Glyphosate-based herbicides with different adjuvants are more potent inhibitors of 3T3-L1 fibroblast proliferation and differentiation to adipocytes than glyphosate alone
Glyphosate-based herbicides are extensively used for weed control all over the world. Thus, it is important to investigate the putative toxic effects of these commercial formulations which contain not only glyphosate but also different adjuvants. 3T3-L1 fibroblasts are a useful tool in the study of...
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Springer-Verlag London Ltd
2016
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| LEADER | 08755caa a22006137a 4500 | ||
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| 001 | PAPER-16014 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204652.0 | ||
| 008 | 190411s2016 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-84964958256 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a CCPOA | ||
| 100 | 1 | |a Martini, C.N. | |
| 245 | 1 | 0 | |a Glyphosate-based herbicides with different adjuvants are more potent inhibitors of 3T3-L1 fibroblast proliferation and differentiation to adipocytes than glyphosate alone |
| 260 | |b Springer-Verlag London Ltd |c 2016 | ||
| 270 | 1 | 0 | |m del Vila, M.C.; Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, Ciudad Universitaria, Argentina; email: mvila@qb.fcen.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 504 | |a Dill, G.M., Cajacob, C.A., Padgette, S.R., Glyphosate-resistant crops: adoption, use and future considerations (2008) Pest Manag Sci, 64, pp. 326-331. , COI: 1:CAS:528:DC%2BD1cXksVGqtLk%3D, PID: 18078304 | ||
| 504 | |a Gasnier, C., Dumont, C., Benachour, N., Clair, E., Chagnon, M.C., Séralini, G.E., Glyphosate-based herbicides are toxic and endocrine disruptors in human cell lines (2009) Toxicology, 262, pp. 184-191. , COI: 1:CAS:528:DC%2BD1MXptlSqsL0%3D, PID: 19539684 | ||
| 504 | |a Gianessi, L.P., Economic and herbicide use impacts of glyphosate-resistant crops (2005) Pest Manag Sci, 61, pp. 241-245. , COI: 1:CAS:528:DC%2BD2MXitFOgurs%3D, PID: 15706602 | ||
| 504 | |a Marc, J., Bellé, R., Morales, J., Cormier, P., Mulner-Lorillon, O., Formulated glyphosate activates the DNA-response checkpoint of the cell cycle leading to the prevention of G2/M transition (2004) Toxicol Sci, 82, pp. 4342-4364 | ||
| 504 | |a Martini, C., Plaza, M.V., Vila, M.C., PKA-dependent and independent cAMP signalling in 3T3-L1 fibroblasts differentiation (2009) Mol Cell Endocrinol, 298, pp. 42-47. , COI: 1:CAS:528:DC%2BD1cXhsFCms7bM, PID: 19010385 | ||
| 504 | |a Martini, C.N., Gabrielli, M., Vila, M.C., A commercial formulation of glyphosate inhibits proliferation and differentiation to adipocytes and induces apoptosis in 3T3-L1 fibroblasts (2012) Toxicol In Vitro, 26, pp. 1007-1013. , COI: 1:CAS:528:DC%2BC38Xms12rt7g%3D, PID: 22546541 | ||
| 504 | |a Martini, C.N., Brandani, J.N., Gabrielli, M., Vila, M.C., Effect of hexavalent chromium on proliferation and differentiation to adipocytes of 3T3-L1 fibroblasts (2014) Toxicol In Vitro, 28, pp. 700-706. , COI: 1:CAS:528:DC%2BC2cXmtVaisbk%3D, PID: 24576443 | ||
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| 504 | |a Peruzzo, P.J., Porta, A.A., Ronco, A.E., Levels of glyphosate in surface waters, sediments and soils associated with direct sowing soybean cultivation in north pampasic region of Argentina (2008) Environ Pollut, 156, pp. 61-66. , COI: 1:CAS:528:DC%2BD1cXhtV2jsLbI, PID: 18308436 | ||
| 504 | |a Piola, L., Fuchs, J., Oneto, M.L., Basack, S., Kesten, E., Casabe, N., Comparative toxicity of two glyphosate-based formulations to Eisenia andrei under laboratory conditions (2013) Chemosphere, 91, pp. 545-551. , COI: 1:CAS:528:DC%2BC3sXht1yitrw%3D, PID: 23332878 | ||
| 504 | |a Poletta, G.L., Larriera, A., Kleinsorge, E., Mudry, M.D., Genotoxicity of the herbicide formulation Roundup (glyphosate) in broad-snouted caiman (Caiman latirostris) evidenced by the comet assay and the micronucleus test (2009) Mutat Res, 672, pp. 95-102. , COI: 1:CAS:528:DC%2BD1MXhtlGntro%3D, PID: 19022394 | ||
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| 504 | |a Wang, Z.X., Jiang, C.S., Liu, L., Wang, X.H., Jin, H.J., Wu, Q., Chen, Q., The role of AKT on arsenic trioxide suppression of 3T3-L1 preadipocyte differentiation (2005) Cell Res, 15, pp. 379-386. , COI: 1:CAS:528:DC%2BD2MXhtFWnsbrF, PID: 15916724 | ||
| 520 | 3 | |a Glyphosate-based herbicides are extensively used for weed control all over the world. Thus, it is important to investigate the putative toxic effects of these commercial formulations which contain not only glyphosate but also different adjuvants. 3T3-L1 fibroblasts are a useful tool in the study of adipocyte differentiation. We have previously reported that a commercial glyphosate formulation inhibits proliferation and differentiation in these cells. In the present investigation, we further evaluated the effect of different commercial glyphosate-based herbicides on 3T3-L1 fibroblast proliferation and differentiation and compared their effect with glyphosate itself. After treatment of 3T3-L1 fibroblasts with different concentrations of three glyphosate formulations or glyphosate itself, the increase in cell number or cytosolic lipid accumulation was determined. To evaluate the presence of polyethoxylated adjuvants, matrix-assisted laser desorption/ionization (MALDI) analysis of the three commercial glyphosate-based herbicides was also performed. We found that the three commercial formulations tested were more potent inhibitors of both physiological processes: proliferation and differentiation to adipocytes of 3T3-L1 fibroblasts than glyphosate. We also found by MALDI analysis that the adjuvants were polyethoxylated in two of the formulations but not in the third one. It is well known the toxic effect of polyethoxylated adjuvants, but according to our results, non-polyethoxylated adjuvants may also contribute to the toxic effects. Our results further support the ability of glyphosate-based herbicides to disturb cellular physiology and highlight the importance of toxicological assessment of commercial formulations rather than glyphosate alone. © 2016, Springer-Verlag London. |l eng | |
| 593 | |a Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, Ciudad Universitaria, Buenos Aires, 1428, Argentina | ||
| 690 | 1 | 0 | |a 3T3-L1 FIBROBLASTS |
| 690 | 1 | 0 | |a ADJUVANTS |
| 690 | 1 | 0 | |a DIFFERENTIATION |
| 690 | 1 | 0 | |a GLYPHOSATE |
| 690 | 1 | 0 | |a GLYPHOSATE-BASED HERBICIDES |
| 690 | 1 | 0 | |a PROLIFERATION |
| 700 | 1 | |a Gabrielli, M. | |
| 700 | 1 | |a Codesido, M.M. | |
| 700 | 1 | |a del Vila, M.C. | |
| 773 | 0 | |d Springer-Verlag London Ltd, 2016 |g v. 25 |h pp. 607-613 |k n. 3 |p Comp. Clin. Pathol. |x 16185641 |t Comparative Clinical Pathology | |
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