β3-Chimaerin, a novel member of the chimaerin Rac-GAP family

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Chimaerins are a family of diacylglycerol- and phorbol ester-regulated GTPase activating proteins (GAPs) for the small G-protein Rac. Extensive evidence indicates that these proteins play important roles in development, axon guidance, metabolism, cell motility, and T cell activation. Four isoforms h...

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Autor principal: Zubeldia-Brenner, L.
Otros Autores: Gutierrez-Uzquiza, A., Barrio-Real, L., Wang, H., Kazanietz, M.G, Leskow, F.C
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: Kluwer Academic Publishers 2014
Acceso en línea:Registro en Scopus
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Biblioteca Central Dr. Luis F. Leloir (FCEN) de Universidad de Buenos Aires
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024 7 |2 scopus  |a 2-s2.0-84897492540 
024 7 |2 Molecular Sequence Numbers  |a GENBANK: ADK47390, NP_004058; 
024 7 |2 cas  |a phorbol 13 acetate 12 myristate, 16561-29-8; chimaerin-beta3 protein, human; Chimerin Proteins; Protein Isoforms; rac GTP-Binding Proteins; Tetradecanoylphorbol Acetate 
040 |a Scopus  |b spa  |c AR-BaUEN  |d AR-BaUEN 
030 |a MLBRB 
100 1 |a Zubeldia-Brenner, L. 
245 1 0 |a β3-Chimaerin, a novel member of the chimaerin Rac-GAP family 
260 |b Kluwer Academic Publishers  |c 2014 
270 1 0 |m Leskow, F.C.; Departamento de Ciencias Básicas, Universidad Nacional de Luján, 6700 Luján Buenos Aires, Argentina; email: federico@fbmc.fcen.uba.ar 
506 |2 openaire  |e Política editorial 
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520 3 |a Chimaerins are a family of diacylglycerol- and phorbol ester-regulated GTPase activating proteins (GAPs) for the small G-protein Rac. Extensive evidence indicates that these proteins play important roles in development, axon guidance, metabolism, cell motility, and T cell activation. Four isoforms have been reported to-date, which are products of CHN1 (α1- and α2-chimaerins) and CHN2 (β1- and β2-chimaerins) genes. Although these gene products are assumed to be generated by alternative splicing, bioinformatics analysis of the CHN2 gene revealed that β1- and β2-chimaerins are the products of alternative transcription start sites (TSSs) in different promoter regions. Furthermore, we found an additional TSS in CHN2 gene that leads to a novel product, which we named β3-chimaerin. Expression profile analysis revealed predominantly low levels for the β3-chimaerin transcript, with higher expression levels in epididymis, plasma blood leucocytes, spleen, thymus, as well as various areas of the brain. In addition to the prototypical SH2, C1, and Rac-GAP domains, β3-chimaerin has a unique N-terminal domain. Studies in cells established that β3-chimaerin has Rac-GAP activity and is responsive to phorbol esters. The enhanced responsiveness of β3-chimaerin for phorbol ester-induced translocation relative to β2-chimaerin suggests differential ligand accessibility to the C1 domain. © 2014 Springer Science+Business Media Dordrecht.  |l eng 
536 |a Detalles de la financiación: National Institutes of Health 
536 |a Detalles de la financiación: 20020090200714, PIP 11220110100573 
536 |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas, R01-CA74197, R01-CA139120 
536 |a Detalles de la financiación: Acknowledgments This work is supported by grants PICT-2008-260 (ANCyP, Argentina), UBACyT 20020090200714 (UBA, Argentina), and PIP 11220110100573 (CONICET, Argentina) to Federico Coluccio Leskow., and Grants R01-CA74197 and R01-CA139120 (NIH) to Marcelo G. Kazanietz. 
593 |a Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, C1428EGA Buenos Aires, Argentina 
593 |a Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6160, United States 
593 |a Departamento de Ciencias Básicas, Universidad Nacional de Luján, 6700 Luján Buenos Aires, Argentina 
690 1 0 |a C1 DOMAIN 
690 1 0 |a CHIMAERIN 
690 1 0 |a CHN2 
690 1 0 |a PHORBOL ESTERS 
690 1 0 |a RAC-GAP 
690 1 0 |a ALPHA1 CHIMAERIN 
690 1 0 |a ALPHA2 CHIMAERIN 
690 1 0 |a BETA1 CHIMAERIN 
690 1 0 |a BETA2 CHIMAERIN 
690 1 0 |a BETA3 CHIMAERIN 
690 1 0 |a CHIMERIN 
690 1 0 |a GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN 
690 1 0 |a ISOPROTEIN 
690 1 0 |a PHORBOL ESTER 
690 1 0 |a UNCLASSIFIED DRUG 
690 1 0 |a CHIMAERIN-BETA3 PROTEIN, HUMAN 
690 1 0 |a CHIMERIN 
690 1 0 |a ISOPROTEIN 
690 1 0 |a PHORBOL 13 ACETATE 12 MYRISTATE 
690 1 0 |a PROTEIN BINDING 
690 1 0 |a RAC PROTEIN 
690 1 0 |a ALTERNATIVE RNA SPLICING 
690 1 0 |a AMINO TERMINAL SEQUENCE 
690 1 0 |a ARTICLE 
690 1 0 |a BIOINFORMATICS 
690 1 0 |a CHN1 GENE 
690 1 0 |a CHN2 GENE 
690 1 0 |a CONTROLLED STUDY 
690 1 0 |a ENZYME ACTIVITY 
690 1 0 |a ENZYME ANALYSIS 
690 1 0 |a EPIDIDYMIS 
690 1 0 |a EXON 
690 1 0 |a GENETIC ANALYSIS 
690 1 0 |a HUMAN 
690 1 0 |a HUMAN CELL 
690 1 0 |a HUMAN TISSUE 
690 1 0 |a LEUKOCYTE 
690 1 0 |a NUCLEOTIDE SEQUENCE 
690 1 0 |a PROMOTER REGION 
690 1 0 |a PROTEIN ANALYSIS 
690 1 0 |a PROTEIN DOMAIN 
690 1 0 |a PROTEIN EXPRESSION 
690 1 0 |a SPLEEN 
690 1 0 |a THYMUS 
690 1 0 |a TISSUE DISTRIBUTION 
690 1 0 |a TRANSCRIPTION INITIATION SITE 
690 1 0 |a AMINO ACID SEQUENCE 
690 1 0 |a ANIMAL 
690 1 0 |a ANTIBODY SPECIFICITY 
690 1 0 |a CELL LINE 
690 1 0 |a CHEMISTRY 
690 1 0 |a CHLOROCEBUS AETHIOPS 
690 1 0 |a COS 1 CELL LINE 
690 1 0 |a DRUG EFFECTS 
690 1 0 |a ENZYME ACTIVATION 
690 1 0 |a GENE EXPRESSION 
690 1 0 |a GENE EXPRESSION PROFILING 
690 1 0 |a GENE EXPRESSION REGULATION 
690 1 0 |a GENE ORDER 
690 1 0 |a GENETICS 
690 1 0 |a METABOLISM 
690 1 0 |a MOLECULAR GENETICS 
690 1 0 |a ALTERNATIVE SPLICING 
690 1 0 |a AMINO ACID SEQUENCE 
690 1 0 |a ANIMALS 
690 1 0 |a BASE SEQUENCE 
690 1 0 |a CELL LINE 
690 1 0 |a CERCOPITHECUS AETHIOPS 
690 1 0 |a CHIMERIN PROTEINS 
690 1 0 |a COS CELLS 
690 1 0 |a ENZYME ACTIVATION 
690 1 0 |a GENE EXPRESSION 
690 1 0 |a GENE EXPRESSION PROFILING 
690 1 0 |a GENE EXPRESSION REGULATION 
690 1 0 |a GENE ORDER 
690 1 0 |a HUMANS 
690 1 0 |a MOLECULAR SEQUENCE DATA 
690 1 0 |a ORGAN SPECIFICITY 
690 1 0 |a PROMOTER REGIONS, GENETIC 
690 1 0 |a PROTEIN BINDING 
690 1 0 |a PROTEIN INTERACTION DOMAINS AND MOTIFS 
690 1 0 |a PROTEIN ISOFORMS 
690 1 0 |a RAC GTP-BINDING PROTEINS 
690 1 0 |a TETRADECANOYLPHORBOL ACETATE 
700 1 |a Gutierrez-Uzquiza, A. 
700 1 |a Barrio-Real, L. 
700 1 |a Wang, H. 
700 1 |a Kazanietz, M.G. 
700 1 |a Leskow, F.C. 
773 0 |d Kluwer Academic Publishers, 2014  |g v. 41  |h pp. 2067-2076  |k n. 4  |p Mol. Biol. Rep.  |x 03014851  |w (AR-BaUEN)CENRE-3497  |t Molecular Biology Reports 
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