A new type of quinoxalinone derivatives affects viability, invasion, and intracellular growth of Toxoplasma gondii tachyzoites in vitro
Quinoxalinone derivatives, identified as VAM2 compounds (7-nitroquinoxalin-2-ones), were evaluated against Toxoplasma gondii tachyzoites of the RH strain. The VAM2 compounds were previously synthesized based on the design obtained from an in silico prediction with the software TOMOCOMD-CARDD. From t...
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Springer Verlag
2016
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| LEADER | 13682caa a22015617a 4500 | ||
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| 001 | PAPER-16049 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204655.0 | ||
| 008 | 190411s2016 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-84958765187 | |
| 024 | 7 | |2 cas |a Quinoxalines | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a PARRE | ||
| 100 | 1 | |a Rivera Fernández, N. | |
| 245 | 1 | 2 | |a A new type of quinoxalinone derivatives affects viability, invasion, and intracellular growth of Toxoplasma gondii tachyzoites in vitro |
| 260 | |b Springer Verlag |c 2016 | ||
| 270 | 1 | 0 | |m Mondragón Flores, R.; Departamento de Bioquímica, Centro de Investigación y de Estudios Avanzados del IPN (CINVESTAV), Avenida IPN No 2508 Delegación Gustavo A Madero, Mexico; email: rmflores@cinvestav.mx |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a Quinoxalinone derivatives, identified as VAM2 compounds (7-nitroquinoxalin-2-ones), were evaluated against Toxoplasma gondii tachyzoites of the RH strain. The VAM2 compounds were previously synthesized based on the design obtained from an in silico prediction with the software TOMOCOMD-CARDD. From the ten VAM2 drugs tested, several showed a deleterious effect on tachyzoites. However, VAM2-2 showed the highest toxoplasmicidal activity generating a remarkable decrease in tachyzoite viability (in about 91 %) and a minimal alteration in the host cell. An evident inhibition of host cell invasion by tachyzoites previously treated with VAM2-2 was observed in a dose-dependent manner. In addition, remarkable alterations were observed in the pellicle parasite, such as swelling, roughness, and blebbing. Toxoplasma motility was inhibited, and subpellicular cytoskeleton integrity was altered, inducing a release of its components to the soluble fraction. VAM2-2 showed a clear and specific deleterious effect on tachyzoites viability, structural integrity, and invasive capabilities with limited effects in host cells morphology and viability. VAM2-2 minimum inhibitory concentration (MIC50) was determined as 3.3 μM ± 1.8. Effects of quinoxalinone derivatives on T. gondii provide the basis for a future therapeutical alternative in the treatment of toxoplasmosis. © 2016, Springer-Verlag Berlin Heidelberg. |l eng | |
| 593 | |a Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, Coyoacán, 07360 DF, Mexico | ||
| 593 | |a Departamento de Bioquímica, Centro de Investigación y de Estudios Avanzados del IPN (CINVESTAV), Avenida IPN No 2508 Delegación Gustavo A Madero07360 DF, Mexico | ||
| 593 | |a Unidad de Microscopía Electrónica (LANSE), CINVESTAV, DF, Mexico | ||
| 593 | |a Departamento de Genética y Biología Molecular, CINVESTAV, DF, Mexico | ||
| 593 | |a Edificio de Especialidades Médicas, Hospital de los Valles, Colegio de Ciencias de la Salud, Universidad de San Francisco de Quito, Av. Interoceánica Km 12 1/2 Cumbayá, Quito, Ecuador | ||
| 593 | |a Instituto de Química Médica, CSIC, c/ Juan de la Cierva 3, Madrid, 28006, Spain | ||
| 593 | |a Centro de Investigaciones en Hidratos de Carbono (CIHIDECAR-CONICET), Departamento de Química Orgánica, FCEN y LabMOr – INTECIN, FI, UBA, Paseo Colón 850, 5to. Piso, Buenos Aires, CP C1063ACV, Argentina | ||
| 690 | 1 | 0 | |a APICOMPLEXAN |
| 690 | 1 | 0 | |a IN SILICO DRUG DESIGN |
| 690 | 1 | 0 | |a PELLICLE |
| 690 | 1 | 0 | |a QUINOXALINONE DERIVATIVES |
| 690 | 1 | 0 | |a TOMOCOMD-CARDD |
| 690 | 1 | 0 | |a TOXOPLASMA GONDII |
| 690 | 1 | 0 | |a ANTIPROTOZOAL AGENT |
| 690 | 1 | 0 | |a QUINOXALINONE DERIVATIVE |
| 690 | 1 | 0 | |a UNCLASSIFIED DRUG |
| 690 | 1 | 0 | |a VAM 2 1 |
| 690 | 1 | 0 | |a VAM 2 10 |
| 690 | 1 | 0 | |a VAM 2 2 |
| 690 | 1 | 0 | |a VAM 2 3 |
| 690 | 1 | 0 | |a VAM 2 4 |
| 690 | 1 | 0 | |a VAM 2 5 |
| 690 | 1 | 0 | |a VAM 2 6 |
| 690 | 1 | 0 | |a VAM 2 7 |
| 690 | 1 | 0 | |a VAM 2 8 |
| 690 | 1 | 0 | |a VAM 2 9 |
| 690 | 1 | 0 | |a QUINOXALINE DERIVATIVE |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ANIMAL MODEL |
| 690 | 1 | 0 | |a ANTIPROTOZOAL ACTIVITY |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CELL MOTILITY |
| 690 | 1 | 0 | |a COMPUTER MODEL |
| 690 | 1 | 0 | |a ELECTRON MICROSCOPY |
| 690 | 1 | 0 | |a HOST CELL |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a HUMAN CELL |
| 690 | 1 | 0 | |a LARYNX SQUAMOUS CELL CARCINOMA |
| 690 | 1 | 0 | |a MINIMUM INHIBITORY CONCENTRATION |
| 690 | 1 | 0 | |a MOUSE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a TACHYZOITE |
| 690 | 1 | 0 | |a TOXOPLASMA GONDII |
| 690 | 1 | 0 | |a TRANSMISSION ELECTRON MICROSCOPY |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a BAGG ALBINO MOUSE |
| 690 | 1 | 0 | |a CYTOSKELETON |
| 690 | 1 | 0 | |a DRUG EFFECTS |
| 690 | 1 | 0 | |a PARASITOLOGY |
| 690 | 1 | 0 | |a PHYSIOLOGY |
| 690 | 1 | 0 | |a TOXOPLASMA |
| 690 | 1 | 0 | |a TOXOPLASMOSIS |
| 690 | 1 | 0 | |a TUMOR CELL LINE |
| 690 | 1 | 0 | |a ULTRASTRUCTURE |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a CELL LINE, TUMOR |
| 690 | 1 | 0 | |a CYTOSKELETON |
| 690 | 1 | 0 | |a HUMANS |
| 690 | 1 | 0 | |a MICE |
| 690 | 1 | 0 | |a MICE, INBRED BALB C |
| 690 | 1 | 0 | |a QUINOXALINES |
| 690 | 1 | 0 | |a TOXOPLASMA |
| 690 | 1 | 0 | |a TOXOPLASMOSIS |
| 653 | 0 | 0 | |a vam 2 1; vam 2 10; vam 2 2; vam 2 3; vam 2 4; vam 2 5; vam 2 6; vam 2 7; vam 2 8; vam 2 9 |
| 700 | 1 | |a Mondragón Castelán, M. | |
| 700 | 1 | |a González Pozos, S. | |
| 700 | 1 | |a Ramírez Flores, C.J. | |
| 700 | 1 | |a Mondragón González, R. | |
| 700 | 1 | |a Gómez de León, C.T. | |
| 700 | 1 | |a Castro Elizalde, K.N. | |
| 700 | 1 | |a Marrero Ponce, Y. | |
| 700 | 1 | |a Arán, V.J. | |
| 700 | 1 | |a Martins Alho, M.A. | |
| 700 | 1 | |a Mondragón Flores, R. | |
| 773 | 0 | |d Springer Verlag, 2016 |g v. 115 |h pp. 2081-2096 |k n. 5 |p Parasitol. Res. |x 09320113 |t Parasitology Research | |
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