Androgen receptors in the diabetic rat
Male rats rendered diabetic by IV streptozotocin (65mg/kg body weight) were treated with exogenous insulin or testosterone. Charcoal-coated dextran and polyacrylemide gel electrophoresis techniques were employed in studying the characteristics of androgen (R1881) binding to prostate cytosol protein....
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| Otros Autores: | , , , , , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
Springer-Verlag
1980
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| Materias: | |
| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 09863caa a22011897a 4500 | ||
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| 001 | PAPER-1337 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203041.0 | ||
| 008 | 190411s1980 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0018889422 | |
| 024 | 7 | |2 cas |a androstanolone, 521-18-6; insulin, 9004-10-8; metribolone, 965-93-5; streptozocin, 18883-66-4; testosterone, 58-22-0; Estrenes; Insulin, Long-Acting; Metribolone, 965-93-5; Receptors, Androgen; Receptors, Steroid; Testosterone, 58-22-0; Testosterone Congeners | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a DBTGA | ||
| 100 | 1 | |a Tesone, M. | |
| 245 | 1 | 0 | |a Androgen receptors in the diabetic rat |
| 260 | |b Springer-Verlag |c 1980 | ||
| 270 | 1 | 0 | |m Tesone, M.; Laboratorio de Esteroides, Instituto de Biología y Medicina ExperimentalArgentina |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Foglia, V.G., Borghelli, R.F., Chieri, R.A., Fernández Collazo, E.L., Spindler, L., Wesely, O., Sexual disturbances in the diabetic rat (1963) Diabetes, 12, pp. 231-237 | ||
| 504 | |a Schöffling, K., Federlin, K., Ditschuneit, H., Pfeiffer, E.F., Disorders of sexual function in male diabetics (1963) Diabetes, 12, pp. 519-527 | ||
| 504 | |a Schöffling, K., Federlin, K., Schmitt, W., Pfeiffer, E.F., Histometric investigations on the testicular tissue of rats with alloxan diabetes and Chinese hamsters with spontaneous diabetes (1967) Acta Endocrinol (Kbh), 54, pp. 335-346 | ||
| 504 | |a Foglia, V.G., El peso de los órganos de la rata diabética (1945) Rev Soc Argent Biol, 21, pp. 45-53 | ||
| 504 | |a Foglia, V.G., Rosner, J.M., de Cattaneo, Lema, B.E., Sexual disturbances in the male diabetic rat (1969) Horm Metab Res, 1, pp. 72-77 | ||
| 504 | |a de Cattaneo, Irusta, O., Foglia, V.G., Acción de las gonadotrofinas e insulina sobre la producción de testosterona por testículos de ratas diabéticas (1973) Rev Soc Argent Biol, 49, pp. 56-60 | ||
| 504 | |a Tesone, M., Valle, L.B.S., Foglia, V.G., Charreau, E.H., Endocrine function of the testis in streptozotocin diabetic rats (1976) Acta Physiol Lat, 26, pp. 387-394 | ||
| 504 | |a Angervall, L., Hesselsjo, R., Nilsson, S., Tisell, L.E., Action of testosterone on ventral prostate, dorsolateral prostate, coagulating glands and seminal vesicles of castrated alloxan-diabetic rats (1967) Diabetologia, 3, pp. 395-401 | ||
| 504 | |a Oksanen, A., Tuohimaa, P., Testicular lesions of streptozotocin diabetic rats (1975) Horm Res, 6, pp. 138-144 | ||
| 504 | |a Calame, S.S., Lostroh, A.J., Effect of insulin and lack of effect of testosterone on the protein of ventral prostates from castrated mice maintained as organ cultures (1964) Endocrinology, 75, pp. 451-454 | ||
| 504 | |a Lostroh, A.J., Effect of testosterone and insulin in vitro on maintenance and repair of the secretory epithelium of the mouse prostate (1971) Endocrinology, 88, pp. 500-503 | ||
| 504 | |a Sufrin, G., Prutkin, L., Experimental diabetes and the response of the sex accessory organs of the castrated male rat to testosterone propionate. Biochemical and electron microscopic observations (1974) Invest Urol, 11, pp. 361-369 | ||
| 504 | |a Bonne, C., Raynaud, J.P., Assay of androgen binding sites by exchange with methyltrienolone (R1881) (1976) Steroids, 27, pp. 497-507 | ||
| 504 | |a Katzenellenbogen, J.A., Johnson, H.S., Carlson, K.E., Studies on the uterine cytoplasmic estrogen binding protein. Thermal stability and ligand dissociation rate. An assay of empty and filled sites by exchange (1973) Biochemistry, 12, pp. 4092-4099 | ||
| 504 | |a Tindall, D.J., Hansson, V., McLean, W.S., Ritzen, E.M., Nayfeh, S.N., French, F.S., Androgen-binding proteins in rat epididymis: properties of a cytoplasmic receptor for androgen similar to the androgen receptor in ventral prostate and different from androgen-binding protein (ABP) (1975) Mol Cell Endocrinol, 3, pp. 83-101 | ||
| 504 | |a Lowry, O.H., Rosebrough, N.J., Farr, A.L., Randall, R.J., Protein measurement with the folin phenol reagent (1951) J Biol Chem, 193, pp. 265-275 | ||
| 504 | |a Scatchard, G., The attraction of proteins for small molecules and ions (1949) Annals of the New York Academy of Sciences, 51, pp. 660-672 | ||
| 504 | |a Hunt, E.L., Bailey, D.W., The effects of alloxan diabetes on the reproductive system of young male rats (1961) Acta Endocrinol (Kbh), 38, pp. 432-440 | ||
| 504 | |a Howland, B.E., Zebrowski, E.J., Serum and pituitary gonadotropin levels in alloxan-diabetic rats (1974) Horm Metab Res, 6, pp. 121-124 | ||
| 504 | |a Jung, L., Baulieu, E.E., Neo-nuclear androgen receptor in rat ventral prostate (1971) Biochimie, 53, pp. 807-817 | ||
| 504 | |a Mainwaring, W.I.P., Mangan, F.R., A study of the androgen receptors in a variety of androgen-sensitive tissues (1973) J Endocrinol, 59, pp. 121-139 | ||
| 504 | |a Sullivan, J.N., Strott, C.A., Evidence for an androgen-independent mechanism regulating the levels of receptor in target tissue (1973) J Biol Chem, 248, pp. 3202-3208 | ||
| 504 | |a Bruchovsky, N., Cravan, S., Prostatic involution: effect on androgen receptors and intracellular androgen transport (1974) Biochem Biophys Res Commun, 62, pp. 837-843 | ||
| 504 | |a Blondeau, J.P., Corpéchot, C., Goascogne, C., Baulieu, E.E., Robel, P., Androgen receptors in the rat ventral prostate and their hormonal control (1975) Vitam Horm, 33, pp. 319-345 | ||
| 504 | |a Howland, B.E., Zebrowsky, E.J., Some effects of experimentally-induced diabetes on pituitary-testicular relationships in rats (1976) Horm Metab Res, 8, pp. 465-469 | ||
| 504 | |a Charreau, E.H., Calvo, J.C., Tesone, M., Valle, L.B.S., Barañao, J.L., Insulin regulation of Leydig cell luteinizing hormone receptors (1978) J Biol Chem, 253, pp. 2504-2506 | ||
| 520 | 3 | |a Male rats rendered diabetic by IV streptozotocin (65mg/kg body weight) were treated with exogenous insulin or testosterone. Charcoal-coated dextran and polyacrylemide gel electrophoresis techniques were employed in studying the characteristics of androgen (R1881) binding to prostate cytosol protein. In comparison with normal (N) rats, the replacement therapy of diabetic (D) animals with insulin (D+I) or testosterone (D+T) was able to restore epididymal weight (N = 0.40 ±0.04 g; D = 0.18 ± 0.02 g; D+I = 0.42 ± 0.05 g; D+T = 0.40 ± 0.06 g) and total prostate weight (N = 0.24 ± 0.02 g; D = 0.15 ± 0.02 g; D+I = 0.24 ± 0.05 g; D+T = 0.35 ± 0.06 g). Testicular endogenous content of testosterone was restored after insulin treatment (N = 154 ± 13 ng/testis; D = 41 ± 5 ng/testis; D+I = 142 ± 9 ng/testis), and significant improvements of serum testosterone levels were also achieved (N = 540 ± 64 ng/100 ml; D = 238 ± 37 ng/100 ml; D+I = 358 ± 18 ng/100 ml). Prostate cytosol of streptozotocin-diabetic rats had strongly lowered capacity for 3H-R1881 binding compared with controls (94 and 12 fmol/mg protein, respectively). Testosterone treatment produced a 3.3-fold improvement of this lowered value, whereas the increment seen with insulin was less (1.5-fold). It is emphasized that some of the improvements caused by insulin replacement therapy in diabetic animals are due to the partial restoration of testosterone secretion. Thus, the combined actions of insulin and testosterone (instead of insulin alone) seem to be of major importance in the maintenance and regulation of accessory sex glands function. © 1980 Springer-Verlag. |l eng | |
| 593 | |a Laboratorio de Esteroides, Instituto de Biología y Medicina Experimental, Argentina | ||
| 593 | |a Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a ANDROGEN RECEPTORS |
| 690 | 1 | 0 | |a CYTOSOL BINDING SITES |
| 690 | 1 | 0 | |a R1881 |
| 690 | 1 | 0 | |a RAT PROSTATE |
| 690 | 1 | 0 | |a STREPTOZOTOCIN-DIABETES |
| 690 | 1 | 0 | |a ANDROGEN RECEPTOR |
| 690 | 1 | 0 | |a ANDROSTANOLONE |
| 690 | 1 | 0 | |a ANDROSTANOLONE H 3 |
| 690 | 1 | 0 | |a DRUG RECEPTOR |
| 690 | 1 | 0 | |a INSULIN |
| 690 | 1 | 0 | |a METHYLTRIENOLONE H 3 |
| 690 | 1 | 0 | |a METRIBOLONE |
| 690 | 1 | 0 | |a RADIOISOTOPE |
| 690 | 1 | 0 | |a STREPTOZOCIN |
| 690 | 1 | 0 | |a TESTOSTERONE |
| 690 | 1 | 0 | |a UNCLASSIFIED DRUG |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a DIABETES MELLITUS |
| 690 | 1 | 0 | |a ENDOCRINE SYSTEM |
| 690 | 1 | 0 | |a MALE GENITAL SYSTEM |
| 690 | 1 | 0 | |a PROSTATE |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a BODY WEIGHT |
| 690 | 1 | 0 | |a CYTOSOL |
| 690 | 1 | 0 | |a DIABETES MELLITUS, EXPERIMENTAL |
| 690 | 1 | 0 | |a EPIDIDYMIS |
| 690 | 1 | 0 | |a ESTRENES |
| 690 | 1 | 0 | |a INSULIN, LONG-ACTING |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a METRIBOLONE |
| 690 | 1 | 0 | |a ORGAN SIZE |
| 690 | 1 | 0 | |a PROSTATE |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a RECEPTORS, ANDROGEN |
| 690 | 1 | 0 | |a RECEPTORS, STEROID |
| 690 | 1 | 0 | |a TESTIS |
| 690 | 1 | 0 | |a TESTOSTERONE |
| 690 | 1 | 0 | |a TESTOSTERONE CONGENERS |
| 653 | 0 | 0 | |a r 1881 |
| 700 | 1 | |a Oliveira-Filho, R.M. | |
| 700 | 1 | |a Biella de Souza Valle, L. | |
| 700 | 1 | |a Calvo, J.C. | |
| 700 | 1 | |a Barañao, J.L.S. | |
| 700 | 1 | |a Foglia, V.G. | |
| 700 | 1 | |a Charreau, E.H. | |
| 773 | 0 | |d Springer-Verlag, 1980 |g v. 18 |h pp. 385-390 |k n. 5 |p Diabetologia |x 0012186X |t Diabetologia | |
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| 856 | 4 | 0 | |u https://doi.org/10.1007/BF00276819 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_0012186X_v18_n5_p385_Tesone |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0012186X_v18_n5_p385_Tesone |y Registro en la Biblioteca Digital |
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| 999 | |c 62290 | ||