Immunization with inactivated antigens of Neospora caninum induces toll-like receptors 3, 7, 8 and 9 in maternal-fetal interface of infected pregnant heifers
Neospora caninum is an obligate parasite and a major cause of abortion in cattle. Pregnancy failures appear to be associated with weak innate defences on the maternal-fetal interface during infection with N. caninum. Herein, we studied the gene expression of Toll-like receptors (TLRs) in pregnant he...
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Elsevier B.V.
2017
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 15304caa a22016937a 4500 | ||
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| 001 | PAPER-14835 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204526.0 | ||
| 008 | 190410s2017 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-85020273480 | |
| 024 | 7 | |2 cas |a gamma interferon, 82115-62-6; toll like receptor 9, 352486-49-8, 390883-32-6; toll like receptor, 409141-78-2; Antigens, Protozoan; Toll-Like Receptors | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a VPARD | ||
| 100 | 1 | |a Marin, M.S. | |
| 245 | 1 | 0 | |a Immunization with inactivated antigens of Neospora caninum induces toll-like receptors 3, 7, 8 and 9 in maternal-fetal interface of infected pregnant heifers |
| 260 | |b Elsevier B.V. |c 2017 | ||
| 270 | 1 | 0 | |m Marin, M.S.; Instituto Nacional de Tecnología Agropecuaria (INTA), Estación Experimental Agropecuaria Balcarce, Ruta 226 Km 73.5, Balcarce, Argentina; email: marin.maia@inta.gob.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 504 | |a Bartley, P.M., Katzer, F., Rocchi, M.S., Maley, S.W., Benavides, J., Nath, M., Pang, Y., Innes, E.A., Development of maternal and foetal immune responses in cattle following experimental challenge with Neospora caninum at day 210 of gestation (2013) Vet. Res., 3, pp. 44-91 | ||
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| 504 | |a Cóceres, V.M., Alonso, A.M., Alomar, M.L., Corvi, M.M., Rabbit antibodies against Toxoplasma Hsp20 are able to reduce parasite invasion and gliding motility in Toxoplasma gondii and parasite invasion in Neospora caninum (2012) Exp. Parasitol., 132, pp. 274-281 | ||
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| 504 | |a Hecker, Y.P., Cóceres, V., Wilkowsky, S.E., Jaramillo Ortiz, J.M., Morrell, E., Verna, A., Ganuza, A., Moore, D.P., A Neospora caninum vaccine using recombinant proteins fails to prevent fetal infection in pregnant cattle after experimental challenge (2014) Vet. Immunol. Immunopathol., 162, pp. 142-153 | ||
| 504 | |a Hecker, Y.P., Cantón, G., Regidor-Cerrillo, J., Chianini, F., Morrell, E., Lischinsky, L., Ortega-Mora, L.M., Moore, D.P., Cell mediated immune responses in the placenta following challenge of vaccinated pregnant heifers with Neospora caninum (2015) Vet. Parasitol., 214, pp. 247-254 | ||
| 504 | |a Hemphill, A., Vonlaufen, N., Naguleswaran, A., Cellular and immunological basis of the host-parasite relationship during infection with Neospora caninum (2006) Parasitology, 133, pp. 261-278 | ||
| 504 | |a Huang, P., Liao, M., Zhang, H., Lee, E.G., Nishikawa, Y., Xuan, X., Dense granule protein NcGRA7, a new marker for the serodiagnosis of Neospora caninum infection in aborting cows (2007) Clin. Vacc. Immunol., 14, pp. 1640-1643 | ||
| 504 | |a Innes, E.A., Wright, S.E., Maley, S., Rae, A., Schock, A., Kirvar, E., Bartley, P., Buxton, D., Protection against vertical transmission in bovine neosporosis (2001) Int. J. Parasitol., 31, pp. 1523-1534 | ||
| 504 | |a Innes, E.A., Andrianarivo, A.G., Björkman, C., Williams, D.J.L., Conrad, P.A., Immune responses to Neospora caninum and prospects for vaccination (2002) Trends Parasitol., 18, pp. 497-504 | ||
| 504 | |a Innes, E.A., The host-parasite relationship in pregnant cattle infected with Neospora caninum (2007) Parasitology, 134, pp. 1903-1910 | ||
| 504 | |a Koga, K., Mor, G., Expression and function of toll-like receptors at the maternal-fetal interface (2008) Reprod. Sci., 15, pp. 231-242 | ||
| 504 | |a Marin, M.S., Quintana, S., Faverín, C., Leunda, M.R., Odeón, A.C., Pérez, S.E., Toll-like receptor activation and expression in bovine alpha-herpesvirus infections (2014) Res. Vet. Sci., 96, pp. 196-203 | ||
| 504 | |a Marin, M.S., Hecker, Y.P., Quintana, S., Pérez, S.E., Leunda, M.R., Cantón, G.J., Cobo, E.R., Odeón, A.C., Toll-like receptors 3, 7 and 8 are upregulated in the placental caruncle and fetal spleen of Neospora caninum experimentally infected cattle (2017) Vet. Parasitol., 236, pp. 58-61 | ||
| 504 | |a McGuire, K., Manuja, A., Russell, G., Springbett, A., Craigmile, S., Nichani, A., Malhotra, D., Glass, E., Quantitative analysis of pro-inflammatory cytokine mRNA expression in Theileria annulata-infected cell lines derived from resistant and susceptible cattle (2004) Vet. Immunol. Immunopathol., 99, pp. 87-98 | ||
| 504 | |a Mineo, T.W., Oliveira, C.J., Gutierrez, F.R., Silva, J.S., Recognition by Toll-like receptor 2 induces antigen-presenting cell activation and Th1 programming during infection by Neospora caninum (2010) Immunol. Cell Biol., 88, pp. 825-833 | ||
| 504 | |a Nishikawa, Y., Zhang, H., Ikehara, Y., Kojima, N., Xuan, X., Yokoyama, N., Immunization with oligomannose-coated liposome-entrapped dense granule protein 7 protects dams and offspring from Neospora caninum infection in mice (2009) Clin. Vacc. Immunol., 16, pp. 792-797 | ||
| 504 | |a Pérez, S., Analysis of Bovine Tonsils and Trigeminal Ganglia Following Infection with Bovine Herpesvirus Type 1 (BHV-1) or a BHV-1 Latency-related Mutant Strain (Doctoral Thesis) (2006), p. 313. , University of Nebrasca-Lincoln USA; Paun, A., Bankoti, R., Joshi, T., Pitha, P.M., Stäger, S., Critical Role of IRF-5 in the Development of T helper 1 responses to Leishmania donovani infection (2011) PLoS Pathog., 7, p. e1001246 | ||
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| 504 | |a Raghupathy, R., Th-1 type immunity is incompatible with successful pregnancy (1997) Immunol. Today, 18, pp. 478-482 | ||
| 504 | |a Reichel, M.P., Ayanegui-Alcérreca, M.A., Gondim, L.F.P., Ellis, J.T., What is theglobal economic impact of Neospora caninum in cattle–the billion dollar question (2013) Int. J. Parasitol., 43, pp. 133-142 | ||
| 504 | |a Ribeiro, D.P., Freitas, M.M., Cardoso, M.R., Pajuaba, A.C., Silva, N.M., Mineo, T.W., Silva, J.S., Silva, D.A., CpG-ODN combined with Neospora caninum lysate, but not with excreted-secreted antigen, enhances protection against infection in mice (2009) Vaccine, 27, pp. 2570-2579 | ||
| 504 | |a Trees, A.J., Williams, D.J.L., Endogenous and exogenous transplacental infection in Neospora caninum and Toxoplasma gondii (2005) Trends Parasitol., 2, pp. 558-561 | ||
| 520 | 3 | |a Neospora caninum is an obligate parasite and a major cause of abortion in cattle. Pregnancy failures appear to be associated with weak innate defences on the maternal-fetal interface during infection with N. caninum. Herein, we studied the gene expression of Toll-like receptors (TLRs) in pregnant heifers immunized with different vaccine formulations against N. caninum before mating and then challenged the heifers with live N. caninum on day 70 of gestation. TLR7 and TLR8 expression was upregulated in the placental caruncle of infected-pregnant heifers previously exposed to live N. caninum as immunogen. However, TLR7 and 8 expression in both placenta and caruncle as well as, TLR3 and 9 expression in caruncle were upregulated when heifers were previously immunized with inactivated soluble whole antigens and recombinant NcSAG1, NcHSP20 and NcGRA7 proteins. All dams were carrying viable fetuses when they were culled at day 104 of gestation. Upregulation of TLR7 and IFNγ expression was detected in fetal spleen when their mothers where previously vaccinated with soluble antigens and recombinant NcSAG1, NcHSP20 and NcGRA7 proteins. These studies demonstrate that soluble or recombinant NcSAG1, NcHSP20 and NcGRA7 antigens induce key TLRs expression at the maternal-fetal interface, probably triggering damaging inflammatory cellular immune responses associated with abortion. Previous infection with N. caninum seems to attenuate the innate immune response at the maternal-fetal interface, which could favour pregnancy maintenance and perpetuation of the disease. This finding represents novel information on how N. caninum vaccination and infection modulate TLRs expression at the placenta and fetal spleen, the possible role in the pregnancy outcomes and transplacental transmission of the protozoa. © 2017 Elsevier B.V. |l eng | |
| 536 | |a Detalles de la financiación: European Environment Agency | ||
| 536 | |a Detalles de la financiación: Instituto Nacional de Tecnología Agropecuaria, PNSA-115053, 2013-0393, PICTs 2008-1421 | ||
| 536 | |a Detalles de la financiación: Faculty of Veterinary Medicine, Cairo University | ||
| 536 | |a Detalles de la financiación: Agencia Nacional de Promoción Científica y Tecnológica | ||
| 536 | |a Detalles de la financiación: This study was financially supported by INTA, Specific Project PNSA-115053 and PICTs 2008-1421 and 2013-0393 (ANPCyT). We especially thank Emily Boucher (University of Calgary, Faculty of Veterinary Medicine) for revising and editing the manuscript and Susana Pereyra (INTA, EEA Balcarce, Argentina) for her contribution and support to the study. | ||
| 593 | |a Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Rivadavia 1917, Buenos Aires, C1033AAJ, Argentina | ||
| 593 | |a Instituto Nacional de Tecnología Agropecuaria (INTA), Estación Experimental Agropecuaria Balcarce, Ruta 226 Km 73.5, Balcarce, Buenos Aires, 7620, Argentina | ||
| 593 | |a Centro de Investigación en Abejas Sociales, Departamento de Biología, Facultad de Ciencias Exactas y Naturales, UNMDP, Funes 3350, Mar del Plata, Buenos Aires, 7600, Argentina | ||
| 593 | |a Centro de Investigación Veterinaria de Tandil (CIVETAN, CONICET-CICPBA), Facultad de Ciencias Veterinarias, UNCPBA, Paraje Arroyo Seco s/n, Tandil, Buenos Aires, 7000, Argentina | ||
| 593 | |a Production Animal Health, Faculty of Veterinary Medicine, University of Calgary, Canada | ||
| 690 | 1 | 0 | |a CATTLE |
| 690 | 1 | 0 | |a MATERNAL-FETAL INTERFACE |
| 690 | 1 | 0 | |a NEOSPORA CANINUM |
| 690 | 1 | 0 | |a TOLL-LIKE RECEPTOR EXPRESSION |
| 690 | 1 | 0 | |a VACCINE |
| 690 | 1 | 0 | |a GAMMA INTERFERON |
| 690 | 1 | 0 | |a HEAT SHOCK PROTEIN 20 |
| 690 | 1 | 0 | |a INACTIVATED VACCINE |
| 690 | 1 | 0 | |a PARASITE ANTIGEN |
| 690 | 1 | 0 | |a PROTEIN GRA7 |
| 690 | 1 | 0 | |a PROTEIN SAG1 |
| 690 | 1 | 0 | |a TOLL LIKE RECEPTOR 3 |
| 690 | 1 | 0 | |a TOLL LIKE RECEPTOR 7 |
| 690 | 1 | 0 | |a TOLL LIKE RECEPTOR 8 |
| 690 | 1 | 0 | |a TOLL LIKE RECEPTOR 9 |
| 690 | 1 | 0 | |a UNCLASSIFIED DRUG |
| 690 | 1 | 0 | |a PARASITE ANTIGEN |
| 690 | 1 | 0 | |a TOLL LIKE RECEPTOR |
| 690 | 1 | 0 | |a ABORTION |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ANIMAL MODEL |
| 690 | 1 | 0 | |a ANIMAL TISSUE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a BREEDING |
| 690 | 1 | 0 | |a CELLULAR IMMUNITY |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a DAM (ANIMAL) |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a FETUS |
| 690 | 1 | 0 | |a HEIFER |
| 690 | 1 | 0 | |a IMMUNITY |
| 690 | 1 | 0 | |a INFLAMMATION |
| 690 | 1 | 0 | |a INNATE IMMUNITY |
| 690 | 1 | 0 | |a MATERNAL FETAL INTERFACE |
| 690 | 1 | 0 | |a NEOSPOROSIS |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PROTEIN EXPRESSION |
| 690 | 1 | 0 | |a SPLEEN |
| 690 | 1 | 0 | |a UPREGULATION |
| 690 | 1 | 0 | |a VACCINATION |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a BOVINE |
| 690 | 1 | 0 | |a CATTLE DISEASE |
| 690 | 1 | 0 | |a COCCIDIOSIS |
| 690 | 1 | 0 | |a IMMUNIZATION |
| 690 | 1 | 0 | |a IMMUNOLOGY |
| 690 | 1 | 0 | |a METABOLISM |
| 690 | 1 | 0 | |a NEOSPORA |
| 690 | 1 | 0 | |a PARASITOLOGY |
| 690 | 1 | 0 | |a PREGNANCY |
| 690 | 1 | 0 | |a PREGNANCY COMPLICATION |
| 690 | 1 | 0 | |a VETERINARY |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a ANTIGENS, PROTOZOAN |
| 690 | 1 | 0 | |a CATTLE |
| 690 | 1 | 0 | |a CATTLE DISEASES |
| 690 | 1 | 0 | |a COCCIDIOSIS |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a IMMUNITY, CELLULAR |
| 690 | 1 | 0 | |a IMMUNIZATION |
| 690 | 1 | 0 | |a NEOSPORA |
| 690 | 1 | 0 | |a PREGNANCY |
| 690 | 1 | 0 | |a PREGNANCY COMPLICATIONS, PARASITIC |
| 690 | 1 | 0 | |a TOLL-LIKE RECEPTORS |
| 650 | 1 | 7 | |2 spines |a PLACENTA |
| 650 | 1 | 7 | |2 spines |a PLACENTA |
| 700 | 1 | |a Hecker, Y.P. | |
| 700 | 1 | |a Quintana, S. | |
| 700 | 1 | |a Pérez, S.E. | |
| 700 | 1 | |a Leunda, M.R. | |
| 700 | 1 | |a Cantón, G.J. | |
| 700 | 1 | |a Cobo, E.R. | |
| 700 | 1 | |a Moore, D.P. | |
| 700 | 1 | |a Odeón, A.C. | |
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