Anti-tissue transglutaminase antibody inhibits apoptotic cell clearance by macrophages in pregnant NOD mice
Autoimmunity is a feature of celiac disease (CD) with tissue transglutaminase (tTG) as a major autoantigen. A correlation between gynecological-obstetric disorders in CD patients and the presence of circulating antibodies anti-tTG that inhibited tTG activity was reported. Serum anti-tTG antibodies w...
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Elsevier Ireland Ltd
2014
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| LEADER | 15566caa a22017657a 4500 | ||
|---|---|---|---|
| 001 | PAPER-14546 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204506.0 | ||
| 008 | 190411s2014 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-84900305237 | |
| 024 | 7 | |2 cas |a immunoglobulin G, 97794-27-9; protein glutamine gamma glutamyltransferase, 80146-85-6; Antibodies; Autoantigens; GTP-Binding Proteins; Immunoglobulin G; transglutaminase 2; Transglutaminases | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a JRIMD | ||
| 100 | 1 | |a Sóñora, C. | |
| 245 | 1 | 0 | |a Anti-tissue transglutaminase antibody inhibits apoptotic cell clearance by macrophages in pregnant NOD mice |
| 260 | |b Elsevier Ireland Ltd |c 2014 | ||
| 270 | 1 | 0 | |m Sóñora, C.; Cátedra de Inmunología, Facultad de Ciencias/Facultad de Química, Universidad de la República, Instituto de Higiene, Alfredo Navarro 3051, CP 11600, Montevideo, Uruguay; email: csonora@fmed.edu.uy |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a Autoimmunity is a feature of celiac disease (CD) with tissue transglutaminase (tTG) as a major autoantigen. A correlation between gynecological-obstetric disorders in CD patients and the presence of circulating antibodies anti-tTG that inhibited tTG activity was reported. Serum anti-tTG antibodies were detected in a non-obese diabetic (NOD) mouse model of type I insulin-dependent diabetes mellitus and Sjögren's syndrome, two comorbid states with CD. Since pregnancy complications have been described in NOD mice, we evaluated the ability of anti-tTG antibodies to affect the functions of tTG relevant to the normal course of an early pregnancy like extracellular matrix assembling and apoptotic cell phagocytosis by macrophages. Circulating IgG antibodies against tTG were detected in NOD mice with titers that decreased at early pregnancy; interestingly, the in vitro transamidating activity of tTG was reduced by NOD serum samples. Particularly, anti-tTG antibody inhibited apoptotic cell phagocytosis by peritoneal macrophages from pregnant NOD mice that express the enzyme on surface. Evidence provided support for a role for anti-tTG antibodies through reduced transamidating activity and reduced apoptotic cell clearance by the macrophages of pregnant NOD mice. © 2013 Elsevier Ireland Ltd. |l eng | |
| 536 | |a Detalles de la financiación: Agencia Nacional de Promoción Científica y Tecnológica, UBACyT 2012–2015 20020090200034 | ||
| 536 | |a Detalles de la financiación: Agencia Nacional de Investigación e Innovación | ||
| 536 | |a Detalles de la financiación: We acknowledge Dr. Roberto Meiss and Dr. Verónica Beovide for collaboration in histological analysis and image acquisition. This study was supported by grants to C.P.L. (UBACyT 2011–2014 20020100100505 and PICT 2011-0144 from ANPCyT ), grant to R.R. (UBACyT 2012–2015 20020090200034) and partial support from PEDECIBA (Programa de Desarrollo de las Ciencias Básicas, PNUD), ANII (Agencia Nacional de Investigación e Innovación) and ESCALA program for teachers exchange of AUGM (Asociación de Universidades del Grupo Montevideo). | ||
| 593 | |a Cátedra de Inmunología, Facultad de Ciencias/Facultad de Química, Universidad de la República, Montevideo, Uruguay | ||
| 593 | |a Escuela Universitaria de Tecnología Médica, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay | ||
| 593 | |a Laboratorio de Inmunofarmacología, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, IQUIBICEN-CONICET, Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a ANTI-TISSUE TRANSGLUTAMINASE ANTIBODIES |
| 690 | 1 | 0 | |a CELIAC DISEASE |
| 690 | 1 | 0 | |a NOD MICE |
| 690 | 1 | 0 | |a AUTOANTIBODY |
| 690 | 1 | 0 | |a IMMUNOGLOBULIN A |
| 690 | 1 | 0 | |a IMMUNOGLOBULIN G |
| 690 | 1 | 0 | |a IMMUNOGLOBULIN G ANTIBODY |
| 690 | 1 | 0 | |a PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE |
| 690 | 1 | 0 | |a PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE ANTIBODY |
| 690 | 1 | 0 | |a ANTIBODY |
| 690 | 1 | 0 | |a AUTOANTIGEN |
| 690 | 1 | 0 | |a GUANINE NUCLEOTIDE BINDING PROTEIN |
| 690 | 1 | 0 | |a IMMUNOGLOBULIN G |
| 690 | 1 | 0 | |a PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE |
| 690 | 1 | 0 | |a PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE 2 |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a APOPTOSIS |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CELIAC DISEASE |
| 690 | 1 | 0 | |a CELL PHAGOCYTOSIS |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a ENZYME ACTIVITY |
| 690 | 1 | 0 | |a ENZYME LINKED IMMUNOSORBENT ASSAY |
| 690 | 1 | 0 | |a EXTRACELLULAR MATRIX |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a FIRST TRIMESTER PREGNANCY |
| 690 | 1 | 0 | |a IMMUNOFLUORESCENCE |
| 690 | 1 | 0 | |a IMMUNOHISTOCHEMISTRY |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MOUSE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a NONOBESE DIABETIC MOUSE |
| 690 | 1 | 0 | |a PERITONEUM MACROPHAGE |
| 690 | 1 | 0 | |a PREGNANCY |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PROTEIN EXPRESSION |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a APOPTOSIS |
| 690 | 1 | 0 | |a BAGG ALBINO MOUSE |
| 690 | 1 | 0 | |a BLOOD |
| 690 | 1 | 0 | |a IMMUNOLOGY |
| 690 | 1 | 0 | |a INSULIN DEPENDENT DIABETES MELLITUS |
| 690 | 1 | 0 | |a MACROPHAGE |
| 690 | 1 | 0 | |a PHAGOCYTOSIS |
| 690 | 1 | 0 | |a PREGNANCY |
| 690 | 1 | 0 | |a PREGNANCY OUTCOME |
| 690 | 1 | 0 | |a SJOEGREN SYNDROME |
| 690 | 1 | 0 | |a UTERUS |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a ANTIBODIES |
| 690 | 1 | 0 | |a APOPTOSIS |
| 690 | 1 | 0 | |a AUTOANTIGENS |
| 690 | 1 | 0 | |a CELIAC DISEASE |
| 690 | 1 | 0 | |a DIABETES MELLITUS, TYPE 1 |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a GTP-BINDING PROTEINS |
| 690 | 1 | 0 | |a IMMUNOGLOBULIN G |
| 690 | 1 | 0 | |a MACROPHAGES |
| 690 | 1 | 0 | |a MICE |
| 690 | 1 | 0 | |a MICE, INBRED BALB C |
| 690 | 1 | 0 | |a MICE, INBRED NOD |
| 690 | 1 | 0 | |a PHAGOCYTOSIS |
| 690 | 1 | 0 | |a PREGNANCY |
| 690 | 1 | 0 | |a PREGNANCY OUTCOME |
| 690 | 1 | 0 | |a SJOGREN'S SYNDROME |
| 690 | 1 | 0 | |a TRANSGLUTAMINASES |
| 690 | 1 | 0 | |a UTERUS |
| 700 | 1 | |a Mourglia-Ettlin, G. | |
| 700 | 1 | |a Calo, G. | |
| 700 | 1 | |a Hauk, V. | |
| 700 | 1 | |a Ramhorst, R. | |
| 700 | 1 | |a Hernández, A. | |
| 700 | 1 | |a Leirós, C.P. | |
| 773 | 0 | |d Elsevier Ireland Ltd, 2014 |g v. 103 |h pp. 59-66 |k n. 1 |p J. Reprod. Immunol. |x 01650378 |t Journal of Reproductive Immunology | |
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