Local VEGF inhibition prevents ovarian alterations associated with ovarian hyperstimulation syndrome
The relationship between human chorionic gonadotropin and ovarian hyperstimulation syndrome (OHSS) is partially mediated by vascular endothelial growth factor A (VEGF). The aim of this study was to investigate the effects of VEGF inhibition on the development of corpora lutea (CL) and cystic structu...
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| Otros Autores: | , , , , , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
Elsevier Ltd
2014
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 24333caa a22021257a 4500 | ||
|---|---|---|---|
| 001 | PAPER-14391 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204454.0 | ||
| 008 | 190411s2014 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-84906856877 | |
| 024 | 7 | |2 cas |a aflibercept, 845771-78-0, 862111-32-8; estradiol, 50-28-2; occludin, 176304-61-3; progesterone, 57-83-0; vasculotropin A, 489395-96-2; vasculotropin receptor, 301253-48-5; vasculotropin, 127464-60-2; aflibercept; Angiogenesis Inhibitors; Claudin-5; Cldn5 protein, rat; Estradiol; Flt1 protein, rat; Occludin; Ocln protein, rat; Progesterone; Receptors, Vascular Endothelial Growth Factor; Recombinant Fusion Proteins; Vascular Endothelial Growth Factor A; vascular endothelial growth factor A, rat; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a JSBBE | ||
| 100 | 1 | |a Scotti, L. | |
| 245 | 1 | 0 | |a Local VEGF inhibition prevents ovarian alterations associated with ovarian hyperstimulation syndrome |
| 260 | |b Elsevier Ltd |c 2014 | ||
| 270 | 1 | 0 | |m Parborell, F.; Instituto de Biología y Medicina Experimental (IByME), CONICET, Buenos Aires, Argentina; email: fparborell@gmail.com |
| 506 | |2 openaire |e Política editorial | ||
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| 504 | |a Herr, D., Fraser, H.M., Konrad, R., Holzheu, I., Kreienberg, R., Wulff, C., Human chorionic gonadotropin controls luteal vascular permeability via vascular endothelial growth factor by down-regulation of a cascade of adhesion proteins (2013) Fertil. Steril., 99, pp. 1749-1758 | ||
| 520 | 3 | |a The relationship between human chorionic gonadotropin and ovarian hyperstimulation syndrome (OHSS) is partially mediated by vascular endothelial growth factor A (VEGF). The aim of this study was to investigate the effects of VEGF inhibition on the development of corpora lutea (CL) and cystic structures, steroidogenesis, apoptosis, cell proliferation, endothelial cell area, VEGF receptors (KDR and Flt-1), claudin-5 and occludin levels in ovaries from an OHSS rat model. The VEGF inhibitor used (VEGF receptor-1 (FLT-1)/Fc chimera, TRAP) decreased the concentrations of progesterone and estradiol as well as the percentage of CL and cystic structures in OHSS rats, and increased apoptosis in CL. Endothelial cell area in CL and KDR expression and its phosphorylation were increased, whereas claudin-5 and occludin levels were decreased in the OHSS compared to the control TRAP reversed these parameters. Our findings indicate that VEGF inhibition prevents the early onset of OHSS and decreases its severity in rats. © 2014 Elsevier Ltd. |l eng | |
| 536 | |a Detalles de la financiación: Agencia Nacional de Promoción Científica y Tecnológica, PICT 2008-747 | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas, PIP 5471 | ||
| 536 | |a Detalles de la financiación: We thank Diana Bas (Instituto de Biología y Medicina Experimental, IByME-CONICET, Argentina) for her technical assistance. This study was supported by ANPCyT (PICT 2008-747 ), CONICET (PIP 5471 ) and Roemmers Foundation , Argentina. | ||
| 593 | |a Instituto de Biología y Medicina Experimental (IByME), CONICET, Buenos Aires, Argentina | ||
| 593 | |a Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a ANGIOGENESIS |
| 690 | 1 | 0 | |a APOPTOSIS |
| 690 | 1 | 0 | |a CELL PROLIFERATION |
| 690 | 1 | 0 | |a OHSS |
| 690 | 1 | 0 | |a OVARY |
| 690 | 1 | 0 | |a VEGF |
| 690 | 1 | 0 | |a AFLIBERCEPT |
| 690 | 1 | 0 | |a ANGIOGENESIS INHIBITOR |
| 690 | 1 | 0 | |a CLAUDIN 5 |
| 690 | 1 | 0 | |a CLDN5 PROTEIN, RAT |
| 690 | 1 | 0 | |a ESTRADIOL |
| 690 | 1 | 0 | |a FLT1 PROTEIN, RAT |
| 690 | 1 | 0 | |a HYBRID PROTEIN |
| 690 | 1 | 0 | |a OCCLUDIN |
| 690 | 1 | 0 | |a OCLN PROTEIN, RAT |
| 690 | 1 | 0 | |a PROGESTERONE |
| 690 | 1 | 0 | |a VASCULAR ENDOTHELIAL GROWTH FACTOR A, RAT |
| 690 | 1 | 0 | |a VASCULOTROPIN A |
| 690 | 1 | 0 | |a VASCULOTROPIN RECEPTOR |
| 690 | 1 | 0 | |a VASCULOTROPIN RECEPTOR 1 |
| 690 | 1 | 0 | |a VASCULOTROPIN RECEPTOR 2 |
| 690 | 1 | 0 | |a CLAUDIN 5 |
| 690 | 1 | 0 | |a ESTRADIOL |
| 690 | 1 | 0 | |a OCCLUDIN |
| 690 | 1 | 0 | |a PROGESTERONE |
| 690 | 1 | 0 | |a UNCLASSIFIED DRUG |
| 690 | 1 | 0 | |a VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 1 FC CHIMERA |
| 690 | 1 | 0 | |a VASCULOTROPIN |
| 690 | 1 | 0 | |a VASCULOTROPIN INHIBITOR |
| 690 | 1 | 0 | |a VASCULOTROPIN RECEPTOR 1 |
| 690 | 1 | 0 | |a VASCULOTROPIN RECEPTOR 2 |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a ANTAGONISTS AND INHIBITORS |
| 690 | 1 | 0 | |a APOPTOSIS |
| 690 | 1 | 0 | |a BLOOD |
| 690 | 1 | 0 | |a CELL PROLIFERATION |
| 690 | 1 | 0 | |a DRUG EFFECTS |
| 690 | 1 | 0 | |a ENDOTHELIUM CELL |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a METABOLISM |
| 690 | 1 | 0 | |a OVARY |
| 690 | 1 | 0 | |a OVARY HYPERSTIMULATION |
| 690 | 1 | 0 | |a PATHOLOGY |
| 690 | 1 | 0 | |a SPRAGUE DAWLEY RAT |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ANIMAL MODEL |
| 690 | 1 | 0 | |a ANIMAL TISSUE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a CORPUS LUTEUM |
| 690 | 1 | 0 | |a ESTRADIOL BLOOD LEVEL |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a OVARY HYPERSTIMULATION |
| 690 | 1 | 0 | |a PROGESTERONE BLOOD LEVEL |
| 690 | 1 | 0 | |a PROTEIN EXPRESSION |
| 690 | 1 | 0 | |a PROTEIN PHOSPHORYLATION |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a STEROIDOGENESIS |
| 690 | 1 | 0 | |a ANGIOGENESIS INHIBITORS |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a APOPTOSIS |
| 690 | 1 | 0 | |a CELL PROLIFERATION |
| 690 | 1 | 0 | |a CLAUDIN-5 |
| 690 | 1 | 0 | |a ENDOTHELIAL CELLS |
| 690 | 1 | 0 | |a ESTRADIOL |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a OCCLUDIN |
| 690 | 1 | 0 | |a OVARIAN HYPERSTIMULATION SYNDROME |
| 690 | 1 | 0 | |a OVARY |
| 690 | 1 | 0 | |a PROGESTERONE |
| 690 | 1 | 0 | |a RATS, SPRAGUE-DAWLEY |
| 690 | 1 | 0 | |a RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR |
| 690 | 1 | 0 | |a RECOMBINANT FUSION PROTEINS |
| 690 | 1 | 0 | |a VASCULAR ENDOTHELIAL GROWTH FACTOR A |
| 690 | 1 | 0 | |a VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1 |
| 690 | 1 | 0 | |a VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2 |
| 700 | 1 | |a Abramovich, D. | |
| 700 | 1 | |a Pascuali, N. | |
| 700 | 1 | |a Irusta, G. | |
| 700 | 1 | |a Meresman, G. | |
| 700 | 1 | |a Tesone, M. | |
| 700 | 1 | |a Parborell, F. | |
| 773 | 0 | |d Elsevier Ltd, 2014 |g v. 144 |h pp. 392-401 |k n. PART B |p J. Steroid Biochem. Mol. Biol. |x 09600760 |w (AR-BaUEN)CENRE-5799 |t Journal of Steroid Biochemistry and Molecular Biology | |
| 856 | 4 | 1 | |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-84906856877&doi=10.1016%2fj.jsbmb.2014.08.013&partnerID=40&md5=6bde86673814442a6b61d370c3d572f2 |y Registro en Scopus |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.jsbmb.2014.08.013 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_09600760_v144_nPARTB_p392_Scotti |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09600760_v144_nPARTB_p392_Scotti |y Registro en la Biblioteca Digital |
| 961 | |a paper_09600760_v144_nPARTB_p392_Scotti |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 999 | |c 75344 | ||