Altered Peripheral and Central Inflammatory Responses in a Mouse Model of Autism
Increasing clinical and experimental evidence links immune and inflammatory alterations with the pathogenesis of autism spectrum disorders (ASD). Autistic individuals show signs of neuroinflammation, altered inflammatory responses, and immune abnormalities throughout life. Mice injected subcutaneous...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
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John Wiley and Sons Inc.
2014
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 16704caa a22016577a 4500 | ||
|---|---|---|---|
| 001 | PAPER-14574 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204507.0 | ||
| 008 | 190411s2014 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-84898877564 | |
| 024 | 7 | |2 cas |a corticosterone, 50-22-6; valproic acid, 1069-66-5, 99-66-1; Corticosterone; Cytokines; Inflammation Mediators; Lipopolysaccharides; Valproic Acid | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 100 | 1 | |a Lucchina, L. | |
| 245 | 1 | 0 | |a Altered Peripheral and Central Inflammatory Responses in a Mouse Model of Autism |
| 260 | |b John Wiley and Sons Inc. |c 2014 | ||
| 270 | 1 | 0 | |m Depino, A.M.; Institute for Physiology, Molecular Biology and Neurosciences, CONICET-UBA. Int., Ciudad Universitaria, Guiraldes S/N, Pabellon 2, 2do piso, C1428EHA, Buenos Aires, Argentina; email: adepino@conicet.gov.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a Increasing clinical and experimental evidence links immune and inflammatory alterations with the pathogenesis of autism spectrum disorders (ASD). Autistic individuals show signs of neuroinflammation, altered inflammatory responses, and immune abnormalities throughout life. Mice injected subcutaneously with 600mg/kg valproic acid (VPA600) at gestational day 12.5 show reduced social interaction in adulthood (at 8 weeks of age), and they have been proposed as a mouse model of autism. Here, we show that these adult animals present signs of chronic glial activation in the hippocampus and the cerebellum. Moreover, when they are challenged with a peripheral inflammatory stimulus (intraperitoneal lipopolysaccharides, LPS), VPA600 animals show an exacerbated inflammatory response. Two hours after LPS injection, VPA600 animals secrete more corticosterone to the blood than control mice, and show an increase in the levels of expression of proinflammatory cytokines in the spleen. After LPS challenge, VPA600 mice also show signs of increased neuroinflammation compared with control mice: they have more microglial cells in the hippocampus, and they show higher levels of proinflammatory cytokines in the cerebellum. Our results provide evidence of basal neuroinflammation and an altered inflammatory response in the VPA model of autism. We propose that this model can be used to evaluate the contribution of inflammatory reactivity to autism-related behaviors. These studies will contribute to elucidate the role of the inflammatory alterations observed in ASD individuals. Autism Res 2013, 7: 273-289. © 2013 International Society for Autism Research, Wiley Periodicals, Inc. |l eng | |
| 593 | |a Institute for Physiology, Molecular Biology and Neurosciences, CONICET-UBA, Buenos Aires, Argentina | ||
| 593 | |a Department of Physiology, Molecular and Cellular Biology, FCEyN, University of Buenos Aires, Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a ASTROGLIA |
| 690 | 1 | 0 | |a BEHAVIOR |
| 690 | 1 | 0 | |a CYTOKINES |
| 690 | 1 | 0 | |a HYPOTHALAMUS-PITUITARY-ADRENAL AXIS |
| 690 | 1 | 0 | |a MICROGLIA |
| 690 | 1 | 0 | |a VALPROIC ACID |
| 690 | 1 | 0 | |a CORTICOSTERONE |
| 690 | 1 | 0 | |a CYTOKINE |
| 690 | 1 | 0 | |a LIPOPOLYSACCHARIDE |
| 690 | 1 | 0 | |a VALPROIC ACID |
| 690 | 1 | 0 | |a AUTACOID |
| 690 | 1 | 0 | |a CORTICOSTERONE |
| 690 | 1 | 0 | |a CYTOKINE |
| 690 | 1 | 0 | |a VALPROIC ACID |
| 690 | 1 | 0 | |a ADULT |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ANIMAL MODEL |
| 690 | 1 | 0 | |a ANIMAL TISSUE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a AUTISM |
| 690 | 1 | 0 | |a CEREBELLUM |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a CORTICOSTERONE RELEASE |
| 690 | 1 | 0 | |a ELEVATED PLUS MAZE TEST |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a GLIA |
| 690 | 1 | 0 | |a HIPPOCAMPUS |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MICROGLIAL CELL CULTURE |
| 690 | 1 | 0 | |a MOUSE |
| 690 | 1 | 0 | |a NERVOUS SYSTEM INFLAMMATION |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PATHOGENESIS |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a SOCIAL INTERACTION |
| 690 | 1 | 0 | |a SPLEEN |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a AUTISM |
| 690 | 1 | 0 | |a BIOLOGICAL MODEL |
| 690 | 1 | 0 | |a BLOOD |
| 690 | 1 | 0 | |a CHEMICALLY INDUCED |
| 690 | 1 | 0 | |a IMMUNOLOGY |
| 690 | 1 | 0 | |a PREGNANCY |
| 690 | 1 | 0 | |a PRENATAL EXPOSURE |
| 690 | 1 | 0 | |a REAL TIME POLYMERASE CHAIN REACTION |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a CEREBELLUM |
| 690 | 1 | 0 | |a CHILD DEVELOPMENT DISORDERS, PERVASIVE |
| 690 | 1 | 0 | |a CORTICOSTERONE |
| 690 | 1 | 0 | |a CYTOKINES |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a HIPPOCAMPUS |
| 690 | 1 | 0 | |a INFLAMMATION MEDIATORS |
| 690 | 1 | 0 | |a LIPOPOLYSACCHARIDES |
| 690 | 1 | 0 | |a MICE |
| 690 | 1 | 0 | |a MODELS, GENETIC |
| 690 | 1 | 0 | |a NEUROGLIA |
| 690 | 1 | 0 | |a PREGNANCY |
| 690 | 1 | 0 | |a PRENATAL EXPOSURE DELAYED EFFECTS |
| 690 | 1 | 0 | |a REAL-TIME POLYMERASE CHAIN REACTION |
| 690 | 1 | 0 | |a VALPROIC ACID |
| 700 | 1 | |a Depino, A.M. | |
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