Effects of airborne particulate matter on alternative pre-mRNA splicing in colon cancer cells
Alternative pre-mRNA splicing plays key roles in determining tissue- and species-specific cell differentiation as well as in the onset of hereditary disease and cancer, being controlled by multiple post- and co-transcriptional regulatory mechanisms. We report here that airborne particulate matter, r...
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| Otros Autores: | , , , , , , , , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
Academic Press Inc.
2015
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 15077caa a22016577a 4500 | ||
|---|---|---|---|
| 001 | PAPER-13381 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204342.0 | ||
| 008 | 190411s2015 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-84926472509 | |
| 024 | 7 | |2 cas |a Bone Morphogenetic Protein 4; DNA Primers; Particulate Matter; RNA Precursors; RNA, Messenger | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a ENVRA | ||
| 100 | 1 | |a Buggiano, V. | |
| 245 | 1 | 0 | |a Effects of airborne particulate matter on alternative pre-mRNA splicing in colon cancer cells |
| 260 | |b Academic Press Inc. |c 2015 | ||
| 270 | 1 | 0 | |m Muñoz, M.J.; Laboratorio de Fisiología y Biología Molecular, Departamento de Fisiología, Biología Molecular y Celular, IFIBYNE-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón 2, Argentina |
| 506 | |2 openaire |e Política editorial | ||
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| 504 | |a Muñoz, M.J., Perez Santangelo, M.S., Paronetto, M.P., de la Mata, M., Pelisch, F., Boireau, S., Glover-Cutter, K., Kornblihtt, A.R., DNA damage regulates alternative splicing through inhibition of RNA polymerase II elongation (2009) Cell, 137, pp. 708-720 | ||
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| 520 | 3 | |a Alternative pre-mRNA splicing plays key roles in determining tissue- and species-specific cell differentiation as well as in the onset of hereditary disease and cancer, being controlled by multiple post- and co-transcriptional regulatory mechanisms. We report here that airborne particulate matter, resulting from industrial pollution, inhibits expression and specifically affects alternative splicing at the 5' untranslated region of the mRNA encoding the bone morphogenetic protein BMP4 in human colon cells in culture. These effects are consistent with a previously reported role for BMP4 in preventing colon cancer development, suggesting that ingestion of particulate matter could contribute to the onset of colon cell proliferation. We also show that the underlying mechanism might involve changes in transcriptional elongation. This is the first study to demonstrate that particulate matter causes non-pleiotropic changes in alternative splicing. © 2015 Elsevier Inc. |l eng | |
| 536 | |a Detalles de la financiación: Agencia Nacional de Promoción Científica y Tecnológica | ||
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires | ||
| 536 | |a Detalles de la financiación: King Abdulaziz University | ||
| 536 | |a Detalles de la financiación: Department of Earth and Environmental Sciences, Open University, 017MET02ARG 02 | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: The research was supported by Grants to A.R.K. from the Agencia Nacional de Promoción de Ciencia y Tecnología of Argentina , the University of Buenos Aires, the Department of Environmental Sciences ( Grant 017MET02ARG 02 ), Faculty of Meteorology, Environment and Arid Land Agriculture, King Abdulaziz University of Saudi Arabia. A.R.K. and M.J.M. are career investigators from the Consejo Nacional de Investigaciones Científicas y Técnicas of Argentina (CONICET). A.R.K. is a Senior International Research Scholar of the Howard Hughes Medical Institute. | ||
| 593 | |a Laboratorio de Fisiología y Biología Molecular, Departamento de Fisiología, Biología Molecular y Celular, IFIBYNE-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón 2, Buenos Aires, C1428EHA, Argentina | ||
| 593 | |a Instituto de Ciencias Básicas y Medicina Experimental, Hospital Italiano de Buenos Aires, Argentina | ||
| 593 | |a Department of Environmental Sciences, Faculty of Meteorology, Environment and Arid Land Agriculture, King Abdulaziz University, Jeddah, Saudi Arabia | ||
| 593 | |a Center of Excellence in Environmental Studies, King Abdulaziz University, Jeddah, Saudi Arabia | ||
| 593 | |a Max F. Perutz Laboratories, Medical University of Vienna, Vienna, A-1030, Austria | ||
| 593 | |a European Molecular Biology Laboratory, Meyerhofstrasse1, Heidelberg, 69117, Germany | ||
| 690 | 1 | 0 | |a AIR POLLUTION |
| 690 | 1 | 0 | |a ALTERNATIVE SPLICING |
| 690 | 1 | 0 | |a BONE MORPHOGENETIC PROTEIN |
| 690 | 1 | 0 | |a COLON CANCER CELLS |
| 690 | 1 | 0 | |a PARTICULATE MATTER |
| 690 | 1 | 0 | |a BONE MORPHOGENETIC PROTEIN |
| 690 | 1 | 0 | |a MESSENGER RNA |
| 690 | 1 | 0 | |a BONE MORPHOGENETIC PROTEIN 4 |
| 690 | 1 | 0 | |a MESSENGER RNA |
| 690 | 1 | 0 | |a PARTICULATE MATTER |
| 690 | 1 | 0 | |a PRIMER DNA |
| 690 | 1 | 0 | |a RNA PRECURSOR |
| 690 | 1 | 0 | |a ATMOSPHERIC POLLUTION |
| 690 | 1 | 0 | |a CANCER |
| 690 | 1 | 0 | |a CYTOLOGY |
| 690 | 1 | 0 | |a INDUSTRIAL WASTE |
| 690 | 1 | 0 | |a PARTICULATE MATTER |
| 690 | 1 | 0 | |a PROTEIN |
| 690 | 1 | 0 | |a RNA |
| 690 | 1 | 0 | |a 5' UNTRANSLATED REGION |
| 690 | 1 | 0 | |a AIR POLLUTION |
| 690 | 1 | 0 | |a ALTERNATIVE RNA SPLICING |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CANCER CELL CULTURE |
| 690 | 1 | 0 | |a CANCER CELL LINE |
| 690 | 1 | 0 | |a CELL PROLIFERATION |
| 690 | 1 | 0 | |a COLON CANCER |
| 690 | 1 | 0 | |a COLON CARCINOGENESIS |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a HUMAN CELL |
| 690 | 1 | 0 | |a PARTICULATE MATTER |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a TRANSCRIPTION ELONGATION |
| 690 | 1 | 0 | |a ALTERNATIVE RNA SPLICING |
| 690 | 1 | 0 | |a COLON TUMOR |
| 690 | 1 | 0 | |a DRUG EFFECTS |
| 690 | 1 | 0 | |a GENETICS |
| 690 | 1 | 0 | |a HEK293 CELL LINE |
| 690 | 1 | 0 | |a NUCLEOTIDE SEQUENCE |
| 690 | 1 | 0 | |a PARTICULATE MATTER |
| 690 | 1 | 0 | |a PATHOLOGY |
| 690 | 1 | 0 | |a PHARMACOLOGY |
| 690 | 1 | 0 | |a REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION |
| 690 | 1 | 0 | |a TUMOR CELL LINE |
| 690 | 1 | 0 | |a ALTERNATIVE SPLICING |
| 690 | 1 | 0 | |a BASE SEQUENCE |
| 690 | 1 | 0 | |a BONE MORPHOGENETIC PROTEIN 4 |
| 690 | 1 | 0 | |a CELL LINE, TUMOR |
| 690 | 1 | 0 | |a COLONIC NEOPLASMS |
| 690 | 1 | 0 | |a DNA PRIMERS |
| 690 | 1 | 0 | |a HEK293 CELLS |
| 690 | 1 | 0 | |a HUMANS |
| 690 | 1 | 0 | |a PARTICULATE MATTER |
| 690 | 1 | 0 | |a REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION |
| 690 | 1 | 0 | |a RNA PRECURSORS |
| 690 | 1 | 0 | |a RNA, MESSENGER |
| 700 | 1 | |a Petrillo, E. | |
| 700 | 1 | |a Alló, M. | |
| 700 | 1 | |a Lafaille, C. | |
| 700 | 1 | |a Redal, M.A. | |
| 700 | 1 | |a Alghamdi, M.A. | |
| 700 | 1 | |a Khoder, M.I. | |
| 700 | 1 | |a Shamy, M. | |
| 700 | 1 | |a Muñoz, M.J. | |
| 700 | 1 | |a Kornblihtt, A.R. | |
| 773 | 0 | |d Academic Press Inc., 2015 |g v. 140 |h pp. 185-190 |p Environ. Res. |x 00139351 |w (AR-BaUEN)CENRE-4630 |t Environmental Research | |
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| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_00139351_v140_n_p185_Buggiano |y Handle |
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