Role of UTX in retinoic acid receptor-mediated gene regulation in leukemia
Human UTX, a member of the Jumonji C family of proteins, associates with mixed-lineage leukemia 3/4 complexes. Stimulation with retinoic acid leads to the recruitment of UTX-containing complexes to HOX genes, which results in demethylation of histone H3 lysine 27 and concomitant methylation of histo...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
American Society for Microbiology
2014
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
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| 003 | AR-BaUEN | ||
| 005 | 20230518204521.0 | ||
| 008 | 190411s2014 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-84906953596 | |
| 024 | 7 | |2 cas |a lysine, 56-87-1, 6899-06-5, 70-54-2; protein, 67254-75-5; retinoic acid, 302-79-4; histone, 9062-68-4 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a MCEBD | ||
| 100 | 1 | |a Rocha-Viegas, L. | |
| 245 | 1 | 0 | |a Role of UTX in retinoic acid receptor-mediated gene regulation in leukemia |
| 260 | |b American Society for Microbiology |c 2014 | ||
| 270 | 1 | 0 | |m Croce, L.D.; Center for Genomic RegulationSpain |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a Human UTX, a member of the Jumonji C family of proteins, associates with mixed-lineage leukemia 3/4 complexes. Stimulation with retinoic acid leads to the recruitment of UTX-containing complexes to HOX genes, which results in demethylation of histone H3 lysine 27 and concomitant methylation of histone H3 lysine 4. Here, we show that UTX interacts with the retinoic acid receptor α (RARα) and that this interaction is essential for proper differentiation of leukemic U937 cells in response to retinoic acid. UTX occupies the promoters of several RAR target genes and regulates their transcriptional output by modulating ASH2L complex recruitment. Overexpression of UTX in promyelocytic NB4 cells results in enhanced cellular differentiation upon retinoic acid treatment. Our results show that UTX is important for RAR-mediated transcription and provide insight into the critical role of cross talk between histone H3 lysine 4 methylation and histone H3 lysine 27 demethylation during cellular differentiation. © 2014, American Society for Microbiology. |l eng | |
| 536 | |a Detalles de la financiación: American Institute for Cancer Research, AICR, 10-0177 | ||
| 593 | |a Center for Genomic Regulation, Barcelona, Spain | ||
| 593 | |a Universitat Pompeu Fabra, Barcelona, Spain | ||
| 593 | |a Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, United States | ||
| 593 | |a Institucio´ Catalana de Recerca i Estudis Avanc¸ats, Barcelona, Spain | ||
| 593 | |a Departamento de Qui´mica Biolo´gica, FCEN, IFIBYNE-CONICET, Universidad de Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a Adolf Butenamdt Institut, Molecular Biology, LMU, Munich, Germany | ||
| 593 | |a Department of Stem Cell Biology and Regenerative Medicine, University of Southern California, Los Angeles, CA, United States | ||
| 690 | 1 | 0 | |a HISTONE H3 |
| 690 | 1 | 0 | |a LYSINE |
| 690 | 1 | 0 | |a PROTEIN |
| 690 | 1 | 0 | |a RETINOIC ACID |
| 690 | 1 | 0 | |a RETINOIC ACID RECEPTOR ALPHA |
| 690 | 1 | 0 | |a UNCLASSIFIED DRUG |
| 690 | 1 | 0 | |a UTX PROTEIN |
| 690 | 1 | 0 | |a ANTINEOPLASTIC AGENT |
| 690 | 1 | 0 | |a ASH2L PROTEIN, HUMAN |
| 690 | 1 | 0 | |a DNA BINDING PROTEIN |
| 690 | 1 | 0 | |a HISTONE |
| 690 | 1 | 0 | |a HISTONE DEMETHYLASE |
| 690 | 1 | 0 | |a NUCLEAR PROTEIN |
| 690 | 1 | 0 | |a RETINOIC ACID |
| 690 | 1 | 0 | |a RETINOIC ACID RECEPTOR |
| 690 | 1 | 0 | |a RETINOIC ACID RECEPTOR ALPHA |
| 690 | 1 | 0 | |a TRANSCRIPTION FACTOR |
| 690 | 1 | 0 | |a UTX PROTEIN, HUMAN |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CELL DIFFERENTIATION |
| 690 | 1 | 0 | |a CELL MATURATION |
| 690 | 1 | 0 | |a CHROMATIN IMMUNOPRECIPITATION |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a FLOW CYTOMETRY |
| 690 | 1 | 0 | |a FLUORESCENCE ACTIVATED CELL SORTING |
| 690 | 1 | 0 | |a GENE ACTIVATION |
| 690 | 1 | 0 | |a GENE CONTROL |
| 690 | 1 | 0 | |a GENE EXPRESSION |
| 690 | 1 | 0 | |a GENE OVEREXPRESSION |
| 690 | 1 | 0 | |a GENE SILENCING |
| 690 | 1 | 0 | |a GENE TARGETING |
| 690 | 1 | 0 | |a GENETIC TRANSCRIPTION |
| 690 | 1 | 0 | |a GENETIC TRANSFECTION |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a HUMAN CELL |
| 690 | 1 | 0 | |a IMMUNOPRECIPITATION |
| 690 | 1 | 0 | |a IN VIVO STUDY |
| 690 | 1 | 0 | |a PROMOTER REGION |
| 690 | 1 | 0 | |a PROMYELOCYTIC LEUKEMIA |
| 690 | 1 | 0 | |a PROTEIN DEPLETION |
| 690 | 1 | 0 | |a PROTEIN INTERACTION |
| 690 | 1 | 0 | |a QUANTITATIVE ANALYSIS |
| 690 | 1 | 0 | |a RETROVIRUS INFECTION |
| 690 | 1 | 0 | |a REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION |
| 690 | 1 | 0 | |a TRANSCRIPTION INITIATION |
| 690 | 1 | 0 | |a U937 CELL LINE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a DRUG EFFECT |
| 690 | 1 | 0 | |a GENE EXPRESSION REGULATION |
| 690 | 1 | 0 | |a GENETICS |
| 690 | 1 | 0 | |a HEK293 CELL LINE |
| 690 | 1 | 0 | |a LEUKEMIA |
| 690 | 1 | 0 | |a METABOLISM |
| 690 | 1 | 0 | |a PATHOLOGY |
| 690 | 1 | 0 | |a TUMOR CELL LINE |
| 690 | 1 | 0 | |a ANTINEOPLASTIC AGENTS |
| 690 | 1 | 0 | |a CELL DIFFERENTIATION |
| 690 | 1 | 0 | |a CELL LINE, TUMOR |
| 690 | 1 | 0 | |a DNA-BINDING PROTEINS |
| 690 | 1 | 0 | |a GENE EXPRESSION REGULATION, NEOPLASTIC |
| 690 | 1 | 0 | |a GENE KNOCKDOWN TECHNIQUES |
| 690 | 1 | 0 | |a HEK293 CELLS |
| 690 | 1 | 0 | |a HISTONE DEMETHYLASES |
| 690 | 1 | 0 | |a HISTONES |
| 690 | 1 | 0 | |a HUMANS |
| 690 | 1 | 0 | |a LEUKEMIA |
| 690 | 1 | 0 | |a NUCLEAR PROTEINS |
| 690 | 1 | 0 | |a PROMOTER REGIONS, GENETIC |
| 690 | 1 | 0 | |a RECEPTORS, RETINOIC ACID |
| 690 | 1 | 0 | |a TRANSCRIPTION FACTORS |
| 690 | 1 | 0 | |a TRETINOIN |
| 690 | 1 | 0 | |a U937 CELLS |
| 700 | 1 | |a Villa, R. | |
| 700 | 1 | |a Gutierrez, A. | |
| 700 | 1 | |a Iriondo, O. | |
| 700 | 1 | |a Shiekhattar, R. | |
| 700 | 1 | |a Croce, L.D. | |
| 773 | 0 | |d American Society for Microbiology, 2014 |g v. 34 |h pp. 3765-3775 |k n. 19 |p Mol. Cell. Biol. |x 02707306 |w (AR-BaUEN)CENRE-878 |t Molecular and Cellular Biology | |
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| 856 | 4 | 0 | |u https://doi.org/10.1128/MCB.00839-14 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_02707306_v34_n19_p3765_RochaViegas |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02707306_v34_n19_p3765_RochaViegas |y Registro en la Biblioteca Digital |
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