tomás Delgadín for their collaboration in the completion of this study. This project received funding from UBACyT, University of Buenos Aires, Argentina ( V006 and 20020100100246 ). | ||
| 593 | |a UBACyT scholarship holder, Argentina | ||
| 593 | |a Hospital Escuela-Unidad de Endocrinología, A. Clínica Médica de Pequeños Animales, Fac. de Ciencias Veterinarias-UBA, Av. Chorroarin 280, Buenos Aires, CP 1427, Argentina | ||
| 593 | |a Cátedra de Histología, Fac. de Ciencias Veterinarias-UBA, Av. Chorroarin 280, Buenos Aires CP, 1427, Argentina | ||
| 593 | |a Laboratorio de Neuroendocrinología del Crecimiento y la Reproducción, DBBE, FCEN-UBA/IBBEA-CONICET-UBA, Ciudad Universitaria, Buenos Aires, C1428EHA, Argentina | ||
| 593 | |a Área de Patología Especial, Fac. De Ciencias Veterinarias, UNLP, Calle 60 y 118, CP Buenos Aires, 1900, Argentina | ||
| 593 | |a Laboratorio de Técnicas Nucleares, Fac. De Ciencias Veterinarias, UDELAR, Lasplacesr 1550-1620, CP Montevideo, 11600, Uruguay | ||
| 690 | 1 | 0 | |a ADRENAL CORTEX |
| 690 | 1 | 0 | |a CORTICOTROPH |
| 690 | 1 | 0 | |a MELANOCORTIN 2 RECEPTOR (MC2R) |
| 690 | 1 | 0 | |a OESTROGEN RECEPTOR |
| 690 | 1 | 0 | |a SEXUAL DIMORPHISM |
| 690 | 1 | 0 | |a CORTICOTROPIN |
| 690 | 1 | 0 | |a ESTROGEN RECEPTOR ALPHA |
| 690 | 1 | 0 | |a MELANOCORTIN 2 RECEPTOR |
| 690 | 1 | 0 | |a ESTROGEN RECEPTOR ALPHA |
| 690 | 1 | 0 | |a ACTH SECRETING CELL |
| 690 | 1 | 0 | |a ANIMAL TISSUE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a DOG |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a IMMUNOHISTOCHEMISTRY |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a OPTICAL DENSITY |
| 690 | 1 | 0 | |a PROTEIN ANALYSIS |
| 690 | 1 | 0 | |a PROTEIN EXPRESSION |
| 690 | 1 | 0 | |a SEASONAL VARIATION |
| 690 | 1 | 0 | |a SEX DIFFERENCE |
| 690 | 1 | 0 | |a SUMMER |
| 690 | 1 | 0 | |a WINTER |
| 690 | 1 | 0 | |a ZONA FASCICULATA |
| 690 | 1 | 0 | |a ANATOMY AND HISTOLOGY |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a CHEMISTRY |
| 690 | 1 | 0 | |a GENETICS |
| 690 | 1 | 0 | |a HYPOPHYSIS ADRENAL SYSTEM |
| 690 | 1 | 0 | |a HYPOTHALAMUS HYPOPHYSIS SYSTEM |
| 690 | 1 | 0 | |a METABOLISM |
| 690 | 1 | 0 | |a PHYSIOLOGY |
| 690 | 1 | 0 | |a SEASON |
| 690 | 1 | 0 | |a SEXUAL DEVELOPMENT |
| 690 | 1 | 0 | |a VETERINARY |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a DOGS |
| 690 | 1 | 0 | |a ESTROGEN RECEPTOR ALPHA |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a HYPOTHALAMO-HYPOPHYSEAL SYSTEM |
| 690 | 1 | 0 | |a IMMUNOHISTOCHEMISTRY |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a PITUITARY-ADRENAL SYSTEM |
| 690 | 1 | 0 | |a SEASONS |
| 690 | 1 | 0 | |a SEX CHARACTERISTICS |
| 700 | 1 | |a Lombardo, D. | |
| 700 | 1 | |a Vissio, P. | |
| 700 | 1 | |a Quiroga, A. | |
| 700 | 1 | |a Caggiano, N. | |
| 700 | 1 | |a Soler, E. | |
| 700 | 1 | |a Meikle, A. | |
| 700 | 1 | |a Castillo, V.A. | |
| 773 | 0 | |d Elsevier B.V., 2016 |g v. 104 |h pp. 10-16 |p Res. Vet. Sci. |x 00345288 |t Research in Veterinary Science | |
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