Endocannabinoids participate in placental apoptosis induced by hypoxia inducible factor-1
During pregnancy, apoptosis is a physiological event critical in the remodeling and aging of the placenta. Increasing evidence has pointed towards the relevance of endocannabinoids (ECs) and hypoxia as modulators of trophoblast cell death. However, the relation between these factors is still unknown...
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| Otros Autores: | , , , , , , , , , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
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Springer New York LLC
2016
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 18243caa a22017897a 4500 | ||
|---|---|---|---|
| 001 | PAPER-15668 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204626.0 | ||
| 008 | 190411s2016 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-84982815581 | |
| 024 | 7 | |2 cas |a caspase 3, 169592-56-7; fatty acid amidase, 153301-19-0; lactate dehydrogenase, 9001-60-9; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase, 58319-92-9; protein bcl 2, 219306-68-0; cobalt, 7440-48-4; cobalt chloride, 1332-82-7, 7646-79-9; BCL2 protein, human; CASP3 protein, human; Caspase 3; Cobalt; cobaltous chloride; Endocannabinoids; Hypoxia-Inducible Factor 1, alpha Subunit; Proto-Oncogene Proteins c-bcl-2 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a APOPF | ||
| 100 | 1 | |a Abán, C. | |
| 245 | 1 | 0 | |a Endocannabinoids participate in placental apoptosis induced by hypoxia inducible factor-1 |
| 260 | |b Springer New York LLC |c 2016 | ||
| 270 | 1 | 0 | |m Abán, C.; Laboratorio de Fisiopatología Placentaria, Centro de Estudios Farmacológicos y Botánicos (CEFYBO, CONICET), Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, 16th floor, Argentina; email: cyntia_aban@yahoo.com.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 504 | |a Di Marzo, V., Fontana, A., Cadas, H., Schinelli, S., Cimino, G., Schwartz, J.C., Piomelli, D., Formation and inactivation of endogenous cannabinoid anandamide in central neurons (1994) Nature, 372 (6507), pp. 686-691. , PID: 7990962 | ||
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| 504 | |a Park, B., Gibbons, H.M., Mitchell, M.D., Glass, M., Identification of the CB1 cannabinoid receptor and fatty acid amide hydrolase (FAAH) in the human placenta (2003) Placenta, 24 (10), pp. 990-995. , COI: 1:CAS:528:DC%2BD3sXot1GrtL0%3D, PID: 14580383 | ||
| 504 | |a Marczylo, T.H., Lam, P.M., Amoako, A.A., Konje, J.C., Anandamide levels in human female reproductive tissues: solid-phase extraction and measurement by ultraperformance liquid chromatography tandem mass spectrometry (2010) Anal Biochem, 400 (2), pp. 155-162. , COI: 1:CAS:528:DC%2BC3cXjs1Oht7s%3D, PID: 20026294 | ||
| 504 | |a Aban, C., Leguizamon, G.F., Cella, M., Damiano, A., Franchi, A.M., Farina, M.G., Differential expression of endocannabinoid system in normal and preeclamptic placentas: effects on nitric oxide synthesis (2013) Placenta, 34 (1), pp. 67-74. , COI: 1:CAS:528:DC%2BC3sXhs1emsro%3D, PID: 23122699 | ||
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| 504 | |a Maccarrone, M., Bisogno, T., Valensise, H., Lazzarin, N., Fezza, F., Manna, C., Di Marzo, V., Finazzi-Agro, A., Low fatty acid amide hydrolase and high anandamide levels are associated with failure to achieve an ongoing pregnancy after IVF and embryo transfer (2002) Mol Hum Reprod, 8 (2), pp. 188-195. , COI: 1:CAS:528:DC%2BD38XitFOgsrY%3D, PID: 11818522 | ||
| 504 | |a Chamley, L.W., Bhalla, A., Stone, P.R., Liddell, H., O’Carroll, S., Kearn, C., Glass, M., Nuclear localization of the endocannabinoid metabolizing enzyme fatty acid amide hydrolase (FAAH) in invasive trophoblasts and an association with recurrent miscarriage (2008) Placenta, 29 (11), pp. 970-975. , COI: 1:CAS:528:DC%2BD1cXht12ltL%2FF, PID: 18805581 | ||
| 504 | |a Habayeb, O.M., Taylor, A.H., Finney, M., Evans, M.D., Konje, J.C., Plasma anandamide concentration and pregnancy outcome in women with threatened miscarriage (2008) JAMA, 299 (10), pp. 1135-1136. , COI: 1:CAS:528:DC%2BD1cXjt1aqtbY%3D, PID: 18334688 | ||
| 504 | |a Endsley, M.P., Thill, R., Choudhry, I., Williams, C.L., Kajdacsy-Balla, A., Campbell, W.B., Nithipatikom, K., Expression and function of fatty acid amide hydrolase in prostate cancer (2008) Int J Cancer, 123 (6), pp. 1318-1326. , COI: 1:CAS:528:DC%2BD1cXhtVCltLzI, PID: 18566995 | ||
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| 504 | |a Caniggia, I., Winter, J.L., Adriana and Luisa Castellucci Award lecture 2001 Hypoxia inducible factor-1: oxygen regulation of trophoblast differentiation in normal and pre-eclamptic pregnancies–a review (2002) Placenta, 23, pp. S47-S57. , PID: 11978059 | ||
| 520 | 3 | |a During pregnancy, apoptosis is a physiological event critical in the remodeling and aging of the placenta. Increasing evidence has pointed towards the relevance of endocannabinoids (ECs) and hypoxia as modulators of trophoblast cell death. However, the relation between these factors is still unknown. In this report, we evaluated the participation of ECs in placental apoptosis induced by cobalt chloride (CoCl2), a hypoxia mimicking agent that stabilizes the expression of hypoxia inducible factor-1 alpha (HIF-1α). We found that HIF-1α stabilization decreased FAAH mRNA and protein levels, suggesting an increase in ECs tone. Additionally, CoCl2 incubation and Met-AEA treatment reduced cell viability and increased TUNEL-positive staining in syncytiotrophoblast layer. Immunohistochemical analysis demonstrated Bax and Bcl-2 protein expression in the cytoplasm of syncytiotrophoblast. Finally, HIF-1α stabilization produced an increase in Bax/Bcl-2 ratio, activation of caspase 3 and PARP cleavage. All these changes in apoptotic parameters were reversed with AM251, a CB1 antagonist. These results demonstrate that HIF-1α may induce apoptosis in human placenta via intrinsic pathway by a mechanism that involves activation of CB1 receptor suggesting a role of the ECs in this process. © 2016, Springer Science+Business Media New York. |l eng | |
| 593 | |a Laboratorio de Fisiopatología Placentaria, Centro de Estudios Farmacológicos y Botánicos (CEFYBO, CONICET), Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, 16th floor, Buenos Aires, C1121ABG, Argentina | ||
| 593 | |a Laboratorio de Biología de la Reproducción, Instituto de Fisiología y Biofísica Bernardo Houssay (IFIBIO) - CONICET- Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a Cátedra de Histología y Embriología, Facultad de Ciencias Veterinarias, UBA, Buenos Aires, Argentina | ||
| 593 | |a Centro de Estudios Biomédicos, Biotecnológicos, Ambientales y Diagnóstico – CEBBAD, Universidad Maimónides, Buenos Aires, Argentina | ||
| 593 | |a Departamento de Química Biológica, Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales, Facultad de Ciencias Exactas y Naturales, UBA, Buenos Aires, Argentina | ||
| 593 | |a Laboratorio de Fisiopatología de la Preñez y el Parto, (CEFYBO, CONICET), Facultad de Medicina, UBA, Buenos Aires, Argentina | ||
| 593 | |a Departamento de Obstetricia y Ginecología, Unidad de Embarazo de Alto Riesgo, Centro de Educación Médica e Investigaciones Clínicas (CEMIC), Buenos Aires, Argentina | ||
| 593 | |a Departamento de Ciencias Biológicas, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a APOPTOSIS |
| 690 | 1 | 0 | |a ENDOCANNABINOIDS |
| 690 | 1 | 0 | |a HIPOXIA INDUCIBLE FACTOR 1 |
| 690 | 1 | 0 | |a CANNABINOID 1 RECEPTOR |
| 690 | 1 | 0 | |a CASPASE 3 |
| 690 | 1 | 0 | |a CHORIONIC GONADOTROPIN BETA SUBUNIT |
| 690 | 1 | 0 | |a ENDOCANNABINOID |
| 690 | 1 | 0 | |a FATTY ACID AMIDASE |
| 690 | 1 | 0 | |a HYPOXIA INDUCIBLE FACTOR 1 |
| 690 | 1 | 0 | |a LACTATE DEHYDROGENASE |
| 690 | 1 | 0 | |a MESSENGER RNA |
| 690 | 1 | 0 | |a NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE |
| 690 | 1 | 0 | |a PROTEIN BAX |
| 690 | 1 | 0 | |a PROTEIN BCL 2 |
| 690 | 1 | 0 | |a BCL2 PROTEIN, HUMAN |
| 690 | 1 | 0 | |a CASP3 PROTEIN, HUMAN |
| 690 | 1 | 0 | |a CASPASE 3 |
| 690 | 1 | 0 | |a COBALT |
| 690 | 1 | 0 | |a COBALT CHLORIDE |
| 690 | 1 | 0 | |a ENDOCANNABINOID |
| 690 | 1 | 0 | |a HYPOXIA INDUCIBLE FACTOR 1ALPHA |
| 690 | 1 | 0 | |a PROTEIN BCL 2 |
| 690 | 1 | 0 | |a APOPTOSIS |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CELL VIABILITY |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a ENZYME ACTIVATION |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a HORMONE SYNTHESIS |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a HUMAN TISSUE |
| 690 | 1 | 0 | |a HYPOXIA |
| 690 | 1 | 0 | |a IMMUNOREACTIVITY |
| 690 | 1 | 0 | |a INTRACELLULAR SIGNALING |
| 690 | 1 | 0 | |a PLACENTA TISSUE |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PROTEIN CLEAVAGE |
| 690 | 1 | 0 | |a PROTEIN EXPRESSION |
| 690 | 1 | 0 | |a PROTEIN INDUCTION |
| 690 | 1 | 0 | |a PROTEIN LOCALIZATION |
| 690 | 1 | 0 | |a PROTEIN STABILITY |
| 690 | 1 | 0 | |a SYNCYTIOTROPHOBLAST |
| 690 | 1 | 0 | |a UPREGULATION |
| 690 | 1 | 0 | |a CELL HYPOXIA |
| 690 | 1 | 0 | |a CELL SURVIVAL |
| 690 | 1 | 0 | |a CYTOLOGY |
| 690 | 1 | 0 | |a DRUG EFFECTS |
| 690 | 1 | 0 | |a GENETICS |
| 690 | 1 | 0 | |a METABOLISM |
| 690 | 1 | 0 | |a PREGNANCY |
| 690 | 1 | 0 | |a SIGNAL TRANSDUCTION |
| 690 | 1 | 0 | |a APOPTOSIS |
| 690 | 1 | 0 | |a CASPASE 3 |
| 690 | 1 | 0 | |a CELL HYPOXIA |
| 690 | 1 | 0 | |a CELL SURVIVAL |
| 690 | 1 | 0 | |a COBALT |
| 690 | 1 | 0 | |a ENDOCANNABINOIDS |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a HUMANS |
| 690 | 1 | 0 | |a HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT |
| 690 | 1 | 0 | |a PREGNANCY |
| 690 | 1 | 0 | |a PROTO-ONCOGENE PROTEINS C-BCL-2 |
| 690 | 1 | 0 | |a SIGNAL TRANSDUCTION |
| 650 | 1 | 7 | |2 spines |a PLACENTA |
| 650 | 1 | 7 | |2 spines |a PLACENTA |
| 650 | 1 | 7 | |2 spines |a PLACENTA |
| 650 | 1 | 7 | |2 spines |a PLACENTA |
| 700 | 1 | |a Martinez, N. | |
| 700 | 1 | |a Carou, C. | |
| 700 | 1 | |a Albamonte, I. | |
| 700 | 1 | |a Toro, A. | |
| 700 | 1 | |a Seyahian, A. | |
| 700 | 1 | |a Franchi, A. | |
| 700 | 1 | |a Leguizamón, G. | |
| 700 | 1 | |a Trigubo, D. | |
| 700 | 1 | |a Damiano, A. | |
| 700 | 1 | |a Farina, M. | |
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