Integration of lectin-glycan recognition systems and immune cell networks in CNS inflammation

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Multiple sclerosis (MS) is a progressive degenerative disorder of the central nervous system (CNS), characterized by inflammation, demyelination and axonal loss. While the majority of MS patients experience relapsing-remitting symptoms followed by a secondary progressive phase, about 10-15% patients...

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Autor principal: Mendez-Huergo, S.P
Otros Autores: Maller, S.M, Farez, M.F, Mariño, K., Correale, J., Rabinovich, G.A
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: Elsevier Ltd 2014
Acceso en línea:Registro en Scopus
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024 7 |2 scopus  |a 2-s2.0-84902076873 
024 7 |2 cas  |a interleukin 13, 148157-34-0; Cytokines; Galectins; Lectins, C-Type; Polysaccharides 
040 |a Scopus  |b spa  |c AR-BaUEN  |d AR-BaUEN 
030 |a CGFRF 
100 1 |a Mendez-Huergo, S.P. 
245 1 0 |a Integration of lectin-glycan recognition systems and immune cell networks in CNS inflammation 
260 |b Elsevier Ltd  |c 2014 
270 1 0 |m Rabinovich, G.A.; Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas (IBYME-CONICET), Laboratorio de Inmunopatología, Vuelta de Obligado 2490, C1428 Ciudad de Buenos Aires, Argentina; email: gabriel.r@ibyme.conicet.gov.ar 
506 |2 openaire  |e Política editorial 
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520 3 |a Multiple sclerosis (MS) is a progressive degenerative disorder of the central nervous system (CNS), characterized by inflammation, demyelination and axonal loss. While the majority of MS patients experience relapsing-remitting symptoms followed by a secondary progressive phase, about 10-15% patients exhibit a primary progressive disease involving continuous progression from its onset. Here we review the role of lectin-glycan recognition systems, including those concerning siglecs, C-type lectins and galectins in the pathogenesis of MS and experimental autoimmune encephalomyelitis. Particularly, we will focus on the role of galectins in the fate of T cells, dendritic cells and CNS cell populations. Understanding the regulatory circuits governed by lectin-glycan interactions and their association with disease-associated cytokine networks will contribute to develop novel therapeutic strategies in MS. © 2014 Elsevier Ltd.  |l eng 
536 |a Detalles de la financiación: American Academy of Neurology 
536 |a Detalles de la financiación: 20020120100276BA 
536 |a Detalles de la financiación: TWAS 
536 |a Detalles de la financiación: PICT 2010-870 
536 |a Detalles de la financiación: Third World Academy of Sciences 
536 |a Detalles de la financiación: John Simon Guggenheim Memorial Foundation 
536 |a Detalles de la financiación: University of Southern California 
536 |a Detalles de la financiación: National Academy of Medicine 
536 |a Detalles de la financiación: National Multiple Sclerosis Society, NMSS-RG 4530A1/1 
536 |a Detalles de la financiación: This work was supported by grants from The National Multiple Sclerosis Society ( NMSS-RG 4530A1/1 ), Argentinean Agency for Promotion of Science and Technology (PICT 2010-870), CONICET , University of Buenos Aires (20020120100276BA) and Sales Foundation (to G.A.R). We thank M.A. Toscano for help in figure preparation. Santiago P. Mendez Huergo is a postgraduate fellow of the National Research Council (CONICET, Argentina). Graduated in Biology from the Faculty of Exact and Natural Sciences of the University of Buenos Aires (2010) with honors and currently a PhD candidate at the Laboratory of Dr. Gabriel Rabinovich. He won a DAAD fellowship and performed international training at the Twincore Institute for Infection Research of the School of Medicine of Hannover (Germany) as a part of a collaborative project with Prof. Tim Sparwasser. He is coauthor of four papers in international peer-reviewed journals. His work was awarded with the “René Barón Foundation Prize in Medical Sciences 2012: Autoimmune Diseases of the Central Nervous System” of the National Academy of Medicine in 2012. Sebastián M. Maller is a master in biology student from the Faculty of Exact and Natural Sciences, University of Buenos Aires. He has been working in a Master Thesis supervised by Dr. Karina Mariño since 2013 and is currently a PhD candidate in Dr. Rabinovich's lab. His study is focused on the biochemical and functional characterization of tandem-repeat galectins in inflammatory diseases. Mauricio Farez is an associate researcher in Dr. Jorge Correale's laboratory at the Institute for Neurological Research Dr. Raúl Carrea (FLENI) in Buenos Aires, Argentina. Mauricio received his M.D. degree with honors in 2006 and continued his training as a research fellow in Dr. Howard Weiner's laboratory at Harvard Medical School followed by a Master of Public Health at Harvard School of Public Health. He has received several awards including the Bruce S. Schoenberg International Award in Neuroepidemiology of the American Academy of Neurology, the Investigator Award by the Allende Foundation and the Young Investigation award of the Argentinean Multiple Sclerosis Society. He is coauthor of 27 papers in international peer reviewed journals and has contributed to several book chapters. Karina Mariño , PhD, is an adjunct researcher at the National Research Council (CONICET, Argentina) and her main area of interest is Glycobiology of inflammatory chronic diseases. In the laboratory of Functional and Molecular Glycomics (IBYME-CONICET) and through the establishment of a glycoanalytical platform, Dr. Mariño is studying the influence of diverse inflammatory factors in the structural alteration of N - and O -glycans in serum and tissue glycoproteins. She has a multidisciplinary profile with cross-discipline training across the Chemistry/Biology interface, with 26 publications in international peer reviewed journals. Her initial training as an Organic Chemist in the University of Buenos Aires, and her postdoctoral positions at the University of Dundee (United Kingdom) and the National Institute for Bioprocessing, Research and Training (Dublin, Ireland) prompted her into the analysis of glycoproteins and the Glyco-biomarker field. Jorge Correale M.D. is the head of Neuroimmunology and Demyelinating Diseases at the Institute for Neurological Research Dr. Raúl Carrea. Research in his group is focused into understanding the role of environmental factors and immunological mechanisms in the development and progression of multiple sclerosis. Likewise, Dr. Correale's group is investigating the immunological factors induced by pregnancy, and assisted reproductive techniques, as well as the role that sexual hormones play under these conditions. He graduated with honors from Buenos Aires University School of Medicine in 1981. Between 1983 and 1988 he completed his Neurology Residency training at the José María Ramos Mejía Hospital in Buenos Aires and was appointed Chief Resident. During 1989 he was visiting physician at the Department of Neuropathology at the same center. Dr. Correale continued his training as fellow in Neuroimmunology at the Karolinska Institute in Stockholm, Sweden between 1989 and 1990. In 1990 he moved to the University of Southern California, receiving a post-graduate fellowship in Neuroimmunology from the National MS Society of New York. In 1993 he was appointed Assistant Professor of Neurology at this University, and in 1995 Assistant Professor of Microbiology and Molecular Immunology. In 1997 Dr. Correale returned to Buenos Aires as Head of Neuroimmunology and Demyelinataing Diseases at the Institute for Neurological Research Dr. Raúl Carrea, position he holds to this day. Between 1999 and 2001 Dr. Correale was Head of the Department of Neurology at the same Institution, and between 1998 and 2010 he was Associate Professor at the Austral University in Buenos Aires. He is member of the Argentine Medical Advisory Board for Multiple Sclerosis and member of the Medical and Scientific Board of the International Federation of Multiple Sclerosis Societies (IFMSS). He is a member of the Editorial Board of several neurological and immunological journals. Likewise, Dr. Correale has served as an ad hoc reviewer for different agencies and Multiple Sclerosis societies. At present he published 120 original and reviews papers in pre-review journals, and is Editor of 4 books related to Neurology, Neuroimmunology, and Multiple Sclerosis. Gabriel A. Rabinovich , PhD, is a principal investigator of the Argentinean National Council Research (CONICET), professor in Immunology of the University of Buenos Aires, vice-director of the Institute of Biology and Experimental Medicine (IBYME) and member of the Argentinean National Academy of Sciences. He heads the Laboratory of Immunopathology at IBYME and the Laboratory of Functional Glycomics at the Faculty of Exact and Natural Sciences of the University of Buenos Aires. Dr. Rabinovich's lab aims to identify different therapeutic targets, based on protein–glycan interactions, to differentially modulate immune-mediated disorders including cancer, autoimmunity and chronic inflammation. Dr. Rabinovich has authored over 170 articles and 30 book chapters, serves as Editor of several journals and received a number of awards including those from the John Simon Guggenheim Foundation (New York), Third World Academy of Science Award in Medical Sciences (TWAS), Baron Foundation (Argentina), Bernardo Houssay (Argentina), Bunge & Born Foundation (Argentina) and Platinum Konex Award (Argentina). 
593 |a Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas (IBYME-CONICET), C1428 Buenos Aires, Argentina 
593 |a Departamento de Neurología, Instituto de Investigaciones Neurológicas Dr. Raúl Carrea, FLENI, C1428 Buenos Aires, Argentina 
593 |a Laboratorio de Glicómica Funcional y Molecular, Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas (IBYME-CONICET), C1428 Buenos Aires, Argentina 
593 |a Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, C1428 Buenos Aires, Argentina 
690 1 0 |a C-TYPE LECTINS 
690 1 0 |a GALECTINS 
690 1 0 |a GLYCANS 
690 1 0 |a MULTIPLE SCLEROSIS 
690 1 0 |a SIGLECS 
690 1 0 |a CYTOTOXIC T LYMPHOCYTE ANTIGEN 4 
690 1 0 |a GALECTIN 
690 1 0 |a INTERLEUKIN 10 
690 1 0 |a INTERLEUKIN 13 
690 1 0 |a INTERLEUKIN 17 
690 1 0 |a INTERLEUKIN 17F 
690 1 0 |a INTERLEUKIN 27 
690 1 0 |a INTERLEUKIN 4 
690 1 0 |a INTERLEUKIN 5 
690 1 0 |a LECTIN 
690 1 0 |a MAJOR HISTOCOMPATIBILITY ANTIGEN 
690 1 0 |a SIALIC ACID BINDING IMMUNOGLOBULIN LIKE LECTIN 
690 1 0 |a SIALOADHESIN 
690 1 0 |a CYTOKINE 
690 1 0 |a GALECTIN 
690 1 0 |a LECTIN 
690 1 0 |a POLYSACCHARIDE 
690 1 0 |a ALLERGIC ENCEPHALOMYELITIS 
690 1 0 |a ASTROCYTE 
690 1 0 |a CD4+ T LYMPHOCYTE 
690 1 0 |a CD8+ T LYMPHOCYTE 
690 1 0 |a CELL DEATH 
690 1 0 |a CELL POPULATION 
690 1 0 |a CYTOKINE PRODUCTION 
690 1 0 |a CYTOKINE RELEASE 
690 1 0 |a DENDRITIC CELL 
690 1 0 |a DISEASE SEVERITY 
690 1 0 |a EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS 
690 1 0 |a GLYCOBIOLOGY 
690 1 0 |a GLYCOSYLATION 
690 1 0 |a HUMAN 
690 1 0 |a IMMUNE RESPONSE 
690 1 0 |a IMMUNOCOMPETENT CELL 
690 1 0 |a IMMUNOPATHOGENESIS 
690 1 0 |a IMMUNOREGULATION 
690 1 0 |a MACROPHAGE 
690 1 0 |a MULTIPLE SCLEROSIS 
690 1 0 |a NONHUMAN 
690 1 0 |a OLIGODENDROGLIA 
690 1 0 |a PHENOTYPE 
690 1 0 |a PRIORITY JOURNAL 
690 1 0 |a PROTEIN EXPRESSION 
690 1 0 |a PROTEIN FUNCTION 
690 1 0 |a PROTEIN PROTEIN INTERACTION 
690 1 0 |a SHORT SURVEY 
690 1 0 |a T LYMPHOCYTE 
690 1 0 |a UPREGULATION 
690 1 0 |a ANIMAL 
690 1 0 |a CENTRAL NERVOUS SYSTEM 
690 1 0 |a IMMUNOLOGY 
690 1 0 |a MULTIPLE SCLEROSIS 
690 1 0 |a PATHOLOGY 
690 1 0 |a ANIMALS 
690 1 0 |a CENTRAL NERVOUS SYSTEM 
690 1 0 |a CYTOKINES 
690 1 0 |a DENDRITIC CELLS 
690 1 0 |a GALECTINS 
690 1 0 |a HUMANS 
690 1 0 |a LECTINS, C-TYPE 
690 1 0 |a MULTIPLE SCLEROSIS 
690 1 0 |a POLYSACCHARIDES 
690 1 0 |a T-LYMPHOCYTES 
700 1 |a Maller, S.M. 
700 1 |a Farez, M.F. 
700 1 |a Mariño, K. 
700 1 |a Correale, J. 
700 1 |a Rabinovich, G.A. 
773 0 |d Elsevier Ltd, 2014  |g v. 25  |h pp. 247-255  |k n. 3  |p Cytokine Growth Factor Rev.  |x 13596101  |w (AR-BaUEN)CENRE-4382  |t Cytokine and Growth Factor Reviews 
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856 4 0 |u https://doi.org/10.1016/j.cytogfr.2014.02.003  |y DOI 
856 4 0 |u https://hdl.handle.net/20.500.12110/paper_13596101_v25_n3_p247_MendezHuergo  |y Handle 
856 4 0 |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13596101_v25_n3_p247_MendezHuergo  |y Registro en la Biblioteca Digital 
961 |a paper_13596101_v25_n3_p247_MendezHuergo  |b paper  |c PE 
962 |a info:eu-repo/semantics/article  |a info:ar-repo/semantics/artículo  |b info:eu-repo/semantics/publishedVersion 
999 |c 75522 

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