Metabolism of [3H]-testosterone by the adranal of the dog: The action of acth

The metabolism of [3H]-testosterone in perfused dog adrenals and in adrenal minces of a normal dog has been studied. Three principal metabolites were studied and identified by isotope dilution and gas-liquid chromatography-mass speetrometry: androstenedione, 11β-hydroxyandrostenedione and 11 β-hydro...

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Autor principal: Wassermann, G.F
Otros Autores: Baldi, A., del Castillo, E., Charreau, E.
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: 1973
Acceso en línea:Registro en Scopus
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024 7 |2 scopus  |a 2-s2.0-0015597533 
024 7 |2 cas  |a androstenedione, 26264-53-9, 63-05-8; corticotropin, 11136-52-0, 9002-60-2, 9061-27-2; testosterone, 58-22-0; tritium, 10028-17-8; Adrenal Cortex Hormones; Androstenedione, 63-05-8; Androstenes; Corticotropin, 9002-60-2; Hydroxysteroids; Ketosteroids; Testosterone, 57-85-2; Tritium, 10028-17-8 
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100 1 |a Wassermann, G.F. 
245 1 0 |a Metabolism of [3H]-testosterone by the adranal of the dog: The action of acth 
260 |c 1973 
270 1 0 |m Wassermann, G.F.; Laboratorio de Esteroides, Instituto de Biología y Medicina Experimental, Obligado 2490 Buenos Aires, Argentina 
506 |2 openaire  |e Política editorial 
504 |a Chang, Mittelman, Dao, (1963) J. biol. Chem., 238, p. 913 
504 |a Bardin, Lipsett, French, (1968) J. clin. Endocr., 28, p. 215 
504 |a Wassennann, Eik-Nes, (1969) Acta Endocr. (Kbh.), 61, p. 33 
504 |a Prunty, (1966) Brit. med. Jl, 2, p. 605 
504 |a Houssay, Magenta, (1924) Rev. Assoc. Med. Arg., 37, p. 389 
504 |a Feldberg, (1941) J. Physiol., 99, p. 104 
504 |a Hartman, Brownell, Liu, (1955) Am. J. Physiol., 180, p. 375 
504 |a Hechter, Macchi, Korman, Frank, Frank, (1955) Am. J. Physiol., 182, p. 29 
504 |a Galli, Wasserman, (1972) Gen. Comp. Endocr., 19, p. 509 
504 |a Zaffaroni, Burton, (1951) J. biol. Chem., 193, p. 749 
504 |a Mattox, Mason, Albert, (1956) J. biol. Chem., 218, p. 359 
504 |a Elliot, Binninghan, Schally, Schonbaum, THE MICRO ESTIMATION OF STEROIDS PRODUCED BY RAT ADRENALS IN VITRO1 (1954) Endocrinology, 55, p. 721 
504 |a Axelrod, Matthijssen, Goldzieher, Pullian, Acta Endocr. (Kbh.) (1965) Acta Endocr. (Kbh.), 49, p. 1 
504 |a Menini, Norymberski, (1965) Biochem. Jl, 95, p. 1 
504 |a Axelrod, Arroyave, (1953) J. Am. Chem. Soc., 75, p. 5729 
504 |a Engel, Dimoline, THE METABOLISM OF 19-HYDROXYANDROST-4-ENE-3, 17-DIONE AND TESTOSTERONE BY HUMAN ADRENAL TISSUE (1963) Journal of Endocrinology, 26, p. 233 
504 |a Rembiesa, Holzbauer, Young, Birmingham, Saffran, (1967) Endocrinology, 81, p. 1278 
504 |a Sharma, Forchielli, Dorfman, (1963) J. biol. Chem., 238, p. 572 
504 |a Skelton, Brownie, Nickerson, Molteni, Gallant, Colby, (1969) Cir-Res, 24, p. 35 
504 |a Griffiths, Click, (1965) Biochem. J., 96, p. 23 
504 |a Kowal, Adrenal cells in tissue culture. III. Effect of adrenocorticotropin and 3',5'-cyclic adenosine monophosphate on 11.beta.-hydroxylase and other steroidogenic enzymes (1969) Biochemistry, 8, p. 1380 
504 |a Laury, Mc Carthy, (1970) Endocrinology, 87, p. 1380 
504 |a Lantos, Birmingham, Traikov, (1967) Acta Physiol Lat. Amer., 17, p. 42 
504 |a Vogt, (1951) J. Physiol., 113, p. 129 
520 3 |a The metabolism of [3H]-testosterone in perfused dog adrenals and in adrenal minces of a normal dog has been studied. Three principal metabolites were studied and identified by isotope dilution and gas-liquid chromatography-mass speetrometry: androstenedione, 11β-hydroxyandrostenedione and 11 β-hydroxytestosterone. The last of these metabolites is obtained in high yield which is further increased after ACTH administration. © 1973.  |l eng 
593 |a Laboratorio de Esteroides, Instituto de Biología y Medicina Experimental, Obligado 2490 Buenos Aires, Argentina 
593 |a Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina 
690 1 0 |a ANDROSTANE DERIVATIVE 
690 1 0 |a ANDROSTENEDIONE 
690 1 0 |a CORTICOSTEROID 
690 1 0 |a CORTICOTROPIN 
690 1 0 |a HYDROXYSTEROID 
690 1 0 |a OXOSTEROID 
690 1 0 |a TESTOSTERONE 
690 1 0 |a TRITIUM 
690 1 0 |a ADRENAL GLAND 
690 1 0 |a ANIMAL 
690 1 0 |a ARTICLE 
690 1 0 |a BIOSYNTHESIS 
690 1 0 |a BLOOD 
690 1 0 |a CRYSTALLIZATION 
690 1 0 |a DOG 
690 1 0 |a DRUG EFFECT 
690 1 0 |a GAS CHROMATOGRAPHY 
690 1 0 |a HYPOPHYSECTOMY 
690 1 0 |a HYPOPHYSIS 
690 1 0 |a IN VITRO STUDY 
690 1 0 |a MALE 
690 1 0 |a MASS SPECTROMETRY 
690 1 0 |a METABOLISM 
690 1 0 |a PERFUSION 
690 1 0 |a PHYSIOLOGY 
690 1 0 |a THIN LAYER CHROMATOGRAPHY 
690 1 0 |a ADRENAL CORTEX HORMONES 
690 1 0 |a ADRENAL GLANDS 
690 1 0 |a ANDROSTENEDIONE 
690 1 0 |a ANDROSTENES 
690 1 0 |a ANIMAL 
690 1 0 |a CHROMATOGRAPHY, GAS 
690 1 0 |a CHROMATOGRAPHY, THIN LAYER 
690 1 0 |a CORTICOTROPIN 
690 1 0 |a CRYSTALLIZATION 
690 1 0 |a DOGS 
690 1 0 |a HYDROXYSTEROIDS 
690 1 0 |a HYPOPHYSECTOMY 
690 1 0 |a IN VITRO 
690 1 0 |a KETOSTEROIDS 
690 1 0 |a MALE 
690 1 0 |a PERFUSION 
690 1 0 |a PITUITARY GLAND 
690 1 0 |a SPECTRUM ANALYSIS, MASS 
690 1 0 |a TESTOSTERONE 
690 1 0 |a TRITIUM 
700 1 |a Baldi, A. 
700 1 |a del Castillo, E. 
700 1 |a Charreau, E. 
773 0 |d 1973  |g v. 4  |h pp. 217-226  |k n. 2  |p J. Steroid Biochem.  |x 00224731  |t Journal of Steroid Biochemistry 
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856 4 0 |u https://doi.org/10.1016/0022-4731(73)90027-7  |y DOI 
856 4 0 |u https://hdl.handle.net/20.500.12110/paper_00224731_v4_n2_p217_Wassermann  |y Handle 
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