Thyroid hormones and their membrane receptors as therapeutic targets for T cell lymphomas

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Thyroid hormones (THs) are important regulators of metabolism, differentiation and cell proliferation. They can modify the physiology of human and murine T cell lymphomas (TCL). These effects involve genomic mechanisms, mediated by specific nuclear receptors (TR), as well as nongenomic mechanisms, t...

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Autor principal: Cremaschi, G.A
Otros Autores: Cayrol, F., Sterle, H.A, Díaz Flaqué, M.C, Barreiro Arcos, M.L
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: Academic Press 2016
Acceso en línea:Registro en Scopus
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Biblioteca Central Dr. Luis F. Leloir (FCEN) de Universidad de Buenos Aires
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024 7 |2 cas  |a cilengitide, 188968-51-6; liothyronine, 6138-47-2, 6893-02-3; thyrotropin, 9002-71-5; thyroxine, 7488-70-2; vasculotropin, 127464-60-2; Receptors, Thyroid Hormone; Thyroid Hormones 
040 |a Scopus  |b spa  |c AR-BaUEN  |d AR-BaUEN 
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100 1 |a Cremaschi, G.A. 
245 1 0 |a Thyroid hormones and their membrane receptors as therapeutic targets for T cell lymphomas 
260 |b Academic Press  |c 2016 
270 1 0 |m Cremaschi, G.A.; Instituto de Investigaciones Biomédicas (BIOMED), Facultad de Ciencias Médicas, Pontificia Universidad Católica Argentina (UCA), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Av. Alicia Moreau de Justo 1600, Argentina; email: graciela_cremaschi@uca.edu.ar 
506 |2 openaire  |e Política editorial 
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504 |a Friess, H., Langrehr, J.M., Oettle, H., Raedle, J., Niedergethmann, M., Dittrich, C., Hossfeld, D.K., Nippgen, J., A randomized multi-center phase II trial of the angiogenesis inhibitor cilengitide (EMD 121974) and gemcitabine compared with gemcitabine alone in advanced unresectable pancreatic cancer (2006) BMC Cancer, 6, p. 285 
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504 |a Yalcin, M., Lin, H.Y., Sudha, T., Bharali, D.J., Meng, R., Tang, H.Y., Davis, F.B., Mousa, S.A., Response of human pancreatic cancer cell xenografts to tetraiodothyroacetic acid nanoparticles (2013) Horm. Cancer, 4, pp. 176-185 
520 3 |a Thyroid hormones (THs) are important regulators of metabolism, differentiation and cell proliferation. They can modify the physiology of human and murine T cell lymphomas (TCL). These effects involve genomic mechanisms, mediated by specific nuclear receptors (TR), as well as nongenomic mechanisms, that lead to the activation of different signaling pathways through the activation of a membrane receptor, the integrin αvβ3. Therefore, THs are able to induce the survival and growth of TCL. Specifically, the signaling induced by THs through the integrin αvβ3 activates proliferative and angiogenic programs, mediated by the regulation of the vascular endothelial growth factor (VEGF). The genomic or pharmacologic inhibition of integrin αvβ3 reduces the production of VEGF and induces cell death both in vitro and in xenograft models of human TCL. Here we review the mechanisms involved in the modulation of the physiology of TCL induced by THs, the analysis of the interaction between genomic and nongenomic actions of THs and their contribution to T cell lymphomagenesis. These actions of THs suggest a novel mechanism for the endocrine modulation of the physiopathology of TCL and they provide a potential molecular target for its treatment. © 2016 Elsevier Ltd.  |l eng 
536 |a Detalles de la financiación: Universidad de Buenos Aires, UBACYT 20020130100289BA 
536 |a Detalles de la financiación: National Council for Scientific Research, PIP-CONICET 00275 
536 |a Detalles de la financiación: Agencia Nacional de Promoción Científica y Tecnológica, PICT-Raíces 2012-1328, PICT 2008-1858 
536 |a Detalles de la financiación: National Science and Technology Development Agency 
536 |a Detalles de la financiación: This work was supported by the National Research Council of Argentina (PIP-CONICET 00275) (G.A.C.), the University of Buenos Aires (UBACYT 20020130100289BA), the National Agency for Science and Technology (ANPCYT, PICT 2008-1858 and PICT-Raíces 2012-1328) 
593 |a Instituto de Investigaciones Biomédicas (BIOMED), Facultad de Ciencias Médicas, Pontificia Universidad Católica Argentina (UCA), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Av. Alicia Moreau de Justo 1600, Ciudad Autónoma de Buenos Aires, C1107AAZ, Argentina 
593 |a Laboratorio de Radioisótopos, Facultad de Farmacia y Bioquímica (FFyB), UBA, Buenos Aires, Argentina 
593 |a Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales (FCEyN), Universidad de Buenos Aires (UBA), Buenos Aires, Argentina 
690 1 0 |a ANGIOGENESIS 
690 1 0 |a INTEGRIN ΑVΒ3 
690 1 0 |a PROLIFERATION 
690 1 0 |a T CELL LYMPHOMA 
690 1 0 |a THYROID HORMONES 
690 1 0 |a CILENGITIDE 
690 1 0 |a LIOTHYRONINE 
690 1 0 |a THYROID HORMONE 
690 1 0 |a THYROID HORMONE RECEPTOR 
690 1 0 |a THYROTROPIN 
690 1 0 |a THYROXINE 
690 1 0 |a VASCULOTROPIN 
690 1 0 |a VITRONECTIN RECEPTOR 
690 1 0 |a THYROID HORMONE 
690 1 0 |a THYROID HORMONE RECEPTOR 
690 1 0 |a CANCER RECURRENCE 
690 1 0 |a CD8+ T LYMPHOCYTE 
690 1 0 |a DRUG TARGETING 
690 1 0 |a GLIOBLASTOMA 
690 1 0 |a HUMAN 
690 1 0 |a HYPERTHYROIDISM 
690 1 0 |a HYPOTHYROIDISM 
690 1 0 |a METASTASIS 
690 1 0 |a NATURAL KILLER CELL 
690 1 0 |a NONHUMAN 
690 1 0 |a PRIORITY JOURNAL 
690 1 0 |a REVIEW 
690 1 0 |a SOLID TUMOR 
690 1 0 |a T CELL LYMPHOMA 
690 1 0 |a T-CELL LYMPHOMA CELL LINE 
690 1 0 |a TUMOR ESCAPE 
690 1 0 |a TUMOR GROWTH 
690 1 0 |a TUMOR MICROENVIRONMENT 
690 1 0 |a TUMOR VASCULARIZATION 
690 1 0 |a ANIMAL 
690 1 0 |a GENETICS 
690 1 0 |a GENOMICS 
690 1 0 |a LYMPHOMA, T-CELL 
690 1 0 |a METABOLISM 
690 1 0 |a T LYMPHOCYTE 
690 1 0 |a ANIMALS 
690 1 0 |a GENOMICS 
690 1 0 |a HUMANS 
690 1 0 |a LYMPHOMA, T-CELL 
690 1 0 |a RECEPTORS, THYROID HORMONE 
690 1 0 |a T-LYMPHOCYTES 
690 1 0 |a THYROID HORMONES 
700 1 |a Cayrol, F. 
700 1 |a Sterle, H.A. 
700 1 |a Díaz Flaqué, M.C. 
700 1 |a Barreiro Arcos, M.L. 
773 0 |d Academic Press, 2016  |g v. 109  |h pp. 55-63  |p Pharmacol. Res.  |x 10436618  |w (AR-BaUEN)CENRE-6437  |t Pharmacological Research 
856 4 1 |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-84971401663&doi=10.1016%2fj.phrs.2016.02.001&partnerID=40&md5=ddc84671ec44358f57208f42fee58cee  |y Registro en Scopus 
856 4 0 |u https://doi.org/10.1016/j.phrs.2016.02.001  |y DOI 
856 4 0 |u https://hdl.handle.net/20.500.12110/paper_10436618_v109_n_p55_Cremaschi  |y Handle 
856 4 0 |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10436618_v109_n_p55_Cremaschi  |y Registro en la Biblioteca Digital 
961 |a paper_10436618_v109_n_p55_Cremaschi  |b paper  |c PE 
962 |a info:eu-repo/semantics/article  |a info:ar-repo/semantics/artículo  |b info:eu-repo/semantics/publishedVersion 
999 |c 76833 

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