Thermosensation and the TRPV channel in Rhodnius prolixus
The thermal sense of triatomine bugs, vectors of Chagas disease, is unique among insects. Not only do these bugs exhibit the highest sensitivity to heat known in any animal up to date, but they can also perceive the infrared radiation emitted by the body of their warm-blooded hosts. The sensory basi...
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2015
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| LEADER | 22128caa a22020897a 4500 | ||
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| 001 | PAPER-13219 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204330.0 | ||
| 008 | 190411s2015 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-84939435397 | |
| 024 | 7 | |2 cas |a capsaicin, 404-86-4; capsazepine, 138977-28-3; Capsaicin; capsazepine; TRPV Cation Channels | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a JIPHA | ||
| 100 | 1 | |a Zermoglio, P.F. | |
| 245 | 1 | 0 | |a Thermosensation and the TRPV channel in Rhodnius prolixus |
| 260 | |b Elsevier Ltd |c 2015 | ||
| 270 | 1 | 0 | |m Lazzari, C.R.; Institut de Recherche sur la Biologie de l'Insecte, Faculté des Sciences et Techniques, Avenue Monge, Parc Grandmont, France |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a The thermal sense of triatomine bugs, vectors of Chagas disease, is unique among insects. Not only do these bugs exhibit the highest sensitivity to heat known in any animal up to date, but they can also perceive the infrared radiation emitted by the body of their warm-blooded hosts. The sensory basis of this capacity has just started to be unravelled. To shed additional light on our understanding of thermosensation, we initiated an analysis of the genetic basis of the thermal sense in Rhodnius prolixus. We tested the hypothesis that a TRPV (transient receptor potential vanilloid) channel receptor is involved in the evaluation of heat in this species. Two different approaches were adopted. Initially, we analysed the expression of a TRPV candidate for this function, i.e., RproIav, in different tissues. Subsequently, we tested the effects of capsaicin and capsazepine, two molecules known to interact with mammal TRPV1, using three different behavioural protocols for evaluating thermal responses: (1) proboscis extension response (PER), (2) thermopreference in a temperature gradient and (3) spatial learning in an operant conditioning context. Bioinformatic analyses confirmed that the characteristic features typical of the TRPV channel subfamily are found in the RproIav protein sequence. Molecular analysis showed that RproIav is expressed in R. prolixus, not only in the antennae, but also in other body structures bearing sensory organs. Behavioural experiments consistently revealed that capsaicin treated insects are less responsive to heat stimuli and prefer lower temperatures than non-treated insects, and that they fail to orient in space. Conversely, capsazepine induces the opposite behaviours. The latter data suggest that triatomine thermoreception is based on the activation of a TRP channel, with a similar mechanism to that described for mammal TRPV1. The expression of RproIav in diverse sensory structures suggests that this receptor channel is potentially involved in bug thermoreception. This constitutes solid evidence that thermosensation could be based on the activation of TRP receptors that are expressed in different tissues in R. prolixus. Whether RproIav channel is a potential target for the compounds tested and whether it mediates the observed effects on behaviour still deserves to be confirmed by further research. © 2015 Elsevier Ltd. |l eng | |
| 536 | |a Detalles de la financiación: Conselho Nacional de Desenvolvimento Científico e Tecnológico, CNPq | ||
| 536 | |a Detalles de la financiación: Fondation Fyssen | ||
| 536 | |a Detalles de la financiación: European Commission | ||
| 536 | |a Detalles de la financiación: Seventh Framework Programme | ||
| 536 | |a Detalles de la financiación: Centre National de la Recherche Scientifique | ||
| 536 | |a Detalles de la financiación: This work received support from the program Science without borders (400091/2013-5, CNPq, Brazil), the CNRS and the University of Tours (France) and Marie Curie Actions IRSES N° 319015 (IBIAL, FP7, European Union). Authors whish to thank the reviewers for their helpful criticism and valuable comments. The work of JEC was possible thanks to a post-doctoral fellowship from Fyssen Foundation (France). | ||
| 593 | |a Institut de Recherche sur la Biologie de l'Insecte, UMR 7261 CNRS, Université François Rabelais de Tours, France | ||
| 593 | |a Centro de Pesquisas René Rachou, FIOCRUZ, Belo Horizonte, Brazil | ||
| 593 | |a Departamento de Ecología, Genética y Evolución, Instituto IEGEBA (CONICET-UBA), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a CAPSAICIN |
| 690 | 1 | 0 | |a CAPSAZEPINE |
| 690 | 1 | 0 | |a CHAGAS DISEASE VECTORS |
| 690 | 1 | 0 | |a THERMAL SENSE |
| 690 | 1 | 0 | |a TRPV |
| 690 | 1 | 0 | |a DATA SET |
| 690 | 1 | 0 | |a DISEASE VECTOR |
| 690 | 1 | 0 | |a HEAT BALANCE |
| 690 | 1 | 0 | |a INFRARED RADIATION |
| 690 | 1 | 0 | |a INSECT |
| 690 | 1 | 0 | |a LOW TEMPERATURE |
| 690 | 1 | 0 | |a ORGANIC COMPOUND |
| 690 | 1 | 0 | |a PARASITIC DISEASE |
| 690 | 1 | 0 | |a PHYSIOLOGICAL RESPONSE |
| 690 | 1 | 0 | |a PROTEIN |
| 690 | 1 | 0 | |a TEMPERATURE EFFECT |
| 690 | 1 | 0 | |a ANIMALIA |
| 690 | 1 | 0 | |a HEXAPODA |
| 690 | 1 | 0 | |a MAMMALIA |
| 690 | 1 | 0 | |a RHODNIUS PROLIXUS |
| 690 | 1 | 0 | |a CAPSAICIN |
| 690 | 1 | 0 | |a CAPSAZEPINE |
| 690 | 1 | 0 | |a VANILLOID RECEPTOR |
| 690 | 1 | 0 | |a AMINO ACID SEQUENCE |
| 690 | 1 | 0 | |a ANALOGS AND DERIVATIVES |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a ANIMAL BEHAVIOR |
| 690 | 1 | 0 | |a CHAGAS DISEASE |
| 690 | 1 | 0 | |a DISEASE CARRIER |
| 690 | 1 | 0 | |a DRUG EFFECTS |
| 690 | 1 | 0 | |a FEEDING BEHAVIOR |
| 690 | 1 | 0 | |a GENE EXPRESSION |
| 690 | 1 | 0 | |a GENETICS |
| 690 | 1 | 0 | |a HEAT |
| 690 | 1 | 0 | |a INSTRUMENTAL CONDITIONING |
| 690 | 1 | 0 | |a METABOLISM |
| 690 | 1 | 0 | |a MOLECULAR GENETICS |
| 690 | 1 | 0 | |a PHYSIOLOGY |
| 690 | 1 | 0 | |a RHODNIUS |
| 690 | 1 | 0 | |a SPATIAL LEARNING |
| 690 | 1 | 0 | |a TEMPERATURE |
| 690 | 1 | 0 | |a TEMPERATURE SENSE |
| 690 | 1 | 0 | |a AMINO ACID SEQUENCE |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a BEHAVIOR, ANIMAL |
| 690 | 1 | 0 | |a CAPSAICIN |
| 690 | 1 | 0 | |a CHAGAS DISEASE |
| 690 | 1 | 0 | |a CONDITIONING, OPERANT |
| 690 | 1 | 0 | |a FEEDING BEHAVIOR |
| 690 | 1 | 0 | |a GENE EXPRESSION |
| 690 | 1 | 0 | |a HOT TEMPERATURE |
| 690 | 1 | 0 | |a INSECT VECTORS |
| 690 | 1 | 0 | |a MOLECULAR SEQUENCE DATA |
| 690 | 1 | 0 | |a RHODNIUS |
| 690 | 1 | 0 | |a SPATIAL LEARNING |
| 690 | 1 | 0 | |a TEMPERATURE |
| 690 | 1 | 0 | |a THERMOSENSING |
| 690 | 1 | 0 | |a TRPV CATION CHANNELS |
| 700 | 1 | |a Latorre-Estivalis, J.M. | |
| 700 | 1 | |a Crespo, J.E. | |
| 700 | 1 | |a Lorenzo, M.G. | |
| 700 | 1 | |a Lazzari, C.R. | |
| 773 | 0 | |d Elsevier Ltd, 2015 |g v. 81 |h pp. 145-156 |p J. Insect Physiol. |x 00221910 |w (AR-BaUEN)CENRE-668 |t Journal of Insect Physiology | |
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| 856 | 4 | 0 | |u https://doi.org/10.1016/j.jinsphys.2015.07.014 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_00221910_v81_n_p145_Zermoglio |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00221910_v81_n_p145_Zermoglio |y Registro en la Biblioteca Digital |
| 961 | |a paper_00221910_v81_n_p145_Zermoglio |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 963 | |a VARI | ||
| 999 | |c 74172 | ||